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    • 22. 发明申请
    • Use of folates for producing a preparation suitable for preventing and treating inflammation and diseases associated with inflammation, especially for influencing the inflammation markers crp and saa
    • 使用叶酸来制备适合于预防和治疗与炎症有关的炎症和疾病的制剂,特别是用于影响炎症标记物crp和saa
    • US20060063768A1
    • 2006-03-23
    • US10505777
    • 2003-02-24
    • Thomas MuellerRudolf MoserMartin Ulmann
    • Thomas MuellerRudolf MoserMartin Ulmann
    • A61K31/525
    • A61K45/06A61K31/375A61K31/4415A61K31/519A61K31/525A61K31/714A61K2300/00
    • This invention relates to the use of folates for producing a pharmaceutical preparation suitable for the prevention and treatment of inflammation and of diseases associated with inflammation, particularly for influencing the inflammation markers C-reactive protein (CRP) and serum amyloid A protein (SAA). The clinical areas of application are all anomalies of the CRP and SM levels. The invention also relates to pharmaceutical preparations for the prevention and treatment of inflammation and of diseases associated with inflammation, particularly for influencing CRP and SM levels, characterised in that as an active ingredient it comprises at least one compound which is selected from the group consisting of pteroic acid monoglutamate (folic acid), dihydrofolic acid, 5-formyltetrahydrofolic acid, 5-methyltetrahydrofolic acid, 5,10-methylenetetrahydrofolic acid, 5,10-methenyl-tetrahydrofolic acid, 10-formyltetrahydrofolic acid or tetrahydrofolic acid, polyglutamates thereof, optical isomers thereof, particularly optically pure natural isomers thereof, and mixtures of optical isomers also, particularly racemic mixtures, as well as pharmaceutically acceptable salts thereof also, together with pharmaceutically acceptable active ingredients and adjuvants.
    • 本发明涉及叶酸用于制备适于预防和治疗炎症及与炎症有关的疾病的药物制剂的用途,特别是用于影响炎症标记物C反应蛋白(CRP)和血清淀粉样蛋白A蛋白(SAA)。 临床应用领域都是CRP和SM水平的异常。 本发明还涉及用于预防和治疗炎症以及与炎症有关的疾病,特别是用于影响CRP和SM水平的药物制剂,其特征在于作为活性成分,其包含至少一种选自以下的化合物: 戊酸单谷氨酸(叶酸),二氢叶酸,5-甲酰四氢叶酸,5-甲基四氢叶酸,5,10-亚甲基四氢叶酸,5,10-甲基四氢叶酸,10-甲酰四氢叶酸或四氢叶酸,聚谷氨酸,旋光异构体 ,特别是光学纯的天然异构体,以及光学异构体的混合物,特别是外消旋混合物,以及其药学上可接受的盐,以及药学上可接受的活性成分和佐剂。
    • 23. 发明申请
    • Coupling for a surgical rotary drive hand piece
    • 联轴器用于手术旋转驱动手部件
    • US20060053974A1
    • 2006-03-16
    • US11226192
    • 2005-09-09
    • Edgar BlustThomas Mueller
    • Edgar BlustThomas Mueller
    • B67B7/00
    • A61B17/162A61B2017/0046A61C1/142B23B31/008
    • In order to simplify the insertion of the tool in the case of a coupling for a surgical rotary drive hand piece including a tool which is mounted in the hand piece and driven thereby in rotary manner and incorporating a sleeve-shaped, rotary driven seating in the hand piece into which a shank of the tool is adapted to be inserted so as to form an interlocking rotary drive means, and including at least one locking body which is adapted to be inserted radially into the interior of the seating and which, in an inserted locking position, engages in a recess in the shank and thereby secures it from axial displacement, whereas, in a radially withdrawn position, it leaves the recess and thus enables an axial displacement of the shank in the seating, it is proposed that a driver having at least one contact surface on the side thereof facing the tool and which rotates with the sleeve and is axially displaceable with respect thereto be arranged in the sleeve-shaped seating for the purposes of forming an interlocking rotary drive means, in that the driver is displaceable by the effect of a spring into a pushed-out position in which the locking body or bodies rest thereon and are thus held in their release position, in that the driver is displaceable by means of the shank of the tool resting thereon against the effect of the spring into a pushed-in position in which the locking body or bodies enter the locking position and can secure the shank of the tool from axial displacement, and in that the shank of the tool in the pushed-in position thereof secured from axial displacement by the locking body or bodies pushes the driver against the effect of the spring into the seating in such a manner that its contact surfaces rest against the contact surfaces of the tool so as to form a rotary drive means.
    • 为了简化在用于手术旋转驱动手柄的联接器的情况下的工具的插入,所述外科旋转驱动手柄包括安装在手持件中并由此以旋转方式驱动的工具,并且将套筒形的旋转从动座部 手柄,其中工具的柄适于插入其中,以形成互锁的旋转驱动装置,并且包括至少一个锁定体,其适于径向插入到座椅的内部,并且在插入 锁定位置,接合在柄部中的凹部,从而使其不被轴向移动,而在径向撤回的位置,其离开凹部,从而使得柄在座椅中的轴向位移,建议具有 其侧面上的至少一个接触表面面向工具,并且与套筒一起旋转并且可相对于该套筒轴向移位以布置在套筒形座中以用于fo 联锁旋转驱动装置,其中驾驶员可通过弹簧的作用移位到被推出的位置,在该位置中,锁定体或身体搁置在其上并因此保持在其释放位置,因为驾驶员可以通过 抵靠弹簧的作用抵靠在其中锁定体或身体进入锁定位置并且可以将工具的柄部固定在轴向位移上的推入位置的工具的柄上的装置的手段, 通过锁定体或身体从轴向位移固定的推入位置中的工具将弹簧抵抗弹簧的作用以使其接触表面抵靠工具的接触表面的方式推动,以便 形成旋转驱动装置。
    • 29. 发明授权
    • Method for the suspended conveying of containers and device for carrying out said method
    • 用于实施所述方法的容器的悬浮输送方法和装置
    • US06209710B1
    • 2001-04-03
    • US09180669
    • 1999-02-16
    • Thomas MuellerErnst Kuenzler
    • Thomas MuellerErnst Kuenzler
    • B65G4784
    • B65G17/323B65G47/31B65G51/035B65G2201/02B65G2201/0244B65G2201/0247
    • The conveying method comprises a flying takeover of containers (1) being fed into a takeover area (U.1) in a container stream, hanging conveyance of the containers along a conveying path (FS) with a freely selectable course and delivery of the containers in a delivery area (U.2). For taking over the containers, a sequence of individual and equidistant holding means (5) is supplied to the takeover area (U.1) along a descending curved path (7′) joining a container feeding path (8) tangentially at the end of the takeover area (U.1) and the holding means (5) are introduced into the container stream each between two containers (1). At the beginning of this introduction, the holding means have a speed (v′) greater than the container speed (v) and during introduction they are decelerated to the container speed (v). Thereby, the feeding of containers and holding means is matched such that each holding means (5) reaches the container feeding speed (v) when it encircles the container downstream, i.e. when it is in an at least potential holding position relative to this container. At the latest in the delivery area, the holding means are turned by 180° around a vertical axis such that for delivery the containers to a container removing means (11), the holding means (5) can be conveyed away along an upward curved path. The curved path of the holding means in the takeover area (U.1) and/or in the delivery area (U.2) may also be realized by individual pivoting of the holding means (5).
    • 输送方法包括将容器(1)的飞行收取物送入容器流中的收容区域(U.1)中,沿着输送路径(FS)悬挂容器的输送,可自由选择的路线和容器的输送 在交付区域(U.2)。 为了接收容器,将一系列单独和等距的保持装置(5)沿着下降的弯曲路径(7')提供给接收区域(U.1),该下降弯曲路径(7')将容器进给路径(8) 收纳区域(U.1)和保持装置(5)被引入到两个容器(1)之间的容器流中。 在该介绍开始时,保持装置具有大于容器速度(v)的速度(v'),并且在引入期间它们减速到容器速度(v)。 因此,容器和保持装置的供给是匹配的,使得每个保持装置(5)在其围绕容器下游即即当其相对于该容器处于至少潜在的保持位置时达到容器进给速度(v)。 最近在交货区域中,保持装置围绕垂直轴转动180度,以便将容器运送到容器移除装置(11),保持装置(5)可沿着向上弯曲的路径 。 收纳区域(U.1)和/或输送区域(U.2)中的保持装置的弯曲路径也可以通过保持装置(5)的单独枢转来实现。