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21. 发明申请

US20180279981A1 Mobile C-Arm System 审中-公开
公开(公告)号：US20180279981A1
公开(公告)日：2018-10-04
申请号：US15764558
申请日：2016-08-09
申请人： Jens Fehre , Alexander Gemmel , Andreas Limmer , Ralf Nanke
发明人： Jens Fehre , Alexander Gemmel , Andreas Limmer , Ralf Nanke
IPC分类号： A61B6/00
摘要： The invention relates to a mobile C-arm system (C1), at least comprising at least three wheels, at least two wheels each having an electric motor, wherein the electric motor has a stator (S) and a rotor (R), the stator (S) being connected to a wheel suspension (T) of the wheel and the rotor (R) being surrounded peripherally by a running wheel (L).

22. 发明授权

US09521994B2 System and method for image guided prostate cancer needle biopsy 有权
标题翻译：图像引导前列腺癌针刺活检的系统和方法
公开(公告)号：US09521994B2
公开(公告)日：2016-12-20
申请号：US12774798
申请日：2010-05-06
申请人： Ali Kamen , Wolfgang Wein , Parmeshwar Khurd , Mamadou Diallo , Ralf Nanke , Jens Fehre , Berthold Kiefer , Martin Requardt , Clifford Weiss
发明人： Ali Kamen , Wolfgang Wein , Parmeshwar Khurd , Mamadou Diallo , Ralf Nanke , Jens Fehre , Berthold Kiefer , Martin Requardt , Clifford Weiss
IPC分类号： A61B8/00 , G06K9/00 , A61B10/02 , A61B17/00 , A61B17/34 , A61B18/00
CPC分类号： A61B10/0241 , A61B8/4254 , A61B34/20 , A61B2017/00274 , A61B2017/00694 , A61B2017/3413 , A61B2018/00547 , A61B2034/105 , A61B2034/107 , A61B2034/2051 , A61B2090/367 , A61B2090/374 , A61B2090/378
摘要： In a method for image guided prostate cancer needle biopsy, a first registration is performed to match a first image of a prostate to a second image of the prostate. Third images of the prostate are acquired and compounded into a three-dimensional (3D) image. The prostate in the compounded 3D image is segmented to show its border. A second registration and then a third registration different from the second registration is performed on distance maps generated from the prostate borders of the first image and the compounded 3D image, wherein the first and second registrations are based on a biomechanical property of the prostate. A region of interest in the first image is mapped to the compounded 3D image or a fourth image of the prostate acquired with the second modality.
摘要翻译：在用于图像引导的前列腺癌针活检的方法中，首先进行配准以将前列腺的第一图像与前列腺的第二图像相匹配。获取前列腺的第三图像并将其复合成三维（3D）图像。复合3D图像中的前列腺被分割以显示其边界。在从第一图像和复合3D图像的前列腺边界产生的距离图上执行与第二登记不同的第二登记，然后第三登记，其中第一和第二登记基于前列腺的生物力学性质。将第一图像中的感兴趣区域映射到复合3D图像或用第二模态获取的前列腺的第四图像。

23. 发明授权

US09232885B2 Method and device for detecting tumorous tissue in the gastrointestinal tract with the aid of an endocapsule 有权
标题翻译：借助于内囊检测胃肠道肿瘤组织的方法和装置
公开(公告)号：US09232885B2
公开(公告)日：2016-01-12
申请号：US13805205
申请日：2011-05-11
申请人： Jens Fehre , Ralf Nanke
发明人： Jens Fehre , Ralf Nanke
IPC分类号： A61B5/05 , A61B1/04 , A61B5/00 , G01N21/64 , G06K9/00
CPC分类号： A61B1/043 , A61B1/041 , A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/4205 , G01N21/6408 , G01N21/6486 , G06K9/00147 , G06K2209/053
摘要： In a method and apparatus for detecting tumorous cell tissue in a gastrointestinal tract, electromagnetic radiation is emitted in a locally defined manner from an endoscope onto cell tissue and, after deactivation of the radiation, the decay of the inherent fluorescence intensity of the irradiated cell tissue, excited by the electromagnetic radiation, is detected, with temporal and spectral resolution and with a known scanning rate for at least one wavelength. From the intensity measurement values obtained in this manner, the difference autocorrelation function of the intensity decay is determined, from which a fractal dimension for the irradiated cell tissue is determined. The value of the fractal dimension is used to classify the irradiated cell tissue as to a degree to which the cell tissue is tumorous.
摘要翻译：在用于检测胃肠道中的肿瘤细胞组织的方法和装置中，电磁辐射以局部限定的方式从内窥镜发射到细胞组织上，并且在辐射失活之后辐射细胞组织的固有荧光强度的衰减被电磁辐射激发，被检测到，具有时间和光谱分辨率，并具有用于至少一个波长的已知扫描速率。根据以这种方式获得的强度测量值，确定强度衰减的差分自相关函数，确定照射的细胞组织的分形维数。分形维数的值用于将照射的细胞组织分类为细胞组织肿瘤程度。

24. 发明申请

US20090062645A1 METHOD FOR DIAGNOSIS AND TREATMENT OF PROSTATE CANCER 审中-公开
标题翻译：诊断和治疗前列腺癌的方法
公开(公告)号：US20090062645A1
公开(公告)日：2009-03-05
申请号：US12203198
申请日：2008-09-03
申请人： Jens Fehre , Ralf Nanke , Martin Stetter
发明人： Jens Fehre , Ralf Nanke , Martin Stetter
IPC分类号： A61B8/13 , A61B5/00
CPC分类号： A61N7/00 , A61B5/055 , A61B5/4381 , A61B8/08
摘要： In a method for diagnosis and treatment of a patient with a tumor relating to prostate cancer, the following steps are implemented. A differential diagnosis of prostate cancer versus prostatitis and/or BPH is conducted on a patient using a cost-effective diagnosis method. If prostate cancer is diagnosed in the patient using a cost-effective measurement method, a characteristic value for the tumor aggressiveness of the prostate cancer is determined. A watchful waiting treatment is implemented with the patient given a characteristic value below a predeterminable first limit value. The size and position of the tumor is determined using a cost-effective method given a characteristic value above the first limit value. A cost-effective ultrasonic theranosis or a conventional therapy is conducted for a size below a second predeterminable limit value. The presence of metastases in the patient is checked, with a cost-intensive method generating image information, for a size above the second limit value. A metastasis treatment is implemented in the event that metastases are present. In the event that no metastases are present, a tumor treatment based on the aforementioned image information generated is implemented.
摘要翻译：在用于诊断和治疗患有与前列腺癌相关的肿瘤的患者的方法中，实施以下步骤。使用成本效益的诊断方法对患者进行前列腺癌与前列腺炎和/或BPH的鉴别诊断。如果使用成本有效的测量方法在患者中诊断前列腺癌，则确定前列腺癌的肿瘤侵袭性的特征值。给予患者给予低于可预定的第一极限值的特征值的注意等待治疗。使用给定特征值高于第一极限值的成本有效的方法确定肿瘤的大小和位置。以低于第二预定极限值的尺寸进行成本有效的超声治疗或常规治疗。检查患者中转移灶的存在，以成本密集型方法产生图像信息，尺寸高于第二限制值。在存在转移的情况下实施转移治疗。在不存在转移的情况下，实现基于上述生成的图像信息的肿瘤治疗。

25. 发明申请

US20090060847A1 CONTRAST AGENT FOR ULTRASOUND EXAMINATION OF THE PROSTATE AND METHOD TO DIAGNOSE PROSTATE CANCER 审中-公开
标题翻译：用于超声检查前列腺癌的对比剂和诊断前列腺癌的方法
公开(公告)号：US20090060847A1
公开(公告)日：2009-03-05
申请号：US12203193
申请日：2008-09-03
申请人： Sueleyman Erguen , Jens Fehre , Ralf Nanke , Bernhard Singer , Derya Tilki
发明人： Sueleyman Erguen , Jens Fehre , Ralf Nanke , Bernhard Singer , Derya Tilki
IPC分类号： A61B8/08
CPC分类号： A61K49/223 , A61K49/225
摘要： A contrast agent for ultrasound examination of the prostate has contrast-intensifying particles on an exterior of which at least one binding molecule is present that specifically binds to CEACAM-1. In a method for ultrasound examination of the prostate, such a contrast agent is administered to the patient and a sonography of the prostate is subsequently implemented.
摘要翻译：用于前列腺超声检查的造影剂具有在其外部具有特异性结合CEACAM-1的至少一个结合分子的造影剂增强颗粒。在用于前列腺超声检查的方法中，将这样的造影剂施用于患者，随后实施前列腺超声检查。

26. 发明申请

US20070016115A1 Shockwave system controlled dependent on patient's blood pressure 有权
标题翻译：冲击波系统依赖于患者的血压
公开(公告)号：US20070016115A1
公开(公告)日：2007-01-18
申请号：US11479347
申请日：2006-06-30
申请人： Gerhard Buchholtz , Jens Fehre , Bernd Granz , Martin Hoheisel , Werner Kruft , Markus Lanski , Matthias Mahler , Christian Meinert , Thomas Mertelmeier , Ralf Nanke , Manfred Rattner
发明人： Gerhard Buchholtz , Jens Fehre , Bernd Granz , Martin Hoheisel , Werner Kruft , Markus Lanski , Matthias Mahler , Christian Meinert , Thomas Mertelmeier , Ralf Nanke , Manfred Rattner
IPC分类号： A61H1/00
CPC分类号： A61B17/2251 , A61B5/021 , A61B17/22004 , A61B2017/00022 , A61B2017/00044 , A61B2017/00119 , A61B2017/00194
摘要： In a shockwave system with a shockwave source for treatment of a patient with shockwaves, a control and evaluation unit for evaluating an input signal supplied directly thereto that is correlated with a blood pressure value of the patient determined during the treatment, and controls the shockwave source dependent on the input signal.
摘要翻译：在具有用于治疗患有冲击波的患者的冲击波源的冲击波系统中，用于评估与其直接供应的输入信号相关联的控制和评估单元，其与在治疗期间确定的患者的血压值相关联，并且控制冲击波源取决于输入信号。

27. 发明申请

US20070016113A1 Method and device for determining an operating parameter of a shockwave source 审中-公开
标题翻译：用于确定冲击波源的运行参数的方法和装置
公开(公告)号：US20070016113A1
公开(公告)日：2007-01-18
申请号：US11478824
申请日：2006-06-30
申请人： Gerhard Buchholtz , Jens Fehre , Bernd Granz , Martin Hoheisel , Werner Kruft , Markus Lanski , Matthias Mahler , Christian Meinert , Thomas Mertelmeier , Ralf Nanke , Manfred Rattner
发明人： Gerhard Buchholtz , Jens Fehre , Bernd Granz , Martin Hoheisel , Werner Kruft , Markus Lanski , Matthias Mahler , Christian Meinert , Thomas Mertelmeier , Ralf Nanke , Manfred Rattner
IPC分类号： A61H1/00
CPC分类号： A61B17/2258 , A61B2017/00194 , A61B2017/00199 , A61B2090/378
摘要： In a method to determine an operating parameter of a shockwave source for the generation of a shockwave to disintegrate a calculus in a patient by a shockwave lithotripsy, a characteristic of the patient and/or of the calculus is determined before and/or during the shockwave lithotripsy and the operating parameter is automatically determined dependent on the characteristic. A device for determining an operating parameter of a shockwave source for the destruction of a calculus in a patient has an acquisition and control unit for determination and/or input of a characteristic of the patient and/or of the calculus, and for automatic determination of the operating parameter dependent on the characteristic.
摘要翻译：在确定用于产生冲击波的冲击波源的操作参数以便通过冲击波碎石碎裂来分解患者的结石的方法中，在冲击波之前和/或期间确定患者和/或微积分的特征碎石术和操作参数根据特性自动确定。用于确定用于破坏患者结石的冲击波源的操作参数的装置具有用于确定和/或输入患者特征和/或微积分的获取和控制单元，并且用于自动确定操作参数取决于特性。

28. 发明授权

US10674979B2 Mobile C-arm system 有权
公开(公告)号：US10674979B2
公开(公告)日：2020-06-09
申请号：US15764558
申请日：2016-08-09
申请人： Jens Fehre , Alexander Gemmel , Andreas Limmer , Ralf Nanke
发明人： Jens Fehre , Alexander Gemmel , Andreas Limmer , Ralf Nanke
IPC分类号： A61B6/00
摘要： The invention relates to a mobile C-arm system (C1), at least comprising at least three wheels, at least two wheels each having an electric motor, wherein the electric motor has a stator (S) and a rotor (R), the stator (S) being connected to a wheel suspension (T) of the wheel and the rotor (R) being surrounded peripherally by a running wheel (L).

29. 发明授权

US08981317B2 Method and device for detecting tumorous living cell tissue 有权
标题翻译：检测肿瘤活细胞组织的方法和装置
公开(公告)号：US08981317B2
公开(公告)日：2015-03-17
申请号：US13320610
申请日：2010-05-12
申请人： Juergen Schreiber , Joerg Opitz , Carola Gerich , Jens Fehre , Georg Salomon , Ralf Nanke
发明人： Juergen Schreiber , Joerg Opitz , Carola Gerich , Jens Fehre , Georg Salomon , Ralf Nanke
IPC分类号： G01N21/64 , A61B5/00
CPC分类号： G01N21/6486 , A61B5/0059 , G01N21/6408
摘要： The invention relates to a method and to an apparatus for recognizing tumorous living cell tissue. It furthermore relates to a method and to an apparatus for recognizing tumorous cell tissue at collected living cell tissue samples. In the method, electromagnetic radiation is emitted with local definition onto cell tissue by a radiation source and, after deactivation of the radiation source, the decay behavior of the inherent fluorescence intensity of the cell tissue excited by the electromagnetic radiation is detected at the cell tissue in a time resolved and spectrally resolved manner at known sampling rate(s) for at least one wavelength using a detector. The difference autocorrelation function C(t) of the intensity decay behavior is determined using the determined measured intensity values, the fractal dimension DF for the respective irradiated cell tissue is calculated from this and the value of the fractal dimension DF is used for a classification with respect to a presence of a tumor in the respective irradiated cell tissue.
摘要翻译：本发明涉及用于识别肿瘤活细胞组织的方法和装置。此外，本发明还涉及用于在收集的活细胞组织样品处识别肿瘤细胞组织的方法和装置。在该方法中，电磁辐射通过辐射源以局部定义发射到细胞组织上，并且在放射源失活之后，在细胞组织处检测由电磁辐射激发的细胞组织的固有荧光强度的衰变行为以使用检测器的至少一个波长的已知采样速率以时间分辨和频谱分辨的方式。使用确定的测量强度值确定强度衰减行为的差分自相关函数C（t），并从其计算相应的照射细胞组织的分形维数DF，并且使用分形维数DF的值进行分类，相对于各自照射的细胞组织中肿瘤的存在。

30. 发明申请

US20110230752A1 SCREENING TEST FOR RECOGNIZING PROSTATE DISEASES AND APPARATUS AND DIAGNOSIS SUBSTANCE FOR CARRYING OUT THE TEST 失效
标题翻译：用于识别前列腺疾病的筛选测试和装置和诊断物质进行测试
公开(公告)号：US20110230752A1
公开(公告)日：2011-09-22
申请号：US12671643
申请日：2008-07-31
申请人： Jens Fehre , Ralf Nanke , Martin Stetter
发明人： Jens Fehre , Ralf Nanke , Martin Stetter
IPC分类号： A61B5/05
CPC分类号： G01R33/1269 , A61B5/06 , A61B5/4381 , A61K49/00 , A61K49/0004
摘要： In a screening test method, and a device for implementing the screening test method, a diagnostic substance is provided that contains at least one biomarker connected with at least one ferromagnetic particle, the biomarker binding specifically to a target molecule that is formed by specific pathological prostrate tissue. The diagnostic substance is administered to the blood stream of a patient. A magnetometer is used to detect enrichment of the ferromagnetic particle in the prostrate, as an indicator of a level of the specific pathological prostrate tissue.
摘要翻译：在筛选试验方法以及实施筛选试验方法的装置中，提供了含有至少一种与至少一个铁磁性粒子连接的生物标志物的诊断物质，特异性结合由特异性病理性前列腺素形成的靶分子的生物标志物组织。将诊断物质施用于患者的血液流。磁力计用于检测前列腺中铁磁颗粒的富集，作为特定病理性pro层组织水平的指标。

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