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21. 发明申请

US20120296349A1 Percutaneous Mitral Annulus Mini-Plication 审中-公开
标题翻译：经皮二尖瓣环微球
公开(公告)号：US20120296349A1
公开(公告)日：2012-11-22
申请号：US13240921
申请日：2011-09-22
申请人： Scott R. Smith , Mark L. Jenson
发明人： Scott R. Smith , Mark L. Jenson
IPC分类号： A61B17/08 , A61B17/10
CPC分类号： A61B17/00234 , A61B17/0644 , A61B17/1227 , A61B17/1285 , A61B2017/00243 , A61B2017/081 , A61F2/2442
摘要： A plication clip comprises a first end portion; a second end portion; and a central portion connecting the first end portion to the second end portion. The first end portion is curved toward the second end portion, and the second end portion is curved toward the first end portion. The central portion has a curvilinear profile such that when the clip is deployed, a shorter length between the first end portion and the second end portion is formed. A delivery catheter and methods for deploying the plication clip are also provided.
摘要翻译：折叠夹包括第一端部; 第二端部; 以及将第一端部连接到第二端部的中心部。第一端部朝向第二端部弯曲，第二端部朝向第一端部弯曲。中心部分具有曲线轮廓，使得当夹子展开时，在第一端部和第二端部之间形成较短的长度。还提供了输送导管和用于展开折叠夹的方法。

22. 发明申请

US20120265198A1 RENAL NERVE DETECTION AND ABLATION APPARATUS AND METHOD 审中-公开
标题翻译：肾脏神经检测和消融装置及方法
公开(公告)号：US20120265198A1
公开(公告)日：2012-10-18
申请号：US13299932
申请日：2011-11-18
申请人： Loren M. Crow , Mark L. Jenson , Scott Smith
发明人： Loren M. Crow , Mark L. Jenson , Scott Smith
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/0016 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61N1/36007 , A61N7/022
摘要： Stimulation energy is delivered to one or more renal artery sites in accordance with a predetermined energy delivery protocol. The stimulation energy is sufficient to elicit a physiologic response from the patient but insufficient to ablate renal nerves. Target renal artery sites that elicit a physiologic response are identified, and renal nerve tissue at or proximate the target sites is ablated.
摘要翻译：根据预定的能量递送方案，将刺激能量递送至一个或多个肾动脉部位。刺激能量足以引起患者的生理反应，但不足以消融肾神经。确定引起生理反应的目标肾动脉部位，消除靶点位置或其附近的肾神经组织。

23. 发明申请

US20120232570A1 APPARATUS AND METHOD FOR TREATING OCCLUDED VASCULATURE 审中-公开
标题翻译：用于治疗闭塞性血管的装置和方法
公开(公告)号：US20120232570A1
公开(公告)日：2012-09-13
申请号：US13481309
申请日：2012-05-25
申请人： Mark L. Jenson , William J. Drasler
发明人： Mark L. Jenson , William J. Drasler
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B2017/00398 , A61B2017/22044 , A61B2017/22077 , A61B2017/22094 , A61M25/0084 , A61M25/0138 , A61M2025/0046 , A61M2025/0063 , A61M2025/1093
摘要： Occluded vasculature such as occluded arterial vasculature can be recanalized using a device that is configured to penetrate an occlusion, while limiting a distance that said penetration structure can extend in order to limit inadvertent vascular damage. The device can include an elongate shaft of a guidewire and a stylet disposed within a lumen of the elongate shaft such that the stylet is selectively actuatable within the elongate shaft.
摘要翻译：封闭的脉管系统如闭塞的动脉脉管系统可以使用被配置为穿透闭塞的装置再次通气，同时限制所述穿透结构可以延伸的距离，以限制无意的血管损伤。该装置可以包括导丝的细长轴和设置在细长轴的内腔中的探针，使得探针可以在细长轴内选择性地致动。

24. 发明申请

US20120123303A1 Minimally Invasive Access for Renal Nerve Ablation 有权
标题翻译：微创获取肾神经消融
公开(公告)号：US20120123303A1
公开(公告)日：2012-05-17
申请号：US13243134
申请日：2011-09-23
申请人： David Sogard , Scott Smith , Mark L. Jenson
发明人： David Sogard , Scott Smith , Mark L. Jenson
IPC分类号： A61B18/18 , A61B18/04 , A61N7/00 , A61B18/00
CPC分类号： A61B18/1492 , A61B90/37 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00791 , A61B2018/00875 , A61B2018/0212 , A61N5/062 , A61N7/022 , A61N2005/067 , A61N2007/003
摘要： An elongated flexible medical device is inserted into a patient's body via a natural orifice, and advanced through the natural orifice to a location proximate innervated tissue that influences renal sympathetic nerve activity. The medical device can be advanced into a body organ and to a location within the organ proximate the innervated tissue. The organ may comprise an organ of the gastrointestinal tract or urinary tract. The medical device may be advanced through and beyond an access hole in a wall of the organ, and situated at a location proximate the innervated tissue. One or both of imaging and ablation energy is delivered from a distal end of the medical device to the innervated tissue. Innervated renal tissue can be ablated using various forms of energy, including RF energy, ultrasound energy, optical energy, and thermal energy.
摘要翻译：细长的柔性医疗装置通过自然孔插入患者体内，并通过自然孔推进到影响肾交感神经活动的靠近神经组织的位置。医疗装置可以进入身体器官和靠近神经组织的器官内的位置。器官可以包括胃肠道或泌尿道的器官。医疗装置可以前进穿过器官壁中的进入孔并且位于邻近神经组织的位置处。成像和消融能量中的一个或两个从医疗装置的远端传送到神经组织。可以使用各种形式的能量消融内源性肾组织，包括射频能量，超声能量，光能和热能。

25. 发明申请

US20120059286A1 Self-Powered Ablation Catheter for Renal Denervation 审中-公开
标题翻译：自吸式消融导管用于肾去神经
公开(公告)号：US20120059286A1
公开(公告)日：2012-03-08
申请号：US13227446
申请日：2011-09-07
申请人： Roger Hastings , Dave Sogard , Kevin Edmunds , Mark L. Jenson
发明人： Roger Hastings , Dave Sogard , Kevin Edmunds , Mark L. Jenson
IPC分类号： A61N7/00 , A61B18/18 , A61B18/12
CPC分类号： A61B18/1206 , A61B5/0002 , A61B18/1492 , A61B34/25 , A61B2017/00734 , A61B2018/00011 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00642 , A61B2018/00678 , A61B2018/00708 , A61B2018/00744 , A61B2018/00821 , A61B2018/00875 , A61B2018/00916 , A61B2018/00994 , A61B2018/1226 , A61B2018/1861 , A61N7/022
摘要： An ablation catheter includes a flexible shaft having length sufficient to access a patient's renal artery. An electrode arrangement is provided at the distal end of the shaft. A handle unit includes a housing configured for hand-held manipulation and is coupled to the catheter. A battery and one or both of a high frequency AC generator and ultrasound generator are provided in the housing. The battery serves as the sole source of power for the generator. The generator is configured to generate energy sufficient to ablate perivascular renal nerve tissue using energy stored in the battery. The catheter may be disposable and the housing re-usable. Both the catheter and the housing may be disposable.
摘要翻译：消融导管包括具有足以接近患者肾动脉的长度的柔性轴。电极布置设置在轴的远端。手柄单元包括构造成用于手持操作的壳体并且联接到导管。电池和高频交流发电机和超声波发生器中的一个或两个设置在壳体中。电池是发电机的唯一电源。发生器被配置为产生足以使用存储在电池中的能量消融血管周围肾神经组织的能量。导管可以是一次性的并且壳体可重新使用。导管和外壳都可以是一次性的。

26. 发明申请

US20120029513A1 PRECISION ELECTRODE MOVEMENT CONTROL FOR RENAL NERVE ABLATION 有权
标题翻译：精神电极运动控制用于神经退行性疾病
公开(公告)号：US20120029513A1
公开(公告)日：2012-02-02
申请号：US13194920
申请日：2011-07-30
申请人： Scott Smith , Leonard B. Richardson , Mark L. Jenson
发明人： Scott Smith , Leonard B. Richardson , Mark L. Jenson
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/1815 , A61B18/20 , A61B90/39 , A61B2018/00011 , A61B2018/00434 , A61B2018/00577 , A61B2018/00589 , A61B2018/00791 , A61B2018/00875 , A61M25/0054 , A61M25/0113 , A61M25/0127 , A61M25/0138 , A61M25/0147
摘要： A catheter is configured to access a renal artery. A lumen of the catheter's shaft is dimensioned to receive a flexible actuation member which extends between the shaft's proximal and distal ends. The actuation member is moveable within the lumen and subject to elastic deformation, friction, and/or whip along its length. A flexible support member is coupled to a distal end of the actuation member and extendible beyond a distal tip of the shaft. An RF ablation electrode at a distal end of the support member is configured to ablated perivascular renal nerve tissue. A position converter at the distal end of the shaft is configured to convert movement of the actuation member into one or both of controlled rotational and axial movement of the support member and electrode to one of a multiplicity of stable circumferential positions substantially free of elastic deformation, friction, and/or whip impacting actuation member movement.
摘要翻译：导管配置成进入肾动脉。导管轴的内腔的尺寸被设计成容纳在轴的近端和远端之间延伸的柔性致动构件。致动构件可在内腔内移动并且沿其长度受到弹性变形，摩擦和/或鞭状。柔性支撑构件联接到致动构件的远端并且可延伸超过轴的远侧末端。在支撑构件的远端处的RF消融电极被配置为消融血管周围肾神经组织。在轴的远端处的位置转换器被配置为将致动构件的运动转换成支撑构件和电极的受控旋转和轴向运动到基本上没有弹性变形的多个稳定的圆周位置中的一个或两个，摩擦和/或搅动撞击致动构件运动。

27. 发明授权

US07686783B2 Perfusion and embolic protection 有权
标题翻译：灌注和栓塞保护
公开(公告)号：US07686783B2
公开(公告)日：2010-03-30
申请号：US11693956
申请日：2007-03-30
申请人： Mark L. Jenson , William J. Drasler
发明人： Mark L. Jenson , William J. Drasler
IPC分类号： A61M29/00
CPC分类号： A61B17/22 , A61B2017/22067 , A61B2017/22074 , A61B2090/3954 , A61F2/013 , A61M25/005 , A61M25/10 , A61M2025/0063 , A61M2025/1052 , A61M2025/1081 , A61M2025/1095 , A61M2025/1097
摘要： Disclosed is a combination perfusion and occlusion device that can have a perfusion member, an occlusive member and an elongate member. The perfusion member can be an elongate perfusion member that can have a collapsed configuration and an expanded configuration. In the collapsed configuration, the perfusion member can be disposed around the elongate member. In the expanded configuration, the perfusion member can define a perfusion lumen. The occlusive member can have a collapsed configuration and an expanded configuration. The occlusive member in the collapsed configuration can have a low profile that can facilitate insertion of the occlusive member in a body lumen. In the expanded configuration the occlusive member can be a structure that restricts the flow of fluids through a body vessel, for example a filter or another structure that restricts the flow of fluids. The occlusive member can be disposed on the elongate member, for example on a distal portion of the elongate member.
摘要翻译：公开了可以具有灌注构件，闭塞构件和细长构件的组合灌注和闭塞装置。灌注构件可以是可以具有收缩构型和扩张构型的细长灌注构件。在折叠构造中，灌注构件可以设置在细长构件周围。在扩张构型中，灌注构件可以限定灌注腔。闭塞构件可以具有折叠构型和扩展构型。塌缩构型中的闭塞构件可以具有可以有助于闭塞构件在体腔中的插入的低轮廓。在膨胀构型中，闭塞构件可以是限制流体流过身体容器的结构，例如限制流体流动的过滤器或其他结构。闭塞构件可以设置在细长构件上，例如在细长构件的远侧部分上。

28. 发明授权

US07603144B2 Active wireless tagging system on peel and stick substrate 失效
标题翻译：剥离和粘贴基材上的主动无线标签系统
公开(公告)号：US07603144B2
公开(公告)日：2009-10-13
申请号：US10336662
申请日：2003-01-02
申请人： Mark L. Jenson , Jody J. Klaassen , Jim Sullivan
发明人： Mark L. Jenson , Jody J. Klaassen , Jim Sullivan
IPC分类号： H04B1/38 , H04M1/00
CPC分类号： H01M6/40 , H01M2/0267 , H01M2/0275 , H01M6/5066 , H01M10/42 , H01M10/4257 , H01M10/46
摘要： A radio frequency identification (RFID) device provided on a thin-film battery. A system includes the RFID device in communication with a remote radio frequency (RF) transmitter and/or receiver. In some embodiments, the RFID device of the system includes a flexible substrate, a thin-film battery deposited on the flexible substrate, an electronic circuit placed on the battery and coupled to the battery to provide power, and a Radio Frequency (RF) antenna connected to the electronic circuit. In some embodiments, the battery of the RFID device is a rechargeable battery, and the battery is recharged when energy is transmitted from the remote device. Another aspect of the invention provides a system for making an RFID device.
摘要翻译：提供在薄膜电池上的射频识别（RFID）装置。系统包括与远程射频（RF）发射机和/或接收机通信的RFID设备。在一些实施例中，系统的RFID设备包括柔性基板，沉积在柔性基板上的薄膜电池，放置在电池上并耦合到电池以提供电力的电子电路，以及射频（RF）天线连接到电子电路。在一些实施例中，RFID设备的电池是可再充电电池，并且当从远程设备发送能量时，电池被再充电。本发明的另一方面提供一种用于制造RFID设备的系统。

29. 发明授权

US07566343B2 Cardiac valve, system, and method 有权
标题翻译：心脏瓣膜，系统和方法
公开(公告)号：US07566343B2
公开(公告)日：2009-07-28
申请号：US10933088
申请日：2004-09-02
申请人： Mark L. Jenson , William J. Drasler , Daniel M. Lafontaine
发明人： Mark L. Jenson , William J. Drasler , Daniel M. Lafontaine
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2230/008
摘要： A cardiac valve with a support frame having a first end member and a second end member opposing the first end member in a substantially fixed distance relationship, and a cover extending over the support frame to allow for unidirectional flow of a liquid through the valve.
摘要翻译：具有支撑框架的心脏瓣膜具有第一端构件和与所述第一端构件基本上固定的距离关系相对的第二端构件，以及在所述支撑框架上延伸以允许液体通过所述瓣膜的单向流动的盖。

30. 发明授权

US07494742B2 Layered barrier structure having one or more definable layers and method 有权
标题翻译：具有一个或多个可定义层的分层屏障结构和方法
公开(公告)号：US07494742B2
公开(公告)日：2009-02-24
申请号：US11031217
申请日：2005-01-06
申请人： Dave J. Tarnowski , Mark L. Jenson
发明人： Dave J. Tarnowski , Mark L. Jenson
IPC分类号： H01M6/12
CPC分类号： H01M6/40 , H01L2224/18 , H01M2/0207 , H01M2/0267 , H01M2/0275 , H01M2/08 , H01M4/02 , H01M4/04 , H01M4/244 , H01M10/052 , H01M10/4242 , H01M10/44 , H01M12/06 , H01M2300/0014
摘要： A system provides an environmental barrier also useful for providing a circuit, for example, one having a thin-film battery such as one that includes lithium or lithium compounds connected to an electronic circuit. An environmental barrier is deposited as alternating layers, at least one of the layers providing a smoothing, planarizing, and/or leveling physical-configuration function, and at least one other layer providing a diffusion-barrier function. The layer providing the physical-configuration function may include a photoresist, a photodefinable, an energy-definable, and/or a maskable layer. The physical-configuration layer may also be a dielectric. A layered structure, including a plurality of pairs of layers, each pair including a physical configuration layer and a barrier layer with low gas-transmission rates, may be used in reducing gas transmission rate to beyond currently detectable levels.
摘要翻译：系统提供了也可用于提供电路的环境屏障，例如具有诸如连接到电子电路的锂或锂化合物的薄膜电池的电路。环境屏障被沉积为交替层，至少一层提供平滑，平坦化和/或调平物理配置功能，以及提供扩散阻挡功能的至少一个其它层。提供物理配置功能的层可以包括光致抗蚀剂，光可定义的，能量可定义的和/或可屏蔽的层。物理构型层也可以是电介质。可以使用包括多对层的层状结构，每对层包括物理配置层和低气体传输速率的阻挡层，以将气体传输速率降低到目前可检测的水平以上。

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