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21. 发明申请

US20060240400A1 High-density cell array board, process for producing the same and method of using the same 审中-公开
标题翻译：高密度电池阵列板，制造方法及其使用方法
公开(公告)号：US20060240400A1
公开(公告)日：2006-10-26
申请号：US10544540
申请日：2003-02-06
申请人： Masayuki Yamato , Teruo Okano
发明人： Masayuki Yamato , Teruo Okano
IPC分类号： C12Q1/00 , C12M1/34 , B05D3/02
CPC分类号： G01N33/5023 , G01N33/5008 , G01N33/5011 , G01N33/5014
摘要： Culture substrates, cell arrays, automatic chemical dispensers and assay systems necessary for conveniently assaying multiple chemicals such as drugs and toxic agents are provided. Herein used is a substrate for a high-density cell array characterized in that it has a surface comprising an ordered array of discrete microdomains coated with a cell adhesive polymer and successively surrounded by a domain coated with a cell non-adhesive hydrophilic polymer and then a domain coated with a cell non-adhesive highly hydrophobic material. This substrate for a high-density cell array and an assay system using it can greatly reduce side effects of drugs and dramatically improve the performance of drug therapy for diseases by optimizing the type and concentration of the drug used (e.g., an anticancer agent). The present invention provides a very useful technology that can also be used for drug development, environmental impact assessment and basic life science researches.
摘要翻译：提供培养基质，细胞阵列，自动化学分配器和方便测定多种化学物质如毒物剂所需的测定系统。这里使用的是用于高密度电池阵列的衬底，其特征在于它具有包括用细胞粘合剂聚合物涂覆的离散微区的有序排列的表面，并且连续地被涂覆有细胞非粘性亲水性聚合物的区域包围，然后是结构域涂覆有细胞非粘性高疏水性材料。用于高密度电池阵列的该底物和使用它的测定系统可以大大降低药物的副作用，并通过优化所用药物的类型和浓度（例如，抗癌剂）来显着改善疾病药物治疗的性能。本发明提供了一种非常有用的技术，也可用于药物开发，环境影响评估和基础生命科学研究。

22. 发明申请

US20060234377A1 Cell sheets for ectocornea formation, method of producing the same and method of using the same 审中-公开
标题翻译：用于外胚叶形成的细胞片，其制造方法及其使用方法
公开(公告)号：US20060234377A1
公开(公告)日：2006-10-19
申请号：US10544541
申请日：2004-02-06
申请人： Teruo Okano , Kohji Nishida , Masayuki Yamato
发明人： Teruo Okano , Kohji Nishida , Masayuki Yamato
IPC分类号： C12N5/08
CPC分类号： A61L27/3891 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L2430/16 , C12N5/0621 , C12N2539/10
摘要： The present invention has as its objective providing acorneal epithelium forming cell sheet that will adhere well to an anterior segment tissue. To attain this objective, a corneal epithelium forming cell sheet is produced by a process comprising the steps of cultivating under specified conditions corneal epithelium forming cells on a cell culture support comprising a substrate having its surface covered with a temperature responsive polymer of which the hydrating force varies in a temperature range of 0-80° C., optionally stratifying the layer of cultured cells, and thereafter, (1) adjusting the temperature of the culture solution to either above an upper critical dissolution temperature or below a lower critical dissolution temperature, (2) bringing the cultured corneal epithelium forming cells into close contact with a carrier, and (3) detaching the sheet together with the carrier under specified conditions.
摘要翻译：本发明的目的是提供能够很好地粘附于前段组织的上皮细胞上皮细胞片。为了实现该目的，通过包括以下步骤的方法制备角膜上皮细胞片，该方法包括以下步骤：在细胞培养载体上在特定条件下培养角膜上皮形成细胞，所述细胞培养载体包含其表面覆盖有温度响应性聚合物的底物，所述温度响应性聚合物的水合力在0-80℃的温度范围内变化，任选地分层培养细胞层，然后（1）将培养溶液的温度调节至高于上临界溶解温度或低于临界溶解温度以下，（2）使培养的角膜上皮形成细胞与载体紧密接触，和（3）在规定的条件下将载片与载体一起分离。

23. 发明授权

US4683220A Novel physiologically active substances K-26, a process for preparation thereof and a pharmaceutical composition containing the same 失效
标题翻译：新型生理活性物质K-26，其制备方法和含有它的药物组合物
公开(公告)号：US4683220A
公开(公告)日：1987-07-28
申请号：US912685
申请日：1986-09-26
申请人： Masayuki Yamato , Hiroshi Kase , Isao Kawamoto , Masaji Kasai , Kunikatsu Shirahata , Takashi Deguchi , Katsuichi Shuto , Akira Karasawa , Ryo Okachi , Kiyoshi Nakayama
发明人： Masayuki Yamato , Hiroshi Kase , Isao Kawamoto , Masaji Kasai , Kunikatsu Shirahata , Takashi Deguchi , Katsuichi Shuto , Akira Karasawa , Ryo Okachi , Kiyoshi Nakayama
IPC分类号： C12P21/00 , A61K35/74 , A61K38/00 , A61P9/12 , C07F9/38 , C07F9/40 , C07K5/06 , C07K14/005 , C07K14/195 , C07K14/41 , C12P21/02 , C12R1/01 , A61K37/64
CPC分类号： C07F9/3808 , C07F9/3882 , C07F9/4006 , C07F9/4056 , C07K5/06191 , A61K38/00
摘要： Disclosed is a novel physiologically active substance, K-26, a process for preparation thereof and a pharmaceutical composition containing the same. The composition of matter, K-26, is useful as a hypotensive agent.
摘要翻译：公开了一种新的生理活性物质K-26，其制备方法和含有该生物活性物质的药物组合物。物质的组成，K-26，作为一种降压剂是有用的。

24. 发明授权

US4948422A Method of manufacturing superfine magnetic metal powder 失效
标题翻译：超细磁性金属粉末的制造方法
公开(公告)号：US4948422A
公开(公告)日：1990-08-14
申请号：US309552
申请日：1989-02-02
申请人： Akinori Yoshizawa , Tomoo Maeda , Masayuki Yamato
发明人： Akinori Yoshizawa , Tomoo Maeda , Masayuki Yamato
IPC分类号： B22F9/28 , G11B5/706 , G11B5/85 , H01F1/06
CPC分类号： G11B5/85 , B22F9/28 , G11B5/70605 , H01F1/065 , B22F2999/00
摘要： In the present invention, reaction is carried out between hydrogen gas and a metal halide vapor while supplying to the reacting region an active gas whose reactivity with the metal halide vapor is higher than the reactivity of the hydrogen gas with the metal halide vapor. The particular technique permits efficiently manufacturing a superfine magnetic metal powder of satisfactory properties while minimizing the amount of the hydrogen gas used.

25. 发明授权

US5089061A Method for producing high silicon steel strip in a continuously treating line 失效
标题翻译：连续处理生产线中高硅钢带的生产方法
公开(公告)号：US5089061A
公开(公告)日：1992-02-18
申请号：US247954
申请日：1988-09-22
申请人： Masahiro Abe , Kazuhisa Okada , Shuzo Fukuda , Yasushi Tanaka , Masayuki Yamato , Yoshikazu Takada
发明人： Masahiro Abe , Kazuhisa Okada , Shuzo Fukuda , Yasushi Tanaka , Masayuki Yamato , Yoshikazu Takada
IPC分类号： C21D8/12 , C23C10/08 , C23C16/24 , C23C16/54 , C23C16/56 , H01F1/147
CPC分类号： C23C16/56 , C21D8/1255 , C23C16/24 , H01F1/14775 , H01F1/14783
摘要： The present invention relates to a method for producing high silicon steel strip in a continuous treatment line through chemical vapor deposition (called "CVD" hereinafter), wherein the steel strip is subjected continuously to siliconization at temperatures between 1023.degree. and 1200.degree. C. by CVD in a non-oxidizing gas atmosphere containing SiCl.sub.4 between 5% and 35% in molar fraction. Subsequently a diffusion treatment is performed in a non-oxidizing gas atmosphere not containing SICl.sub.4 for diffusing Si uniformly throughout the steel strip, which is then cooled and coiled. If required, the steel strip may be coated with an insolating film and subjected to a baking treatment, before cooling and coiling.
摘要翻译：本发明涉及通过化学气相沉积（称为“CVD”）在连续处理线中生产高硅钢带的方法，其中钢带在1023℃和1200℃之间的温度下连续进行硅化，由在含有SiCl 4的摩尔分数为5％至35％的非氧化性气体气氛中进行CVD。随后，在不含SIC14的非氧化性气体气氛中进行扩散处理，以均匀地将Si均匀地扩散到钢带上，然后将其冷却并盘绕。如果需要，可以在冷却和卷取之前，用剥离膜涂覆钢带并进行烘烤处理。

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