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21. 发明申请

US20050065160A1 Substituted dihydroquinazolines 有权
标题翻译：取代的二氢喹唑啉
公开(公告)号：US20050065160A1
公开(公告)日：2005-03-24
申请号：US10832109
申请日：2004-04-26
申请人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Thomas Lampe , Susanne Nikolic , Jurgen Reefschlager , Rudolf Schohe-Loop , Frank Sussmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Dieter Lang , Peter Nell
发明人： Tobias Wunberg , Judith Baumeister , Ulrich Betz , Mario Jeske , Thomas Lampe , Susanne Nikolic , Jurgen Reefschlager , Rudolf Schohe-Loop , Frank Sussmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Jorg Keldenich , Dieter Lang , Peter Nell
IPC分类号： A61P31/22 , C07D239/84 , A61K31/517 , C07D43/04
CPC分类号： C07D239/84
摘要： The invention relates to substituted dihydroquinazolines and to processes for their preparation and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular for use as antiviral agents, in particular against cytomegalo viruses.
摘要翻译：本发明涉及取代的二氢喹唑啉及其制备方法，也涉及其用于制备用于治疗和/或预防疾病，特别是用作抗病毒剂，特别是针对巨细胞病毒的药物的用途。

22. 发明授权

US06693102B2 Pyridine-substituted pyrazolopyridine derivatives 失效
标题翻译：吡啶取代的吡唑并吡啶衍生物
公开(公告)号：US06693102B2
公开(公告)日：2004-02-17
申请号：US10001569
申请日：2001-11-01
申请人： Johannes-Peter Stasch , Achim Feurer , Stefan Weigand , Elke Stahl , Dietmar Flubacher , Cristina Alonso-Alija , Frank Wunder , Dieter Lang , Klaus Dembowsky , Alexander Straub , Elisabeth Perzborn
发明人： Johannes-Peter Stasch , Achim Feurer , Stefan Weigand , Elke Stahl , Dietmar Flubacher , Cristina Alonso-Alija , Frank Wunder , Dieter Lang , Klaus Dembowsky , Alexander Straub , Elisabeth Perzborn
IPC分类号： C07D47104
CPC分类号： C07D471/04 , A61K31/505 , A61K45/06 , A61K2300/00
摘要： The present invention relates to new pyrazolopyridine derivatives of the formula (I) in which R1 represents 4-pyridinyl or 3-pyridinyl; R2 represents H, NH2 or halogen; and salts, isomers and hydrates thereof as stimulators of soluble guanylate cyclase and for use as agents for the treatment of cardiovascular disorders, hypertension, of thromboembolic disorders and ischaemia, sexual dysfunction or inflammation, and for the treatment of disorders of the central nervous system.
摘要翻译：本发明涉及式（I）的新的吡唑并吡啶衍生物，其中R 1表示4-吡啶基或3-吡啶基; R 2表示H，NH 2或卤素; 其盐，异构体和水合物作为可溶性鸟苷酸环化酶的刺激剂，并用作治疗心血管疾病，高血压，血栓栓塞障碍和局部缺血，性功能障碍或炎症以及用于治疗中枢神经系统疾病的药剂。

23. 发明授权

US06177080B1 Polypeptides encoded by Kaposi sarcoma-associated herpes virus the use thereof in diagnosis and therapy 失效
标题翻译：卡波西肉瘤相关疱疹病毒编码的多肽在诊断和治疗中的应用
公开(公告)号：US06177080B1
公开(公告)日：2001-01-23
申请号：US09112248
申请日：1998-07-08
申请人： Bernhard Fleckenstein , Jens-Christian Albrecht , Frank Neipel , Dieter Lang
发明人： Bernhard Fleckenstein , Jens-Christian Albrecht , Frank Neipel , Dieter Lang
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/085 , C12N2710/16222 , C12N2710/16422
摘要： The invention relates to polypeptides of the Kaposi sarcoma-associated herpes virus which have a part-sequence of at least 10 consecutive amino acids from the sequence Met Ser Ser Thr Gln Ile Arg Thr Glu Ile Pro Val Ala Leu Leu Ile Leu Cys Leu Cys Leu Val Ala Cys His Ala Asn Cys Pro Thr Tyr Arg Ser His Leu Gly Phe Trp Gln Glu Gly Trp Ser Gly Gln Val Tyr Gln Asp Trp Leu Gly Arg Met Asn Cys Ser Tyr Glu Asn Met Thr Ala Leu Glu Ala Val Ser Leu Asn Gly Thr Arg Leu Ala Ala Gly Ser Pro Ser Ser Glu Tyr Pro Asn Val Ser Val Ser Val Glu Asp Thr Ser Ala Ser Gly Ser Gly Glu Asp Ala Ile Asp Glu Ser Gly Ser Gly Glu Glu Glu Arg Pro Val Thr Ser His Val Thr Phe Met Thr Gln Ser Val Gln Ala Thr Thr Glu Leu Thr Asp Ala Leu Ile Ser Ala Phe Ser Gly Val Leu His Val Ser Thr Val Ile Pro Arg Asn Trp Val Asn Arg Arg Cys Val Gly Ile Lys Arg Asn Leu Thr Phe Cys Leu Ile Tyr Arg Ile Ile Phe Ile Trp Gly Thr Ile Gln Asp His Ala Asn Ser Arg Ile Thr Gly Arg Arg Lys Arg Gln Lys and to the use thereof in therapy and diagnosis.
摘要翻译：本发明涉及卡波西肉瘤相关疱疹病毒的多肽，其在序列中具有至少10个连续氨基酸的部分序列，并且在治疗和诊断中的用途。

24. 发明授权

US5936351A Ceramic discharge vessel 失效
标题翻译：陶瓷放电容器
公开(公告)号：US5936351A
公开(公告)日：1999-08-10
申请号：US949523
申请日：1997-10-14
申请人： Dieter Lang
发明人： Dieter Lang
IPC分类号： H01J61/88 , H01J61/30 , H01J61/82 , H01J17/16 , H01J1/62 , H01J63/04
CPC分类号： H01J61/30 , H01J61/82
摘要： A ceramic discharge vessel for a high-pressure discharge lamp is formed of a cylindrical central part and two hemispherical end pieces, whereby the length of the central part is smaller than or equal to the radius of the end pieces. In this way, the isothermy of the discharge vessel is improved.
摘要翻译：用于高压放电灯的陶瓷放电容器由圆柱形中心部分和两个半球形端部片形成，由此中心部分的长度小于或等于端片的半径。以这种方式，放电容器的等温线得到改善。

25. 发明授权

US5893482A Product-dispensing device of a vending machine 失效
标题翻译：自动售货机的产品分配装置
公开(公告)号：US5893482A
公开(公告)日：1999-04-13
申请号：US794305
申请日：1997-02-03
申请人： Dieter Lang
发明人： Dieter Lang
IPC分类号： G07F11/08 , B65G59/00
CPC分类号： G07F11/08
摘要： A rocker, which is pivotable for dispensing products and has a lower product support part, is arranged at the bottom of a product shaft in a product-dispensing device of a vending machine. To achieve trouble-free dispensing even in the case of bottles or cans made of a soft material, an upper product support part is formed by an attachment mounted tiltably on the rocker. A stop device, by which the rocker pivots the attachment with it, is provided between the rocker and the attachment. A free-running angle is provided between the rocker and the attachment.
摘要翻译：摇杆，其可枢转用于分配产品并具有较低的产品支撑部件，布置在自动售货机的产品分配装置中的产品轴的底部。为了即使在由软质材料制成的瓶子或罐的情况下也能实现无故障分配，通过可倾斜地安装在摇臂上的附件形成上部产品支撑部分。在摇杆和附件之间设置有一个停止装置，通过该止动装置使摇臂枢转该附件。在摇杆和附件之间提供自由行程的角度。

26. 发明授权

US5726532A High-pressure discharge lamp and process for producing it 失效
标题翻译：高压放电灯及其生产工艺
公开(公告)号：US5726532A
公开(公告)日：1998-03-10
申请号：US556912
申请日：1995-11-20
申请人： Christian Wittig , Dieter Lang
发明人： Christian Wittig , Dieter Lang
IPC分类号： H01J9/26 , H01J61/34
CPC分类号： H01J61/34 , H01J9/266
摘要： The invention relates to a high-pressure discharge lamp with an outer bulb urrounding the discharge vessel, and to a process for producing a high-pressure discharge lamp. The outer bulb (1) comprises a glass that has a low viscosity and in particular a lower softening temperature than the quartz glass of the discharge vessel (2), and is melted directly onto the ends (5a, 5b) of the discharge vessel (2), which is sealed on both ends. As the glass for the outer bulb, a quartz glass doped with viscosity-lowering additives, in particular alkaline-earth metal borates, is used, while the discharge vessel comprises undoped quartz glass. In addition, the quartz glass of the outer bulb is preferably doped with rare earth metal additives that absorb UV radiation. To avoid projection errors, the axis of symmetry of the substantially rotationally symmetrical outer bulb (1) is shifted parallel relative to the path connecting the electrode heads by an amount that, for a horizontal lamp operating position, is defined by the convection-dictated curvature of the discharge arc.
摘要翻译： PCT No.PCT / DE94 / 00600 Sec。 371日期：1995年11月20日 102（e）1995年11月20日日期PCT 1994年5月25日PCT PCT。公开号WO94 / 28576 日期1994年12月8日本发明涉及一种具有围绕放电容器的外灯泡的高压放电灯以及用于生产高压放电灯的工艺。外灯泡（1）包括与放电容器（2）的石英玻璃相比具有低粘度，特别是较低的软化温度的玻璃，并且直接熔化到放电容器的端部（5a，5b）上 2），两端密封。作为外部灯泡的玻璃，使用掺有降粘添加剂，特别是碱土金属硼酸盐的石英玻璃，而放电容器包括未掺杂的石英玻璃。此外，外部灯泡的石英玻璃优选掺杂有吸收紫外线辐射的稀土金属添加剂。为了避免投影误差，基本上旋转对称的外灯泡（1）的对称轴线相对于连接电极头的路径平行移动一定量，对于水平灯的工作位置，由对流规定的曲率的放电电弧。

27. 发明授权

US08859569B2 Substituted annellated pyrimidines and use thereof 有权
标题翻译：取代的环状嘧啶及其用途
公开(公告)号：US08859569B2
公开(公告)日：2014-10-14
申请号：US13599975
申请日：2012-08-30
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Walter Hübsch , Niels Lindner , Alexandros Vakalopoulos , Adrian Tersteegen
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Nils Griebenow , Dieter Lang , Frank Wunder , Walter Hübsch , Niels Lindner , Alexandros Vakalopoulos , Adrian Tersteegen
IPC分类号： A01N43/90 , A61K31/519 , C07D487/00 , A61K31/541 , A61K31/5383 , A61K31/5377 , C07D498/08 , C07D519/00 , C07D471/04 , A61K45/06 , C07D487/04 , C07D491/20
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/5383 , A61K31/5386 , A61K31/541 , A61K45/06 , C07D471/04 , C07D487/04 , C07D491/20 , C07D498/08 , C07D519/00
摘要： The present application relates to novel substituted annellated pyrimidines, methods for production thereof, use thereof alone or in combinations for treating and/or preventing diseases and use thereof for the production of medicinal products for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.
摘要翻译：本申请涉及新颖的取代的环状嘧啶，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防心血管疾病。

28. 发明授权

US08343981B2 Heterocyclyl-substituted dihydroquinazolines and their use as antiviral agents 有权
标题翻译：杂环取代的二氢喹唑啉及其作为抗病毒剂的用途
公开(公告)号：US08343981B2
公开(公告)日：2013-01-01
申请号：US10556198
申请日：2004-04-28
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Suessmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Joerg Keldenich , Dieter Lang
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Suessmeier , Holger Zimmermann , Rolf Grosser , Kerstin Henninger , Guy Hewlett , Joerg Keldenich , Dieter Lang
IPC分类号： A01N43/54 , A61K31/517
CPC分类号： C07D487/04
摘要： The invention relates to heterocyclyl-substituted dihydroquinazolines of formula (I), to processes for their preparation, to medicaments containing them, and to methods for the treatment and/or prophylaxis of diseases, in particular, for use as anti-viral agents, in particular, against cytomegaloviruses.
摘要翻译：本发明涉及式（I）的杂环基取代的二氢喹唑啉，其制备方法，含有它们的药物，以及用于治疗和/或预防疾病，特别是用作抗病毒剂的方法特别是针对巨细胞病毒。

29. 发明授权

US08314113B2 Substituted dihydroquinazolines II 有权
标题翻译：取代的二氢喹唑啉II
公开(公告)号：US08314113B2
公开(公告)日：2012-11-20
申请号：US10579253
申请日：2004-10-28
申请人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Suessmeier , Holger Zimmermann , Rolf Grosser , Guy Hewlett , Jorg Keldenich , Dieter Lang , Kerstin Henninger
发明人： Tobias Wunberg , Judith Baumeister , Mario Jeske , Peter Nell , Susanne Nikolic , Frank Suessmeier , Holger Zimmermann , Rolf Grosser , Guy Hewlett , Jorg Keldenich , Dieter Lang , Kerstin Henninger
IPC分类号： A01N43/54 , A61K31/517
CPC分类号： C07D401/04
摘要： The invention relates to substituted dihydroquinazolines and to a method for the production thereof, the use thereof for treating and/or preventing diseases and for producing drugs for treating and/or preventing diseases, in particular for the use of the inventive dihydroquinazolines in the form of antiviral agents, in particular against cytomegaloviruses.
摘要翻译：本发明涉及取代的二氢喹唑啉及其制备方法，其用于治疗和/或预防疾病和用于生产用于治疗和/或预防疾病的药物的用途，特别是用于本发明的二氢喹唑啉抗病毒剂，特别是针对巨细胞病毒。

30. 发明授权

US07977349B2 Substituted quinolones III 有权
标题翻译：取代喹诺酮III
公开(公告)号：US07977349B2
公开(公告)日：2011-07-12
申请号：US12188940
申请日：2008-08-08
申请人： Chantal Fuerstner , Kai Thede , Holger Zimmermann , David Brueckner , Kerstin Henninger , Dieter Lang , Rudolf Schohe-Loop
发明人： Chantal Fuerstner , Kai Thede , Holger Zimmermann , David Brueckner , Kerstin Henninger , Dieter Lang , Rudolf Schohe-Loop
IPC分类号： A61K31/4709 , A61P31/12 , C07D401/10 , C07D498/10 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D471/10
摘要： The invention relates to substituted quinolones and to methods for their preparation as well as to their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially for use as antiviral agents, particularly against cytomegaloviruses.
摘要翻译：本发明涉及取代的喹诺酮类及其制备方法，以及它们用于生产用于治疗和/或预防疾病的药物的用途，特别是用作抗病毒剂，特别是用于巨细胞病毒的药物。

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