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21. 发明授权

US07034941B2 Color detection using spectroscopic imaging and processing in random array of microspheres 失效
标题翻译：使用随机阵列的微球的光谱成像和处理进行颜色检测
公开(公告)号：US07034941B2
公开(公告)日：2006-04-25
申请号：US10607146
申请日：2003-06-26
申请人： Samuel Chen , Anthony E. Taddei , Joaquin Calcines , Krishnan Chari , Martin C. Kaplan , Douglas L. Vizard
发明人： Samuel Chen , Anthony E. Taddei , Joaquin Calcines , Krishnan Chari , Martin C. Kaplan , Douglas L. Vizard
IPC分类号： G01J3/46
CPC分类号： G01N33/54313 , G01N33/582 , G01N33/583
摘要： A method of determining one or more color characteristics of a colored microsphere comprising: providing a microarray of microspheres, including at least one colored microsphere which has a color characteristic; producing a magnified optical image of individual microspheres of the microarray; locating a microsphere in the aperture of a spectrometer to confine the color region of interest of the located microsphere in order to determine one or more color characteristics thereof; and determining one or more color characteristics of the located microsphere by means of the spectrometer.
摘要翻译：确定着色微球的一种或多种颜色特性的方法，包括：提供微球的微阵列，所述微球包括至少一种具有颜色特征的有色微球; 产生微阵列的单个微球的放大的光学图像; 将微球定位在光谱仪的孔中以限制所定位的微球的感兴趣的颜色区域，以便确定其一个或多个颜色特性; 并通过光谱仪确定所定位的微球的一种或多种颜色特性。

22. 发明授权

US07031084B2 Imaging system using combined dichroic/high-pass filters 失效
标题翻译：使用组合二向色/高通滤波器的成像系统
公开(公告)号：US07031084B2
公开(公告)日：2006-04-18
申请号：US10625376
申请日：2003-07-23
申请人： Douglas L. Vizard , William E. Mclaughlin
发明人： Douglas L. Vizard , William E. Mclaughlin
IPC分类号： G02B5/22
CPC分类号： G01N21/6456 , G02B5/20
摘要： An imaging system including: a lens; a dichroic filter positioned in front of the lens; and a high pass filter positioned between the lens and the dichroic filter. An appropriate design coordinating the components of such an imaging system diminishes imaging artifacts related to wide-angle imaging of fluorescent objects.
摘要翻译：一种成像系统，包括：透镜; 位于透镜前方的二向色滤光片; 以及位于透镜和二向色滤光片之间的高通滤光器。协调这种成像系统的组件的适当设计降低了与荧光物体的广角成像相关的成像伪影。

23. 发明授权

US6143459A Photosensitive film assembly having reflective support 失效
标题翻译：具有反射支撑的感光膜组件
公开(公告)号：US6143459A
公开(公告)日：2000-11-07
申请号：US467853
申请日：1999-12-20
申请人： Douglas L. Vizard
发明人： Douglas L. Vizard
IPC分类号： G03C1/005 , G03C1/76 , G03C5/17 , G03C1/95
CPC分类号： G03C5/17 , G03C1/76 , G03C1/0051
摘要： A photosensitive film assembly comprising;a polymeric support having first and second side, said support being reflective to non penetrating radiation; anda photosensitive layer on at least one of said first and second sides of said support.
摘要翻译：一种感光膜组件，包括：具有第一和第二侧面的聚合物支撑体，所述支撑件反射不透射辐射; 以及在所述支撑件的所述第一和第二侧中的至少一个上的感光层。

24. 发明授权

US09113784B2 Apparatus and method for multi-modal imaging 有权
标题翻译：多模态成像装置及方法
公开(公告)号：US09113784B2
公开(公告)日：2015-08-25
申请号：US13238290
申请日：2011-09-21
申请人： Gilbert D. Feke , William E. McLaughlin , Douglas L. Vizard
发明人： Gilbert D. Feke , William E. McLaughlin , Douglas L. Vizard
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B6/4417 , A61B5/0035 , A61B5/0059 , A61B5/0071 , A61B6/00 , A61B6/5247 , A61B2562/17
摘要： An imaging system and method for imaging an immobilized object. The imaging system includes a support member adapted to receive the object in an immobilized state. The system also includes means for imaging the immobilized object in various imaging modes to capture images of the object. The imaging system further includes a movable phosphor screen. The phosphor screen is adapted to be movable without moving the immobilized object and support member.
摘要翻译：一种用于对固定物体进行成像的成像系统和方法。成像系统包括适于在固定状态下接收物体的支撑构件。该系统还包括用于在各种成像模式下成像固定的物体以捕获物体的图像的装置。成像系统还包括可移动荧光屏。荧光屏适于可移动而不移动固定的物体和支撑构件。

25. 发明授权

US07011945B2 Random array of micro-spheres for the analysis of nucleic acids 失效
公开(公告)号：US07011945B2
公开(公告)日：2006-03-14
申请号：US10036828
申请日：2001-12-21
申请人： Tiecheng A. Qiao , Krishnan Chari , Douglas L. Vizard
发明人： Tiecheng A. Qiao , Krishnan Chari , Douglas L. Vizard
IPC分类号： C12Q1/68 , C12M1/36 , C07H21/04
CPC分类号： B01J19/0046 , B01J2219/00466 , B01J2219/00529 , B01J2219/00545 , B01J2219/00547 , B01J2219/00576 , B01J2219/00648 , B01J2219/00702 , G06F19/20
摘要： A method of identifying nucleic acid samples comprising: providing a mircoarray including a substrate coated with a composition including a population of micro-spheres dispersed in a fluid containing a gelling agent or a precursor to a gelling agent and immobilized at random positions on the substrate, at least one sub-population of said population micro-spheres containing an optical barcode generated from at least one colorant associated with the micro-spheres and including a nucleic acid probe sequence; contacting said array with a target nucleic acid sequence; and detecting the color barcode of said sub-population of micro-spheres due to the interaction of said probe nucleic acid sequence and said target nucleic acid sequence.

26. 发明授权

US06916620B2 Random array of micro-spheres for the analysis of nucleic acid using enzyme digestion 失效
标题翻译：随机阵列的微球用于分析核酸酶消化
公开(公告)号：US06916620B2
公开(公告)日：2005-07-12
申请号：US10098642
申请日：2002-03-15
申请人： Tiecheng A. Qiao , Krishnan Chari , Douglas L. Vizard
发明人： Tiecheng A. Qiao , Krishnan Chari , Douglas L. Vizard
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B70/00 , G01N37/00 , C07H21/04 , C12M1/36 , C12N11/16 , G01N15/06
CPC分类号： C12Q1/6837 , B01J2219/00466 , B01J2219/00545 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , C40B40/06 , C40B70/00 , C12Q2565/513 , C12Q2565/102 , C12Q2563/149
摘要： A method of identifying nucleic acid samples comprising: providing a mircoarray including a substrate coated with a composition including a population of nucleic acid probe modified micro-spheres immobilized in a coating containing a gelling agent or a precursor to a gelling agent, wherein a first portion of the micro-spheres is submerged in the gelatin coating and a second portion is exposed above the gelatin coating and is substantially free of gelatin, at least one sub-population of the population micro-spheres containing an optical barcode generated from at least one colorant associated with the micro-spheres and including a nucleic acid probe sequence; contacting the array with a target nucleic acid sequence; and detecting the color barcode of the sub-population of micro-spheres due to the interaction of the probe nucleic acid sequence and the fluorescently/chemiluminescently labeled nucleic acid sample target nucleic acid sequence.
摘要翻译：一种鉴定核酸样品的方法，包括：提供包含底物的微阵列，所述底物涂覆有组合物，所述组合物包含固定在包含胶凝剂或胶凝剂前体的涂层中的核酸探针修饰微球体群体，其中第一部分的微球浸没在明胶涂层中，第二部分暴露在明胶涂层上方并且基本上不含明胶，至少一个群体微球的亚群包含由至少一种着色剂产生的光学条形码与微球相关并包括核酸探针序列; 使阵列与靶核酸序列接触; 并且由于探针核酸序列和荧光/化学发光标记的核酸样品靶核酸序列的相互作用，检测微球子群体的颜色条形码。

27. 发明授权

US06444988B1 Electronic imaging screen with optical interference coating 失效
标题翻译：具有光学干涉涂层的电子成像屏幕
公开(公告)号：US06444988B1
公开(公告)日：2002-09-03
申请号：US09467409
申请日：1999-12-20
申请人： Douglas L. Vizard
发明人： Douglas L. Vizard
IPC分类号： G01T1164
CPC分类号： G21K4/00 , G21K2004/06
摘要： An electronic imaging system including; a transparent support having first and second sides; an optical interference coating on the first side of the transparent support; and a first prompt phosphor layer overlaying the interference coating for use in high resolution ionizing radiation imaging application or in low energy ionizing radiation imaging applications. The system also includes a second prompt phosphor layer which is removably overlaid on the first prompt phosphor layer for use in high energy ionizing radiation applications; and an electronic camera for converting the light image produced by the first and the second prompt phosphor layers when exposed to an ionizing radiation image, into an electronic image; wherein the phosphor of the first and second prompt phosphor layers emits radiation at wavelengths which are passed by the optical interference coating.
摘要翻译：一种电子成像系统，包括：具有第一和第二侧面的透明支撑件; 在透明支撑体的第一面上的光学干涉涂层; 以及覆盖用于高分辨率电离辐射成像应用或低能电离辐射成像应用中的干涉涂层的第一提示荧光体层。该系统还包括可拆卸地覆盖在第一提示荧光体层上以用于高能电离辐射应用的第二提示荧光体层; 以及电子照相机，用于将暴露于电离辐射图像时由第一和第二迅速荧光体层产生的光图像转换成电子图像; 其中第一和第二迅速荧光体层的磷光体以波长经过光学干涉涂层发射辐射。

28. 发明授权

US06346707B1 Electronic imaging system for autoradiography 失效
标题翻译：用于放射自显影的电子成像系统
公开(公告)号：US06346707B1
公开(公告)日：2002-02-12
申请号：US09123283
申请日：1998-07-28
申请人： Douglas L. Vizard , Joel N. Helfer , William E. McLaughlin , David J. Steklenski
发明人： Douglas L. Vizard , Joel N. Helfer , William E. McLaughlin , David J. Steklenski
IPC分类号： G01T120
CPC分类号： G01T1/2942
摘要： An imaging system with an imaging assemblage including a prompt phosphor layer for converting an ionizing radiation image into a light image, and a transparent layer supporting the phosphor layer; wherein the light image is transmitted through the transparent layer; an electronic camera for converting the light image into an electronic image; and a light image transmission system between the imaging assemblage and the electronic camera for transmitting the light image to the electronic camera.
摘要翻译：一种具有成像组件的成像系统，包括用于将电离辐射图像转换成光图像的迅速荧光层，以及支撑荧光体层的透明层; 其中所述光图像透射通过所述透明层; 用于将光图像转换成电子图像的电子照相机; 以及在成像组件和用于将光图像传送到电子照相机的电子照相机之间的光图像传输系统。

29. 发明授权

US5779869A Low fog electrophoresis device 失效
标题翻译：低雾电泳装置
公开(公告)号：US5779869A
公开(公告)日：1998-07-14
申请号：US754463
申请日：1996-11-22
申请人： Joel Norman Helfer , Douglas L. Vizard
发明人： Joel Norman Helfer , Douglas L. Vizard
IPC分类号： G01N27/447 , C25B9/00
CPC分类号： G01N27/44704
摘要： An electrophoresis device consists of a housing which has opening(s) for the movement of gases from inside the housing to outside the housing and opening(s) for the movement of gases from outside the housing to inside the housing, whereby the condensation of gases on the inside of the housing is avoided or minimized.
摘要翻译：电泳装置由一个壳体组成，该壳体具有用于使气体从壳体内部移动到壳体外部的开口和用于将气体从壳体外部移动到壳体内部的开口，由此气体冷凝避免或最小化在外壳的内部。

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