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21. 发明授权

US06417328B1 Trail receptors, nucleic acids encoding the same, and methods of use thereof 失效
公开(公告)号：US06417328B1
公开(公告)日：2002-07-09
申请号：US09134618
申请日：1998-08-14
申请人： Emad S. Alnemri
发明人： Emad S. Alnemri
IPC分类号： C07K14715
摘要： In accordance with the present invention, there are provided isolated mammalian TRAIL receptor proteins, antibodies thereto, therapeutic compositions, and nucleic acids encoding such. Bioassays and therapeutic methods employing invention DR5 and TRAIL-R3 proteins are also provided.

22. 发明授权

US06379950B1 Recombinant, active caspases and uses thereof 有权
标题翻译：重组，活性半胱天冬酶及其用途
公开(公告)号：US06379950B1
公开(公告)日：2002-04-30
申请号：US09227721
申请日：1999-01-08
申请人： Emad S. Alnemri
发明人： Emad S. Alnemri
IPC分类号： C12P2106
CPC分类号： C12N9/6475 , A61K48/00
摘要： Rev-caspases comprising a primary product in which the small subunit is N-terminal to the large subunit are provided. Rev-caspases are used for screening and identifying caspase inhibitors and enhancers. Rev-caspase genes can be delivered to cells for gene therapy.
摘要翻译：提供了包含其中小亚基与大亚基N末端的初级产物的Rev-胱天蛋白酶。 Rev-caspase用于筛选和鉴定半胱天冬酶抑制剂和增强子。可将Rev-caspase基因递送至细胞进行基因治疗。

23. 发明授权

US06274318B1 Apoptotic protease Mch6, nucleic acids encoding same and methods of us 有权
标题翻译：凋亡蛋白酶Mch6，编码相同的核酸和使用方法
公开(公告)号：US06274318B1
公开(公告)日：2001-08-14
申请号：US09311760
申请日：1999-05-13
申请人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack
发明人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack
IPC分类号： C12Q168
CPC分类号： C12N9/6475 , C07K16/40
摘要： The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch6 nucleotide sequences. The invention further provides an isolated Mch6 polypeptide and isolated large and small subunits of the Mch6 polypeptide, including functional fragments thereof.
摘要翻译：本发明提供编码Mch6的分离基因及其功能片段。还提供了编码Mch6的分离的核酸序列或其功能片段。基因或核酸序列可以是对应于Mch6核苷酸序列的编码链或非编码链的单链或双链核酸。本发明还提供了分离的Mch6多肽和分离的Mch6多肽的大和小亚基，包括其功能片段。

24. 发明授权

US06207801B1 FADD-like anti-apoptotic molecules, methods of using the same, and compositions for and methods of making the same 有权
标题翻译： FADD样抗凋亡分子，其使用方法，组合物及其制备方法
公开(公告)号：US06207801B1
公开(公告)日：2001-03-27
申请号：US09276993
申请日：1999-03-26
申请人： Emad S. Alnemri
发明人： Emad S. Alnemri
IPC分类号： C07K1447
CPC分类号： B82Y30/00 , A61K38/00 , C07K14/47 , C07K14/4747
摘要： Two FADD-like anti-apoptotic proteins that regulate Fas/TNFR1- or UV-induced apoptosis are disclosed. Nucleotide sequences encoding the proteins are disclosed as are methods of using the nucleic acid molecules and making the proteins. Pharmaceutical compositions and methods of using the same are disclosed. Reagents, kits and methods of identifying compounds that inhibit anti-apoptotic activity of the proteins and methods of identifying compounds that inhibit binding activity of the proteins are disclosed.
摘要翻译：公开了调节Fas / TNFR1或UV诱导的凋亡的两种FADD样抗凋亡蛋白。公开了编码蛋白质的核苷酸序列，作为使用核酸分子和制备蛋白质的方法。公开了药物组合物及其使用方法。公开了鉴定抑制蛋白质的抗凋亡活性的化合物的试剂，试剂盒和方法以及鉴定抑制蛋白质结合活性的化合物的方法。

25. 发明授权

US5861498A Nucleotides encoding immunophilin FKBP46 and fragments thereof 失效
标题翻译：编码免疫亲和素FKBP46的核苷酸及其片段
公开(公告)号：US5861498A
公开(公告)日：1999-01-19
申请号：US741134
申请日：1996-10-31
申请人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack
发明人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack
IPC分类号： C07K14/47 , C07H21/04
CPC分类号： C07K14/4702
摘要： A substantially pure protein, immunophilin FKBP46, is disclosed. An isolated nucleic acid molecule that comprises a nucleic acid sequence that encodes immunophillin FKBP46, is disclosed. An isolated nucleic acid molecule consisting of a nucleic acid sequence that encodes immunophillin FKBP46, or a fragment thereof having at least 10 nucleotides is disclosed. Recombinant expression vector comprising a nucleic acid sequence that encodes immunophillin FKBP46 and host cells comprising the recombinant expression vector are disclosed. Oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleic acid sequence that encodes immunophillin FKBP46 of at least 5 nucleotides are disclosed. Antibodies that binds to an epitope on FKBP46 are disclosed. Methods of identifying immunosuppressive drugs comprising the steps of contacting FKBP46 or a homologous protein derived from yeast with a test compound and determining whether the protein binds to the test compound are disclosed.
摘要翻译：公开了一种基本上纯的蛋白质，即免疫亲和素FKBP46。公开了包含编码免疫抑制素FKBP46的核酸序列的分离的核酸分子。公开了由编码免疫抑制素FKBP46的核酸序列或其至少10个核苷酸的片段组成的分离的核酸分子。公开了包含编码免疫球蛋白FKBP46的核酸序列和包含重组表达载体的宿主细胞的重组表达载体。公开了包含与编码至少5个核苷酸的免疫抑制素FKBP46的核酸序列互补的核苷酸序列的寡核苷酸分子。公开了与FKBP46上的表位结合的抗体。鉴定免疫抑制药物的方法包括以下步骤：将FKBP46或衍生自酵母的同源蛋白质与测试化合物接触并确定蛋白质是否与测试化合物结合。

26. 发明授权

US06716960B2 Mch3, a novel apoptotic protease, nucleic acids encoding and methods of use 有权
公开(公告)号：US06716960B2
公开(公告)日：2004-04-06
申请号：US10337060
申请日：2003-01-02
申请人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack , Robert Armstrong , Kevin Tomaselli
发明人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack , Robert Armstrong , Kevin Tomaselli
IPC分类号： C07K1640
CPC分类号： C12N9/6475 , C07K2319/00
摘要： The invention provides an isolated gene encoding Mch3, or functional fragment thereof. Also provided is an isolated nucleic acid sequence encoding Mch3 or functional fragment thereof. The gene or nucleic acid sequence can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch3 nucleotide sequence. An isolated Mch3 polypeptide or functional fragment thereof is also provided.

27. 发明授权

US06576751B1 FADD-like anti-apoptotic molecules, methods of using the same, and compositions for and methods of making the same 有权
标题翻译： FADD样抗凋亡分子，其使用方法，组合物及其制备方法
公开(公告)号：US06576751B1
公开(公告)日：2003-06-10
申请号：US09723450
申请日：2000-11-28
申请人： Emad S. Alnemri
发明人： Emad S. Alnemri
IPC分类号： A01H300
CPC分类号： B82Y30/00 , A61K38/00 , C07K14/47 , C07K14/4747
摘要： Two FADD-like anti-apoptotic proteins that regulate Fas/TNFR1- or UV-induced apoptosis are disclosed. Nucleotide sequences encoding the proteins are disclosed as are methods of using the nucleic acid molecules and making the proteins. Pharmaceutical compositions and methods of using the same are disclosed. Reagents, kits and methods of identifying compounds that inhibit anti-apoptotic activity of the proteins and methods of identifying compounds that inhibit binding activity of the proteins are disclosed.
摘要翻译：公开了调节Fas / TNFR1或UV诱导的凋亡的两种FADD样抗凋亡蛋白。公开了编码蛋白质的核苷酸序列，作为使用核酸分子和制备蛋白质的方法。公开了药物组合物及其使用方法。公开了鉴定抑制蛋白质的抗凋亡活性的化合物的试剂，试剂盒和方法以及鉴定抑制蛋白质结合活性的化合物的方法。

28. 发明授权

US06566505B2 Antibodies to Mch6 polypeptides 有权
公开(公告)号：US06566505B2
公开(公告)日：2003-05-20
申请号：US10059749
申请日：2002-01-29
申请人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack
发明人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack
IPC分类号： C07K1600
CPC分类号： C12N9/6475 , C07K16/40
摘要： The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch6 nucleotide sequences. The invention further provides an isolated Mch6 polypeptide and isolated large and small subunits of the Mch6 polypeptide, including functional fragments thereof.

29. 发明授权

US06455296B2 Apoptotic protease Mch6, nucleic acids encoding same and methods of use 失效
标题翻译：凋亡蛋白酶Mch6，编码相同的核酸和使用方法
公开(公告)号：US06455296B2
公开(公告)日：2002-09-24
申请号：US08865579
申请日：1997-05-29
申请人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack
发明人： Emad S. Alnemri , Teresa Fernandes-Alnemri , Gerald Litwack
IPC分类号： C12N964
CPC分类号： C12N9/6475 , C07K16/40
摘要： The invention provides an isolated gene encoding Mch6 as well as functional fragments thereof. Also provided are isolated nucleic acid sequences encoding Mch6 or functional fragments thereof. The gene or nucleic acid sequences can be single or double stranded nucleic acids corresponding to coding or non-coding strands of the Mch6 nucleotide sequences. The invention further provides an isolated Mch6 polypeptide and isolated large and small subunits of the Mch6 polypeptide, including functional fragments thereof.
摘要翻译：本发明提供编码Mch6的分离基因及其功能片段。还提供了编码Mch6的分离的核酸序列或其功能片段。基因或核酸序列可以是对应于Mch6核苷酸序列的编码链或非编码链的单链或双链核酸。本发明还提供了分离的Mch6多肽和分离的Mch6多肽的大和小亚基，包括其功能片段。

30. 发明授权

US06359127B1 MCH2, an apoptotic cysteine protease, and compositions for making and methods of using the same 有权
标题翻译： MCH2，凋亡半胱氨酸蛋白酶，以及用于制备的组合物及其使用方法
公开(公告)号：US06359127B1
公开(公告)日：2002-03-19
申请号：US09375256
申请日：1999-08-16
申请人： Gerald Litwack , Emad S. Alnemri , Teresa Fernandez-Alnemri
发明人： Gerald Litwack , Emad S. Alnemri , Teresa Fernandez-Alnemri
IPC分类号： C07H2102
CPC分类号： C12N9/6475 , A61K38/00
摘要： A substantially pure protein that is a member of the apoptotic Ced-3/Ice cysteine protease gene family, Mch2&agr;, and an inactive isoform of it, Mch2&bgr;, are disclosed. Isolated nucleic acid molecules that encode Mch2&agr; and Mch2&bgr;, respectively, are disclosed. Pharmaceutical compositions comprising a pharmaceutically acceptable carrier in combination with the protein or the nucleic acid molecules are disclosed. Fragments of nucleic acid molecules that encode Mch2&agr; and Mch2&bgr; having at least 10 nucleotides and oligonucleotide molecule comprising a nucleotide sequence complimentary to a nucleotide sequence of at least 10 nucleotides are disclosed. Recombinant expression vectors that comprise the nucleic acid molecule that encode Mch2&agr; or Mch2&bgr;, and host cells that comprise such recombinant vectors are disclosed. Antibodies that bind to an epitope on Mch2&agr; and/or Mch2&bgr; are disclosed. Methods of identifying inhibitors, activators and substrates of Mch2&agr; are disclosed. Antisense compounds and methods of using the same are disclosed.
摘要翻译：公开了一种基本上纯的蛋白质，其是凋亡Ced-3 / Ice半胱氨酸蛋白酶基因家族Mch2alpha及其非活性同种型Mch2beta的成员。公开了分别编码Mch2alpha和Mch2beta的分离的核酸分子。公开了包含与蛋白质或核酸分子组合的药学上可接受的载体的药物组合物。公开了编码具有至少10个核苷酸的Mch2alpha和Mch2beta的核酸分子的片段和包含与至少10个核苷酸的核苷酸序列互补的核苷酸序列的寡核苷酸分子。公开了包含编码Mch2alpha或Mch2beta的核酸分子的重组表达载体和包含这种重组载体的宿主细胞。公开了结合Mch2alpha和/或Mch2beta上的表位的抗体。公开了鉴定Mch2alpha的抑制剂，活化剂和底物的方法。公开了反义化合物及其使用方法。

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