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21. 发明申请

US20100099093A1 Biomarkers for the Identification Monitoring and Treatment of Head and Neck Cancer 审中-公开
标题翻译：用于头颈部癌症鉴别监测和治疗的生物标志物
公开(公告)号：US20100099093A1
公开(公告)日：2010-04-22
申请号：US12466291
申请日：2009-05-14
申请人： David Weaver , XioaZhe Wang , Kam Marie Sprott
发明人： David Weaver , XioaZhe Wang , Kam Marie Sprott
IPC分类号： C12Q1/68
CPC分类号： G01N33/57407 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N2800/52
摘要： This present invention compositions and methods of treating cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound.
摘要翻译：本发明的治疗癌症的组合物和方法以及获取/监测癌细胞对治疗化合物的反应性的方法。

22. 发明申请

US20070239495A1 Application Risk and Control Assessment Tool 有权
标题翻译：应用风险与控制评估工具
公开(公告)号：US20070239495A1
公开(公告)日：2007-10-11
申请号：US11279301
申请日：2006-04-11
申请人： Frank Osborn , Jacob Firestone , David Weaver , Peter Murphy
发明人： Frank Osborn , Jacob Firestone , David Weaver , Peter Murphy
IPC分类号： G06F17/50
CPC分类号： G06Q10/00 , G06Q10/0635 , G06Q10/0639
摘要： A tool to assess risks associated with software applications, and controls implemented to mitigate these risks, includes a first software component configured to gather information about the risks and controls, and a second software component configured to display the gathered information. The first software component includes a self-assessment tool which is invoked by a user to enter information reflective of risk levels over a number of risk categories. These risk levels are used to calculate a risk score associated with a particular application. The user also enters information as to whether or not a number of specific control attributes have been implemented, and this information is used to calculate a control score. This process may be repeated for each of several software applications. The second software component allows one to selectively display various subsets, or even the entire population, of the collected information by invoking various combinations of parametric filters on the compiled information.
摘要翻译：评估与软件应用程序相关的风险的工具，以及为减轻这些风险而实施的控制措施，包括配置为收集风险和控制信息的第一个软件组件，以及配置为显示收集的信息的第二个软件组件。第一个软件组件包括一个自评估工具，由用户调用以输入反映多个风险类别的风险级别的信息。这些风险水平用于计算与特定应用相关联的风险评分。用户还输入关于是否已经实现了多个特定控制属性的信息，并且该信息用于计算控制分数。对于几个软件应用中的每一个可以重复该过程。第二软件组件允许通过调用编译信息上的参数滤波器的各种组合来选择性地显示收集的信息的各种子集，或甚至整个群体。

23. 发明申请

US20130330362A1 HUMANIZED ANTI-EGFR ANTIBODY L4-H3 AND CODING GENE THEREOF 有权
标题翻译：人类抗EGFR抗体L4-H3及其编码基因
公开(公告)号：US20130330362A1
公开(公告)日：2013-12-12
申请号：US13982173
申请日：2011-03-25
申请人： Yanwen Jin , David Weaver , Michael Rynkiewicz , Cheng Cao
发明人： Yanwen Jin , David Weaver , Michael Rynkiewicz , Cheng Cao
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , C07K16/2863 , C07K2317/24 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： A humanized anti-EGFR antibody L4-H3 and gene encoding the antibody are disclosed. The antibody is composed of a heavy chain and a light chain. The amino acid sequence of the heavy chain variable region is shown as positions 1-145 of SEQ ID NO: 3, the heavy chain constant region is the heavy chain constant region of the human antibody IgG1, and the amino acid sequence of the light chain is shown as SEQ ID NO: 1.
摘要翻译：公开了人源化抗EGFR抗体L4-H3和编码抗体的基因。抗体由重链和轻链组成。重链可变区的氨基酸序列显示为SEQ ID NO：3的位置1-145，重链恒定区是人抗体IgG1的重链恒定区，轻链的氨基酸序列如SEQ ID NO：1所示。

24. 发明申请

US20120321643A1 ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODIES AND USES THEREOF 有权
标题翻译：抗生殖生长因子受体抗体及其用途
公开(公告)号：US20120321643A1
公开(公告)日：2012-12-20
申请号：US13509235
申请日：2009-12-30
申请人： David Weaver , Michael Rynkiewicz , Cheng Cao , Yanwen Jin
发明人： David Weaver , Michael Rynkiewicz , Cheng Cao , Yanwen Jin
IPC分类号： C07K16/28 , C12N15/63 , C12N1/21 , C12N5/10 , C09K3/00 , C12P19/34 , A61K39/395 , A61K31/711 , A61P35/00 , C12N15/13 , C12P21/02
CPC分类号： C07K16/2863 , C07K2317/24 , C07K2317/92
摘要： The present invention discloses humanized anti-epidermal growth factor receptor antibodies, which have favorable binding activity (the binding affinity being 6.13×10−10 mol/L) and are able to inhibit the growth and migration of tumor cells. The present invention also discloses the preparation methods and uses of the antibodies
摘要翻译：本发明公开了具有良好结合活性（结合亲和力为6.13×10 -10 mol / L）的人源化抗表皮生长因子受体抗体，能够抑制肿瘤细胞的生长和迁移。本发明还公开了抗体的制备方法和用途

25. 发明申请

US20120216011A1 APPARATUS AND METHOD OF SINGLE-INSTRUCTION, MULTIPLE-DATA VECTOR OPERATION MASKING 审中-公开
标题翻译：单指令的方法和方法，多数据向量操作的掩蔽
公开(公告)号：US20120216011A1
公开(公告)日：2012-08-23
申请号：US13030515
申请日：2011-02-18
申请人： Darryl Gove , David Weaver
发明人： Darryl Gove , David Weaver
IPC分类号： G06F15/76 , G06F9/30
CPC分类号： G06F15/8053
摘要： An apparatus, method, and medium for performing a vector operation on portions of one or more source vector registers. A vector unit performs an operation on the source vector registers and only stores results in the target vector register for elements which are selected by the vector operation mask. The vector operation mask can be read by the vector unit or loaded into the vector unit for each instruction cycle. The vector operation mask allows the vector unit to be used with partially filled source vector registers and eliminates the need for scalar operations to be performed on vector data.
摘要翻译：一种用于对一个或多个源向量寄存器的部分执行向量操作的装置，方法和介质。向量单元对源向量寄存器执行操作，并将结果存储在由向量操作掩码选择的元素的目标向量寄存器中。向量操作掩码可以由向量单元读取，或者在每个指令周期内加载到向量单元中。向量操作掩码允许矢量单元与部分填充的源向量寄存器一起使用，并且不需要对向量数据执行标量运算。

26. 发明申请

US20090239229A1 DNA Repair Proteins Associated With Triple Negative Breast Cancers and Methods of Use Thereof 审中-公开
标题翻译：与三重阴性乳腺癌相关的DNA修复蛋白及其使用方法
公开(公告)号：US20090239229A1
公开(公告)日：2009-09-24
申请号：US12405028
申请日：2009-03-16
申请人： David Weaver , Kam Marie Sprott , XioaZhe Wang
发明人： David Weaver , Kam Marie Sprott , XioaZhe Wang
IPC分类号： C12Q1/68 , C12Q1/02 , C12Q1/48 , G01N33/573
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/158 , G01N2800/50 , G01N2800/52 , G01N2800/54 , G01N2800/56
摘要： The present invention provides methods of detecting triple negative breast cancer recurrence using biomarkers.
摘要翻译：本发明提供使用生物标志物检测三阴性乳腺癌复发的方法。

27. 发明申请

US20080177423A1 Automatic energy management and energy consumption reduction, especially in commercial and multi-building systems 有权
标题翻译：自动能源管理和能源消耗降低，特别是在商业和多建筑系统中
公开(公告)号：US20080177423A1
公开(公告)日：2008-07-24
申请号：US11889513
申请日：2007-08-14
申请人： Peter J. Brickfield , Dirk Mahling , Mark Noyes , David Weaver
发明人： Peter J. Brickfield , Dirk Mahling , Mark Noyes , David Weaver
IPC分类号： G05D11/00
CPC分类号： H02J3/14 , H02J3/008 , H02J2003/003 , H02J2003/007 , Y02B70/3225 , Y02E40/76 , Y02E60/76 , Y02P80/11 , Y04S10/54 , Y04S10/545 , Y04S20/222 , Y04S20/224 , Y04S40/22 , Y04S50/10 , Y10T307/461
摘要： Automatic energy management is provided, in even the most complex multi-building system. The necessity of a human operator for managing energy in a complex, multi-building system is reduced and even eliminated. Computer-based monitoring and computer-based recognition of adverse energy events (such as the approach of a new energy peak) is highly advantageous in energy management. Immediate automatic querying of energy users within a system of buildings for energy curtailment possibilities is provided. Such immediate, automatic querying may be answered by the energy users through artificial intelligence and/or neural network technology provided to or programmed into the energy users, and the queried energy users may respond in real-time. Those real-time computerized responses with energy curtailment possibilities may be received automatically by a data processing facility, and processed in real-time. Advantageously, the responses from queried energy users with energy curtailment possibilities may be automatically processed into a round-robin curtailment rotation which may be implemented by a computer-based control system. Thus, impact on occupants is minimized, and energy use and energy cost may be beneficially reduced in an intelligent, real-time manner. The invention also provides for early-recognition of impending adverse energy events, optimal response to a particular energy situation, real-time analysis of energy-related data, etc.
摘要翻译：即使是最复杂的多建筑系统，也提供自动能源管理。在复杂的多层建筑系统中，人力资源管理能源管理的必要性被减少甚至消除。基于计算机的监控和基于计算机的不利能源事件识别（如新能源峰值的方法）在能源管理方面是非常有利的。提供了建筑物系统内能源使用者的即时自动查询能力削减的可能性。这种即时的自动查询可以由能量用户通过提供给或编程到能量用户中的人工智能和/或神经网络技术来回答，并且查询的能量用户可以实时地进行响应。这些具有能量削减可能性的实时计算机化响应可以由数据处理设备自动接收并被实时处理。有利地，来自具有能量削减可能性的查询能量用户的响应可以被自动处理成可以由基于计算机的控制系统实现的循环削减旋转。因此，对居民的影响最小化，能够以智能，实时的方式有利地减少能源消耗和能源成本。本发明还提供即将到来的不利能量事件的早期识别，对特定能量情况的最佳响应，能量相关数据的实时分析等。

28. 发明申请

US20050143317A1 Compounds and methods for treatment of thrombosis 有权
标题翻译：用于治疗血栓形成的化合物和方法
公开(公告)号：US20050143317A1
公开(公告)日：2005-06-30
申请号：US10817248
申请日：2004-04-02
申请人： Sherin Abdel-Meguid , Robert Babine , Hongfeng Deng , Lei Jin , Jian Lin , Scott Magee , Harold Meyers , Pramod Pandey , Michael Rynkiewicz , David Weaver , Zihong Gho , Thomas Bannister
发明人： Sherin Abdel-Meguid , Robert Babine , Hongfeng Deng , Lei Jin , Jian Lin , Scott Magee , Harold Meyers , Pramod Pandey , Michael Rynkiewicz , David Weaver , Zihong Gho , Thomas Bannister
IPC分类号： A61K20060101 , A61K38/00 , A61K38/04 , C07K2/00 , C07K5/04 , C07K5/06 , C07K5/065 , C07K5/078
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/06034 , C07K5/06139 , C07K5/06191
摘要： The present invention provides compounds that inhibit Factor XIa and methods of preventing or treating undesired thrombosis by administering a compound of the invention to a mammal. The invention also provides three-dimensional structures of Factor XIa and methods for designing or selecting additional Factor XIa inhibitors using these structures.
摘要翻译：本发明提供了通过向哺乳动物施用本发明的化合物来抑制因子XIa的化合物和预防或治疗不期望的血栓形成的方法。本发明还提供了因子XIa的三维结构以及使用这些结构设计或选择另外的因子XIa抑制剂的方法。

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