专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US5162042A Electrotransport transdermal system 失效
标题翻译：电传递透皮系统
公开(公告)号：US5162042A
公开(公告)日：1992-11-10
申请号：US815558
申请日：1991-12-27
申请人： J. Richard Gyory , Ronald P. Haak , Felix Theeuwes
发明人： J. Richard Gyory , Ronald P. Haak , Felix Theeuwes
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444 , A61N1/0448
摘要： A transdermal therapeutic system which utilizes electrical current to facilitate drug delivery.
摘要翻译：一种透皮治疗系统，其利用电流来促进药物递送。

22. 发明授权

US5158537A Iontophoretic delivery device and method of hydrating same 失效
标题翻译：静电输送装置及其液压方法
公开(公告)号：US5158537A
公开(公告)日：1992-10-27
申请号：US605046
申请日：1990-10-29
申请人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
发明人： Ronald P. Haak , J. Richard Gyory , Felix Theeuwes , Felix A. Landrau , Nathan Roth , Robert M. Myers
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/0448 , A61N1/044
摘要： A dry-state iontophoretic drug delivery device (10, 70, 80) is provided. The device has drug and electrolyte reservoirs (15, 16) which are initially in a non-hydrated condition. A liquid-containing pouch (21, 22) is provided. In certain embodiments the liquid is contained in breakable capsules within the pouch. Water or other liquid can be released from the capsules in the pouch by squeezing or flexing the pouches (21, 22). Alternatively, the liquid can be released from the pouches (21, 22) using pouch piercing pins (36, 37). The liquid released from the pouches (21, 22) hydrates the drug and electrolyte reservoirs (15, 16) and activates the device. In another embodiment, the device (20, 20a) has liquid-containing gel layers (31, 32) which are initially separated from their respective electrode assemblies (8, 9). Liquid-wicking pathways (27, 28) are provided to carry the liquid from the gel layers (31, 32) to the drug and electrolyte layers (15, 16).
摘要翻译：提供了干态离子电渗药物输送装置（10,70,80）。该装置具有最初处于非水合状态的药物和电解质储存器（15,16）。提供含液囊（21,22）。在某些实施方案中，液体包含在小袋内的可破坏胶囊中。水或其它液体可以通过挤压或弯曲袋（21,22）从袋中的胶囊释放。或者，可以使用袋刺穿销（36,37）从袋（21,22）中释放液体。从袋（21,22）释放的液体使药物和电解质储存器（15,16）水合，并激活装置。在另一个实施例中，装置（20,20a）具有最初与其各自的电极组件（8,9）分离的含液体凝胶层（31,32）。提供液体芯吸路径（27,28）以将液体从凝胶层（31,32）运送到药物和电解质层（15,16）。

23. 发明授权

US07212853B1 Electrotransport agent delivery method and apparatus 失效
标题翻译：电子输送剂输送方法和装置
公开(公告)号：US07212853B1
公开(公告)日：2007-05-01
申请号：US08952368
申请日：1996-06-07
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
IPC分类号： A61N1/30
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448
摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state. Most preferably the length of the applied current pulses is at least 5 msec and preferably at least 10 msec.
摘要翻译：提供了一种用于通过完整皮肤递送治疗剂的电转运剂递送装置（10）及其操作方法。该装置施加脉冲电输送电流，其中电流脉冲具有高于皮肤转化为更高的电转运递送效率（E）状态的临界水平（I C）以上的幅度。最优选地，施加的电流脉冲的长度为至少5毫秒，优选至少10毫秒。

24. 发明授权

US06718201B1 Electrotransport agent delivery method and apparatus 失效
标题翻译：电子输送剂输送方法和装置
公开(公告)号：US06718201B1
公开(公告)日：2004-04-06
申请号：US08952367
申请日：1997-11-17
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
IPC分类号： A61N130
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/325
摘要： An electrotransport device and method of operating same provides a pulsed DC current of specified frequency and duration which transforms the skin into a higher electrotransport delivery efficiency state.
摘要翻译：电输送装置及其操作方法提供指定频率和持续时间的脉冲直流电流，其将皮肤转变成更高的电输送输送效率状态。

25. 发明授权

US07572252B1 Electrotransport agent delivery method and apparatus 失效
标题翻译：电子输送剂输送方法和装置
公开(公告)号：US07572252B1
公开(公告)日：2009-08-11
申请号：US08484934
申请日：1995-06-07
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Suneel Gupta , Felix Theeuwes
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Suneel Gupta , Felix Theeuwes
IPC分类号： A61M31/00
CPC分类号： A61M37/00 , A61K9/0009 , A61K9/0014 , A61K9/06 , A61K31/4468 , A61M2037/0007 , A61N1/30
摘要： A method of increasing the delivery efficiency of an agent through a body surface by electrotransport is disclosed wherein the electrotransport current is applied for durations at a higher current density values followed by durations of lower current density values wherein the higher current density applications transform the body surface to an enhanced, non-transitory agent delivery efficiency state.
摘要翻译：公开了一种通过电运输提高试剂通过身体表面的输送效率的方法，其中电传输电流以较高电流密度值施加持续时间，随后是较低电流密度值的持续时间，其中较高的电流密度应用转变体表面以增强，非临时代理分配效率状态。

26. 发明授权

US5983130A Electrotransport agent delivery method and apparatus 失效
标题翻译：电子输送剂输送方法和装置
公开(公告)号：US5983130A
公开(公告)日：1999-11-09
申请号：US483069
申请日：1995-06-07
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Suneel Gupta , Felix Theeuwes
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Suneel Gupta , Felix Theeuwes
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/325 , A61N1/044 , A61N1/0448
摘要： An electrotransport agent delivery device for delivering a therapeutic agent through a body surface, and a method for increasing agent delivery efficiency, is provided. The device includes a current controller which delivers a pulsating electrotransport current and peak current density I.sub.max, I.sub.max being greater than a critical current density level I.sub.c above which the body exhibits a non-transitory higher agent delivery efficiency. Methods for increasing electrotransport delivery efficiency (E) of an agent through a body surface by creation of a higher agent delivery efficiency state are also provided.
摘要翻译：提供了一种用于通过身体表面递送治疗剂的电转运剂递送装置和用于提高药剂输送效率的方法。该装置包括电流控制器，该电流控制器提供脉动电输送电流和峰值电流密度Imax，Imax大于临界电流密度水平Ic，在该临界电流密度水平以上，身体表现出非瞬时更高的药剂输送效率。还提供了通过创建更高的试剂递送效率状态来提高试剂通过身体表面的电传送递送效率（E）的方法。

27. 发明授权

US5445606A Indicator for iontophoresis system 失效
标题翻译：离子电渗系统指示剂
公开(公告)号：US5445606A
公开(公告)日：1995-08-29
申请号：US69061
申请日：1993-05-28
申请人： Ronald P. Haak , Felix Theeuwes , David K. Roe
发明人： Ronald P. Haak , Felix Theeuwes , David K. Roe
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0448 , A61N1/325 , A61N1/0436 , A61N1/044
摘要： Apparatus (11) for delivery of a medicament, drug or other therapeutic agent transdermally to a body by iontophoresis is provided. The apparatus (11) provides a means (13) for measuring and displaying the cumulative amount of the medicament delivered to the body by monitoring the amount of a metal, initially present at the anode (45), that is transferred to the cathode (41) in a subsidiary electrolyte cell (47) through which the drive current for the apparatus (11) passes. Optionally, the apparatus also provides a plurality of light emitting devices (63-1) that display a measure of the cumulative amount of medicament delivered, by use of visually distinguishable light colors or by use of binary encoding in the light display.
摘要翻译：提供了用于通过离子电渗法将药物，药物或其它治疗剂透皮地递送到身体的装置（11）。装置（11）提供了一种装置（13），用于通过监测最初存在于阳极（45）的金属的量来测量和显示递送到身体的药物的累积量，该金属的量转移到阴极（41））连接在辅助电解质电池（47）中，用于装置（11）的驱动电流通过该辅助电解质电池（47）。可选地，该装置还提供多个发光装置（63-1），其通过使用视觉上可区分的光色或通过在光显示器中使用二进制编码来显示传送的药物的累积量的量度。

28. 发明授权

US07136698B2 Electrotransport agent delivery apparatus 有权
标题翻译：电子输送装置
公开(公告)号：US07136698B2
公开(公告)日：2006-11-14
申请号：US10778748
申请日：2004-02-12
申请人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
发明人： J. Bradley Phipps , Gary A. Lattin , Ronald P. Haak , Felix Theeuwes , Suneel K. Gupta
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0448 , A61N1/325
摘要： An electrotransport agent delivery device (10) for delivering a therapeutic agent through intact skin, and a method of operating same, is provided. The device applies a pulsing electrotransport current wherein the length of the applied current pulses is at least 5 msec and preferably at least 10 msec. Most preferably, the current pulses have a magnitude above a critical level (Ic) at which the skin is transformed into a higher electrotransport delivery efficiency (E) state.
摘要翻译：提供了一种用于通过完整皮肤递送治疗剂的电转运剂递送装置（10）及其操作方法。该装置施加脉冲电输送电流，其中所施加的电流脉冲的长度为至少5毫秒，优选至少10毫秒。最优选地，电流脉冲具有高于临界水平（I C）的幅度，在该临界水平下皮肤被转换成更高的电运送输送效率（E）状态。

29. 发明授权

US5246417A Indicator for iontophoresis system 失效
标题翻译：指示系统
公开(公告)号：US5246417A
公开(公告)日：1993-09-21
申请号：US806055
申请日：1991-12-11
申请人： Ronald P. Haak , Felix Theeuwes , David K. Roe
发明人： Ronald P. Haak , Felix Theeuwes , David K. Roe
IPC分类号： A61N1/30 , A61N1/32
CPC分类号： A61N1/0448 , A61N1/325 , A61N1/0436 , A61N1/044
摘要： Apparatus (11) for delivery of a medicament, drug or other therapeutic agent transdermally to a body by iontophoresis is provided. The apparatus (11) provides a means (13) for measuring and displaying the cumulative amount of the medicament delivered to the body by monitoring the amount of a metal, initially present at the anode (45), that is transferred to the cathode (41) in a subsidiary electrolyte cell (47) through which the drive current for the apparatus (11) passes. Optionally, the apparatus also provides a plurality of light emitting devices (63-1) that display a measure of the cumulative amount of medicament delivered, by use of visually distinguishable light colors or by use of binary encoding in the light display.
摘要翻译：提供了用于通过离子电渗法将药物，药物或其它治疗剂透皮地递送到身体的装置（11）。装置（11）提供了一种装置（13），用于通过监测最初存在于阳极（45）的金属的量来测量和显示递送到身体的药物的累积量，该金属的量转移到阴极（41））连接在辅助电解质电池（47）中，用于装置（11）的驱动电流通过该辅助电解质电池（47）。可选地，该装置还提供多个发光装置（63-1），其通过使用视觉上可区分的光色或通过在光显示器中使用二进制编码来显示传送的药物的累积量的量度。

30. 发明授权

US6049733A Electrotransport system with ion exchange material competitive ion capture 失效
标题翻译：电离传输系统采用离子交换材料竞争离子捕获
公开(公告)号：US6049733A
公开(公告)日：2000-04-11
申请号：US938769
申请日：1997-09-26
申请人： J. Bradley Phipps , Lyn C. Moodie , J. Richard Gyory , Felix Theeuwes
发明人： J. Bradley Phipps , Lyn C. Moodie , J. Richard Gyory , Felix Theeuwes
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0444 , Y10S977/949
摘要： An electrotransport apparatus using dispersed ion exchange material (19,83) is disclosed. The ion exchange material (19,83) may be dispersed in either the donor electrode assembly (10), the counter electrode assembly (10) or both electrode assemblies. The dispersed ion exchange material (83) comprises mobile ionic species (84-2) and substantially immobile ionic species (P). The dispersed ion exchange material (83, 84-2) interacts with competitive species (86) generated during electrotransport to render those species substantially immobile (87). Electrotransport devices exhibiting reduced polarization are also disclosed.
摘要翻译：公开了一种使用分散离子交换材料（19,83）的电转运装置。离子交换材料（19,83）可以分散在供体电极组件（10），对电极组件（10）或两个电极组件中。分散的离子交换材料（83）包括移动离子物质（84-2）和基本上不可移动的离子物质（P）。分散的离子交换材料（83,84-2）与在电输运期间产生的竞争物种（86）相互作用以使这些物质基本上不可移动（87）。还公开了表现出减小的极化的电子传输器件。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式