专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08841303B2 Melt-processed imatinib dosage form 有权
标题翻译：熔融加工的伊马替尼剂型
公开(公告)号：US08841303B2
公开(公告)日：2014-09-23
申请号：US12447508
申请日：2007-11-08
申请人： Jörg Breitenbach , Norbert Steiger , Harald Hach , Ulrich Westedt , Martin Knobloch , Ralf Altenburger , Nicoletta Loggia , Jörg Ogorka
发明人： Jörg Breitenbach , Norbert Steiger , Harald Hach , Ulrich Westedt , Martin Knobloch , Ralf Altenburger , Nicoletta Loggia , Jörg Ogorka
IPC分类号： A61K31/497 , A61K9/20
CPC分类号： A61K9/2095 , A61K9/2054
摘要： The invention provides a dosage form, comprising a melt-processed mixture of (a) a pharmaceutically effective amount of imatinib or a salt thereof, (b) at least one polymeric binder, and (c) at least one pharmaceutically acceptable non-ionic surfactant. The invention provides imatinib dosage forms with high drug loading which can be prepared in a simple and efficient manner, imatinib dosage forms from which the active principle is released in an essentially pH-independent fashion, and extended release imatinib dosage forms.
摘要翻译：本发明提供了一种剂型，其包含（a）药学有效量的伊马替尼或其盐的熔融加工混合物，（b）至少一种聚合物粘合剂，和（c）至少一种药学上可接受的非离子表面活性剂。本发明提供具有高药物负荷的伊马替尼剂型，其可以以简单和有效的方式制备，以基本上不依赖于pH的方式释放活性成分的伊马替尼剂型和延长释放的伊马替尼剂型。

2. 发明授权

US06251945B1 Pharmaceutical mixture comprising a combination of a profen and other active compounds 有权
标题翻译：药物混合物，其包含丙烯酸和其它活性化合物的组合
公开(公告)号：US06251945B1
公开(公告)日：2001-06-26
申请号：US09245112
申请日：1999-01-14
申请人： Heinz Einig , Harald Hach , Raymond Eason , Bernd W. Müller , Richard C. Thompson
发明人： Heinz Einig , Harald Hach , Raymond Eason , Bernd W. Müller , Richard C. Thompson
IPC分类号： A01N3710
CPC分类号： A61K31/19 , A61K9/2013 , A61K31/485 , A61K31/52 , A61K2300/00
摘要： A pharmaceutical mixture comprising a profen and one or more additional active compounds is described which has a total active compound content of over 85% and contains up to 1%, based on the content of the profen, of a nonionic surfactant having an HLB of ≧9 and a customary disintegrant and a lubricant.
摘要翻译：描述了包含丙烯和一种或多种另外的活性化合物的药物混合物，其具有超过85％的总活性化合物含量，并且基于特性含量高达1％，HLB> = 9和常规的崩解剂和润滑剂。

3. 发明授权

US08337733B2 Preparation of compositions with essentially noncrystalline embedded macrolide antibiotics 有权
标题翻译：具有基本上非晶体嵌入的大环内酯类抗生素的组合物的制备
公开(公告)号：US08337733B2
公开(公告)日：2012-12-25
申请号：US12673230
申请日：2008-08-14
申请人： Ulrich Westedt , Jörg Rosenberg , Martin Knobloch , Norbert Steiger , Harald Hach
发明人： Ulrich Westedt , Jörg Rosenberg , Martin Knobloch , Norbert Steiger , Harald Hach
IPC分类号： B29C47/00
CPC分类号： A61K9/146 , B29C47/40 , B29C47/6056 , B29C47/64
摘要： A description is given of a process for the preparation of a pharmaceutical composition of a macrolide antibiotic in essentially noncrystalline form, in which the macrolide antibiotic, a water-swellable polymer and a proton donor are blended in an extruder in the presence of water and forced through a die, the ratio by weight of the sum of macrolide antibiotic, water-swellable polymer and proton donor to water being at least 1:1. The macrolide antibiotic is preferably clarithromycin and the water-swellable polymer is preferably chosen from crosslinked polyvinylpyrrolidone, crosslinked sodium carboxymethylcellulose and crosslinked polyacrylic acid.
摘要翻译：描述了制备基本上非结晶形式的大环内酯类抗生素药物组合物的方法，其中大环内酯类抗生素，水溶胀性聚合物和质子供体在水和挤出机的存在下在挤出机中共混通过模具，大环内酯类抗生素，水溶胀性聚合物和质子供体与水的总量的重量比至少为1:1。大环内酯类抗生素优选为克拉霉素，水溶胀性聚合物优选选自交联聚乙烯吡咯烷酮，交联羧甲基纤维素钠和交联聚丙烯酸。

4. 发明申请

US20090050262A1 Production of Dosing Molds from Active Substance-Containing Melts 审中-公开
标题翻译：从含活性物质的熔体生产计量模具
公开(公告)号：US20090050262A1
公开(公告)日：2009-02-26
申请号：US11884521
申请日：2006-02-17
申请人： Jorg Rosenberg , Norbert Steiger , Harald Hach , Jorg Breitenbach
发明人： Jorg Rosenberg , Norbert Steiger , Harald Hach , Jorg Breitenbach
IPC分类号： B32B37/10
CPC分类号： A61J3/10 , A61J2200/20 , B30B11/16
摘要： Disclosed is a method for producing dosing molds, according to which two separating films (7) are contacted with each other in a defined area, an active substance-containing melt is introduced between the separating films (7) such that a pocket for receiving a portion of the melt is embodied in at least one of the separating films, and the separating films (7) are separated from each other in order to eject the portion. Preferably, a method is disclosed in which the separating films (7) are contacted with each other in the gap of two molding rolls (2, 3) which rotate in opposite directions and are provided with opposite recesses (4, 5) on the surface thereof, and into which the separating films (7) can be pressed when the active substance-containing melt is introduced so as to form pockets. The separating films (7) make it possible to avoid a direct contact between the melt and the rolls (4,5) and thus prevent the melt from adhering to the roll (2, 3). Elastically deformable separating films (7) support the ejection process as a result of the stress thereof being released after leaving the roll gap (2, 3).
摘要翻译：公开了一种用于生产定量给料模具的方法，根据该方法，两个分离膜（7）在限定的区域中彼此接触，含活性物质的熔体被引入到分离膜（7）之间，使得用于接收熔体的一部分体现在至少一个分离膜中，并且分离膜（7）彼此分离以便喷射该部分。优选地，公开了一种方法，其中分离膜（7）在沿相反方向旋转的两个成型辊（2,3）的间隙中彼此接触并且在表面上设置有相对的凹部（4,5）并且当引入含活性物质的熔体以形成袋时，分离膜（7）可以被压入其中。分离膜（7）使得可以避免熔体与辊（4,5）之间的直接接触，从而防止熔体粘附到辊（2,3）上。弹性变形分离膜（7）由于在离开辊间隙（2,3）之后其应力释放而支持喷射过程。

5. 发明申请

US20120001361A1 PREPARATION OF COMPOSITIONS WITH ESSENTIALLY NONCRYSTALLINE EMBEDDED MACROLIDE ANTIBIOTICS 有权
标题翻译：具有非天然嵌合抗体的组合物的制备
公开(公告)号：US20120001361A1
公开(公告)日：2012-01-05
申请号：US12673230
申请日：2008-08-14
申请人： Ulrich Westedt , Jörg Rosenberg , Martin Knobloch , Norbert Steiger , Harald Hach
发明人： Ulrich Westedt , Jörg Rosenberg , Martin Knobloch , Norbert Steiger , Harald Hach
IPC分类号： B29C47/36
CPC分类号： A61K9/146 , B29C47/40 , B29C47/6056 , B29C47/64
摘要： A description is given of a process for the preparation of a pharmaceutical composition of a macrolide antibiotic in essentially noncrystalline form, in which the macrolide antibiotic, a water-swellable polymer and a proton donor are blended in an extruder in the presence of water and forced through a die, the ratio by weight of the sum of macrolide antibiotic, water-swellable polymer and proton donor to water being at least 1:1. The macrolide antibiotic is preferably clarithromycin and the water-swellable polymer is preferably chosen from crosslinked polyvinylpyrrolidone, crosslinked sodium carboxymethylcellulose and crosslinked polyacrylic acid.
摘要翻译：描述了制备基本上非结晶形式的大环内酯类抗生素药物组合物的方法，其中大环内酯类抗生素，水溶胀性聚合物和质子供体在水和挤出机的存在下在挤出机中共混通过模具，大环内酯类抗生素，水溶胀性聚合物和质子供体与水的总量的重量比至少为1:1。大环内酯类抗生素优选为克拉霉素，并且水溶胀性聚合物优选选自交联聚乙烯吡咯烷酮，交联羧甲基纤维素钠和交联聚丙烯酸。

6. 发明申请

US20100240672A1 MELT-PROCESSED IMATINIB DOSAGE FORM 有权
标题翻译： MELT-PROCESSED IMATINIB剂型
公开(公告)号：US20100240672A1
公开(公告)日：2010-09-23
申请号：US12447508
申请日：2004-11-08
申请人： Jorg Breitenbach , Norbert Steiger , Harald Hach , Ulrich Westedt , Martin Knobloch , Ralf Altenburger , Nicoletta Loggia , Jörg Ogorka
发明人： Jorg Breitenbach , Norbert Steiger , Harald Hach , Ulrich Westedt , Martin Knobloch , Ralf Altenburger , Nicoletta Loggia , Jörg Ogorka
IPC分类号： A61K31/496 , A61P35/00
CPC分类号： A61K9/2095 , A61K9/2054
摘要： The invention provides a dosage form, comprising a melt-processed mixture of (a) a pharmaceutically effective amount of imatinib or a salt thereof, (b) at least one polymeric binder, and (c) at least one pharmaceutically acceptable non-ionic surfactant. The invention provides imatinib dosage forms with high drug loading which can be prepared in a simple and efficient manner, imatinib dosage forms from which the active principle is released in an essentially pH-independent fashion, and extended release imatinib dosage forms.
摘要翻译：本发明提供了一种剂型，其包含（a）药学有效量的伊马替尼或其盐的熔融加工混合物，（b）至少一种聚合物粘合剂，和（c）至少一种药学上可接受的非离子表面活性剂。本发明提供具有高药物负荷的伊马替尼剂型，其可以以简单和有效的方式制备，以基本上不依赖于pH的方式释放活性成分的伊马替尼剂型和延长释放的伊马替尼剂型。

7. 发明申请

US20090274731A1 PRODUCTION OF ENVELOPED PHARMACEUTICAL DOSAGE FORMS 审中-公开
标题翻译：生产包装药物剂型
公开(公告)号：US20090274731A1
公开(公告)日：2009-11-05
申请号：US12301558
申请日：2007-05-23
申请人： Jörg Rosenberg , Harald Hach , Ulrich Westedt , Martin Knobloch , Jörg Breitenbach
发明人： Jörg Rosenberg , Harald Hach , Ulrich Westedt , Martin Knobloch , Jörg Breitenbach
IPC分类号： A61K9/00 , B32B37/06 , B32B37/16
CPC分类号： A61K9/2893 , A61K9/1617 , A61K9/1652 , A61K9/2027 , A61K9/2059 , A61K9/284 , A61K9/2866 , A61K9/5026 , A61K9/5047 , A61K9/5089
摘要： A process for at least partially enveloping a pharmaceutical dosage form, in which the dosage form is surrounded by a shrinkable film, and the film is subsequently shrunk is described.
摘要翻译：描述了至少部分包封药物剂型的方法，其中剂型被可收缩膜包围，并且膜随后被收缩。

8. 发明授权

US06726929B1 Pharmaceutical mixture comprising a profen 有权
标题翻译：药物混合物
公开(公告)号：US06726929B1
公开(公告)日：2004-04-27
申请号：US09868092
申请日：2001-06-14
申请人： Heinz Einig , Harald Hach , Richard C. Thompson , Raymond Eason , Bernd W. Müller
发明人： Heinz Einig , Harald Hach , Richard C. Thompson , Raymond Eason , Bernd W. Müller
IPC分类号： A61K914
CPC分类号： A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2866 , A61K31/19 , A61K31/192
摘要： A pharmaceutical mixture comprising a profen is described which has a profen content of over 85% and contains up to 1% of a nonionic surfactant having an HLB of ≧9 and also a customary disintegrant and a lubricant and optionally a microcrystalline cellulose.
摘要翻译：描述了包含丙烯的药物混合物，其具有超过85％的性能含量，并且含有高达1％的HLB> 9的非离子表面活性剂，以及常规的崩解剂和润滑剂以及任选的微晶纤维素。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式