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21. 发明申请

US20070010489A1 Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds 审中-公开
标题翻译：蜂窝状蛋白酶抑制剂化合物的膦酸酯类似物的细胞积累
公开(公告)号：US20070010489A1
公开(公告)日：2007-01-11
申请号：US10511998
申请日：2003-04-25
申请人： Murty Arimilli , Mark Becker , Clifford Bryant , James Chen , Xiaowu Chen , Azar Dastgah , Maria Fardis , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard Mackman , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Wiliams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang
发明人： Murty Arimilli , Mark Becker , Clifford Bryant , James Chen , Xiaowu Chen , Azar Dastgah , Maria Fardis , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard Mackman , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Wiliams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang
IPC分类号： A61K31/663 , C07F9/6515 , C07F9/6512
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
摘要翻译：公开了具有用作治疗剂和其它工业目的的具有HIV蛋白酶抑制性质的膦酸酯取代的化合物。该组合物抑制5种HIV蛋白酶活性和/或用于治疗AIDS和其它抗病毒感染以及用于检测HIV蛋白酶的测定。

22. 发明申请

US20050239054A1 Method and compositions for identifying anti-HIV therapeutic compounds 审中-公开
标题翻译：用于鉴定抗HIV治疗化合物的方法和组合物
公开(公告)号：US20050239054A1
公开(公告)日：2005-10-27
申请号：US10740694
申请日：2003-12-22
申请人： Murty Arimilli , Mark Becker , Gabriel Birkus , Clifford Bryant , James Chen , Xiaowu Chen , Tomas Cihlar , Azar Dastgah , Eugene Eisenberg , Maria Fardis , Marcos Hatada , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard MacKman , Martin McDermott , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Williams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang
发明人： Murty Arimilli , Mark Becker , Gabriel Birkus , Clifford Bryant , James Chen , Xiaowu Chen , Tomas Cihlar , Azar Dastgah , Eugene Eisenberg , Maria Fardis , Marcos Hatada , Gong-Xin He , Haolun Jin , Choung Kim , William Lee , Christopher Lee , Kuei-Ying Lin , Hongtao Liu , Richard MacKman , Martin McDermott , Michael Mitchell , Peter Nelson , Hyung-Jung Pyun , Tanisha Rowe , Mark Sparacino , Sundaramoorthi Swaminathan , James Tario , Jianying Wang , Matthew Williams , Lianhong Xu , Zheng-Yu Yang , Richard Yu , Jiancun Zhang , Lijun Zhang
IPC分类号： C12N9/99 , A61K31/4155 , A61K31/66 , A61K31/665 , A61K31/675 , A61P31/18 , A61P43/00 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/48 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F20060101 , C07F9/02 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/62 , C07F9/645 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/653 , C07F9/6533 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07F9/6584 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C12Q1/70 , G01N33/04 , G01N33/50
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04 , G01N2500/20
摘要： Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
摘要翻译：提供了用于鉴定被羧基酯或膦酸酯基取代的抗HIV治疗化合物的方法。可以使用新型GS-7340酯水解酶来筛选这些化合物的文库。还提供了与GS-7340酯水解酶有关的组合物和方法。

23. 发明申请

US20050197320A1 Non nucleoside reverse transcriptase inhibitors 有权
标题翻译：非核苷逆转录酶抑制剂
公开(公告)号：US20050197320A1
公开(公告)日：2005-09-08
申请号：US10424130
申请日：2003-04-25
申请人： James Chen , Xiaowu Chen , Choung Kim , William Lee , Christopher Lee , Peter Nelson , James Tario , Lianhong Xu
发明人： James Chen , Xiaowu Chen , Choung Kim , William Lee , Christopher Lee , Peter Nelson , James Tario , Lianhong Xu
IPC分类号： C12N9/99 , A61K31/4155 , A61K31/66 , A61K31/665 , A61K31/675 , A61P31/18 , A61P43/00 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/48 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F20060101 , C07F9/02 , C07F9/38 , C07F9/40 , C07F9/44 , C07F9/58 , C07F9/62 , C07F9/645 , C07F9/6506 , C07F9/6509 , C07F9/6512 , C07F9/653 , C07F9/6533 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07F9/6584 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C12Q1/70 , G01N33/04 , G01N33/50
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes, as well as in assays for the detection of such enzymes.
摘要翻译：公开了具有用作治疗剂和其它工业目的的具有抗HIV性质的磷取代的咪唑化合物。组合物抑制逆转录酶活性，并且可用于抑制这些酶以及用于检测这些酶的测定中。

24. 发明申请

US20170236514A1 Integration and Probabilistic Control of Electronic Devices 审中-公开
公开(公告)号：US20170236514A1
公开(公告)日：2017-08-17
申请号：US15433965
申请日：2017-02-15
申请人： Peter Nelson
发明人： Peter Nelson
IPC分类号： G10L15/22 , G10L15/18 , G06N99/00
CPC分类号： G10L15/22 , G06N20/00 , G10L15/18 , G10L15/1815 , G10L2015/223 , G10L2015/225
摘要： A computer system may receive, from an acoustic transducer and/or a portable electronic device, information specifying one or more desired operations that are to be performed. This information may include natural language describing the one or more desired operations. In response, the computer system may transform the natural language into the one or more desired operations, and may identify a subset of the electronic devices based on the one or more desired operations and a predetermined supervised learning model that relates desired operations and the electronic devices. Next, the computer system may determine a set of commands based on the one or more desired operations and the subset of the electronic devices, and the computer system may provide the set of commands to the identified subset of the electronic devices, which may perform the one or more desired operations.

25. 发明授权

US08458169B2 Mini-form view for data records 有权
标题翻译：数据记录的微型视图
公开(公告)号：US08458169B2
公开(公告)日：2013-06-04
申请号：US12567722
申请日：2009-09-25
申请人： Ryan Griggs , Peter Nelson
发明人： Ryan Griggs , Peter Nelson
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F3/0482 , G06F17/30572 , G06F17/30973
摘要： Methods, program products, and systems for mini-form view of data records are described. Each data records can be formatted according to a layout. The layout can define an arrangement of various data fields for display. To display multiple data records, an image can be created for each formatted data record. Each image can be a snapshot of the formatted data record. The image can have a size that is smaller than the size of the layout. The arrangement of the data fields can be preserved in the image. Multiple images of formatted data records can be displayed in a single window. By displaying formatted data records in images, the “look and feel” in the layout of each data record can be preserved, even when multiple records are displayed. The mini-form view can display data records from multiple shared databases.
摘要翻译：描述了数据记录的微型视图的方法，程序产品和系统。每个数据记录可以根据布局进行格式化。布局可以定义用于显示的各种数据字段的布置。要显示多个数据记录，可以为每个格式化的数据记录创建一个图像。每个图像可以是格式化数据记录的快照。图像的尺寸可以小于布局的大小。可以在图像中保留数据字段的排列。可以在单个窗口中显示格式化数据记录的多个图像。通过在图像中显示格式化的数据记录，即使显示多个记录，也可以保留每个数据记录的布局中的“外观和感觉”。微型窗体视图可以显示来自多个共享数据库的数据记录。

26. 发明申请

US20120117509A1 Intelligent Data Caching 有权
标题翻译：智能数据缓存
公开(公告)号：US20120117509A1
公开(公告)日：2012-05-10
申请号：US12941007
申请日：2010-11-05
申请人： Wesley Powell , Adam Ward , Edward L. Ford , Peter Nelson
发明人： Wesley Powell , Adam Ward , Edward L. Ford , Peter Nelson
IPC分类号： G06F3/048 , G06F17/30
CPC分类号： G06F17/30528
摘要： Methods, program products, and systems implementing intelligent data caching are disclosed. A client can send a request for data to a server. The request can include a query and a query context. The query can retrieve more data than can be displayed in a current page. The query context can specify a quantity of data records that can be displayed in the current page. The client can receive from the server two sets of data in response to the request. The first set of data can include row identifiers of data records that satisfy the query. The second set of data can include data records that can be displayed in the current page. The client can store the two sets of data in one or more buffers (e.g., two buffers) and update buffer(s) when different data records are displayed (e.g., when a user scrolls through pages).
摘要翻译：公开了实现智能数据缓存的方法，程序产品和系统。客户端可以向服务器发送数据请求。请求可以包括查询和查询上下文。该查询可以检索比当前页面中显示的数据更多的数据。查询上下文可以指定可显示在当前页面中的数据记录数量。客户端可以根据请求从服务器接收两组数据。第一组数据可以包括满足查询的数据记录的行标识符。第二组数据可以包括可以显示在当前页面中的数据记录。当显示不同的数据记录时（例如，当用户滚动页面时），客户端可以将两组数据存储在一个或多个缓冲器（例如，两个缓冲器）和更新缓冲器中。

27. 发明申请

US20120117462A1 Dynamic Data Association 有权
标题翻译：动态数据协会
公开(公告)号：US20120117462A1
公开(公告)日：2012-05-10
申请号：US12940991
申请日：2010-11-05
申请人： Eric Jacobson , Les Thomas , Peter Nelson
发明人： Eric Jacobson , Les Thomas , Peter Nelson
IPC分类号： G06F3/14 , G06F3/048
CPC分类号： G06F17/30292
摘要： Methods, program products, and systems implementing dynamic data association are described. Relations between a first data item and a second data item can be created in an ad hoc manner. The first data item can include a row of data in a table in a relational database. The second data item can include a row of data in the same table, in another table in the relational database, or a document outside the relational database. Configurable metadata can be created to link the first data item and the second data item. The link can be directional. The configurable metadata can include data specified by a user. The configurable metadata can be stored in one or more system tables in the relational database. The configurable metadata can be specific to the user, or to a work group of the user. The configurable metadata can change when the first data item or the second data item is modified.
摘要翻译：描述了实现动态数据关联的方法，程序产品和系统。第一数据项和第二数据项之间的关系可以以专门的方式创建。第一个数据项可以包括关系数据库中的表中的一行数据。第二数据项可以包括同一表中的数据行，关系数据库中的另一个表，或关系数据库外的文档。可以创建可配置元数据以链接第一数据项和第二数据项。链接可以是定向的。可配置元数据可以包括用户指定的数据。可配置元数据可以存储在关系数据库中的一个或多个系统表中。可配置的元数据可以是用户的特定的，也可以是用户的工作组。当第一数据项或第二数据项被修改时，可配置元数据可以改变。

28. 发明申请

US20120087901A1 Engineered Mesenchymal Stem Cells and Methods of Using Same to Treat Tumors 有权
标题翻译：工程化间充质干细胞及其使用方法治疗肿瘤
公开(公告)号：US20120087901A1
公开(公告)日：2012-04-12
申请号：US13264084
申请日：2010-04-13
申请人： Peter Nelson
发明人： Peter Nelson
IPC分类号： A61K35/12 , C12N5/10 , C12N15/63 , A61P35/00
CPC分类号： C12N5/0663 , A61K35/28 , A61K2035/124 , C12N15/86 , C12N2510/00 , C12N2740/15043 , C12N2830/002
摘要： This invention provides a method for treating a subject afflicted with a tumor using genetically modified mesenchymal stem cells, wherein each genetically modified mesenchymal stem cell contains an exogenous nucleic acid comprising (i) a cytotoxic protein-encoding region operably linked to (ii) a promoter or promoter/enhancer combination, whereby the cytotoxic protein is selectively expressed when the genetically modified mesenchymal stem cells come into proximity with the tumor's stromal tissue. This invention further provides genetically modified mesenchymal stem cells for use in this method.
摘要翻译：本发明提供了使用遗传修饰的间充质干细胞治疗患有肿瘤的受试者的方法，其中每个经遗传修饰的间充质干细胞含有外源核酸，其包含（i）与（ii）启动子有效连接的细胞毒性蛋白质编码区或启动子/增强子组合，由此当遗传修饰的间充质干细胞与肿瘤的基质组织接近时，细胞毒性蛋白质被选择性地表达。本发明进一步提供用于该方法的遗传修饰的间充质干细胞。

29. 发明申请

US20110078109A1 MINI-FORM VIEW FOR DATA RECORDS 有权
标题翻译：用于数据记录的MINI-FORM VIEW
公开(公告)号：US20110078109A1
公开(公告)日：2011-03-31
申请号：US12567722
申请日：2009-09-25
申请人： Ryan Griggs , Peter Nelson
发明人： Ryan Griggs , Peter Nelson
IPC分类号： G06F17/00 , G06F3/048 , G06F17/30
CPC分类号： G06F3/0482 , G06F17/30572 , G06F17/30973
摘要： Methods, program products, and systems for mini-form view of data records are described. Each data records can be formatted according to a layout. The layout can define an arrangement of various data fields for display. To display multiple data records, an image can be created for each formatted data record. Each image can be a snapshot of the formatted data record. The image can have a size that is smaller than the size of the layout. The arrangement of the data fields can be preserved in the image. Multiple images of formatted data records can be displayed in a single window. By displaying formatted data records in images, the “look and feel” in the layout of each data record can be preserved, even when multiple records are displayed. The mini-form view can display data records from multiple shared databases.
摘要翻译：描述了数据记录的微型视图的方法，程序产品和系统。每个数据记录可以根据布局进行格式化。布局可以定义用于显示的各种数据字段的布置。要显示多个数据记录，可以为每个格式化的数据记录创建一个图像。每个图像可以是格式化数据记录的快照。图像的尺寸可以小于布局的大小。可以在图像中保留数据字段的排列。可以在单个窗口中显示格式化数据记录的多个图像。通过在图像中显示格式化的数据记录，即使显示多个记录，也可以保留每个数据记录的布局中的“外观和感觉”。微型窗体视图可以显示来自多个共享数据库的数据记录。

30. 发明申请

US20060128692A1 Non nucleoside reverse transcriptase inhibitors 审中-公开
标题翻译：非核苷逆转录酶抑制剂
公开(公告)号：US20060128692A1
公开(公告)日：2006-06-15
申请号：US10511182
申请日：2003-04-25
申请人： James Chen , Xiaowu Chen , Choung Kim , William Lee , Christopher Lee , Peter Nelson , James Tario , Lianhong Xu
发明人： James Chen , Xiaowu Chen , Choung Kim , William Lee , Christopher Lee , Peter Nelson , James Tario , Lianhong Xu
IPC分类号： A61K31/551 , A61K31/444 , A61K31/44 , C07D487/14
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/58 , C07F9/645 , C07F9/6506 , C07F9/650905 , C07F9/650947 , C07F9/6512 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphorus-substituted imidazole compounds with anti-HIV properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit reverse transcriptase activity and are useful therapeutically for the inhibition of such enzymes, as well as in assays for the detection of such enzymes.
摘要翻译：公开了具有用作治疗剂和其它工业目的的具有抗HIV性质的磷取代的咪唑化合物。组合物抑制逆转录酶活性，并且可用于抑制这些酶以及用于检测这些酶的测定中。

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