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21. 发明申请

US20110118456A1 Interfering RNA Molecules 有权
标题翻译：干扰RNA分子
公开(公告)号：US20110118456A1
公开(公告)日：2011-05-19
申请号：US12986389
申请日：2011-01-07
申请人： Klaus Giese , Jörg Kaufmann , Anke Klippel-Giese
发明人： Klaus Giese , Jörg Kaufmann , Anke Klippel-Giese
IPC分类号： C07H21/02
CPC分类号： C12N15/1137 , A61K31/713 , A61K38/00 , C12N5/10 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/3183 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/343 , C12N2310/346 , C12N2310/3521 , C12N2310/3525 , C12N2310/53 , C12N2310/531 , C12N2320/51 , C12Q1/68 , C12Y207/11001
摘要： The present invention is related to a ribonucleic acid comprising a double stranded structure whereby the double-stranded structure comprises a first strand and a second strand, whereby the first strand comprises a first stretch of contiguous nucleotides and whereby said first stretch is at least partially complementary to a target nucleic acid, and the second strand comprises a second stretch of contiguous nucleotides whereby said second stretch is at least partially identical to a target nucleic acid, and whereby the double stranded structure is blunt ended.
摘要翻译：本发明涉及包含双链结构的核糖核酸，由此双链结构包含第一链和第二链，其中第一链包含连续核苷酸的第一段，其中所述第一段至少部分互补并且第二链包含连续核苷酸的第二段，其中所述第二段与靶核酸至少部分相同，由此双链结构是平端的。

22. 发明申请

US20070178509A1 Metastatic breast and colon cancer regulated genes 失效
公开(公告)号：US20070178509A1
公开(公告)日：2007-08-02
申请号：US11657337
申请日：2007-01-24
申请人： Hong Xin , Klaus Giese
发明人： Hong Xin , Klaus Giese
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C12N9/64 , C07K16/40
CPC分类号： C12N9/6478 , A61K38/00 , C07K14/4748 , C07K2319/00 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/57415 , G01N33/57419 , G01N2500/00
摘要： Gene sequences as shown in SEQ ID NO:1-18 have been discovered and isolated, and found to be significantly associated with metastatic spread of breast and colon cancer cells to other organs. Methods are provided for determining the risk of metastasis of a breast or colon tumor, which involve determining whether a tissue sample from a tumor expresses a polypeptide encoded by a gene as shown in SEQ ID NOS:1-18, or a substantial portion thereof. One of the gene sequences encodes a novel aspartyl protease termed CSP56, which can be used to provide reagents and methods for determining which tumors are likely to metastasize and for suppressing metastases of these tumors. Clinicians can use this information to predict which tumors will metastasize to other organs and to provide relevant therapies to appropriate patients.

23. 发明授权

US4796283A Surge counter for an overvoltage arrester 失效
标题翻译：用于过电压避雷器的浪涌计数器
公开(公告)号：US4796283A
公开(公告)日：1989-01-03
申请号：US27549
申请日：1987-03-18
申请人： Kurt Brunner , Rudolf Fischer , Klaus Giese
发明人： Kurt Brunner , Rudolf Fischer , Klaus Giese
IPC分类号： H01T1/12 , G01R19/17 , G01R31/00 , G01W1/16 , H01T15/00 , H02H3/04 , G06M3/00 , H02H9/04
CPC分类号： H02H3/048 , Y10T307/858
摘要： A device for counting the overvoltage surges discharged by a gapless overvoltage arrester contains a sensing head and a counting mechanism which follows the sensing head. In the sensing head, the discharge current carried by the overvoltage arrester in a ground return line during the occurrence of an overvoltage surge is detected. The counting mechanism records an overvoltage surge as soon as the discharge current exceeds a threshold value. During this process, an effective connection between the sensing head and a counter is established for a brief time by means of a switch. This device is intended to be characterized, with a high counting accuracy, by a dead time which is independent of the components used. This is achieved by the measure that the switch is followed by a threshold detector which responds above the threshold value of the discharge current. This threshold detector acts both on the counter and on a control member, such as a monostable multivibrator, which switches the switch off after the threshold detector has responded and holds it in the switched-off position during a predetermined period which is essentially determined by the duration of the overvoltage surge.
摘要翻译：用于对由无间隙过电压避雷器放电的过电压浪涌进行计数的装置包括感测头和跟随感测头的计数机构。在感测头中，检测出现过电压浪涌期间过电压避雷器在接地回路中承受的放电电流。一旦放电电流超过阈值，计数机制记录过压浪涌。在此过程中，传感头和计数器之间的有效连接通过开关建立短暂的时间。该装置的特征在于具有高的计数精度，其死区时间与所使用的组件无关。这是通过这样的措施实现的：开关之后是响应于放电电流的阈值之上的阈值检测器。该阈值检测器在计数器和诸如单稳态多谐振荡器的控制构件上起作用，该阈值检测器在阈值检测器响应之后将其切断，并且在预定时段内将其保持在关闭位置，该预定时间段基本上由过电压浪涌的持续时间。

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