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21. 发明授权

US06521406B1 SpnG, a gene for spinosyn insecticide biosynthesis 有权
标题翻译： SpnG，一种用于多杀菌素杀虫剂生物合成的基因
公开(公告)号：US06521406B1
公开(公告)日：2003-02-18
申请号：US09603207
申请日：2000-06-23
申请人： Richard H. Baltz , M. Christine Broughton , Kathryn P. Crawford , Krishnamurthy Madduri , Donald J. Merlo , Patti J. Treadway , Jan R. Turner , Clive Waldron
发明人： Richard H. Baltz , M. Christine Broughton , Kathryn P. Crawford , Krishnamurthy Madduri , Donald J. Merlo , Patti J. Treadway , Jan R. Turner , Clive Waldron
IPC分类号： C12Q168
CPC分类号： C12N15/52 , C07K14/195 , C12P19/62
摘要： Spinosyn biosynthetic genes from Saccharopolyspora spinosa, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms are provided.
摘要翻译：提供了来自酿酒酵母的Spinosyn生物合成基因，用生物合成基因转化的多杀菌素生成微生物，使用生物合成基因增加多杀菌素杀虫大环内酯的产生的方法，以及使用其基因或片段改变由产梭菌产生的微生物产生的产物的方法。

22. 发明授权

US06350934B1 Nucleic acid encoding delta-9 desaturase 失效
标题翻译：编码Δ-9去饱和酶的核酸
公开(公告)号：US06350934B1
公开(公告)日：2002-02-26
申请号：US08679645
申请日：1996-07-12
申请人： Michael G. Zwick , Brent E. Edington , James A. McSwiggen , Patricia Ann Owens Merlo , Lining Guo , Thomas A. Skokut , Scott A. Young , Otto Folkerts , Donald J. Merlo
发明人： Michael G. Zwick , Brent E. Edington , James A. McSwiggen , Patricia Ann Owens Merlo , Lining Guo , Thomas A. Skokut , Scott A. Young , Otto Folkerts , Donald J. Merlo
IPC分类号： C12N504
CPC分类号： C12N15/113 , C12N9/0083 , C12N9/1051 , C12N15/8216 , C12N15/8218 , C12N15/8243 , C12N15/8245 , C12N15/8247 , C12N15/8255 , C12N2310/12 , C12N2310/121 , C12N2310/122
摘要： The present invention relates to nucleic acid molecules encoding delta 9 desaturase gene, and expression vectors, plant cells, and transgenic plants expressing delta 9 desaturase nucleic acid. The nucleic acid molecules of the present invention can be used, for example, to decrease delta 9 desaturase activity in plant cells, resulting in decreased unsaturated fatty acid production.
摘要翻译：本发明涉及编码Δ9去饱和酶基因的核酸分子和表达载体，植物细胞和表达Δ9去饱和酶核酸的转基因植物。本发明的核酸分子可以用于例如降低植物细胞中δ9去饱和酶的活性，导致不饱和脂肪酸的产生降低。

23. 发明授权

US5567600A Synthetic insecticidal crystal protein gene 失效
标题翻译：合成杀虫晶体蛋白基因
公开(公告)号：US5567600A
公开(公告)日：1996-10-22
申请号：US369835
申请日：1995-01-06
申请人： Michael J. Adang , Thomas A. Rocheleau , Donald J. Merlo , Elizabeth E. Murray
发明人： Michael J. Adang , Thomas A. Rocheleau , Donald J. Merlo , Elizabeth E. Murray
IPC分类号： C07K14/325 , C12N15/82 , C12N15/32
CPC分类号： C12N15/8216 , C07K14/325 , C12N15/8286
摘要： Synthetic Baccilus thuringiensis toxin genes designed to be expressed in plants at a level higher than naturally-occurring Bt genes are provided. These genes utilize codons preferred in highly expressed monocot or dicot proteins.
摘要翻译：提供了设计用于在高于天然存在的Bt基因的植物中表达的合成的苏木精苏木精毒素基因。这些基因使用在高度表达的单子叶植物或双子叶植物蛋白质中优选的密码子。

24. 发明授权

US5380831A Synthetic insecticidal crystal protein gene 失效
标题翻译：合成杀虫晶体蛋白基因
公开(公告)号：US5380831A
公开(公告)日：1995-01-10
申请号：US57191
申请日：1993-05-03
申请人： Michael J. Adang , Thomas A. Rocheleau , Donald J. Merlo , Elizabeth E. Murray
发明人： Michael J. Adang , Thomas A. Rocheleau , Donald J. Merlo , Elizabeth E. Murray
IPC分类号： C07K14/325 , C12N15/32 , C12N15/82
CPC分类号： C07K14/325 , C12N15/8216 , C12N15/8286
摘要： Synthetic Bacillus thuringiensis toxin genes designed to be expressed in plants at a level higher than naturally-occurring Bt genes are provided. These genes utilize codons preferred in highly expressed monocot or dicot proteins.
摘要翻译：提供了设计为在高于天然存在的Bt基因的植物中表达的合成苏云金芽孢杆菌毒素基因。这些基因使用在高度表达的单子叶植物或双子叶植物蛋白质中优选的密码子。

25. 发明授权

US08283522B2 Herbicide resistance genes 有权
标题翻译：除草剂抗性基因
公开(公告)号：US08283522B2
公开(公告)日：2012-10-09
申请号：US12091896
申请日：2006-10-27
申请人： Terry R. Wright , Justin M. Lira , Terence Anthony Walsh , Donald J. Merlo , Jayakumar P. Samuel , Gaofeng Lin
发明人： Terry R. Wright , Justin M. Lira , Terence Anthony Walsh , Donald J. Merlo , Jayakumar P. Samuel , Gaofeng Lin
IPC分类号： C12N15/82
CPC分类号： C12N15/8274 , C12N9/0071 , C12N15/8275
摘要： The subject invention provides novel plants that are not only resistant to 2,4-D, but also to pyridyloxyacetate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention “stacked” together with one or more other herbicide resistance genes. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the development of, and controlling, strains of weeds that are resistant to one or more herbicides such as glyphosate. The preferred enzyme and gene for use according to the subject invention are referred to herein as AAD-12 (AryloxyAlkanoate Dioxygenase). This highly novel discovery is the basis of significant herbicide tolerant crop trait and selectable marker opportunities.
摘要翻译：本发明提供了不仅对2,4-D有抗性的新型植物，而且还提供了对吡啶氧基乙酸酯除草剂的抗性。迄今为止，没有任何期望或建议，通过引入单一基因可以产生具有这两种有利性质的植物。本发明还包括产生本发明一种或多种与一种或多种除草剂抗性基因堆叠在一起的酶的植物。本发明能够以新的方式使用除草剂的新型组合。此外，本发明提供了防止对一种或多种除草剂如草甘膦具有抗性的杂草的发育和控制菌株的新方法。根据本发明使用的优选酶和基因在本文中称为AAD-12（丙烯酰氧基烷酸酯加氧酶）。这种高度新颖的发现是显着的除草剂耐受性作物性状和选择性标记机会的基础。

26. 发明授权

US08278505B2 Herbicide resistance genes for resistance to aryloxyalkanoate herbicides 有权
标题翻译：抗草甘膦酸除草剂抗除草剂抗性基因
公开(公告)号：US08278505B2
公开(公告)日：2012-10-02
申请号：US12599385
申请日：2008-05-09
申请人： Justin M. Lira , Erika Megan Snodderley , Andrew E. Robinson , Terry R. Wright , Donald J. Merlo
发明人： Justin M. Lira , Erika Megan Snodderley , Andrew E. Robinson , Terry R. Wright , Donald J. Merlo
IPC分类号： A01H1/00 , A01H5/00 , A01H5/10 , C12N5/14 , C07H21/04
CPC分类号： C12N15/8274 , C12N9/0004 , C12N15/8275
摘要： The subject invention provides novel plants that are not only resistant to 2,4-D, but also to a pyridyloxyacetate herbicide. The subject invention also includes plants that produce one or more enzymes of the subject invention “stacked” together with one or more other herbicide resistance genes. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the development of, and controlling, strains of weeds that are resistant to one or more herbicides such as glyphosate. The preferred enzyme and gene for use according to the subject invention are referred to herein as AAD-13 (AryloxyAlkanoate Dioxygenase). This highly novel discovery is the basis of significant herbicide tolerant crop trait and selectable marker opportunities.
摘要翻译：本发明提供了不仅对2,4-D有抗性的新型植物，而且还涉及吡啶氧基乙酸酯除草剂。本发明还包括产生与一种或多种其它除草剂抗性基因堆叠在一起的本发明一种或多种酶的植物。本发明能够以新的方式使用除草剂的新型组合。此外，本发明提供了防止对一种或多种除草剂如草甘膦具有抗性的杂草的发育和控制菌株的新方法。根据本发明使用的优选酶和基因在本文中称为AAD-13（丙烯酰氧基烷酸酯加氧酶）。这种高度新颖的发现是显着的除草剂耐受性作物性状和选择性标记机会的基础。

27. 发明申请

US20100261884A1 CLOSTRIDIUM PERFRINGENS ALPHA TOXIN PROTEINS 失效
标题翻译： UM ENS HA。。。。。。。。。。
公开(公告)号：US20100261884A1
公开(公告)日：2010-10-14
申请号：US12821815
申请日：2010-06-23
申请人： William M. Ainley , Janna Armstrong , Krishna Madduri , Donald J. Merlo , Kelley A. Smith , Mark A. Thompson , Steven R. Webb , Liu Y. Shen
发明人： William M. Ainley , Janna Armstrong , Krishna Madduri , Donald J. Merlo , Kelley A. Smith , Mark A. Thompson , Steven R. Webb , Liu Y. Shen
IPC分类号： C07K14/33
CPC分类号： A61K39/08 , A61K2039/552 , A61K2039/55577 , C07K14/33
摘要： This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic Clostridium perfringens (Cp) α-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing the Pseudomonas fluorescens system, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cp is also disclosed.
摘要翻译：本发明部分涉及针对坏死性肠炎（NE）的家禽疫苗的开发。该疫苗使用作为突变的全长无毒产气荚膜梭菌（Cp）α-毒素蛋白（Mcpa）的保护性抗原。例如，通过减少NE攻击路径中的病变严重程度来证明该疫苗的效用。本文还公开了用于大量生产该疫苗的新方法。一个例举的方法涉及在细菌表达系统中产生NE疫苗（突变的α毒素），优选利用荧光假单胞菌系统，用于商业用于控制家禽业中的NE。本发明的疫苗可以以几种不同的方式优选施用于鸡。还公开了来自Cp的鸡分离株的新型VI型α毒素。

28. 发明授权

US07745175B2 Polynucleotides encoding Clostridium perfringens alpha toxin proteins 失效
标题翻译：编码产气荚膜梭菌α毒素蛋白的多核苷酸
公开(公告)号：US07745175B2
公开(公告)日：2010-06-29
申请号：US11925300
申请日：2007-10-26
申请人： William M. Ainley , Janna Armstrong , Krishna Madduri , Donald J. Merlo , Kelley A. Smith , Mark A. Thompson , Steven R. Webb , Liu Y. Shen
发明人： William M. Ainley , Janna Armstrong , Krishna Madduri , Donald J. Merlo , Kelley A. Smith , Mark A. Thompson , Steven R. Webb , Liu Y. Shen
IPC分类号： A61K8/00 , C07H21/04
CPC分类号： A61K39/08 , A61K2039/552 , A61K2039/55577 , C07K14/33
摘要： This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic Clostridium perfringens (Cp) α-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing the Pseudomonas fluorescens system, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cp is also disclosed.
摘要翻译：本发明部分涉及针对坏死性肠炎（NE）的家禽疫苗的开发。该疫苗使用作为突变的全长无毒产气荚膜梭菌（Cp）α-毒素蛋白（Mcpa）的保护性抗原。例如，通过减少NE攻击路径中的病变严重程度来证明该疫苗的效用。本文还公开了用于大量生产该疫苗的新方法。一个例举的方法涉及在细菌表达系统中产生NE疫苗（突变的α毒素），优选利用荧光假单胞菌系统，用于商业用于控制家禽业中的NE。本发明的疫苗可以以几种不同的方式优选施用于鸡。还公开了来自Cp的鸡分离株的新型VI型α毒素。

29. 发明授权

US07569748B2 Nucleic acid encoding an insecticidal protein toxin from photorhabdus 失效
标题翻译：核酸编码来自火炬虫的杀虫蛋白毒素
公开(公告)号：US07569748B2
公开(公告)日：2009-08-04
申请号：US10262794
申请日：2002-10-02
申请人： Jerald C. Ensign , David J. Bowen , James Petell , Raymond Fatig , Sue Schoonover , Richard H. Ffrench-Constant , Thomas A. Rocheleau , Michael B. Blackburn , Timothy D. Hey , Donald J. Merlo , Gregory L Orr , Jean L. Roberts , James A. Strickland , Lining Guo , Todd A. Ciche , Kitisri Sukhapinda
发明人： Jerald C. Ensign , David J. Bowen , James Petell , Raymond Fatig , Sue Schoonover , Richard H. Ffrench-Constant , Thomas A. Rocheleau , Michael B. Blackburn , Timothy D. Hey , Donald J. Merlo , Gregory L Orr , Jean L. Roberts , James A. Strickland , Lining Guo , Todd A. Ciche , Kitisri Sukhapinda
IPC分类号： A01H5/00 , C12N15/82 , C12N15/31
CPC分类号： A01N63/02 , C07K14/195 , C07K14/24 , C12N9/52 , C12N15/8286 , Y02A40/162
摘要： Proteins from the genus Photorhabdus are toxic to insects upon exposure. Photorhabdus luminescens (formerly Xenorhabdus luminescens) have been found in mammalian clinical samples and as a bacterial symbiont of entomopathogenic nematodes of genus Heterohabditis. These protein toxins can be applied to, or genetically engineered into, insect larvae food and plants for insect control.
摘要翻译：来自火炬属的蛋白质在接触时对昆虫有毒。已经在哺乳动物临床样品中和作为异源真菌属的昆虫病原性线虫的细菌共生体中发现了Photorhabdus luminescens（以前的Xenorhabdus luminescens）。这些蛋白质毒素可以应用于昆虫幼虫食品和植物进行昆虫控制或遗传工程化。

30. 发明授权

US07015001B2 DNA encoding SPNF of the spinosyn cluster 有权
标题翻译：编码多杀菌素簇的SPNF的DNA
公开(公告)号：US07015001B2
公开(公告)日：2006-03-21
申请号：US10329148
申请日：2002-12-23
申请人： Richard H. Baltz , M. Christine Broughton , Kathryn P. Crawford , Krishnamurthy Madduri , Donald J. Merlo , Patti J. Treadway , Jan R. Turner , Clive Waldron
发明人： Richard H. Baltz , M. Christine Broughton , Kathryn P. Crawford , Krishnamurthy Madduri , Donald J. Merlo , Patti J. Treadway , Jan R. Turner , Clive Waldron
IPC分类号： C12Q1/68
CPC分类号： C12N15/52 , C07K14/195 , C12P19/62
摘要： Spinosyn biosynthetic genes from Saccharopolyspora spinosa, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms are provided.
摘要翻译：提供了来自酿酒酵母的Spinosyn生物合成基因，用生物合成基因转化的多杀菌素生成微生物，使用生物合成基因增加多杀菌素杀虫大环内酯的产生的方法，以及使用其基因或片段改变由产梭菌产生的微生物产生的产物的方法。

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