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21. 发明申请

US20100217368A1 CONTROLLED DETACHMENT OF INTRA-LUMINAL MEDICAL DEVICE 有权
标题翻译：内镜医疗器械的控制分离
公开(公告)号：US20100217368A1
公开(公告)日：2010-08-26
申请号：US12698811
申请日：2010-02-02
申请人： David A DINSMOOR , Mark A. Christopherson
发明人： David A DINSMOOR , Mark A. Christopherson
IPC分类号： A61N1/00
CPC分类号： A61B5/6882 , A61B5/145 , A61B5/14539 , A61N1/36007 , A61N1/372
摘要： An intra-luminal medical device includes a fixation mechanism to attach the medical device to tissue within a body lumen, and a detachment mechanism to permit selective detachment of the medical device from the tissue attachment site without the need for endoscopic or surgical intervention. An electromagnetic device may be provided to mechanically actuate the detachment mechanism. Alternatively, a fuse link may be electrically blown to detach the medical device. As a further alternative, a rapidly degradable bonding agent may be exposed to a degradation agent to detach the medical device from a bonding surface within the body lumen. The medical device may eliminate problems associated with uncertain and inconsistent detachment of intra-luminal medical devices.
摘要翻译：管腔内医疗装置包括用于将医疗装置附接到体腔内的组织的固定机构，以及允许医疗装置从组织附着部位选择性分离而不需要内窥镜或外科手术的分离机构。可以提供电磁装置以机械地致动分离机构。或者，可以电熔接熔丝链以分离医疗装置。作为另一替代方案，快速降解的粘合剂可暴露于降解剂以将医疗装置与体腔内的结合表面分离。医疗设备可以消除与腔内医疗设备的不确定和不一致的分离相关的问题。

22. 发明申请

US20080262491A1 Tuna Device with Integrated Saline Reservoir 有权
标题翻译：金枪鱼装置与综合盐水库
公开(公告)号：US20080262491A1
公开(公告)日：2008-10-23
申请号：US11573417
申请日：2005-08-10
申请人： John M. Swoyer , Mark A. Christopherson , Yelena G. Tropsha , Julie M. Woessner
发明人： John M. Swoyer , Mark A. Christopherson , Yelena G. Tropsha , Julie M. Woessner
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B2018/1472 , A61B2018/1475
摘要： Methods and apparatus for ablating a target tissue are discussed. Such methods and apparatus include those that simplify tissue ablation. For example, a tissue ablation device having an actuator, such as a trigger mechanism, coupled to a power source and an electrode is discussed. A single step of engaging the actuator causes the electrode to be introduced into the target tissue and causes energy to be delivered from the power supply to the tissue via the electrode. Devices that include an electrode actuator for causing the electrode to be introduced into the target tissue and a fluid actuator for causing the fluid to flow to the target tissue are also discussed. Methods of causing the electrode to be introduced into the target tissue and fluid to flow to the target tissue with a single step and more than one step are also discussed.
摘要翻译：讨论了用于烧蚀靶组织的方法和装置。这些方法和装置包括简化组织消融的方法和装置。例如，讨论了具有耦合到电源和电极的诸如触发机构的致动器的组织消融装置。使执行器接合的一个步骤使得电极被引入目标组织中，并且通过电极将能量从电源传送到组织。还讨论了包括用于使电极引入目标组织的电极致动器和用于使流体流向目标组织的流体致动器的装置。还讨论了将电极引入目标组织中的方法和流体以单步和多于一个步骤流向目标组织。

23. 发明授权

US07203551B2 Implantable lead-based sensor powered by piezoelectric transformer 有权
标题翻译：由压电变压器驱动的可植入铅基传感器
公开(公告)号：US07203551B2
公开(公告)日：2007-04-10
申请号：US10424584
申请日：2003-04-25
申请人： Richard P. M. Houben , Mark A. Christopherson , Adrianus P. Donders , Robert Leinders , Curtis D. Deno
发明人： Richard P. M. Houben , Mark A. Christopherson , Adrianus P. Donders , Robert Leinders , Curtis D. Deno
IPC分类号： A61N1/00 , H01L41/07
CPC分类号： A61N1/08 , A61N1/36542
摘要： In general, the invention is directed to an IMD having a piezoelectric transformer to power a lead-based sensor. The IMD powers the piezoelectric transformer with a low amplitude signal. The piezoelectric transformer serves to convert the voltage level of the low amplitude signal to a higher voltage level to drive the sensor produced by a battery in the IMD to voltage levels appropriate for IMD operation. A piezoelectric transformer offers small size and low profile, as well as operational efficiency, and permits the IMD to transmit a low amplitude signal to a remote sensor deployed within an implantable lead. In addition, the piezoelectric transformer provides electrical isolation that reduces electromagnetic interference among different sensors.
摘要翻译：通常，本发明涉及具有压电变压器以为基于铅的传感器供电的IMD。 IMD用低幅度信号为压电变压器供电。压电变压器用于将低振幅信号的电压电平转换为更高的电压电平，以将由IMD中的电池产生的传感器驱动到适于IMD操作的电压电平。压电变压器提供小尺寸和低轮廓以及操作效率，并允许IMD将低振幅信号传输到部署在可植入导线内的远程传感器。此外，压电变压器提供电隔离，减少不同传感器之间的电磁干扰。

24. 发明授权

US6099479A Method and apparatus for operating therapy system 失效
标题翻译：手术治疗系统的方法和装置
公开(公告)号：US6099479A
公开(公告)日：2000-08-08
申请号：US683808
申请日：1996-06-26
申请人： Mark A. Christopherson , Johann J. Neisz
发明人： Mark A. Christopherson , Johann J. Neisz
IPC分类号： A61N1/378 , A61F9/007 , A61N1/08 , A61N1/36 , A61B5/08
CPC分类号： A61N1/3601
摘要： A method for operating an implantable therapy system to conserve energy includes providing an implantable sensing device that generates a signal as a function of a physiological parameter of a patient during a treatment period. The signal is monitored during at least portions of the treatment period to detect a physiological event for use in controlling therapy of the patient during the treatment period. Energy consumption by the sensing device is terminated during the treatment period for at least portions of the treatment period when signal monitoring is not performed. Another method for operating an implantable therapy system for conserving energy includes providing an implantable component for performance of a function during a treatment period for the therapy system. The implantable component is operable in at least a first state during the treatment period and a second state outside of the treatment period; the first state using more energy than the second state. The implantable component is operated in the first state when performance of the function during a treatment period is required and operated in the second state when performance of the function is not required outside the treatment period. Another method of operating an implantable therapy system includes monitoring a periodic physiological parameter for controlling therapy of a patient during a treatment period. The measured physiological period for the parameter of the patient is compared to at least one predetermined period threshold to determine nonperiodic behavior of the monitored periodic physiological parameter and suspending therapy of the patient as a function thereof. Systems for use with such methods are also provided.
摘要翻译：用于操作可植入治疗系统以节省能量的方法包括提供可植入感测装置，其在治疗期间产生作为患者生理参数的函数的信号。在治疗周期的至少部分期间监测信号以检测在治疗期间用于控制患者治疗的生理事件。在不执行信号监视的情况下，处理期间的至少部分处理期间，感测装置的能量消耗被终止。用于操作用于节省能量的可植入治疗系统的另一种方法包括提供用于治疗系统的治疗周期期间执行功能的可植入组件。可植入部件在治疗期间至少处于第一状态，处于治疗期以外的第二状态; 第一个状态比第二个状态使用更多的能量。当处理期间的功能的执行需要并且在第二状态下操作时，可植入部件在第一状态下操作，当在治疗周期之外不需要执行功能时。操作可植入治疗系统的另一种方法包括监测周期性生理参数，用于在治疗期间控制患者的治疗。将测量的患者参数的生理期与至少一个预定周期阈值进行比较，以确定所监视的周期性生理参数的非周期性行为以及作为其功能的患者的暂停治疗。还提供了与这种方法一起使用的系统。

25. 发明授权

US5944680A Respiratory effort detection method and apparatus 失效
标题翻译：呼吸力检测方法和装置
公开(公告)号：US5944680A
公开(公告)日：1999-08-31
申请号：US674494
申请日：1996-06-26
申请人： Mark A. Christopherson , Johann J. Neisz , John Hammargren
发明人： Mark A. Christopherson , Johann J. Neisz , John Hammargren
IPC分类号： A61B5/08 , A61B5/03 , A61B5/07 , A61B5/113 , A61N1/36 , A61B19/00 , A61N1/08 , A61N1/10 , A61N1/18
CPC分类号： A61B5/03 , A61B5/07 , A61B5/113 , A61N1/3601
摘要： A method of predicting critical points in patient respiration includes monitoring at least one characteristic of a respiratory effort waveform of a patient to detect a respiratory event. A refractory period is defined that includes a hard refractory period during which time the respiratory event cannot be responded to and a soft refractory period following the hard refractory period. The respiratory event outside of the refractory period is detected as a function of a first set of predetermined parameters for the monitored at least one characteristic and the respiratory event within the soft refractory period is detected as a function of a second set of predetermined parameters for the monitored at least one characteristic. The respiratory event may be inspiration onset and the characteristic of the respiratory effort waveform monitored is at least one of slope and amplitude. The refractory period may be defined based on detection of inspiration offset and further may be defined based on inspiration offset, an average respiratory period, and an average time of inspiration. Further, stimulation may be provided in response to a detected inspiration onset. Another method of predicting critical points includes sampling the amplitude of the respiratory effort waveform of a patient. A sample signal is generated representative of at least one characteristic of the respiratory effort waveform based on each amplitude sample. The sample signals representative of the at least one characteristic of the respiratory effort waveform are monitored and a respiratory event is detected as a function of at least two sample signals. Apparatus and systems for use with such methods are also described.
摘要翻译：预测患者呼吸中的关键点的方法包括监测患者的呼吸努力波形的至少一个特征以检测呼吸事件。定义了不应期，其包括难治性期间，在此期间呼吸事件不能应对，并且在难治性难治期之后的软不应期。根据所监测的至少一个特征的第一组预定参数来检测不应期的外部呼吸事件，并且根据第二组预定参数检测软不应期内的呼吸事件的功能。监控至少一个特征。呼吸事件可以是启发开始，并且所监测的呼吸努力波形的特征是斜率和幅度中的至少一个。可以基于吸气偏移的检测来定义不应期，并且可以基于吸气偏移，平均呼吸周期和平均呼吸时间来定义不应期。此外，可以响应于检测到的吸气开始来提供刺激。预测关键点的另一种方法包括对患者的呼吸努力波形的振幅进行采样。基于每个振幅样本产生代表呼吸努力波形的至少一个特性的采样信号。监测表示呼吸努力波形的至少一个特征的样本信号，并且根据至少两个采样信号检测呼吸事件。还描述了与这种方法一起使用的装置和系统。

26. 发明授权

US5895360A Gain control for a periodic signal and method regarding same 失效
标题翻译：增益控制周期信号和方法相关
公开(公告)号：US5895360A
公开(公告)日：1999-04-20
申请号：US673718
申请日：1996-06-26
申请人： Mark A. Christopherson , Johann J. Neisz
发明人： Mark A. Christopherson , Johann J. Neisz
IPC分类号： A61B5/08 , A61N1/36 , A61N1/37 , A61B5/02
CPC分类号： A61N1/3601 , A61N1/3704
摘要： A gain control method for providing a gain controlled signal representative of a periodic physiological parameter of a patient includes providing a signal characteristic of the periodic physiological parameter. The periodic physiological parameter includes a plurality of periodic cycles. Gain of the signal is updated only once per periodic cycle following detection of a periodic event. The updating is performed by monitoring an amplitude of the signal between detection of periodic events and comparing the amplitude to a gain control amplitude threshold. Gain of the signal is updated as a function of the comparison. Further, gain is updated following expiration of a predetermined period of time if a periodic event is not detected within the predetermined period of time. The physiological parameter may be respiratory effort. An apparatus for providing such gain control is also provided.
摘要翻译：用于提供表示患者的周期性生理参数的增益控制信号的增益控制方法包括提供周期性生理参数的特征信号。周期性生理参数包括多个周期周期。在检测到周期性事件之后，每周期周期，信号的增益只会更新一次。通过监视周期性事件的检测之间的信号的幅度并将幅度与增益控制幅度阈值进行比较来执行更新。作为比较的函数更新信号的增益。此外，如果在预定时间段内没有检测到周期性事件，则在预定时间段期满之后更新增益。生理参数可能是呼吸力。还提供了一种用于提供这种增益控制的装置。

27. 发明申请

US20170258525A9 APPARATUS AND METHOD FOR CREATING, MAINTAINING, AND CONTROLLING A VIRTUAL ELECTRODE USED FOR THE ABLATION OF TISSUE 审中-公开
公开(公告)号：US20170258525A9
公开(公告)日：2017-09-14
申请号：US11782134
申请日：2007-07-24
申请人： Michael F. Hoey , Mark A. Christopherson , Steven M. Goetz
发明人： Michael F. Hoey , Mark A. Christopherson , Steven M. Goetz
IPC分类号： A61N1/00
CPC分类号： A61B18/18 , A61B18/1206 , A61B18/1233 , A61B18/14 , A61B18/1402 , A61B18/1815 , A61B2018/00029 , A61B2018/00196 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00875 , A61B2018/1213 , A61B2018/1253 , A61B2018/1417 , A61B2018/1472 , A61B2018/1475 , A61B2218/002 , A61B2218/007
摘要： An apparatus and a method for producing a virtual electrode within or upon a tissue to be treated with radio frequency alternating electric current. An apparatus in accord with the present disclosure includes a supply of a conductive or electrolytic fluid to be provided to the patient, an alternating current generator, and a processor for creating, maintaining, and controlling the ablation process by the interstitial or surficial delivery of the fluid to a tissue and the delivery of electric power to the tissue via the virtual electrode. A method in accord with the present disclosure includes delivering a conductive fluid to a predetermined tissue ablation site for a predetermined time period, applying a predetermined power level of radio frequency current to the tissue, monitoring at least one of several parameters, and adjusting either the applied power and/or the fluid flow in response to the measured parameters.

28. 发明授权

US08540679B2 Controlled detachment of intra-luminal medical device 有权
标题翻译：腔内医疗器械的控制分离
公开(公告)号：US08540679B2
公开(公告)日：2013-09-24
申请号：US12698811
申请日：2010-02-02
申请人： David A Dinsmoor , Mark A. Christopherson
发明人： David A Dinsmoor , Mark A. Christopherson
IPC分类号： A61M5/32 , A61B5/05
CPC分类号： A61B5/6882 , A61B5/145 , A61B5/14539 , A61N1/36007 , A61N1/372
摘要： An intra-luminal medical device includes a fixation mechanism to attach the medical device to tissue within a body lumen, and a detachment mechanism to permit selective detachment of the medical device from the tissue attachment site without the need for endoscopic or surgical intervention. An electromagnetic device may be provided to mechanically actuate the detachment mechanism. Alternatively, a fuse link may be electrically blown to detach the medical device. As a further alternative, a rapidly degradable bonding agent may be exposed to a degradation agent to detach the medical device from a bonding surface within the body lumen. The medical device may eliminate problems associated with uncertain and inconsistent detachment of intra-luminal medical devices.
摘要翻译：管腔内医疗装置包括用于将医疗装置附接到体腔内的组织的固定机构，以及允许医疗装置从组织附着部位选择性分离而不需要内窥镜或外科手术的分离机构。可以提供电磁装置以机械地致动分离机构。或者，可以电熔接熔丝链以分离医疗装置。作为另一替代方案，快速降解的粘合剂可暴露于降解剂以将医疗装置与体腔内的结合表面分离。医疗设备可以消除与腔内医疗设备的不确定和不一致的分离相关的问题。

29. 发明授权

US08235984B2 Tuna device with integrated saline reservoir 有权
标题翻译：金枪鱼装置与综合盐水库
公开(公告)号：US08235984B2
公开(公告)日：2012-08-07
申请号：US11950751
申请日：2007-12-05
申请人： John M. Swoyer , Yelena G. Tropsha , Julie M. Woessner , Mark A. Christopherson
发明人： John M. Swoyer , Yelena G. Tropsha , Julie M. Woessner , Mark A. Christopherson
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B2018/1472 , A61B2018/1475
摘要： Methods and apparatus for ablating a target tissue are discussed. Such methods and apparatus include those that simplify tissue ablation. For example, a tissue ablation device having an actuator, such as a trigger mechanism, coupled to a power source and an electrode is discussed. A single step of engaging the actuator causes the electrode to be introduced into the target tissue and causes energy to be delivered from the power supply to the tissue via the electrode. By way of additional example, a tissue ablation device having an actuator coupled to a fluid source and an electrode is discussed. A single step of engaging the actuator causes conductive fluid to flow from the fluid source to the target tissue location and causes the electrode to be introduced to the target tissue location. The fluid source may be a conductive fluid, such as saline, which may increase the efficiency of ablation. Various other configurations and methods that simplify tissue ablation are also discussed.
摘要翻译：讨论了用于烧蚀靶组织的方法和装置。这些方法和装置包括简化组织消融的方法和装置。例如，讨论了具有耦合到电源和电极的诸如触发机构的致动器的组织消融装置。使执行器接合的一个步骤使得电极被引入目标组织中，并且通过电极将能量从电源传送到组织。作为另外的示例，讨论了具有耦合到流体源和电极的致动器的组织消融装置。使致动器接合的一个步骤导致导电流体从流体源流动到目标组织位置，并且使电极被引入目标组织位置。流体源可以是诸如盐水的导电流体，其可以提高消融效率。还讨论了简化组织消融的各种其它配置和方法。

30. 发明授权

US07261710B2 Transurethral needle ablation system 有权
标题翻译：经尿道针消融系统
公开(公告)号：US07261710B2
公开(公告)日：2007-08-28
申请号：US10964551
申请日：2004-10-13
申请人： Ahmed Elmouelhi , Mark A. Christopherson , John M. Swoyer , Shahn S. Sage
发明人： Ahmed Elmouelhi , Mark A. Christopherson , John M. Swoyer , Shahn S. Sage
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/1477 , A61B2017/00274 , A61B2018/00083 , A61B2018/00196 , A61B2018/00547 , A61B2018/00988 , A61B2018/1425 , A61B2018/143 , A61B2018/1475
摘要： A one-piece, single-use disposable device for transurethral needle ablation (TUNA) of prostate tissue to alleviate BPH is disclosed. The device may include a flexible catheter tip including a rigid core and a flexible tip. The device may also include a single use lockout to help ensure that the device is used to perform only one ablation procedure on a single patient. The device may further include a simplified needle deployment mechanism and/or an automatic needle retraction mechanism.
摘要翻译：公开了一种用于经尿道针消融（TUNA）的前列腺组织以缓解BPH的单件式一次性一次性装置。该装置可以包括柔性导管尖端，其包括刚性芯和柔性尖端。该装置还可以包括单次使用锁定，以帮助确保该装置仅用于在单个患者上执行一个消融程序。该装置还可以包括简化的针展开机构和/或自动针回缩机构。

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