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21. 发明申请

US20100297223A1 PHARMACEUTICAL DOSAGE FORM COMPRISING A LIQUID OR FLOWABLE CORE COMPOSITION 审中-公开
标题翻译：包含液体或流动核心组成的药物剂型
公开(公告)号：US20100297223A1
公开(公告)日：2010-11-25
申请号：US12746474
申请日：2008-12-18
申请人： Jörg Rosenberg , Markus Mägerlein , Jörg Breitenbach , Tina Jung , Ulrich Westedt
发明人： Jörg Rosenberg , Markus Mägerlein , Jörg Breitenbach , Tina Jung , Ulrich Westedt
IPC分类号： A61K9/48
CPC分类号： A61K9/4816 , A61K9/06 , A61K9/4825 , A61K9/4858 , A61K31/498 , A61K47/10
摘要： A pharmaceutical dosage form, comprising a) a liquid or flowable core, b) a shell of a polysaccharide or proteinaceous material completely enclosing said core, the core comprising an active ingredient dissolved in a pharmaceutically acceptable compound of the formula (I) wherein n is an integer from 3 to 5, and wherein the (i) the at least one active ingredient and the compound of the formula (I) account for at least 50% by weight of the composition; and (ii) the water activity aw of the composition is less than 0.4.
摘要翻译：一种药物剂型，其包含a）液体或可流动的核心，b）完全包围所述核心的多糖或蛋白质材料的壳，所述核心包含溶解在药学上可接受的式（I）化合物中的活性成分，其中n为 3至5的整数，并且其中（i）所述至少一种活性成分和式（I）的化合物占所述组合物的至少50重量％。和（ii）组合物的水活度aw小于0.4。

22. 发明申请

US20090274731A1 PRODUCTION OF ENVELOPED PHARMACEUTICAL DOSAGE FORMS 审中-公开
标题翻译：生产包装药物剂型
公开(公告)号：US20090274731A1
公开(公告)日：2009-11-05
申请号：US12301558
申请日：2007-05-23
申请人： Jörg Rosenberg , Harald Hach , Ulrich Westedt , Martin Knobloch , Jörg Breitenbach
发明人： Jörg Rosenberg , Harald Hach , Ulrich Westedt , Martin Knobloch , Jörg Breitenbach
IPC分类号： A61K9/00 , B32B37/06 , B32B37/16
CPC分类号： A61K9/2893 , A61K9/1617 , A61K9/1652 , A61K9/2027 , A61K9/2059 , A61K9/284 , A61K9/2866 , A61K9/5026 , A61K9/5047 , A61K9/5089
摘要： A process for at least partially enveloping a pharmaceutical dosage form, in which the dosage form is surrounded by a shrinkable film, and the film is subsequently shrunk is described.
摘要翻译：描述了至少部分包封药物剂型的方法，其中剂型被可收缩膜包围，并且膜随后被收缩。

23. 发明授权

US06599528B1 Mechanically stable pharmaceutical presentations form containing liquid or semisolid surface-active substances 有权
标题翻译：包含液体或半固体表面活性物质的机械稳定的药物呈现形式
公开(公告)号：US06599528B1
公开(公告)日：2003-07-29
申请号：US09936349
申请日：2001-09-11
申请人： Jörg Rosenberg , Gunther Berndl , Bernd Liepold , Jörg Breitenbach
发明人： Jörg Rosenberg , Gunther Berndl , Bernd Liepold , Jörg Breitenbach
IPC分类号： A61K948
CPC分类号： A61K9/1617 , A61K9/1635 , A61K9/1694
摘要： The present invention relates to mechanically stable pharmaceutical presentations for oral administration, comprising in addition to one or more active ingredients and at least one melt-processable matrix-forming excipient more than 10 and up to 40% by weight of a surface-active substance with an HLB of from 2 to 18, which is liquid at 20° C. or has a drop point in the range from 20 to 50° C.
摘要翻译：本发明涉及用于口服给药的机械稳定的药物表现，除了一种或多种活性成分和至少一种可熔融加工的基质形成赋形剂之外，还含有超过10重量％至多40重量％的表面活性物质， HLB为2至18，其在20℃下为液体或具有在20至50℃范围内的下降点。

24. 发明授权

US07846477B2 Method for producing solid galenic formulations using a crosslinked non-thermoplastic carrier 有权
标题翻译：使用交联的非热塑性载体制备固体盖仑制剂的方法
公开(公告)号：US07846477B2
公开(公告)日：2010-12-07
申请号：US10530483
申请日：2003-10-09
申请人： Jörg Rosenberg , Gunther Berndl , Markus Magerlein
发明人： Jörg Rosenberg , Gunther Berndl , Markus Magerlein
IPC分类号： A61K9/20 , B27N3/00
CPC分类号： A61K31/513 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2095
摘要： The invention concerns a method for producing solid galenic formulations which consists in: forming a processable paste comprising a) 50 to 99.4 wt. % of at least one non-thermoplastic carrier, b) 0.5 to 30 wt. % of at least an adjuvant selected among thermoplastic polymers, lipids, sugar alcohols and solubilizing agents, c) 0.1 to 49.5 wt. % of at least one active principle, at a temperature not less than the softening temperature of the adjuvant but rising to at least 70° C.; then in cooling the resulting paste. Said solid galenic formulations quickly disintegrate in an aqueous medium.
摘要翻译：本发明涉及一种制备固体盖仑制剂的方法，其中包括：形成可加工的糊剂，其包含a）50至99.4wt。％的至少一种非热塑性载体，b）0.5〜30wt。至少选自热塑性聚合物，脂质，糖醇和增溶剂中的佐剂的％，c）0.1至49.5wt。％的至少一种活性成分，在不低于佐剂的软化温度但升至至少70℃的温度下。然后冷却所得糊状物。所述固体盖仑制剂在水性介质中快速崩解。

25. 发明授权

US06737005B1 Method of producing solid dosage forms 有权
标题翻译：生产固体剂型的方法
公开(公告)号：US06737005B1
公开(公告)日：2004-05-18
申请号：US09831397
申请日：2001-05-09
申请人： Jörg Rosenberg , Werner Maier
发明人： Jörg Rosenberg , Werner Maier
IPC分类号： B26B102
CPC分类号： A61J3/10 , B30B11/165
摘要： A process for producing solid dosage forms by a) producing a plastic mixture which comprises at least one active ingredient and at least one polymeric binder, and b) shaping the plastic mixture to the solid dosage forms in a molding calender with two counterrotating molding rolls, wherein one molding roll has at least one annular groove running along its periphery and the other molding roll has at least one ring, running along its periphery, of teeth extending radially outward and able to engage in the annular groove is described.
摘要翻译：一种生产固体剂型的方法，包括：a）制备包含至少一种活性成分和至少一种聚合物粘合剂的塑料混合物，以及b）使用两个反向旋转成型辊将塑料混合物在成型压延机中成形为固体剂型，其中一个成型辊具有沿着其周边延伸的至少一个环形槽，并且另一个成型辊具有至少一个沿着其周边延伸的环，径向向外延伸并能够接合在环形槽中的环。

26. 发明授权

US08337733B2 Preparation of compositions with essentially noncrystalline embedded macrolide antibiotics 有权
标题翻译：具有基本上非晶体嵌入的大环内酯类抗生素的组合物的制备
公开(公告)号：US08337733B2
公开(公告)日：2012-12-25
申请号：US12673230
申请日：2008-08-14
申请人： Ulrich Westedt , Jörg Rosenberg , Martin Knobloch , Norbert Steiger , Harald Hach
发明人： Ulrich Westedt , Jörg Rosenberg , Martin Knobloch , Norbert Steiger , Harald Hach
IPC分类号： B29C47/00
CPC分类号： A61K9/146 , B29C47/40 , B29C47/6056 , B29C47/64
摘要： A description is given of a process for the preparation of a pharmaceutical composition of a macrolide antibiotic in essentially noncrystalline form, in which the macrolide antibiotic, a water-swellable polymer and a proton donor are blended in an extruder in the presence of water and forced through a die, the ratio by weight of the sum of macrolide antibiotic, water-swellable polymer and proton donor to water being at least 1:1. The macrolide antibiotic is preferably clarithromycin and the water-swellable polymer is preferably chosen from crosslinked polyvinylpyrrolidone, crosslinked sodium carboxymethylcellulose and crosslinked polyacrylic acid.
摘要翻译：描述了制备基本上非结晶形式的大环内酯类抗生素药物组合物的方法，其中大环内酯类抗生素，水溶胀性聚合物和质子供体在水和挤出机的存在下在挤出机中共混通过模具，大环内酯类抗生素，水溶胀性聚合物和质子供体与水的总量的重量比至少为1:1。大环内酯类抗生素优选为克拉霉素，水溶胀性聚合物优选选自交联聚乙烯吡咯烷酮，交联羧甲基纤维素钠和交联聚丙烯酸。

27. 发明授权

US06488939B1 Cleavable solid dosage forms and method for the production thereof 有权
标题翻译：可切割的固体剂型及其制备方法
公开(公告)号：US06488939B1
公开(公告)日：2002-12-03
申请号：US09857018
申请日：2001-05-31
申请人： Jürgen Zeidler , Jörg Rosenberg , Werner Maier , Jörg Neumann
发明人： Jürgen Zeidler , Jörg Rosenberg , Werner Maier , Jörg Neumann
IPC分类号： A61K900
CPC分类号： A61K9/2072 , A61J3/10
摘要： Solid, elongate dosage forms (10) with a long axis (11) and with a length (L) which is defined by projection of the ends (12, 13) of the dosage form to the long axis, where a cross-sectional area (14, 15, 16) oriented perpendicular to the long axis (11) has an area which is variable along the long axis (11) and increases from a cross-sectional area (15) which is located between the ends (12, 13) and has a minimal area essentially continuously toward the two ends (12, 13) up to in each case a cross-sectional area (14 and 16 respectively) with a maximal area, wherein the distance of the maximal cross-sectional area (14) which is located near one end (12) from the maximal cross-sectional area (16) which is located near the other end (13) is, projected on the long axis (11), more than half the length (L) of the dosage form (10), are described.
摘要翻译：具有长轴（11）和长度（L）的固体，细长剂型（10），其长度（L）通过将剂型的端部（12,13）投影到长轴而限定，其中横截面积垂直于长轴线（11）定向的区域（14,15,16）具有沿着长轴线（11）可变的区域，并且从位于端部（12,13）之间的横截面积（15）增加）并且具有基本上连续朝向两端（12,13）的最小面积，直到在每种情况下具有最大面积的截面面积（14和16），其中最大横截面积（14,13）的距离）位于靠近另一端（13）的最大横截面积（16）附近的一端（12）处，突出在长轴（11）上，大于其长度（L）的一半描述了剂型（10）。

28. 发明申请

US20100143459A1 PHARMACEUTICAL DOSAGE FORM FOR ORAL ADMINISTRATION OF TYROSINE KINASE INHIBITOR 审中-公开
标题翻译：酪氨酸激酶抑制剂口服给药的药物剂型
公开(公告)号：US20100143459A1
公开(公告)日：2010-06-10
申请号：US12447488
申请日：2007-11-08
申请人： Bernd Liepold , Jörg Rosenberg , Martin Knobloch , Christian Nehen
发明人： Bernd Liepold , Jörg Rosenberg , Martin Knobloch , Christian Nehen
IPC分类号： A61K31/416 , A61K31/44 , A61K31/506 , A61K31/517 , A61K31/553 , A61K31/404 , A61K31/4439 , A61K31/519 , A61P35/00 , A61P35/02 , A61P9/00 , A61P27/02 , A61K9/48
CPC分类号： A61K9/146 , A61K9/2018 , A61K9/2027
摘要： A pharmaceutical dosage form comprises a solid dispersion product of at least one tyrosine kinase inhibitor, at least one pharmaceutically acceptable polymer, and at least one pharmaceutically acceptable solubilizer.
摘要翻译：药物剂型包含至少一种酪氨酸激酶抑制剂，至少一种药学上可接受的聚合物和至少一种药学上可接受的增溶剂的固体分散体产物。

29. 发明授权

US06669883B1 Method and device for producing different solid dosage forms 有权
标题翻译：用于生产不同固体剂型的方法和装置
公开(公告)号：US06669883B1
公开(公告)日：2003-12-30
申请号：US09869666
申请日：2001-07-02
申请人： Jörg Rosenberg , Werner Maier
发明人： Jörg Rosenberg , Werner Maier
IPC分类号： B29B910
CPC分类号： B29C43/24 , A61J3/10 , A61J2200/20 , A61K9/2095 , B29C43/222 , B30B11/16 , B30B11/165
摘要： The invention relates to a process and an apparatus for producing solid dosage forms by molding plastic active ingredient-containing mixtures with use of a continuously operating molding tool with two parts which cooperate to mold the plastic mixture, with at least one part having a plurality of depressions to receive and mold the plastic mixture, wherein one part has at least two groups, which differ in volume and/or shape, of depressions. Dosage forms which differ in shape or size are obtained in one step.
摘要翻译：本发明涉及通过使用连续操作的模制工具模制含有塑料活性成分的混合物来生产固体剂型的方法和设备，所述模具具有两个部分，其配合模塑塑料混合物，其中至少一个部分具有多个凹陷以接收和模塑塑料混合物，其中一个部分具有凹陷的体积和/或形状不同的至少两个组。在一个步骤中获得形状和尺寸不同的剂型。

30. 发明授权

US06669879B1 Method for producing solid dosing forms 有权
标题翻译：生产固体剂型的方法
公开(公告)号：US06669879B1
公开(公告)日：2003-12-30
申请号：US09763662
申请日：2001-02-26
申请人： Reinhard Spengler , Jörg Rosenberg
发明人： Reinhard Spengler , Jörg Rosenberg
IPC分类号： B29B910
CPC分类号： A61K9/2095 , A61K9/2893
摘要： A process for producing solid dosage forms by forming a plastic mixture of at least one polymeric binder, at least one active ingredient and, where appropriate, conventional additives, and shaping the plastic mixture to the solid dosage forms using a mold, wherein an agent which modifies the surface properties is applied in finely divided form to the surface of the plastic, mixture during the shaping is described. The agent which modifies the surface properties is preferably a surfactant, a lipophilic compound, an antioxidant, a coloring agent or an agent with antistatic effect and/or lubricant effect.
摘要翻译：一种通过形成至少一种聚合物粘合剂，至少一种活性成分和适当的常规添加剂的塑性混合物并且使用模具将塑料混合物成型为固体剂型的方法来制备固体剂型的方法，改变表面性质以细碎形式施加到塑料表面，描述了在成形过程中的混合物。修饰表面性质的试剂优选为表面活性剂，亲油性化合物，抗氧化剂，着色剂或具有抗静电效果和/或润滑剂效果的试剂。

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