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21. 发明授权

US07825206B2 Process for reacting polyorganosiloxanes and their use 有权
标题翻译：聚有机硅氧烷的反应及其用途
公开(公告)号：US07825206B2
公开(公告)日：2010-11-02
申请号：US11956525
申请日：2007-12-14
申请人： Thomas Neumann , Wilfried Knott
发明人： Thomas Neumann , Wilfried Knott
IPC分类号： C08G77/18
CPC分类号： C08G77/08 , C08G77/16 , C08G77/42
摘要： The invention provides a process for preparing SiOC-bonded polyorganosiloxanes by reacting, by processes known per se, hydroxyl-containing compounds with a stoichiometric excess of polyorganosiloxanes which contain —Si(H) units and are of the general formula (I) in the presence of one or more element compounds of main group III and/or of transition group 3 as a catalyst, wherein the reaction, on completion of conversion of the compounds containing hydroxyl groups, is continued until no further ≡Si—H groups are detectable by gas volumetric means, and also the compounds prepared in this way and their use.
摘要翻译：本发明提供了一种制备SiOC键合的聚有机硅氧烷的方法，其通过本身已知的方法使含羟基化合物与含有-Si（H）单元的化学计量过量的聚有机硅氧烷在通式（I）的存在下反应，的主要III族和/或过渡族3的元素化合物作为催化剂，其中在含羟基的化合物的转化完成时的反应继续进行，直到不再有气体可以检测到≡Si-H基团体积的方法，以及以这种方式制备的化合物及其用途。

22. 发明申请

US20090317787A1 METHOD FOR CREATING PERFUSABLE MICROVESSEL SYSTEMS 有权
标题翻译：创造可靠的微电子系统的方法
公开(公告)号：US20090317787A1
公开(公告)日：2009-12-24
申请号：US12541707
申请日：2009-08-14
申请人： Thomas Neumann
发明人： Thomas Neumann
IPC分类号： A01N1/02 , C12N5/08
CPC分类号： C12N5/0691 , C12M21/08 , C12M23/06 , C12M23/16 , C12M23/20 , C12M29/10 , C12N2533/50
摘要： Creating a tissue structure in vitro includes juxtaposing mandrels on a culture/perfusion device frame where the mandrels are spaced apart substantially parallel to each other and connecting the mandrels to tubes including an upstream tubes and downstream tubes. The upstream tubes are connected with an upstream manifold and the downstream tubes are connected to a downstream manifold. The frame and the mandrels are sterilized, coated and seeded with cells that multiply and form circular layers around each of the mandrels until the circular layers merge into a tissue structure which is subjected to a growth medium. The mandrels are extracted and the tissue structure is perfused.
摘要翻译：在体外创建组织结构包括在培养/灌注装置框架上并置心轴，其中心轴彼此间隔开并且将心轴连接到包括上游管和下游管的管。上游管与上游歧管连接，下游管连接到下游歧管。框架和心轴被消毒，涂覆并种植有细胞，每个细胞在每个心轴周围形成圆形层，直到圆形层合并成经历生长培养基的组织结构。提取心轴并灌注组织结构。

23. 发明申请

US20090107364A1 Hydraulic binding agent 失效
标题翻译：液压粘合剂
公开(公告)号：US20090107364A1
公开(公告)日：2009-04-30
申请号：US11911720
申请日：2006-03-13
申请人： Horst-Michael Ludwig , Thomas Neumann
发明人： Horst-Michael Ludwig , Thomas Neumann
IPC分类号： C04B14/02 , B32B5/16 , B28C7/04
CPC分类号： C04B22/064 , C04B28/02 , C04B2103/004 , C04B2103/12 , C04B2111/00146 , C04B2111/0075 , C04B2111/60 , C04B2111/72 , Y10T428/2982 , C04B20/008 , C04B14/06 , C04B2103/30 , C04B20/10
摘要： The invention relates to a hydraulic binding agent comprising a binding agent component having free-flowing or solidifying properties when water is added and an acceleration component which is used to accelerate solidification. The acceleration component contains ultrafine calcium hydroxide having a high specific surface and low grain size.
摘要翻译：本发明涉及一种水硬性粘合剂，其包含当加入水时具有自由流动或固化性能的粘合剂组分和用于加速固化的加速组分。加速成分含有比表面积高，粒径小的超细氢氧化钙。

24. 发明申请

US20080227923A1 PROCESS FOR THE TREATMENT OF SiC-BONDED POLYETHERSILOXANES 审中-公开
标题翻译：用于处理SiC结合的聚乙二醇的方法
公开(公告)号：US20080227923A1
公开(公告)日：2008-09-18
申请号：US11755441
申请日：2007-05-30
申请人： Klaus-Deiter Klein , Thomas Neumann
发明人： Klaus-Deiter Klein , Thomas Neumann
IPC分类号： C08F8/04
CPC分类号： C08G77/46 , C08G77/34
摘要： The invention relates to a process for the treatment of polyoxyalkylene-polysiloxane block copolymers or alkylpolysiloxane-polyoxyalkylenepolysiloxane block copolymers in which the polysiloxane blocks are bonded to the polyether blocks or alkyl radicals by SiC bonds, wherein the polyoxyalkylene-polysiloxane block copolymers or alkylpolysiloxane-polyoxyalkylenepolysiloxane block copolymers or the solutions thereof are treated with flowing hydrogen gas and optionally a further inert gas in the presence of a combination of hydrogenation catalysts known per se and acid-activated carrier materials and water at temperatures of from 20 to 200° C. and atmospheric pressure over a period of from 0.5 to 10 hours.
摘要翻译：本发明涉及一种用于处理聚氧化烯 - 聚硅氧烷嵌段共聚物或烷基聚硅氧烷 - 聚氧亚烷基聚硅氧烷嵌段共聚物的方法，其中聚硅氧烷嵌段通过SiC键与聚醚嵌段或烷基键合，其中聚氧化烯 - 聚硅氧烷嵌段共聚物或烷基聚硅氧烷 - 聚氧亚烷基聚硅氧烷嵌段共聚物或其溶液在流动的氢气和任选的另外的惰性气体下，在本身已知的氢化催化剂和酸活化的载体材料和水的温度下，在20〜200℃的温度和大气压下进行处理压力为0.5〜10小时。

25. 发明申请

US20070224677A1 Method for creating perfusable microvessel systems 有权
标题翻译：创建可灌注微血管系统的方法
公开(公告)号：US20070224677A1
公开(公告)日：2007-09-27
申请号：US11388920
申请日：2006-03-24
申请人： Thomas Neumann
发明人： Thomas Neumann
IPC分类号： C12N5/08 , C12M3/00 , C12N5/06
CPC分类号： C12N5/0691 , C12M21/08 , C12M23/06 , C12M23/16 , C12M23/20 , C12M29/10 , C12N2533/50
摘要： Microvessel networks are produced in vitro from tissue-engineered parent vessels sprouting into a supporting matrix, as for example gels, of extracellular matrix proteins. The microvessel systems are integrated into devices that allow for controlled perfusion with fluids. The vessels may include cells from one cell type, for example, endothelial cells, or from combinations of two or more cell types.
摘要翻译：微血管网络在体外从组织工程化的母体血管发育成支持基质，例如凝胶，细胞外基质蛋白。微血管系统集成到允许用流体控制灌注的装置中。血管可以包括来自一种细胞类型的细胞，例如内皮细胞，或两种或多种细胞类型的组合。

26. 发明授权

US07163803B2 Method for characterizing polypeptides 失效
标题翻译：表征多肽的方法
公开(公告)号：US07163803B2
公开(公告)日：2007-01-16
申请号：US10479843
申请日：2002-06-07
申请人： Christian Hamon , Andrew Thompson , Thomas Neumann , Robert Johnstone , Abdul Karim Abed Mohammed
发明人： Christian Hamon , Andrew Thompson , Thomas Neumann , Robert Johnstone , Abdul Karim Abed Mohammed
IPC分类号： C12Q1/37
CPC分类号： G01N33/6848 , C07K1/12 , G01N33/6821
摘要： Provided is a method for characterizing a polypeptide, which method comprises the steps of: (a) optionally reducing cysteine disulphide bridges in the polypeptide to form free thiols, and capping the free thiols; (b) cleaving the polypeptide with a sequence specific cleavage reagent to form peptide fragments; (c) optionally deactivating the cleavage reagent; (d) capping one or more ε-amino groups that are present with a lysine reactive agent; (e) analyzing peptide fragments by mass spectrometry to form a mass fingerprint for the polypeptide; and (f) determining the identity of the polypeptide from the mass fingerprint.
摘要翻译：提供了表征多肽的方法，该方法包括以下步骤：（a）任选地减少多肽中的半胱氨酸二硫键形成游离硫醇，并封端游离硫醇; （b）用序列特异性切割试剂切割多肽以形成肽片段; （c）任选地使切割试剂失活; （d）封端与赖氨酸反应剂一起存在的一个或多个ε-氨基; （e）通过质谱分析肽片段以形成多肽的质量指纹图谱; 和（f）从质量指纹图谱确定多肽的身份。

27. 发明申请

US20110070183A1 CROSSLINKED POLYSILOXANES, A PROCESS FOR THEIR PREPARATION AND USE OF THE CROSSLINKED POLYSILOXANES IN EMULSIFIER SYSTEMS FOR WATER-IN-OIL EMULSIONS 有权
标题翻译：交联聚硅氧烷，其用于制备和使用交联的聚硅氧烷在乳化剂系统中用于油脂乳化的方法
公开(公告)号：US20110070183A1
公开(公告)日：2011-03-24
申请号：US12888603
申请日：2010-09-23
申请人： Thomas Neumann , Burghard Gruning , Anna Howe , Dana Adkins , Jerry Reddinger
发明人： Thomas Neumann , Burghard Gruning , Anna Howe , Dana Adkins , Jerry Reddinger
IPC分类号： A61K8/89 , C08G77/38 , A61Q19/00 , A61Q19/04 , A61Q1/10 , A61Q1/00
CPC分类号： C08G77/46 , A61K8/06 , A61K8/891 , A61Q1/06 , A61Q1/10 , A61Q17/00 , A61Q17/04 , A61Q19/00 , A61Q19/002 , A61Q19/04 , B01F17/0071 , C08G77/38 , C08L83/12
摘要： The invention relates to crosslinked organopolysiloxanes which are linked by a polyether building block via the Si atoms, to emulsifier systems which have these crosslinked organopolysiloxanes, and also to cosmetic, dermatological or pharmaceutical formulations comprising a crosslinked organopolysiloxane or an emulsifier system comprising these.
摘要翻译：本发明涉及通过Si原子由聚醚结构单元连接的交联的有机聚硅氧烷，具有这些交联的有机聚硅氧烷的乳化剂体系，以及包含交联的有机聚硅氧烷或包含它们的乳化剂体系的化妆品，皮肤病学或药物制剂。

28. 发明申请

US20100279268A1 METHOD FOR CREATING PERFUSABLE MICROVESSEL SYSTEMS 有权
标题翻译：创造可靠的微电子系统的方法
公开(公告)号：US20100279268A1
公开(公告)日：2010-11-04
申请号：US12679429
申请日：2008-09-24
申请人： Thomas Neumann , Anna V. Tourovskaia , Mark E. Fauver , Julia Oi Yan Yu
发明人： Thomas Neumann , Anna V. Tourovskaia , Mark E. Fauver , Julia Oi Yan Yu
IPC分类号： C12N5/02 , C12M1/00
CPC分类号： A61L27/3808 , A61L27/3886 , C12M21/08 , C12M25/14 , C12M29/10 , C12N5/0068 , C12N5/0691 , C12N2533/50
摘要： A method for creating networks of perfusable microvessels in vitro. Cells including cell types capable of sprouting are seeded 1300 into a channel in a matrix at to activate competency 1304 of the cells for sprouting as microvessels based on the seeding density. The matrix channel is perfused with medium to allow parent vessels to form and for viability 1324. The parent vessels and matrix are incubated and perfused to provide for sprouting of microvessels from parent vessels into the surrounding matrix 1328. The sprouting parent vessels are grown until network forms 1332.
摘要翻译：一种在体外创建可灌注微血管网络的方法。将包括能够发芽的细胞类型的细胞接种在基质中的通道中，以激活基于种子密度的作为微血管发芽的细胞的能力1304。基质通道用培养基灌注以允许母体血管形成和存活力1324.将母体血管和基质温育并灌注以提供将微血管从亲本血管发芽到周围基质1328中。将发芽的母血管生长直至网络表格1332。

29. 发明授权

US07732378B2 Mass labels 有权
标题翻译：批量标签
公开(公告)号：US07732378B2
公开(公告)日：2010-06-08
申请号：US10489341
申请日：2002-09-16
申请人： Andrew Hugin Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
发明人： Andrew Hugin Thompson , Christian Hamon , Jurgen Schafer , Karsten Kuhn , Joseph Schwarz , Thomas Neumann
IPC分类号： C40B40/00
CPC分类号： G01N33/6848 , G01N33/68 , G01N33/6851 , G01N2458/15 , H01J49/04
摘要： Provided is a set of two or more mass labels, each label in the set comprising a mass marker moiety attached via a cleavable linker having at least one amide bond to a mass normalization moiety, wherein the aggregate mass of each label in the set may be the same or different and the mass of the mass marker moiety of each label in the set may be the same or different, and wherein in any group of labels within the set having a mass marker moiety of a common mass each label has an aggregate mass different from all other labels in that group, and wherein in any group of labels within the set having a common aggregate mass each label has a mass marker moiety having a mass different from that of all other mass marker moieties in that group, such that all of the mass labels in the set are distinguishable from each other by mass spectrometry, and wherein the mass marker moiety comprises an amino acid and the mass normalization moiety comprises an amino acid.
摘要翻译：提供了一组两个或更多个质量标签，该组中的每个标签包含通过具有至少一个酰胺键与质量标准化部分连接的质量标记部分，其中该组中每个标签的总质量可以是相同或不同，组中每个标记物的质量标记物部分的质量可以相同或不同，并且其中在具有共同质量的质量标记物部分的组中的任何标签组中，每个标签具有总体质量不同于该组中的所有其它标记，并且其中在组中具有共同聚集体的任何标签组中，每个标记具有与该组中所有其他质量标记部分的质量不同的质量标记部分，使得全部组中的质量标记物通过质谱法彼此区分，并且其中质量标记物部分包含氨基酸，质量标准化部分包含氨基酸。

30. 发明授权

US07700306B2 Method for charcterising analytes 失效
标题翻译：分析物识别方法
公开(公告)号：US07700306B2
公开(公告)日：2010-04-20
申请号：US10510246
申请日：2003-04-04
申请人： Andrew H. Thompson , Christian Hamon , Karsten Kuhn , Markus Meyer , Schafer Juergen , Thomas Neumann
发明人： Andrew H. Thompson , Christian Hamon , Karsten Kuhn , Markus Meyer , Schafer Juergen , Thomas Neumann
IPC分类号： G01N33/00
CPC分类号： G01N33/6848 , C07K1/13 , G01N33/6851
摘要： Provided is a method for characterizing an analyte by matrix assisted laser desorption ionization (MALDI) mass spectrometry, which method comprises: (a) labelling the analyte with a light-absorbing label that absorbs light at a pre-determined frequency, to form a labelled analyte; (b) embedding the labelled analyte in a matrix formed from at least one compound that absorbs light, to form an embedded labelled analyte; (c) desorbing the embedded labelled analyte by exposing it to light having the pre-determined frequency, to form a desorbed analyte; and (d) detecting the desorbed analyte by mass spectrometry to characterize the analyte.
摘要翻译：本发明提供了一种通过基质辅助激光解吸电离（MALDI）质谱法分析分析物的方法，该方法包括：（a）用预吸收光量的光吸收标记标记分析物，以形成标记的分析物; （b）将标记的分析物包埋在由吸收光的至少一种化合物形成的基质中，以形成嵌入的标记分析物; （c）通过将嵌入的标记分析物暴露于具有预定频率的光来解吸，形成解吸附的分析物; 和（d）通过质谱检测解吸附的分析物来表征分析物。

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