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21. 发明授权

US11999999B2 Synthesis of novel disulfide linker based nucleotides as reversible terminators for DNA sequencing by synthesis 有权
公开(公告)号：US11999999B2
公开(公告)日：2024-06-04
申请号：US17373295
申请日：2021-07-12
申请人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
发明人： Jingyue Ju , Xiaoxu Li , Xin Chen , Zengmin Li , Shiv Kumar , Shundi Shi , Cheng Guo , Jianyi Ren , Min-Kang Hsieh , Minchen Chien , Chuanjuan Tao , Ece Erturk , Sergey Kalachikov , James J. Russo
IPC分类号： C12Q1/68 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q1/6869
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/14 , C07H19/20 , C12Q1/6869 , C12Q2525/117 , C12Q2563/107
摘要： Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing of a nucleic acid.

22. 发明申请

US20180327828A1 ION SENSOR DNA AND RNA SEQUENCING BY SYNTHESIS USING NUCLEOTIDE REVERSIBLE TERMINATORS 审中-公开
公开(公告)号：US20180327828A1
公开(公告)日：2018-11-15
申请号：US15777416
申请日：2016-11-18
申请人： Jingyue Ju , Xiaoxu Li , Zengmin Li , Shiv Kumar , Xin Chen , Cheng Guo , Shundi Shi , Jianyi Ren , Chuanjuan Tao , Minchen Chien , James J. Russo , Lin Yu
发明人： Jingyue Ju , Xiaoxu Li , Zengmin Li , Shiv Kumar , Xin Chen , Cheng Guo , Shundi Shi , Jianyi Ren , Chuanjuan Tao , Minchen Chien , James J. Russo , Lin Yu
IPC分类号： C12Q1/6869
CPC分类号： C12Q1/6869 , C07H19/10 , C07H19/20 , C12Q2525/101 , C12Q2527/119 , C12Q2565/607
摘要： This disclosure is related to a method for determining the identity of a nucleotide residue of a single-stranded DNA or RNA, or sequencing DNA or RNA, in a solution using an ion-sensing field effect transistor and reversible nucleotide terminators.

23. 发明授权

US08575114B2 SGLT-2 inhibitors, methods of making them, and uses thereof 失效
标题翻译： SGLT-2抑制剂，其制备方法及其应用
公开(公告)号：US08575114B2
公开(公告)日：2013-11-05
申请号：US13052171
申请日：2011-03-21
申请人： Shuang Liu , Cheng Guo
发明人： Shuang Liu , Cheng Guo
IPC分类号： A01N43/04 , A61K31/70 , C07H5/04 , C07H5/06
CPC分类号： A61K31/706
摘要： The present invention relates to compounds which are inhibitors of sodium dependent glucose co-transporter-2 (SGLT-2). These compounds are used in the treatment of various disorders, including diabetes, impaired glucose tolerance, insulin resistance, retinopathy, nephropathy, neuropathy, cataracts, hyperglycemia, hyperinsulinemia, hyperchlolesterolemia, elevated blood level of free fatty acids or glycerol, hyperlipidemia, hypertriglyceridemia, obesity, wound healing, tissue ischemia, atherosclerosis, and hypertension. These compounds and compositions are also useful for treating and preventing kidney stones, hyperuricemia, gout, and hyponatremia. Methods of making these compounds are also described in the present invention.
摘要翻译：本发明涉及作为钠依赖性葡萄糖共转运体-2（SGLT-2）抑制剂的化合物。这些化合物用于治疗各种疾病，包括糖尿病，葡萄糖耐量降低，胰岛素抵抗，视网膜病变，肾病，神经病，白内障，高血糖症，高胰岛素血症，高胆固醇血症，游离脂肪酸或甘油血液水平升高，高脂血症，高甘油三酯血症，肥胖伤口愈合，组织缺血，动脉粥样硬化和高血压。这些化合物和组合物还可用于治疗和预防肾结石，高尿酸血症，痛风和低钠血症。制备这些化合物的方法也在本发明中描述。

24. 外观设计

USD675621S1 Interactive input system component 有权
标题翻译：交互式输入系统组件
公开(公告)号：USD675621S1
公开(公告)日：2013-02-05
申请号：US29408920
申请日：2011-12-19
申请人： Mark Andrew Fletcher , Alan Peter Boykiw , Cheng Guo , Paul Anthony Auger
设计人： Mark Andrew Fletcher , Alan Peter Boykiw , Cheng Guo , Paul Anthony Auger

25. 发明申请

US20110169736A1 INTERACTIVE INPUT SYSTEM AND TOOL TRAY THEREFOR 审中-公开
标题翻译：互动输入系统和工具托盘
公开(公告)号：US20110169736A1
公开(公告)日：2011-07-14
申请号：US12709424
申请日：2010-02-19
申请人： Stephen Patrick Bolt , Trevor Mitchell Akitt , Cheng Guo , Sean Thompson
发明人： Stephen Patrick Bolt , Trevor Mitchell Akitt , Cheng Guo , Sean Thompson
IPC分类号： G06F3/033 , H05K7/00
CPC分类号： G06F1/1639 , G06F3/039 , G06F3/0428
摘要： An interactive input system comprises an interactive surface and a tool tray supporting at least one tool to be used to interact with the interactive surface. The tool tray comprises processing structure for communicating with at least one imaging device and processing data received from the at least one imaging device for locating a pointer positioned in proximity with the interactive surface.
摘要翻译：交互式输入系统包括交互式表面和支持用于与交互表面交互的至少一个工具的工具托盘。工具托盘包括用于与至少一个成像装置进行通信并处理从至少一个成像装置接收的数据的处理结构，用于定位位于交互表面附近的指示器。

26. 发明申请

US20100216777A1 AMINOPYRAZINE ANALOGS FOR TREATING GLAUCOMA AND OTHER RHO KINASE-MEDIATED DISEASES AND CONDITIONS 审中-公开
标题翻译：用于治疗葡萄球菌和其他RHO激酶介导的疾病和病症的氨基吡嗪类似物
公开(公告)号：US20100216777A1
公开(公告)日：2010-08-26
申请号：US12774399
申请日：2010-05-05
申请人： Mark R. Hellberg , Andrew Rusinko , Alan J. Henderson , Cheng Guo , Mark Hadden , Hélène Y. Decornez
发明人： Mark R. Hellberg , Andrew Rusinko , Alan J. Henderson , Cheng Guo , Mark Hadden , Hélène Y. Decornez
IPC分类号： A61K31/551 , A61K31/55 , A61K31/497 , C07D401/14 , C07D401/04 , A61P27/06 , C07D403/14 , C07D471/04 , A61P27/02
CPC分类号： C07D471/04 , A61K31/4965 , A61K31/497 , C07D401/04 , C07D401/14 , C07D403/14
摘要： Methods for using aminopyrazine analogs to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of aminopyrazine analogs, are also disclosed.
摘要翻译：公开了使用氨基吡嗪类似物治疗rho激酶介导的疾病或rho激酶介导的病症（包括控制眼内压和治疗青光眼）的方法。还公开了可用于治疗眼睛疾病例如青光眼并且还可用于控制眼内压的眼用药物组合物，所述组合物包含有效量的氨基吡嗪类似物。

27. 发明授权

US06919150B2 Structures useful in electron beam lithography 失效
标题翻译：用于电子束光刻的结构
公开(公告)号：US06919150B2
公开(公告)日：2005-07-19
申请号：US10792011
申请日：2004-03-03
申请人： Cheng Guo , Stephen Moffatt
发明人： Cheng Guo , Stephen Moffatt
IPC分类号： G03F1/20 , G03F9/00
CPC分类号： G03F1/20 , H01J2237/31794
摘要： A method for forming a mask assembly for use in lithography, typically electron-beam lithography, first forms in a substrate one half of a plurality of opening therethrough and then fills the openings with a removable fill material. Thereafter are formed the other half of the openings which are then filled with the removable fill material. After all the openings have been formed and filled, a support membrane is formed over the substrate and covers the filled windows. A mask layer is then formed over the membrane and patterned. The fill is then removed from all of the windows.
摘要翻译：用于形成用于光刻（例如电子束光刻）的掩模组件的方法首先在衬底中形成通过其中的多个开口的一半，然后用可移除的填充材料填充开口。此后形成开口的另一半，然后填充可移除的填充材料。在所有开口已经形成和填充之后，在基板上形成支撑膜，并覆盖填充的窗户。然后在膜上形成掩模层并图案化。然后从所有窗口中删除填充。

28. 发明授权

US06689817B1 Process for preparing guaifenesin tannate 失效
标题翻译：制备愈创甘油单宁酸盐的方法
公开(公告)号：US06689817B1
公开(公告)日：2004-02-10
申请号：US10017137
申请日：2001-12-14
申请人： Cheng Guo , Vilas M. Chopdekar
发明人： Cheng Guo , Vilas M. Chopdekar
IPC分类号： A61K31075
CPC分类号： C07H13/08
摘要： The invention pertains to a process for preparing guaifenesin tannate. The process involves the steps of mixing guaifenesin with tannic acid in the presence of water, continuing to mix the reaction mixture for about 5 minutes to about 4 hours and thereafter removing at least about 80 wt.% of the water by freeze-drying the reaction mixture.
摘要翻译：本发明涉及制备庚烷酸鞣酸酯的方法。该方法包括在水存在下将愈创木酚与鞣酸混合的步骤，继续将反应混合物混合约5分钟至约4小时，然后通过冷冻干燥反应除去至少约80重量％的水混合物。

29. 发明授权

US5705103A Composition for producing chemiluminescent light of controllable duration 失效
标题翻译：用于生产持续时间可控的化学发光的组合物
公开(公告)号：US5705103A
公开(公告)日：1998-01-06
申请号：US755131
申请日：1996-11-22
申请人： Vilas M. Chopdekar , James R. Schleck , Cheng Guo , Amanda J. Hall
发明人： Vilas M. Chopdekar , James R. Schleck , Cheng Guo , Amanda J. Hall
IPC分类号： C09K11/07 , C09K3/00
CPC分类号： C09K11/07
摘要： A chemiluminescent composition comprising an oxalate component comprising polystyrene or homopoly-.alpha.-methylstyrene containing an oxalate ester; an activator component comprising a solution of a peroxide compound and a catalyst in a first solvent; and a fluorescer contained in the oxalate component, activator component, or in both the oxalate component and the activator component. The first solvent is preferably a propylene glycol dialkyl ether. The chemiluminescent composition, when activated, permits light to be produced of controllable duration.
摘要翻译：包含草酸盐组分的化学发光组合物，其包含聚苯乙烯或含有草酸酯的均聚-α-甲基苯乙烯; 活化剂组分，其包含在第一溶剂中的过氧化物化合物和催化剂的溶液; 和包含在草酸盐组分，活化剂组分中，或在草酸盐组分和活化剂组分中的荧光剂。第一溶剂优选为丙二醇二烷基醚。化学发光组合物在被激活时允许产生可控持续时间的光。

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