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21. 发明授权

US5400788A Apparatus that generates acoustic signals at discrete multiple frequencies and that couples acoustic signals into a cladded-core acoustic waveguide 失效
标题翻译：在离散的多个频率处产生声信号并将声信号耦合到包层芯声波导中的装置
公开(公告)号：US5400788A
公开(公告)日：1995-03-28
申请号：US72828
申请日：1993-06-07
申请人： J. Fleming Dias , Hewlett E. Melton, Jr.
发明人： J. Fleming Dias , Hewlett E. Melton, Jr.
IPC分类号： A61B8/08 , A61B8/12 , A61B17/22 , A61B19/00 , G02B6/26 , G10K11/24 , H03H9/145 , A61B8/00
CPC分类号： G10K11/24 , A61B8/0833 , A61B8/12 , A61B8/445 , A61B8/4461 , G02B6/26 , A61B2017/22017 , A61B2034/2063 , A61B2090/3925 , A61B8/4488 , A61B8/485
摘要： Spherical annulus piezoelectric transducers 62, 64 and spherical disc piezoelectric transducer 66 form a spherical shell having a radius of curvature R with a focal point 70 near the end of cladded-core acoustic waveguide 72. Each transducer 62, 64, 66 generates a bulk acoustic wave of a unique frequency and transmits it to focal point 70 where it enters core 74 of cladded-core acoustic waveguide 72. Alternatively, a conical annulus piezoelectric transducers 92, 116 on a prism 90 generate bulk acoustic waves of multiple discrete frequencies and focus them through cladding 75 and into core 74 of cladded-core acoustic waveguide 72. Surface acoustic waves of multiple discrete frequencies can be generated by multiple sets of curvilinear interdigital conductors 132, 134 on a piezoelectric substrate 122. The shape of curvilinear interdigital conductors 132, 134 focuses the surface acoustic waves at focal point 70 located near the end of acoustic waveguide 72. The surface acoustic waves are converted into bulk/longitudinal waves by either curvilinear corrugations 142, 146 or by a coupling medium that causes the surface acoustic waves to become leaky longitudinal waves. Alternatively, the surface acoustic waves can be coupled to the core of the acoustic waveguide by converting them into either bulk/longitudinal waves or leaky longitudinal waves and guiding them through the cladding to the core. When the acoustic signals travel through the cladding to couple to the core, the acoustic waveguide can transmit optical signals.
摘要翻译：球形环形压电换能器62,64和球形盘式压电换能器66形成具有曲率半径R的球形壳体，焦点70靠近包层芯声波导72的端部。每个换能器62,64,66产生体声波的独特频率，并将其传输到焦点70，在其中它进入包芯芯声波导72的核心74.或者，棱镜90上的锥形环形压电换能器92,116产生多个离散频率的体声波，并将它们聚焦通过包层75并进入包芯芯声波导72的芯74中。多个离散频率的表面声波可以由压电基片122上的多组曲线交叉指导导体132,134产生。曲线形叉指导线132,134的形状将表面声波聚焦在位于声波导72端部附近的焦点70处。表面声波为c 通过曲线波纹142,146或通过使表面声波变成泄漏的纵波的耦合介质而被转换成体/纵波。或者，表面声波可以通过将它们转换成体/纵波或泄漏的纵波并且将它们引导穿过包层到芯来耦合到声波导的芯。当声信号穿过包层耦合到芯时，声波导可传输光信号。

22. 发明授权

US06717598B1 Medical navigator and systems therefor 失效
公开(公告)号：US06717598B1
公开(公告)日：2004-04-06
申请号：US09568555
申请日：2000-05-09
申请人： Hewlett E. Melton, Jr. , John McIntyre Douglass
发明人： Hewlett E. Melton, Jr. , John McIntyre Douglass
IPC分类号： G06F300
CPC分类号： G06Q50/24 , G06F19/00 , G06F19/3456 , G06F19/3475 , G06Q10/10 , G16H40/63
摘要： The present invention provides a medical device, or medical navigator, based not on a programming perspective, but a use perspective. Medication to be taken is displayed on a color screen, actual size where possible. A color display is used because the pharmaceutical industry worldwide has substantially standardized on the colors; e.g., black and yellow pills mean barbiturates. Capsules and caplets are uniquely colored for the medicines. Pharmacists can readily tell what the medication is by looking at it. And, patients identify medications by their color and size. Input mechanisms are provided for indicating compliance with the mediation schedule and the physical condition of the patient.

23. 发明授权

US06367314B1 Functional status assessment scale 失效
标题翻译：功能状态评估量表
公开(公告)号：US06367314B1
公开(公告)日：2002-04-09
申请号：US09489446
申请日：2000-01-21
申请人： Hewlett E. Melton, Jr.
发明人： Hewlett E. Melton, Jr.
IPC分类号： G01N100
CPC分类号： A61B5/1036 , A61B5/0022 , G06F19/00 , G16H40/67
摘要： A system and a method of objectively assessing the functional status of a subject utilize a functional status scale to extract objective measures that are indicative of the subject's functional status. The objective measures are extracted from center-of-weight (C.O.W.) data gathered from the functional status scale when the subject is standing on the scale. These objective measures can then be used to assess the current functional status of the subject by a health care provider. The functional status scale can be remotely stationed at the subject's home, which eliminates the need for office visits, expensive home nurse visits, telephone interviews or video visits to assess the current functional status of the subject. The functional status scale includes weight sensors that are connected to a C.O.W. computer. The C.O.W. computer is configured to compute x and y coordinates of the C.O.W. from weight signals generated by the weight sensors. These x and y coordinates are then used to extract the objective measures by analysis modules. The objective measures may be statistical measures, frequency domain measures, or other analytical measures that can be utilized for assessment of a subject's functional status. In one configuration, the analysis modules are included in remote computers that can access a heath care provider's patient database, which receives and stores the x and y coordinates from the functional status scale. In an alternative configuration, the analysis modules are included in the functional status scale.
摘要翻译：客观地评估对象的功能状态的系统和方法利用功能状态量表来提取表示受试者的功能状态的客观测量。当主体站在规模上时，从功能状态量表中收集到的中心重量（C.O.W.）数据中提取客观指标。然后，这些客观措施可用于评估医疗保健提供者当前的主体功能状态。功能状态量表可以远程驻留在受试者的家中，无需办公室访问，昂贵的家庭护士访问，电话访问或视频访问，以评估该主题的当前功能状态。功能状态量表包括与C.O.W.连接的重量传感器。电脑。 C.O.W. 计算机被配置为计算C.O.W的x和y坐标。由重量传感器产生的重量信号。然后，这些x和y坐标用于通过分析模块提取客观量度。客观措施可能是统计学措施，频域措施，或其他可用于评估受试者功能状态的分析措施。在一个配置中，分析模块包括在远程计算机中，可以访问健康护理提供者的病人数据库，该数据库从功能状态量表接收和存储x和y坐标。在替代配置中，分析模块包含在功能状态标尺中。

24. 发明授权

US5509417A Method and apparatus for phased array coupling ultrasonic energy into an acoustic waveguide wire 失效
标题翻译：用于将超声能量耦合到声波导线中的相控阵的方法和装置
公开(公告)号：US5509417A
公开(公告)日：1996-04-23
申请号：US358279
申请日：1994-12-19
申请人： Fleming Dias , Hewlett E. Melton, Jr.
发明人： Fleming Dias , Hewlett E. Melton, Jr.
IPC分类号： G01N29/24 , A61B8/00 , A61B8/12 , A61B17/22 , B06B1/06 , G10K11/24 , G10K11/34 , H04R1/40
CPC分类号： A61B8/4483 , A61B17/22012 , A61B8/12 , A61B8/445 , B06B1/0611 , G10K11/24 , G10K11/346 , A61B2017/22028
摘要： A method and apparatus for coupling ultrasonic energy into a clad or unclad waveguide include using phased array techniques to increase the area and intensity of radiation into the waveguide. An array of ultrasound transducers is positioned at the exterior of the waveguide and at dissimilar distances from the end of the waveguide. The transducers are individually fired by applying separate phase-shifted excitation signals. The phase shifting achieves a selected phase-differential relationship with respect to signals applied to adjacent transducers. The selected phase-differential relationship defines an angle of radiation into the waveguide. In the preferred embodiment, the apparatus is a medical device, such as an angioplasty device or ultrasound imaging device.
摘要翻译：用于将超声能量耦合到包层或未包层波导中的方法和装置包括使用相控阵技术来增加辐射进入波导的面积和强度。超声波换能器阵列位于波导的外部，距离波导端部不同的距离。通过施加单独的相移激励信号来单独地发射换能器。相移相对于施加到相邻换能器的信号获得选定的相位差。所选择的相位差关系定义到波导中的辐射角。在优选实施例中，该装置是诸如血管成形术装置或超声成像装置的医疗装置。

25. 发明授权

US5419328A Mean squared speed and myocardial performance 失效
标题翻译：平均速度和心肌表现
公开(公告)号：US5419328A
公开(公告)日：1995-05-30
申请号：US104292
申请日：1993-08-09
申请人： Christiana Goh , Hewlett E. Melton, Jr.
发明人： Christiana Goh , Hewlett E. Melton, Jr.
IPC分类号： A61B8/00 , A61B8/08 , G06F17/00 , G06F19/00 , G06T7/20
CPC分类号： G06T7/206 , A61B8/08
摘要： A method and system of monitoring performance of a heart include echocardiographic transmission and reception to form time series of frames containing mean squared difference data. Mean squared signal change, mean squared speed or root mean squared speed may be used to form functional images, such as average speed over a selected time interval or peak speed over a selected time interval.
摘要翻译：监测心脏性能的方法和系统包括超声心动图发射和接收，以形成包含均方差数据的帧的时间序列。可以使用均方信号变化，均方速度或均方根速度来形成功能图像，例如在所选择的时间间隔内的所选时间间隔或峰值速度的平均速度。

26. 发明授权

US5352582A Holographic based bio-assay 失效
标题翻译：全息生物检测
公开(公告)号：US5352582A
公开(公告)日：1994-10-04
申请号：US144919
申请日：1993-10-28
申请人： Kay Lichtenwalter , Hewlett E. Melton, Jr.
发明人： Kay Lichtenwalter , Hewlett E. Melton, Jr.
IPC分类号： G01N21/78 , C12M1/34 , C12Q1/68 , G01N21/47 , G01N33/53 , G02B5/32 , G01N33/543
CPC分类号： G01N33/53 , C12Q1/68 , G01N21/4788 , G03H1/0005 , G03H1/0244 , G03H1/0486 , G03H2001/0033 , G03H2001/0292 , G03H2001/0413 , G03H2001/2244 , G03H2001/226 , Y10S435/808 , Y10S436/805
摘要： An apparatus detects a target reactant that binds to an immobilized reactant. The apparatus generates a holographic image at a predetermined location when the reactants are present and bound to one another. The immobilized reactant is bound to a support surface at selected locations. The locations are chosen such that a holographic plate is generated when the target reactant binds to the immobilized reactant. An associated method may be used to detect antibody-antigen reactions, the binding of two strands of nucleic acid, the binding of an enzyme to one of its substrates, and so on.
摘要翻译：一种装置检测与固定的反应物结合的目标反应物。当反应物存在并且彼此结合时，该装置在预定位置产生全息图像。固定的反应物在选定的位置结合到支撑表面。选择这些位置使得当靶反应物与固定的反应物结合时产生全息板。可以使用相关联的方法来检测抗体 - 抗原反应，两条核酸的结合，酶与其底物之一的结合等等。

27. 发明授权

US5313946A Method and apparatus for the characterization of tissue or other structure 失效
标题翻译：用于表征组织或其他结构的方法和装置
公开(公告)号：US5313946A
公开(公告)日：1994-05-24
申请号：US639486
申请日：1991-01-09
申请人： Hewlett E. Melton, Jr.
发明人： Hewlett E. Melton, Jr.
IPC分类号： A61B8/08 , G01N29/40 , G01N29/44 , G01N29/50 , G01S7/52 , A61B8/00
CPC分类号： G01S7/52036 , A61B8/08 , G01N29/40 , G01N29/4472 , G01N29/50
摘要： A method and apparatus are provided for determining correlation length of body tissue, metals, crystals, or other materials, substances and the like having an ordered internal stucture (hereinafter structures) and for utilizing such correlation length to test, classify or otherwise characterize the structure. The structure is scanned using standard ultrasonic scanning technology and the output from such scan is processed to determine correlation length in one dimension (length), two dimensions (area), three dimensions (volume). A fourth dimension of time may also be used with one or more of the other three dimensions in the correlation length determination.
摘要翻译：提供了一种用于确定具有有序内部结构（以下称为结构）的身体组织，金属，晶体或其他材料，物质等的相关长度并利用这种相关长度来测试，分类或以其他方式表征结构的方法和装置。使用标准超声波扫描技术扫描结构，并对来自这种扫描的输出进行处理，以确定一维（长度），二维（面积），三维（体积）的相关长度。时间的第四维度也可以与相关长度确定中的其他三个维度中的一个或多个一起使用。

28. 发明授权

US5284148A Intracavity ultrasound diagnostic probe using fiber acoustic waveguides 失效
标题翻译：使用纤维声波导管的腔内超声诊断探头
公开(公告)号：US5284148A
公开(公告)日：1994-02-08
申请号：US918298
申请日：1992-07-22
申请人： J. Fleming Dias , Hewlett E. Melton, Jr.
发明人： J. Fleming Dias , Hewlett E. Melton, Jr.
IPC分类号： A61B5/00 , A61B8/06 , A61B8/08 , A61B8/12 , A61B17/22 , A61B19/00 , G02B6/26 , G10K11/24 , H03H9/145
CPC分类号： A61B8/12 , A61B5/1459 , A61B8/06 , A61B8/0833 , A61B8/4461 , A61B8/483 , G02B6/26 , G10K11/24 , A61B2017/22017 , A61B2034/2063 , A61B2090/3925 , A61B8/445 , A61B8/4488
摘要： An intracavity ultrasound diagnostic probe has a fiber acoustic waveguide that guides acoustic signals generated by a piezoelectric transducer located outside the body, through a body cavity and to an imaging site within the body where they reflect back into the ultrasound diagnostic probe that guides them back to the piezoelectric transducer located at the proximal end of the waveguide. The intracavity ultrasound diagnostic probe has one or more acoustic waveguides that could be optical fibers. The numerous advantages of placing the piezoelectric transducer outside the body include: electric power does not enter the body; a reusable piezoelectric transducer; the ability to use several acoustic signals at once including a mixture of doppler and imaging acoustic signals; the ability to adjust the frequency of each acoustic signal independently of the other acoustic signals to obtain the most desirable focus and resolution for a particular imaging site; and lower cost of complying with sterility regulations since they require discarding only the inexpensive fiber acoustic waveguide and the inexpensive catheter-radome.
摘要翻译：腔内超声诊断探针具有纤维声波导，其引导由位于身体外部的压电换能器产生的声信号，通过体腔和身体内的成像部位反射回超声诊断探针，引导他们回到位于波导近端的压电换能器。腔内超声诊断探针具有一个或多个可以是光纤的声波导。将压电传感器放置在身体外部的众多优点包括：电力不进入身体; 可重复使用的压电换能器; 能够一次使用多个声信号，包括多普勒和成像声信号的混合; 独立于其他声学信号调整每个声学信号的频率的能力，以获得特定成像部位最理想的焦点和分辨率; 并且降低了符合不育规定的成本，因为它们仅需要丢弃便宜的纤维声波导和廉价的导管天线罩。

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