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21. 发明授权

US08916387B2 Diagnosis and treatment of Alzheimer's disease 有权
标题翻译：阿尔茨海默病的诊断和治疗
公开(公告)号：US08916387B2
公开(公告)日：2014-12-23
申请号：US13881387
申请日：2011-10-28
申请人： Jonas Nilsson , Adnan Halim , Göran Larson , Kaj Blennow , Gunnar Brinkmalm , Erik Portelius , Henrik Zetterberg
发明人： Jonas Nilsson , Adnan Halim , Göran Larson , Kaj Blennow , Gunnar Brinkmalm , Erik Portelius , Henrik Zetterberg
IPC分类号： G01N24/00 , G01N24/14 , G01N33/68 , H01J49/00 , A61K39/00
CPC分类号： G01N33/6896 , A61K39/0007 , C07K16/18 , G01N2333/4709 , G01N2440/38 , G01N2800/2821 , G01N2800/50 , G01N2800/52 , H01J49/0027 , Y10T436/24
摘要： Methods are provided for the prevention, treatment and diagnosis of Alzheimer's disease, based on the glycosylation pattern of amyloid-beta peptides in body fluids and tissues.
摘要翻译：基于体液和组织中淀粉样蛋白-β肽的糖基化模式，提供了用于预防，治疗和诊断阿尔茨海默病的方法。

22. 发明申请

US20140037658A1 Diagnosis and Treatment of Alzheimer's Disease 有权
标题翻译：阿尔茨海默病的诊断和治疗
公开(公告)号：US20140037658A1
公开(公告)日：2014-02-06
申请号：US13881387
申请日：2011-10-28
申请人： Jonas Nilsson , Adnan Halim , Göran Larson , Kaj Blennow , Gunnar Brinkmalm , Erik Portelius , Henrik Zetterberg
发明人： Jonas Nilsson , Adnan Halim , Göran Larson , Kaj Blennow , Gunnar Brinkmalm , Erik Portelius , Henrik Zetterberg
IPC分类号： G01N33/68 , H01J49/00 , A61K39/00
CPC分类号： G01N33/6896 , A61K39/0007 , C07K16/18 , G01N2333/4709 , G01N2440/38 , G01N2800/2821 , G01N2800/50 , G01N2800/52 , H01J49/0027 , Y10T436/24
摘要： Methods are provided for the prevention, treatment and diagnosis of Alzheimer's disease, based on the glycosylation pattern of amyloid-beta peptides in body fluids and tissues.
摘要翻译：基于体液和组织中淀粉样蛋白-β肽的糖基化模式，提供了用于预防，治疗和诊断阿尔茨海默病的方法。

23. 发明授权

US08428821B2 Operating method and system for supporting lane keeping of a vehicle 有权
标题翻译：支持车辆车道保养的操作方法和系统
公开(公告)号：US08428821B2
公开(公告)日：2013-04-23
申请号：US12670415
申请日：2007-08-15
申请人： Jonas Nilsson
发明人： Jonas Nilsson
IPC分类号： A01B69/00
CPC分类号： B62D15/025 , B60W10/20 , B60W50/14 , B60W2050/0026 , B60W2420/403 , B60W2420/52 , B60W2510/20 , B60W2520/14 , B60W2520/28 , B60W2550/402 , B62D6/003
摘要： A system and an operating method are provided for supporting lane keeping of a vehicle equipped with a steering device. The system and operating method include providing vehicle related information; providing environment related information; combining vehicle and environment related information; predicting a future trajectory of the vehicle based on vehicle and environment related information; estimating a desired lateral lane position of the vehicle and/or a guiding force; comparing the future trajectory and the desired lateral lane position; deciding if a guiding force is to be provided to the steering device; and, if guiding force is to be provided, defining an amount of said guiding force depending on a hierarchically ordered set describing a predetermined driving behavior of the vehicle, adapting the amount of guiding force depending on the direction in which the vehicle is intended to move and activating one or more actuators for supplying the adapted amount of guiding force to the steering device.
摘要翻译：提供了一种用于支持配备有转向装置的车辆的车道保持的系统和操作方法。系统和操作方法包括提供车辆相关信息; 提供环境相关信息; 结合车辆与环境相关信息; 基于车辆和环境相关信息预测车辆的未来轨迹; 估计车辆的期望侧车道位置和/或导向力; 比较未来轨迹和所需的横向车道位置; 决定是否向转向装置提供引导力; 并且如果要提供导向力，则根据描述车辆的预定驾驶行为的分级有序集来限定所述导向力的量，根据车辆将要移动的方向来适配导向力量以及致动一个或多个致动器，以向转向装置提供适当量的引导力。

24. 发明授权

US08312861B2 Engine brake detection 有权
标题翻译：发动机制动检测
公开(公告)号：US08312861B2
公开(公告)日：2012-11-20
申请号：US12739157
申请日：2008-10-22
申请人： Erik Ott , Jonas Nilsson
发明人： Erik Ott , Jonas Nilsson
IPC分类号： F02D13/04
CPC分类号： F01L13/065 , F01L1/08 , F01L1/181 , F01L1/20 , F01L1/267 , F01L9/02 , F01L9/026 , F01L2105/00 , F01L2820/01 , F02D13/04 , F02D41/221 , Y02T10/40
摘要： In a method for reducing engine vibrations during engine braking with a malfunctioning engine brake, the engine brake includes an arrangement for altering a timing of at least one exhaust valve and an arrangement for varying an exhaust gas back pressure. The method includes detecting piston acceleration for each cylinder in the engine during the use of the engine brake, comparing the detected piston acceleration with a predetermined reference value, decreasing exhaust gas back pressure during engine braking if at least one piston is detected with a piston acceleration deviating more than a predefined amount from the predetermined reference value so that the piston acceleration will be falling within the predefined amount from the predetermined reference value.
摘要翻译：在用发动机制动故障的发动机制动期间减少发动机振动的方法中，发动机制动器包括用于改变至少一个排气门的定时和用于改变排气背压的装置的装置。该方法包括在发动机制动器的使用期间检测发动机中的每个气缸的活塞加速度，将检测到的活塞加速度与预定的参考值进行比较，如果在活塞加速度下检测到至少一个活塞，则在发动机制动期间减小排气背压从预定的参考值偏移大于预定义的量，使得活塞加速度将从预定参考值落入预定义的量。

25. 发明申请

US20070274855A1 Steel Alloy For Cutting Details 审中-公开
标题翻译：钢合金切割细节
公开(公告)号：US20070274855A1
公开(公告)日：2007-11-29
申请号：US10584246
申请日：2005-03-22
申请人： Jonas Nilsson , Andreas Rosberg
发明人： Jonas Nilsson , Andreas Rosberg
IPC分类号： C22C38/44 , C22C38/22 , C22C38/52 , C22C38/30
CPC分类号： C22C38/44 , C22C38/001 , C22C38/02 , C22C38/04
摘要： The invention relates to a steel alloy of the following composition (in % by weight) C 0.40-0.60 Si 0.1-1.0 Mn 0.3-1.0 Cr 12-15 MO 2.5-4.0 Ni 0-1.0 Co 0-4.0 N 0.15-0.20, with the balance Fe as well as normally occurring impurities, the hardness being >56 HRC, which has been attained without deep freezing, as well as PRE>25, defined as PRE=% Cr+3.3•% Mo+16•% N. Furthermore, the steel alloy comprises carbides, nitrides and/or carbonitrides the maximal diameter of which does not exceed 5 μm. This steel alloy has turned out surprisingly well suitable as edge material for a plurality of cutting operations.
摘要翻译：本发明涉及以下组成的钢合金（重量％）C 0.40-0.60 Si 0.1-1.0 Mn 0.3-1.0 Cr 12-15 MO 2.5-4.0 Ni 0-1.0 Co 0-4.0 N 0.15-0.20，余量为Fe以及通常出现的杂质，硬度> 56 HRC，无深度冻结，PRE> 25，定义为PRE =％Cr + 3.3％Mo + 16.％N. 此外，钢合金包括最大直径不超过5um的碳化物，氮化物和/或碳氮化物。这种钢合金出人意料地非常适合作为用于多个切割操作的边缘材料。

26. 发明授权

US07071180B2 Certain arylaliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases 失效
公开(公告)号：US07071180B2
公开(公告)日：2006-07-04
申请号：US10873852
申请日：2004-06-22
申请人： Björn Nilsson , Jan Tejbrant , Benjamin Pelcman , Erik Ringberg , Markus Thor , Jonas Nilsson , Mattias Jönsson
发明人： Björn Nilsson , Jan Tejbrant , Benjamin Pelcman , Erik Ringberg , Markus Thor , Jonas Nilsson , Mattias Jönsson
IPC分类号： A61K31/33 , A61K31/502 , A61K31/497 , C07D401/04 , C07D241/36
CPC分类号： C07D401/12 , C07D241/18 , C07D241/20 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D491/04
摘要： The invention relates to compounds of the general formula (I): wherein Ar is optionally substituted aryl or heteroaryl; A is (i) —O—, —S—, —SO2—, —NH—, (ii) a C1-4-alkyl- or C1-6-acyl-substituted nitrogen atom or (iii) a C1-8-alkylene chain or a heteroalkylene chain having 2 to 8 chain atoms, which optionally contains at least one unsaturation, and which may be substituted and/or contain a bridge to form a saturated or partially or fully unsaturated ring having 3-8 ring members; B is —C(R4)(R5)—, —OC(R4)(R5)—, —N(R6)C(R4)(R5)—, —N(R6)—, —O—, —S— or —SO2—; R is optionally substituted C3-8-cycloalkyl, aryl or heteroaryl; R1 is (i) a saturated or unsaturated azacyclic or aminoazacyclic ring, or a saturated diazacyclic or aminodiazacyclic ring, which has 4 to 7 ring members, or a saturated aminoazabicyclic, azabicyclic or diazabicyclic ring which has 7 to 10 ring members, which rings optionally are substituted in one or more positions, or a group —[C(R4)(R5)]xN(R2a)(R3a)]; R2a, R3a, R4, R5, R6 and x are as defined in the claims, and n is 0 or 1; and pharmaceutically acceptable salts, hydrates and prodrug forms thereof. The compounds may be prepared by per se conventional methods and can be used for treating a human or animal subject suffering from a serotonin-related disorder, such as eating disorders, especially obesity, memory disorders, schizophrenia, mood disorders, anxiety disorders, pain, sexual dysfunctions, and urinary disorders. The invention also relates to such use as well as to pharmaceutical compositions comprising a compound of formula (I).

27. 发明申请

US20050239841A1 New compounds 审中-公开
标题翻译：新化合物
公开(公告)号：US20050239841A1
公开(公告)日：2005-10-27
申请号：US10997675
申请日：2004-11-24
申请人： Andrew Browning , Jonas Nilsson , Martin Scobie , Johan Angbrant , Rune Ringom
发明人： Andrew Browning , Jonas Nilsson , Martin Scobie , Johan Angbrant , Rune Ringom
IPC分类号： A61K31/405 , A61K31/416 , A61K31/4178 , A61K31/454 , C07D209/12 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D43/02
CPC分类号： C04B35/632 , C07D209/08 , C07D209/12 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of the general formula (I) wherein R0, R1, R2, R3, R4, R5, R6, R7, R8, R9, Ar, and X are as defined in the description, or a pharmaceutically acceptable salt, hydrates, geometrical isomers, racemates, tautomers, optical isomers, N-oxides and prodrug forms thereof. The compounds may be used for the treatment or prophylaxis of disorders related to the MCH1R receptor and for modulation of appetite. The invention also relates to such use as well as to pharmaceutical formulations comprising a compound of formula (I).
摘要翻译：本发明涉及通式（I）的化合物，其中R 0，R 1，R 2，R 3，R 3， R 4，R 4，R 5，R 6，R 7，R 8， R 9，R 9，Ar和X如说明书中所定义，或其药学上可接受的盐，水合物，几何异构体，外消旋体，互变异构体，旋光异构体，N-氧化物和前药形式。该化合物可用于治疗或预防与MCH1R受体相关的病症并调节食欲。本发明还涉及这样的用途以及包含式（I）化合物的药物制剂。

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