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21. 发明申请

US20130015342A1 Fixed Connection Assembly For an RF Drive Circuit in a Mass Spectrometer 有权
标题翻译：用于质谱仪中RF驱动电路的固定连接组件
公开(公告)号：US20130015342A1
公开(公告)日：2013-01-17
申请号：US13184225
申请日：2011-07-15
申请人： Urs Steiner , Lawrence B. Jones
发明人： Urs Steiner , Lawrence B. Jones
IPC分类号： H01J49/26 , H01J49/00
CPC分类号： H01J49/4255 , H01J49/02 , H01J49/022 , H01J49/22 , H01J49/36 , H01J49/42 , H01J49/4215 , Y10T307/391 , Y10T307/461
摘要： In one embodiment, a mass spectrometer includes an RF drive circuit for generating RF signals, a quadrupole mass filter, and a fixed connection assembly for delivering RF signals from the RF drive circuit to the quadrupole mass filter, the fixed connection assembly representing the entire delivery path of RF signals from the RF drive circuit to the quadrupole mass filter. By avoiding flexible components such as a freestanding wires or flexible circuit boards, the need for retuning when parts are removed or disturbed for testing or servicing is reduced, and a modular instrument in which components and connections are standardized and therefore interchangeable is realized.
摘要翻译：在一个实施例中，质谱仪包括用于产生RF信号的RF驱动电路，四极质量过滤器和用于将RF信号从RF驱动电路传送到四极质量过滤器的固定连接组件，固定连接组件代表整个输送从RF驱动电路到四极质量过滤器的RF信号的路径。通过避免诸如独立电线或柔性电路板的柔性部件，减少零件被拆除或干扰以进行测试或维修时的重新调整的需要，以及实现标准化和可互换的组件和连接的模块化仪器。

22. 发明授权

US07745781B2 Real-time control of ion detection with extended dynamic range 有权
标题翻译：离子检测的实时控制具有扩展的动态范围
公开(公告)号：US07745781B2
公开(公告)日：2010-06-29
申请号：US12130182
申请日：2008-05-30
申请人： Urs Steiner
发明人： Urs Steiner
IPC分类号： H01J49/26
CPC分类号： H01J49/025
摘要： In a method controlling an ion detector, one or more ion input signals are received at the ion detector. A data point indicative of an intensity of at least one of the received ion input signals is acquired. Asynchronously with acquiring the data point, a drive voltage applied to the ion detector is regulated to operate the ion detector at a gain optimal for the intensity of at least one of the received ion input signals. An ion detector for implementing the method is also provided.
摘要翻译：在控制离子检测器的方法中，在离子检测器处接收一个或多个离子输入信号。获取指示所接收的离子输入信号中的至少一个的强度的数据点。与获取数据点异步地，调节施加到离子检测器的驱动电压以使离子检测器以对于所接收的离子输入信号中的至少一个的强度最佳的增益进行操作。还提供了一种用于实现该方法的离子检测器。

23. 发明授权

US06599410B1 Device for rehydration and electrophoresis of gel strips and method of using the same 有权
标题翻译：凝胶条的再水化和电泳装置及其使用方法
公开(公告)号：US06599410B1
公开(公告)日：2003-07-29
申请号：US09819061
申请日：2000-09-01
申请人： Urs Steiner , Mohammed Rezaul Islam , Eric R. Hungerman
发明人： Urs Steiner , Mohammed Rezaul Islam , Eric R. Hungerman
IPC分类号： G01N27447
CPC分类号： G01N27/44795 , G01N27/44704 , G01N27/44713
摘要： The present invention involves a gel strip carrier module for a gel strip that reduces the handling of the gel strip and the hands-on-time during preparation of the gel strip for isoelectric focusing. The gel carrier module includes a gel strip chamber that serves as both a rehydration and focusing chamber, and allows the sample to be applied either throughout the entire gel or in a defined zone. The gel carrier module includes a pair of electrodes near opposite ends of the chamber that the gel strip rests on, gel side facing down. The gel carrier module includes a cover with hold-down blocks or pressure blocks to assure reliable, light contact between the gel and the electrodes during focusing. A rehydration buffer is added into the chamber, and the gel strip is gently placed in the chamber, gel side down, for rehydration. The rehydration buffer may include the sample, or, in the event that the sample needs to be applied after rehydration, the gel carrier module includes sample application wells between the electrodes that the sample can be added to after rehydration of the gel strip.
摘要翻译：本发明涉及一种用于凝胶条的凝胶带载体模块，其减少了在制备用于等电聚焦的凝胶条时凝胶条的处理和手动接触时间。凝胶载体模块包括用作再水化和聚焦室两者的凝胶条带，并允许将样品施用于整个凝胶或限定区域。凝胶载体模块包括一对电极，其位于腔室的相对端附近，凝胶条位于其上，凝胶面朝下。凝胶载体模块包括具有压紧块或压块的盖，以确保在聚焦期间凝胶和电极之间可靠的轻微接触。将补液缓冲液加入到室中，并将凝胶条轻轻地放置在腔室中，凝胶侧向下放置，用于补液。再补充缓冲液可以包括样品，或者在再水合后需要应用样品的情况下，凝胶载体模块包括在电极之间的样品施加孔，在凝胶条的再水合之后可以加入样品。

24. 发明授权

US5843295A Gel electrophoresis well-forming and loading-guide comb 失效
标题翻译：凝胶电泳形成和加载导向梳
公开(公告)号：US5843295A
公开(公告)日：1998-12-01
申请号：US992928
申请日：1997-12-18
申请人： Urs Steiner , Tim O. Lau , Terry A. Landers
发明人： Urs Steiner , Tim O. Lau , Terry A. Landers
IPC分类号： G01N27/447 , G01N27/26 , C12M3/00
CPC分类号： G01N27/44743
摘要： A well-forming and loading-guide comb for electrophoresis gels. The comb includes a comb body, to which well-forming teeth and a loading guide are attached in an opposing fashion. The comb can be used with the teeth pointing downward into the gel to form sample wells in either vertical or horizontal electrophoresis gels. Upon hardening of the gel, the comb is once removed from the gels, leaving sample wells therein. The comb is then rotated 180 degrees, and notches (in the case of vertical electrophoresis gels) or L-shaped extensions (in the case of horizontal electrophoresis gels) of the loading guide are aligned with the sample wells so as to provide for easy guided access of a sample delivering instrument during the loading of samples into the wells.
摘要翻译：电泳凝胶的成型和加载导向梳。梳子包括梳体，成形齿和装载导向器以相对的方式附接到该梳体上。梳子可以与牙齿向下指向凝胶一起使用，以在垂直或水平电泳凝胶中形成样品孔。凝胶固化后，将梳子从凝胶中取出，留下样品孔。然后将梳子旋转180度，加载引导件的凹槽（在垂直电泳凝胶的情况下）或L形延伸部（在水平电泳凝胶的情况下）与样品阱对准，以提供容易的导向在将样品装载到井中时，样品传送仪器的通路。

25. 发明授权

US5389785A ION filter apparatus and method of production thereof 失效
标题翻译： ION过滤装置及其制造方法
公开(公告)号：US5389785A
公开(公告)日：1995-02-14
申请号：US54523
申请日：1993-04-28
申请人： Urs Steiner , Nigel P. Gore , Helmut Rother
发明人： Urs Steiner , Nigel P. Gore , Helmut Rother
IPC分类号： G01N27/62 , H01J9/14 , H01J49/42 , B01D59/44 , H01J49/00
CPC分类号： H01J49/4215 , H01J49/068 , H01J49/4255
摘要： The invention relates to an ion filter and a method for the production of the ion filter. The ion filter comprises a plurality of elongated solid, rod assemblies. Typically, four rod assemblies, corresponding to four rod electrodes, are utilized. Each rod assembly has a curved rod surface, and at least two abutment surfaces. In one embodiment, the rod is hyperbolic in curvature. These surfaces are formed with one profiled grinding tool simultaneously in such a manner and angle of contact from a processing direction such that no undercuts are formed from this processing direction. The abutment surfaces are shaped such that one abutment surface of one rod assembly can be aligned with another abutment surface of another rod assembly when the rod surfaces are directed toward a longitudinal axis located in the interior of the ion filter. The rod assemblies are electrically insulated from each other with an insulating piece adhesively bonded to each rod assembly.
摘要翻译：本发明涉及离子过滤器和用于生产离子过滤器的方法。离子过滤器包括多个细长的固体棒组件。通常，使用对应于四个杆电极的四个杆组件。每个杆组件具有弯曲的杆表面和至少两个邻接表面。在一个实施例中，杆是弯曲的双曲线。这些表面由一个成型研磨工具同时以这样的方式和从加工方向接触的角度形成，使得从该加工方向不会形成底切。邻接表面被成形为使得当杆表面指向位于离子过滤器内部的纵向轴线时，一个杆组件的一个邻接表面可以与另一个杆组件的另一个邻接表面对准。杆组件彼此电绝缘，绝缘片粘合到每个杆组件上。

26. 发明授权

US4682508A Inlet valve for probe apparatus 失效
标题翻译：探针装置入口阀
公开(公告)号：US4682508A
公开(公告)日：1987-07-28
申请号：US840513
申请日：1986-03-06
申请人： Urs Steiner , James Hurst , J. Alan Schier
发明人： Urs Steiner , James Hurst , J. Alan Schier
IPC分类号： B01L1/02 , G01N1/00 , F16K31/06
CPC分类号： B01L1/02 , B82Y15/00 , Y10T137/612 , Y10T137/613
摘要： A valve assembly for allowing entry of a sampling device or probe device from an ambient atmosphere to a vacuum chamber comprises an electromagnet means which controls a ball made of magnetic material. Upon entry of the device into an entry inlet of the apparatus, the ball is seated in response to activation of the electromagnet means so as to seal an aperture leading to the vacuum chamber. As the device is moved towards the vacuum chamber, the magnetic force is removed, which allows the ball to drop away from the aperture allowing entry of the device into the vacuum chamber. Upon withdrawal of the device from the vacuum chamber, the ball is actuated by the electromagnet to seal the aperture, thereby maintaining the integrity of the vacuum system.
摘要翻译：用于允许取样装置或探针装置从环境气氛进入真空室的阀组件包括控制由磁性材料制成的球的电磁装置。当设备进入设备的进入入口时，响应于电磁体装置的激活而使球就位，以便密封通向真空室的孔。当装置朝向真空室移动时，磁力被去除，这允许球离开孔径而允许装置进入真空室。在将设备从真空室中取出时，球由电磁体驱动以密封孔，从而保持真空系统的完整性。

27. 发明授权

US09384954B2 Time of flight tubes and methods of using them 有权
标题翻译：飞行时间管和使用它们的方法
公开(公告)号：US09384954B2
公开(公告)日：2016-07-05
申请号：US14291417
申请日：2014-05-30
申请人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
发明人： Anthony Chiappetta , Urs Steiner , Keith Ferrara
IPC分类号： H01J49/40 , H01J49/02 , H01J49/24
CPC分类号： H01J49/405 , H01J49/02 , H01J49/24 , H01J49/40
摘要： Certain embodiments described herein are directed to time of flight tubes comprising a cylindrical tube comprising an inner surface and an outer surface, the cylindrical tube comprising an effective thickness and sized and arranged to couple to and support a reflectron assembly inside the cylindrical tube. In some configurations, the cylindrical tube further comprises a conductive material disposed on the inner surface of the cylindrical tube, the conductive material present in an effective amount to provide a field free region for ions when the conductive material is charged.
摘要翻译：本文描述的某些实施例涉及包括包括内表面和外表面的圆柱形管的飞行管的时间，圆柱形管包括有效厚度，并且其尺寸和布置成联接到圆柱形管内部并支撑反射器组件。在一些构造中，圆柱形管还包括设置在圆柱形管的内表面上的导电材料，导电材料以有效的量存在，以便在导电材料充电时为离子提供无场区域。

28. 发明授权

US09355831B2 Ion guide or filters with selected gas conductance 有权
标题翻译：离子导向器或具有选定气体导电性的过滤器
公开(公告)号：US09355831B2
公开(公告)日：2016-05-31
申请号：US14293073
申请日：2014-06-02
申请人： Urs Steiner
发明人： Urs Steiner
IPC分类号： H01J49/06 , H01J49/42
CPC分类号： H01J49/063 , H01J49/24 , H01J49/421 , H01J49/4255
摘要： Certain embodiments described herein are directed to rod assemblies such as, for example, quadrupole, hexapole and octupole rod assemblies. In some instances, the rod assemblies include at least one pole comprising an integral fluid path configured to fluidically couple an ion volume formed by the assembly to an outer volume of the assembly to remove fluid within the ion volume to the outer volume while containing ions of a selected mass-to-charge range.
摘要翻译：本文描述的某些实施例涉及杆组件，例如四极杆，六极棒和八极棒组件。在一些情况下，杆组件包括至少一个极，所述至少一个极包括一体式流体路径，其被构造成将由组件形成的离子体流动地耦合到组件的外部体积，以将离子体内的流体除去到外部体积，一个选定的质量到电荷范围。

29. 发明申请

US20150021492A1 ION GUIDE OR FILTERS WITH SELECTED GAS CONDUCTANCE 审中-公开
标题翻译：离子导轨或过滤器与选择的气体导管
公开(公告)号：US20150021492A1
公开(公告)日：2015-01-22
申请号：US14293073
申请日：2014-06-02
申请人： Urs Steiner
发明人： Urs Steiner
IPC分类号： H01J49/06
CPC分类号： H01J49/063 , H01J49/24 , H01J49/421 , H01J49/4255
摘要： Certain embodiments described herein are directed to rod assemblies such as, for example, quadrupole, hexapole and octupole rod assemblies. In some instances, the rod assemblies include at least one pole comprising an integral fluid path configured to fluidically couple an ion volume formed by the assembly to an outer volume of the assembly to remove fluid within the ion volume to the outer volume while containing ions of a selected mass-to-charge range.
摘要翻译：本文描述的某些实施例涉及杆组件，例如四极杆，六极棒和八极棒组件。在一些情况下，杆组件包括至少一个极，所述至少一个极包括一体式流体路径，其被构造成将由组件形成的离子体流动耦合到组件的外部体积，以将离子体内的流体除去到外部体积，一个选定的质量到电荷范围。

30. 发明申请

US20140151549A1 ION DETECTORS AND METHODS OF USING THEM 审中-公开
标题翻译：离子检测器及其使用方法
公开(公告)号：US20140151549A1
公开(公告)日：2014-06-05
申请号：US14082512
申请日：2013-11-18
申请人： Urs Steiner , Daniel Robert Marshak
发明人： Urs Steiner , Daniel Robert Marshak
IPC分类号： H01J49/02
CPC分类号： G01N27/62 , G01T1/208 , H01J43/18 , H01J43/30 , H01J49/025 , H01J49/04
摘要： Certain embodiments described herein are directed to ion detectors and systems. In some examples, the ion detector can include a plurality of dynodes, in which one or more of the dynodes are coupled to an electrometer. In other configurations, each dynode can be coupled to a respective electrometer. Methods using the ion detectors are also described.
摘要翻译：本文描述的某些实施例涉及离子检测器和系统。在一些示例中，离子检测器可以包括多个倍增电极，其中一个或多个倍增电极耦合到静电计。在其他配置中，每个倍增极可以耦合到相应的静电计。还描述了使用离子检测器的方法。

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