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21. 发明申请

US20110160801A1 COMMUNICATION WITH AN IMPLANTABLE MEDICAL DEVICE DURING IMPLANTATION 有权
标题翻译：在植入期间与可植入医疗设备的通信
公开(公告)号：US20110160801A1
公开(公告)日：2011-06-30
申请号：US12732433
申请日：2010-03-26
申请人： H. Toby Markowitz , Can Cinbis
发明人： H. Toby Markowitz , Can Cinbis
IPC分类号： A61N1/08
CPC分类号： A61B5/0028 , A61B5/0031 , A61B2034/2053 , A61B2560/0271 , A61N1/37205 , A61N1/37217 , A61N1/37241 , A61N1/3756
摘要： A system and method are described for delivering an implantable medical device in a patient and through a catheter. The delivery catheter comprises telemetry means for communicatively coupling the implantable medical device with an external instrumentation during implantation.
摘要翻译：描述了用于将可植入医疗装置递送到患者体内并通过导管的系统和方法。递送导管包括用于在植入期间将可植入医疗装置与外部装置通信地连接的遥测装置。

22. 发明申请

US20090264742A1 Determining and Illustrating a Structure 有权
标题翻译：确定和说明结构
公开(公告)号：US20090264742A1
公开(公告)日：2009-10-22
申请号：US12423477
申请日：2009-04-14
申请人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
发明人： H. Toby Markowitz , Mustafa Karamanoglu , Pooja Mehta , Ioana Fleming , David A. Scanlon , Michael Kryger , Sean Campbell-Massa , Chad Giese , Steven L. Waldhauser , Shangqian Peter Zhang , Jeff Jannicke , Phillip Falkner , Don Hefner , Eduardo N. Warman , James Steeves , Rogier Receveur , Koen Michels , Olaf Eick , Vincent Larik
IPC分类号： A61B5/05
CPC分类号： A61B5/061 , A61B5/0422 , A61B5/04288 , A61B5/0432 , A61B5/044 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/062 , A61B5/063 , A61B5/066 , A61B5/4836 , A61B5/742 , A61B8/06 , A61B8/4472 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/00336 , A61B2017/22051 , A61B2034/105 , A61B2090/376 , A61B2090/378 , A61B2090/3983
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.
摘要翻译：可以用可操作以识别多个位置并且存储映射仪器的多个位置的系统来映射患者体积。映射仪器可以包括一个或多个电极，其可以感测在感测或测量时可以与电极的三维位置相关联的电压。因此，可以基于多个点的感测而不使用其它成像装置来确定体积的映射。然后可以相对于映射数据导航可植入医疗装置。

23. 发明申请

US20090264727A1 METHOD AND APPARATUS FOR MAPPING A STRUCTURE 有权
公开(公告)号：US20090264727A1
公开(公告)日：2009-10-22
申请号：US12421332
申请日：2009-04-09
申请人： H. Toby Markowitz , Sean Campbell-Massa , Phillip Falkner , Ioana Fleming , Chad Giese , Mustafa Karamanoglu , Michael Kryger , Karl Evan Nowak , Pooja Mehta , James Steeves , Lane A. Phillips , Shangqian Peter Zhang , Steven L. Waldhauser , David A. Scanlon , Brian Houston Craig , Eduardo N. Warman , Koen Michels , Marie P. Smith , Noelle Christine Hurtig , Olaf Eick , Rogier Receveur , Vincent Larik , Brent Chelgren , Victoria Interrante
发明人： H. Toby Markowitz , Sean Campbell-Massa , Phillip Falkner , Ioana Fleming , Chad Giese , Mustafa Karamanoglu , Michael Kryger , Karl Evan Nowak , Pooja Mehta , James Steeves , Lane A. Phillips , Shangqian Peter Zhang , Steven L. Waldhauser , David A. Scanlon , Brian Houston Craig , Eduardo N. Warman , Koen Michels , Marie P. Smith , Noelle Christine Hurtig , Olaf Eick , Rogier Receveur , Vincent Larik , Brent Chelgren , Victoria Interrante
IPC分类号： A61B5/05 , A61B5/0402 , A61B5/0205
CPC分类号： G06T19/003 , A61B5/0422 , A61B5/05 , A61B5/053 , A61B5/0538 , A61B5/063 , A61B5/066 , A61B5/068 , A61B8/06 , A61B34/20 , A61B34/25 , A61B2017/00022 , A61B2017/00026 , A61B2017/00053 , A61B2017/00084 , A61B2017/00243 , A61B2017/22051 , A61B2034/102 , A61B2034/105 , A61B2034/2051 , A61B2034/2068 , A61B2034/2072 , A61B2090/061 , A61B2090/063 , A61B2090/371 , A61B2090/376 , A61B2090/378
摘要： An volume of a patient can be mapped with a system operable to identify a plurality of locations and save a plurality of locations of a mapping instrument. The mapping instrument can include one or more electrodes that can sense a voltage that can be correlated to a three dimensional location of the electrode at the time of the sensing or measurement. Therefore, a map of a volume can be determined based upon the sensing of the plurality of points without the use of other imaging devices. An implantable medical device can then be navigated relative to the mapping data.

24. 发明申请

US20080183083A1 SYSTEMS AND METHODS FOR MONITORING EFFECTIVENESS OF CONGESTIVE HEART FAILURE THERAPY 审中-公开
标题翻译：用于监测心脏失效治疗有效性的系统和方法
公开(公告)号：US20080183083A1
公开(公告)日：2008-07-31
申请号：US11669396
申请日：2007-01-31
申请人： H. Toby Markowitz , Sameh Sowelam
发明人： H. Toby Markowitz , Sameh Sowelam
IPC分类号： A61B5/0205 , A61N1/36
CPC分类号： A61B5/6826 , A61B5/0285 , A61B5/042 , A61B5/053 , A61B5/08 , A61B5/14551 , A61B5/4818 , A61B5/6838
摘要： A method for monitoring a patient includes measuring a series of consecutive pulse transit times (PTT's) of the patient, and processing the resulting PTT signal to detect a presence or absence of central sleep apnea (CSA). The method further includes determining an effectiveness of congestive heart failure therapy, which is being provided to the patient, based on the detected presence or absence of CSA. A system incorporating the method includes an electrode of an implantable medical device, which is adapted to pick up the patient's ventricular depolarization signals, a sensor, which is adapted to pick up peripheral arterial pulse signals of the patient, and a signal processor, which is adapted to receive the two types of signals and to process the signals according to the method. The system may provide the therapy via cardiac resynchronization pacing and, upon detection of CSA, the system may adjust at least one pacing parameter.
摘要翻译：用于监测患者的方法包括测量患者的一系列连续脉冲传递时间（PTT），并且处理所得到的PTT信号以检测中枢性睡眠呼吸暂停（CSA）的存在或不存在。该方法还包括基于检测到的CSA的存在或不存在来确定正在提供给患者的充血性心力衰竭治疗的有效性。包括该方法的系统包括可植入医疗装置的电极，其适于拾取患者的心室去极化信号，适于拾取患者的外周动脉脉冲信号的传感器，以及信号处理器，其是适于接收两种类型的信号并根据该方法处理信号。系统可以通过心脏再同步起搏提供治疗，并且在检测到CSA时，系统可以调整至少一个起搏参数。

25. 发明授权

US06445952B1 Apparatus and method for detecting micro-dislodgment of a pacing lead 失效
标题翻译：用于检测起搏引线的微移位的装置和方法
公开(公告)号：US06445952B1
公开(公告)日：2002-09-03
申请号：US09573507
申请日：2000-05-18
申请人： Christopher M. Manrodt , H. Toby Markowitz , Bradley C. Peck
发明人： Christopher M. Manrodt , H. Toby Markowitz , Bradley C. Peck
IPC分类号： A61N108
CPC分类号： A61N1/37 , A61N1/37241 , A61N2001/083
摘要： An apparatus and method for detecting micro-dislodgment at a heart tissue/pacing lead electrode interface involves measuring a first pacing threshold parameter at a first time in a patient's cardiac cycle and measuring a second pacing threshold parameter at a second time in the patient's cardiac cycle. Micro-dislodgment occurring at the heart tissue/pacing lead electrode interface is detected using the first and second pacing threshold parameters. Micro-dislodgment may be detected by comparing a difference between, or a ratio of, the first and second pacing threshold parameters to a preestablished maximum allowable deviation value. A difference between the first and second pacing threshold parameters or a ratio in excess of the preestablished maximum allowable deviation value indicates a problem at the heart tissue/pacing lead interface. The first and second pacing threshold parameters are preferably pacing threshold voltages, and the preestablished maximum allowable deviation value is either a voltage ranging from about 0.2 volts to about 2 volts or a percentage ranging from about 5% to about 100%. The micro-dislodgment procedure may be performed in-situ an implantable pulse generator (IPG), with data indicative of a detected change at the heart tissue/pacing electrode interface being stored in a memory coupled to the IPG and subsequently read out of memory for evaluation. Alternatively, the micro-dislodgment procedure may be performed using an external programmer and may further be performed during implantation of a pacing lead electrode at the heart tissue/pacing lead electrode interface to assure a physician of proper lead attachment.
摘要翻译：用于检测心脏组织/起搏引线电极界面处的微移位的装置和方法包括在患者的心动周期中第一时间测量第一起搏阈值参数，并在患者的心动周期中第二时间测量第二起搏阈值参数。使用第一和第二起搏阈值参数检测在心脏组织/起搏引线电极界面处发生的微移动。可以通过将第一和第二起搏阈值参数之间的差值或比例与预先建立的最大允许偏差值进行比较来检测微移动。第一和第二起搏阈值参数之间的差异或超过预先建立的最大允许偏差值的比值表示在心脏组织/起搏引线界面处的问题。第一和第二起搏阈值参数优选为起搏阈值电压，并且预先建立的最大允许偏差值是约0.2伏特至约2伏范围内的电压或约5％至约100％的百分比。微移动程序可以原位执行可植入脉冲发生器（IPG），其中指示心脏组织/起搏电极界面上检测到的变化的数据被存储在耦合到IPG的存储器中，随后读出存储器评估。或者，可以使用外部编程器执行微移动过程，并且可以在心脏组织/起搏引线电极界面处植入起搏引线电极期间进一步执行微移动过程，以确保医生适当的引线附着。

26. 发明授权

US5759196A Modification of pacemaker tachy response based on FFRW sensing 失效
标题翻译：基于FFRW感知的起搏器速度响应的修改
公开(公告)号：US5759196A
公开(公告)日：1998-06-02
申请号：US536715
申请日：1995-09-29
申请人： Michael F. Hess , H. Toby Markowitz , James W. Busacker , Carleen J. Juran
发明人： Michael F. Hess , H. Toby Markowitz , James W. Busacker , Carleen J. Juran
IPC分类号： A61N1/362 , A61N1/368 , A61N1/365
CPC分类号： A61N1/3622 , A61N1/3688
摘要： A pacemaker control method and apparatus for determining the presence of atrial tachyarrhythmias uses a true interval value and compares it to a predetermined tachy value. The true interval value is updated based on the presence of far field R waves in PVARP that meet certain sequencing criteria. The criteria selected allows the control method and apparatus to reduce or eliminate event sequences that will generate false positive tachy detection and subsequent mode switching, while still allowing for the detection of tachy events in PVARP.
摘要翻译：用于确定心房快速性心律失常的起搏器控制方法和装置使用真实间隔值并将其与预定的速度值进行比较。基于PVARP中符合某些排序标准的远场R波的存在来更新真实间隔值。所选择的标准允许控制方法和装置减少或消除将产生假正向检测和随后的模式切换的事件序列，同时仍允许检测PVARP中的快速事件。

27. 发明授权

US5514163A Dual chamber pacing system and method with optimized adjustment of the AV escape interval for treating cardiomyopathy 失效
标题翻译：双室起搏系统和方法优化AV治疗心肌病逃逸间隔的调整
公开(公告)号：US5514163A
公开(公告)日：1996-05-07
申请号：US391947
申请日：1995-02-21
申请人： H. Toby Markowitz , Tom D. Bennett
发明人： H. Toby Markowitz , Tom D. Bennett
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3682
摘要： A dual chamber pacemaker system and method are provided for HOCM and like pacing therapy, with the feature of searching or scanning values of AV escape interval to define an optimized value at about the longest AV escape interval value consistent with full capture in response to a delivered ventricular pace pulse. In a preferred embodiment of the invention, the system and method sense and process FFRS signals derived from the atrial lead and otherwise, and obtain therefrom a characteristic which is evaluated for a determination of optimized AV escape interval. In one specific embodiment, the time durations between delivered ventricular pacing pulses and resulting FFRS signals are analyzed as a function of AV escape interval, and the optimized AV escape interval is chosen at about the longest AV escape interval corresponding to the longest such time duration, i.e., at about the knee of the FFRS time duration vs. AV escape interval curve. In another embodiment, the FFRS characteristic utilized is duration, and the system determines the longest AV escape interval corresponding to the highest duration value. The system and method can be utilized either with an external programmer or can be adapted to operate automatically in an implanted pacemaker.
摘要翻译：为HOCM和类似起搏治疗提供双室起搏器系统和方法，具有搜索或扫描AV逃逸间隔值的特征，以在与所传送的全部捕获相一致的大多数AV逃逸间隔值下定义优化值心室起搏脉搏。在本发明的优选实施例中，系统和方法感测和处理从心房线导出的FFRS信号，否则获得被评估用于确定优化的AV逃逸间隔的特性。在一个具体实施例中，作为AV逃逸间隔的函数分析递送的心室起搏脉冲和所产生的FFRS信号之间的时间持续时间，并且在对应于最长的这样的持续时间的大约最长的AV逃逸间隔中选择优化的AV逃逸间隔，即，在FFRS持续时间与AV逃逸间隔曲线的大约膝盖处。在另一个实施例中，所使用的FFRS特征是持续时间，并且系统确定对应于最高持续时间值的最长的AV逃逸间隔。该系统和方法可以与外部编程器一起使用，或者可以适用于在植入式心脏起搏器中自动操作。

28. 发明授权

US5238006A Apnea stimulation lead 失效
标题翻译：呼吸暂停刺激引线
公开(公告)号：US5238006A
公开(公告)日：1993-08-24
申请号：US719929
申请日：1991-06-24
申请人： H. Toby Markowitz
发明人： H. Toby Markowitz
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0519 , A61N1/0548 , A61N1/3601
摘要： A stimulation lead for electrically coupling an implantable pulse generator to an electrode in an apnea treatment system and method of making same. The lead employs a thin substrate of polyurethane or other highly flexible implantable material. Conductors are placed on the substrate by silk screening a conductive ink. The ends of the lead are electrically terminated using rivets which couple through the substrate. The substrate is folded to enclose the conductors, thereby insulating them and protecting them from bodily fluids. Suitable connectors may be attached to either end. The resulting lead is easily fabricated and is extremely thin and flexible.
摘要翻译：刺激引线，用于将植入式脉冲发生器电耦合到呼吸暂停治疗系统中的电极及其制造方法。铅使用聚氨酯或其他高度柔性可植入材料的薄基材。通过丝网印刷导电油墨将导体放置在基材上。引线的端部使用铆接在基板上的铆钉进行电气端接。将基板折叠以包围导体，从而使其绝缘并保护它们免于体液。合适的连接器可以连接到任一端。所得到的引线易于制造，并且非常薄且灵活。

29. 发明授权

US4343311A Atrial refractory control for R-wave rejection in pacemakers 失效
$Atrial refractory control for R-wave rejection in pacemakers$
标题翻译：心房起搏器R波消除的心房难治性控制
公开(公告)号：US4343311A
公开(公告)日：1982-08-10
申请号：US145052
申请日：1980-04-30
申请人： H. Toby Markowitz
发明人： H. Toby Markowitz
IPC分类号： A61N1/368 , A61N1/362 , A61N1/365 , A61N1/36
CPC分类号： A61N1/3622
摘要： An artificial heart pacemaker and control circuit having an atrial synchronous pacing mode includes an output pulse generator for delivering stimulating pulses to the ventricle of the heart, and atrial and ventricular sensing amplifiers for detecting, respectively, atrial and ventricular contractions. The atrial sense amplifier starts an A-V delay timer which provides a delayed triggering pulse to the pulse generator to maintain A-V synchrony. Circuitry is provided for blanking or turning off the atrial sensing amplifier during the time that the ventricular sensing amplifier is refractory, and preferably for a short time interval thereafter, to prevent delivery of an output pulse in response to a premature ventricular contraction erroneously sensed as an atrial contraction.
摘要翻译：具有心房同步起搏模式的人造心脏起搏器和控制电路包括用于将刺激脉冲输送到心脏心室的输出脉冲发生器，以及分别用于检测心房和心室收缩的心房和心室感测放大器。心律感知放大器启动A-V延迟定时器，为脉冲发生器提供延迟的触发脉冲以保持A-V同步。提供电路用于在心室感测放大器难治的时间期间消隐或关闭心房感测放大器，并且优选地在此之后的短时间间隔内，以防止输出脉冲响应于错误地感测为过早的心室收缩心房收缩。

30. 发明申请

US20180085554A1 DEVICES, SYSTEMS, AND METHODS USEFUL TO ENGAGE TISSUE USING SUCTION AND TO PERFORM MEDICAL PROCEDURES DURING SUCTIONAL ENGAGEMENT 审中-公开
公开(公告)号：US20180085554A1
公开(公告)日：2018-03-29
申请号：US15821825
申请日：2017-11-23
申请人： Ghassan S. Kassab , Matthew Phillips , H. Toby Markowitz
发明人： Ghassan S. Kassab , Matthew Phillips , H. Toby Markowitz
IPC分类号： A61M25/00 , A61B17/34
CPC分类号： A61M25/0067 , A61B17/00491 , A61B17/3401 , A61B17/3403 , A61B17/3415 , A61B17/3478 , A61B18/02 , A61B18/14 , A61B2017/00026 , A61B2017/00044 , A61B2017/00084 , A61B2017/00247 , A61B2017/308 , A61B2018/00291 , A61M25/0026 , A61M25/0084 , A61M25/06 , A61M25/09 , A61M2025/0057
摘要： Devices, systems, and methods useful to engage tissue using suction and to perform medical procedures during sectional engagement. The present disclosure includes disclosure of a tension apparatus, comprising an elongated portion; and a head portion at a distal end of the elongated portion, the head portion comprising one or more arms, whereby a suction lumen extending along the elongated portion and the one or more arms terminates at one or more suction openings at each of the one or more arms.

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