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21. 发明授权

US5773286A Inner supported biocompatible cell capsules 失效
标题翻译：内支持的生物相容性细胞胶囊
公开(公告)号：US5773286A
公开(公告)日：1998-06-30
申请号：US449568
申请日：1995-05-24
申请人： Keith E. Dionne , Orion D. Hegre , Thomas R. Flanagan , Tyrone F. Hazlett , Edward J. Doherty
发明人： Keith E. Dionne , Orion D. Hegre , Thomas R. Flanagan , Tyrone F. Hazlett , Edward J. Doherty
IPC分类号： A61F2/02 , A61K9/00 , A61K35/12 , B01J13/02 , C12N5/00 , C12N5/071 , C12N11/00 , C12N11/04
CPC分类号： A61K9/0024 , A61F2/022 , B01J13/02 , C12N5/0012 , C12N5/0614 , A61K2035/128 , C12N2533/30
摘要： A biocompatible capsule for containing cells for implantation is prepared containing an inner support that provides tensile strength to the capsule. Cells within the capsule are suspended in a liquid medium or immobilized in a hydrogel or extracellular matrix material, and are surrounded by a semipermeable membrane across which biologically active molecules can be delivered from the capsule to surroundings or from the surroundings into the capsule. The inner support may be formed as an integral part of the capsule during a coextrusion process to form the capsule. Alternatively, the inner support may be a discrete component within a tube having top and bottom sealing fittings that are linked withing the tube by the support. The inner support may have external features such as flutes or a roughened or irregularly-shaped surface, and may be coated with cell-adhesive substance or a cell-viability-enhancing substance. The inner support may be a hollow tube having two channels, one communicating with a filling port that permits injecting cells through the support into the capsule and the other communicating with another port that allows gas to escape through the support as cells are introduced. The capsule may be made immunoisolatory by controlling membrane permselectivity or by substances in the membrane that reduce immune response, and may contain a tether for retrieval that can be formed integrally with the inner support.
摘要翻译：制备用于包含用于植入的细胞的生物相容性胶囊，其包含向胶囊提供拉伸强度的内部支撑物。胶囊内的细胞悬浮在液体培养基中或固定在水凝胶或细胞外基质材料中，并且被半透膜围绕，生物活性分子可以从该膜渗透到周围或周围环境或胶囊中。在共挤出过程中，内部支撑可以形成为胶囊的整体部分以形成胶囊。或者，内部支撑件可以是具有顶部和底部密封配件的管内的分立部件，其通过支撑件与管连接。内部支撑件可以具有外部特征，例如凹槽或粗糙或不规则形状的表面，并且可以涂覆有细胞粘附物质或细胞活力增强物质。内部支撑件可以是具有两个通道的中空管，一个与填充口连通，其允许将细胞通过支撑件注入到胶囊中，另一个与另一个端口连通，允许气体在引入电池时通过支撑件逸出。可以通过控制膜选择性或通过减少免疫应答的膜中的物质使胶囊免疫免疫，并且可以包含可与内支架一体形成的用于提取的系绳。

22. 发明授权

US5713887A Method and apparatus for sealing implantable, membrane encapsulation devices 失效
公开(公告)号：US5713887A
公开(公告)日：1998-02-03
申请号：US488560
申请日：1995-06-06
申请人： John F. Mills , Edward J. Doherty , Tyrone F. Hazlett , Keith E. Dionne , Nicholas F. Warner , Brian M. Cain , David H. Rein
发明人： John F. Mills , Edward J. Doherty , Tyrone F. Hazlett , Keith E. Dionne , Nicholas F. Warner , Brian M. Cain , David H. Rein
IPC分类号： A61M31/00 , A61K9/00 , A61K9/22 , A61F2/00
CPC分类号： A61K9/0024
摘要： A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner surface (33) defining an access port (34). A permselective, porous, membrane (21), having an interior surface (22), cooperates with the fitting inner surface (33) to form a storage cavity (23) therebetween. The membrane interior surface (22) is in substantially cell-tight dry sealing engagement with fitting (32) to seal cavity (23). Living cells (24) are disposed in the cavity (23) which are capable of secreting the biologically active product to an individual. The membrane (21) is of a material capable of permitting the passage of substances between the individual and cells required to provide the biological product or function. A plug member (35) is positioned in the access port (34) and seated in cell-tight sealing engagement with the fitting inner surface (33). A method for sealing the implantable encapsulation device (20) is also provided.

23. 发明授权

US5298206A Method and apparatus for casting hollow fiber membranes 失效
标题翻译：铸造中空纤维膜的方法和装置
公开(公告)号：US5298206A
公开(公告)日：1994-03-29
申请号：US984829
申请日：1992-12-03
申请人： Robert D. Milliken , David R. Barnes , Amy L. Foley , Karen E. Dunleavy , Edward J. Doherty
发明人： Robert D. Milliken , David R. Barnes , Amy L. Foley , Karen E. Dunleavy , Edward J. Doherty
IPC分类号： B01D69/08 , B29C47/00 , B29C47/20 , B29C47/88 , B29C47/92 , D01D5/24
CPC分类号： D01D5/24 , B01D69/08 , B29C47/0014 , B29C47/0035 , B29C47/92 , B29C2947/92571 , B29C2947/9258 , B29C2947/9259 , B29C2947/92666 , B29C2947/92904 , B29C2947/92952 , B29C47/0026 , B29K2105/258 , B29L2031/753 , B29L2031/755 , B29L2031/756
摘要： An automated system for casting hollow fiber membranes into a variety of prescribed shapes, including spiral, linear, circular and rectangular. The system also has the capability to change the configuration during casting, which increases productivity. A co-extrusion die is rotated over a stationary coagulation bath A computer is used to control the motion of the die to make a membrane with the desired shape The nozzle is oriented in a manner that will compensate for distortions that occur in wall thickness in the area of a bend. In addition, the nozzle's annulus is offset to make the leading portion of the annulus slightly thicker and the trailing portion thinner at the point where the fluids exit the nozzle, which results in a uniformly symmetric wall thickness. A system embodying the invention includes X, Y and .theta.-directional servomotors 1A-1C (FIG. 1), each of which is coupled to an associated position encoder 2A-2C. The motors are controlled by a computer 3 via servodrivers 4 and an associated interface card. Also included in the system are a tub 5 for holding a coagulation bath, bearings 6, carriage 7, screw drive 8, rotary table 9 and co-extrusion die 10.
摘要翻译：一种用于将中空纤维膜铸造成各种规格形状的自动化系统，包括螺旋，线性，圆形和矩形。该系统还具有在铸造过程中改变配置的能力，从而提高了生产效率。共挤出模头在固定的凝固浴上旋转使用计算机来控制模具的运动以制造具有所需形状的膜。喷嘴被定向成能够补偿在壁厚中发生的变形弯曲区域。此外，喷嘴的环带被偏移以使得环形物的前导部分稍微更厚，并且尾部部分在流体离开喷嘴的点处更薄，这导致均匀对称的壁厚度。体现本发明的系统包括X，Y和（θ）方向伺服电动机1A-1C（图1），每个伺服电动机联接到相关联的位置编码器2A-2C。电动机由计算机3通过伺服驱动器4和相关的接口卡来控制。系统中还包括用于保持凝固浴的滚筒5，轴承6，滑架7，螺杆驱动器8，旋转台9和共挤出模头10。

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