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21. 发明申请

US20120157324A1 METHYLATION BIOMARKERS AND METHODS OF USE 审中-公开
标题翻译：甲基生物标志物及其使用方法
公开(公告)号：US20120157324A1
公开(公告)日：2012-06-21
申请号：US13390669
申请日：2010-08-17
申请人： Paul M. Lizardi , Sebastian Szpakowski , Min Chen , Jose Costa , Hongyu Zhao
发明人： Paul M. Lizardi , Sebastian Szpakowski , Min Chen , Jose Costa , Hongyu Zhao
IPC分类号： C12Q1/68 , C40B50/00 , C40B20/00 , C07H21/04 , C07H1/00
CPC分类号： C12Q1/6886 , C12Q2600/154
摘要： Disclosed are methods and compositions of assessing one or more statuses of a subject. Also disclosed are methods and compositions of identifying status biomarkers associated with a status of a subject. Also disclosed are sets of one or more status biomarkers. Also disclosed are methods and compositions of producing status biomarker capture probes.
摘要翻译：公开了评估受试者的一种或多种状态的方法和组合物。还公开了鉴定与受试者状态相关的状态生物标志物的方法和组合物。还公开了一种或多种状态生物标志物。还公开了生产状态生物标志物捕获探针的方法和组合物。

22. 发明授权

US09187483B2 Modulators of 5-HT receptors and methods of use thereof 有权
标题翻译： 5-HT受体的调节剂及其使用方法
公开(公告)号：US09187483B2
公开(公告)日：2015-11-17
申请号：US12784624
申请日：2010-05-21
申请人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
发明人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
IPC分类号： A61K31/55 , C07D487/04 , C07D491/04 , C07D495/04
CPC分类号： C07D513/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D495/04 , C07D495/16
摘要： The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译：本申请涉及式（I）的芳基 - 和杂芳基 - 稠合十氢吡咯并氮平，二氢八氢化吡咯并噻吩，十氢环庚三烯并[c]吡咯和八氢环庚三烯并[c]吡咯衍生物，其中R1，R2，R3，R4，R5，A，Y1 ，Y2和Y3如说明书中所定义。本申请还涉及包含这些化合物的组合物，制备此类化合物的方法，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

23. 发明授权

US08846951B2 Modulators of 5-HT receptors and methods of use thereof 有权
标题翻译： 5-HT受体的调节剂及其使用方法
公开(公告)号：US08846951B2
公开(公告)日：2014-09-30
申请号：US12950029
申请日：2010-11-19
申请人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
发明人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
IPC分类号： C07D491/12 , C07D498/12 , C07D487/12 , A61K31/407 , A61K31/553 , A61K31/554 , A61K31/55 , C07D513/04 , C07D495/04 , C07D487/04 , C07D491/04
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译：本申请涉及式（I）的芳基 - 和杂芳基 - 稠合十氢吡咯并氮平，二氢八氢化吡咯并噻吩，十氢环庚三烯并[c]吡咯和八氢环庚三烯并[c]吡咯衍生物，其中R1，R2，R3，R4，R5，A，Y1 ，Y2和Y3如说明书中所定义。本申请还涉及包含这些化合物的组合物，制备此类化合物的方法，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

24. 发明申请

US20130160261A1 APPARATUS FOR MANUFACTURING SEMICONDUCTOR WAFER 有权
标题翻译：制造半导体波形的装置
公开(公告)号：US20130160261A1
公开(公告)日：2013-06-27
申请号：US13701880
申请日：2012-06-13
申请人： Hongyu Zhao , Xiaohong Zhang , Likun Pei , Bao Zhang , Ruiting Wang
发明人： Hongyu Zhao , Xiaohong Zhang , Likun Pei , Bao Zhang , Ruiting Wang
IPC分类号： H01L21/677
CPC分类号： H01L21/67769 , H01L21/67017 , H01L21/67742 , H01L21/67766 , Y10T29/41
摘要： The present invention provides an apparatus for manufacturing semiconductor wafer comprising at least two manipulators, at least one set of chemical gas/liquid distribution unit and an air circulating and filtering unit. The air circulating and filtering unit is separated into three regions, including the front region, the middle region, and the side region, which are controlled by respective control electric motors to achieve uniform air flow and uniform pressure in the respective regions. The cleaning degree in the internal of the apparatus can be improved by the regional control of the air circulating and filtering unit; the wafer transport efficiency can be enhanced by the double-armed manipulators having multiple degrees of freedom; and the product yield per unit area can be increased by the chemical gas/liquid distribution unit providing stable and uniform gas/liquid flow and pressure.
摘要翻译：本发明提供了一种用于制造半导体晶片的装置，其包括至少两个操纵器，至少一组化学气体/液体分配单元和空气循环和过滤单元。空气循环和过滤单元被分为包括前区域，中间区域和侧区域的三个区域，这三个区域由相应的控制电动机控制，以在各个区域中实现均匀的气流和均匀的压力。通过空气循环和过滤单元的区域控制可以改善设备内部的清洁度; 可以通过具有多个自由度的双臂操纵器来提高晶片输送效率; 可以通过化学气体/液体分配单元提高单位面积的产品产量，提供稳定和均匀的气/液流量和压力。

25. 发明申请

US20130102788A1 Method for Synthesizing 1,3,5-Tri-(N-Phenylbenzimidazolyl) Benzene 审中-公开
标题翻译：合成1,3,5-三（N-苯基苯并咪唑基）苯的方法
公开(公告)号：US20130102788A1
公开(公告)日：2013-04-25
申请号：US13582060
申请日：2011-02-09
申请人： Lifei Cai , Lei Dai , Hongyu Zhao , Yanfeng Ding , Weilong Zhang , Junhao Lian
发明人： Lifei Cai , Lei Dai , Hongyu Zhao , Yanfeng Ding , Weilong Zhang , Junhao Lian
IPC分类号： C07D403/14
CPC分类号： C07D403/14 , C07D235/20
摘要： The present invention relates to efficient synthetic method of 1,3,5-tris (N-Phenylbenzimidazole) Benzene and pertains to the field of synthesis of organic light-emitting materials. The method and process of the patent are as following: 1,3,5-tris (N-Phenyl-N Phenylammonium) Benzamide is treated by shrinking agent but no high temperature required, and then high purity product can be reached after raw material dissolved. The reaction only takes a few minutes and through recrystallization the purity can be over 99%, and then the material with stable crystal phase reached after sublimation step. The method introduced by the present patent is easy to operate, and with high in yield and purity, which adapt industrial production and has important significance for the industrialization.
摘要翻译：本发明涉及1,3,5-三（N-苯基苯并咪唑）苯的有效合成方法，涉及有机发光材料的合成领域。该专利的方法和方法如下：1,3,5-三（N-苯基-N苯基铵）苯甲酰胺通过收缩剂处理，但不需要高温，然后原料溶解后可以达到高纯度产物。反应仅需几分钟，通过重结晶，纯度可达99％以上，升华后达到稳定晶相的物质。本专利引进的方法易于操作，产率高，纯度高，适应工业生产，对工业化具有重要意义。

26. 发明申请

US20120065445A1 Process For Synthesis of 9,9'-Dianthracene 审中-公开
标题翻译： 9,9'-二蒽的合成方法
公开(公告)号：US20120065445A1
公开(公告)日：2012-03-15
申请号：US13321799
申请日：2010-05-05
申请人： Lifei Cai , Lei Dai , Hongyu Zhao
发明人： Lifei Cai , Lei Dai , Hongyu Zhao
IPC分类号： C07C1/20
CPC分类号： C07C1/2076 , C07C2523/06 , C07C2527/11 , C07C2531/04 , C07C2603/90 , C07C13/605
摘要： This invention, which involves “the synthetic method of 9, 9′-biantnthracine”, belongs to the field of synthetic technology of organic electroluminesent materials. Synthetic method of 9, 9′-bianthracine is to add anthraquinone as raw material and zinc as reducing agent in glacial acetic acid solution, then batch addition of hydrochloric acid at 70-120°, maintain the temperature unchanged and react, then 9, 9′-bianthracine is achieved. This invention uses one-step method to synthesize 9, 9′-bianthracine, which reduces not only cost but also generation of side products, in addition, the products obtained need no purification and can be directly used to synthesize related similar compounds, therefore, it is very suitable for large-scale industrial production.
摘要翻译：本发明涉及“9,9-双蒽”的合成方法，属于有机电致发光材料合成技术领域。 9,9'-双蒽的合成方法是在冰醋酸溶液中加入蒽醌作为原料，还加入锌作为还原剂，然后在70-120℃下分批加入盐酸，保持温度不变，反应9,9 实现了“ - ” - 本发明使用一步法合成9,9'-双蒽并不仅降低成本而且降低副产物的产生，此外，所得产物不需要纯化，可直接用于合成相关的相似化合物，因此，非常适合大型工业生产。

27. 发明申请

US20110118231A1 MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF 有权
标题翻译： 5-HT受体的调节剂及其使用方法
公开(公告)号：US20110118231A1
公开(公告)日：2011-05-19
申请号：US12950029
申请日：2010-11-19
申请人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
发明人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
IPC分类号： A61K31/554 , C07D487/04 , C07D491/044 , C07D513/04 , A61K31/55 , A61K31/407 , A61P25/28 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/22 , A61P25/16 , A61P25/08 , A61P25/06 , A61P25/30 , A61P3/04 , A61P3/10 , A61P9/12 , A61P29/00 , A61P15/10 , A61P15/00 , A61P17/06
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译：本申请涉及式（I）的芳基 - 和杂芳基 - 稠合十氢吡咯并氮平，二氢八氢化吡咯并噻吩，十氢环庚三烯并[c]吡咯和八氢环庚三烯并[c]吡咯衍生物，其中R1，R2，R3，R4，R5，A，Y1 ，Y2和Y3如说明书中所定义。本申请还涉及包含这些化合物的组合物，制备此类化合物的方法，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

28. 发明申请

US20050048547A1 Classification of disease states using mass spectrometry data 审中-公开
标题翻译：使用质谱数据对疾病状态进行分类
公开(公告)号：US20050048547A1
公开(公告)日：2005-03-03
申请号：US10893434
申请日：2004-07-19
申请人： Hongyu Zhao , Kenneth Williams , Baolin Wu , Kathryn Stone , Walter McMurray , Thomas Abbott
发明人： Hongyu Zhao , Kenneth Williams , Baolin Wu , Kathryn Stone , Walter McMurray , Thomas Abbott
IPC分类号： C12Q1/68 , G01N20060101 , G01N33/48 , G01N33/50 , G06F19/00 , H01J49/04
CPC分类号： H01J49/00 , G16B40/00 , Y02A90/26
摘要： A method for identification of biological characteristics is achieved by collecting a data set relating to individuals having known biological characteristics and analyzing the data set to identify biomarkers potentially relating to selected biological state classes. A system for identification of biological characteristics is also provided. A methodology is also provided for utilizing mass spectroscopy data to identify peptide and protein biomarkers that can be used to optimally discriminate experimental from control samples—where the experimental samples may, for instance, be derived from patients with various diseases such as ovarian cancer.
摘要翻译：通过收集与具有已知生物学特征的个体相关的数据集并分析数据集以识别潜在地与所选择的生物状态类相关的生物标志物来实现生物学特征的识别方法。还提供了用于识别生物特性的系统。还提供了一种方法，用于利用质谱数据来鉴定肽和蛋白质生物标志物，其可用于最佳地区分对照样品的实验，其中实验样品例如可衍生于患有各种疾病如卵巢癌的患者。

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