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21. 发明授权

US08577093B2 Long distance multimodal biometric system and method 有权
标题翻译：长距离多模态生物识别系统及方法
公开(公告)号：US08577093B2
公开(公告)日：2013-11-05
申请号：US13400499
申请日：2012-02-20
申请人： Marc D. Friedman , Nicholas A. Accomando , Faisal Bashir , Pablo Casaverde , Stephen F. Daly , David J. Hitchcock , Romina Marie Johnson Jose , Tim McNerney , David Muller , Vladimir Ruzhitsky , Yasunari Tosa , David Usher
发明人： Marc D. Friedman , Nicholas A. Accomando , Faisal Bashir , Pablo Casaverde , Stephen F. Daly , David J. Hitchcock , Romina Marie Johnson Jose , Tim McNerney , David Muller , Vladimir Ruzhitsky , Yasunari Tosa , David Usher
IPC分类号： G06K9/00 , H04N7/18
CPC分类号： G06K9/00604 , G06K9/00255
摘要： A system for multimodal biometric identification has a first imaging system that detects one or more subjects in a first field of view, including a targeted subject having a first biometric characteristic and a second biometric characteristic; a second imaging system that captures a first image of the first biometric characteristic according to first photons, where the first biometric characteristic is positioned in a second field of view smaller than the first field of view, and the first image includes first data for biometric identification; a third imaging system that captures a second image of the second biometric characteristic according to second photons, where the second biometric characteristic is positioned in a third field of view which is smaller than the first and second fields of view, and the second image includes second data for biometric identification. At least one active illumination source emits the second photons.
摘要翻译：一种用于多模式生物识别的系统具有第一成像系统，其检测第一视场中的一个或多个被摄体，包括具有第一生物特征和第二生物特征的目标对象; 第二成像系统，其根据第一光子捕获第一生物特征的第一图像，其中第一生物特征位于小于第一视场的第二视野中，并且第一图像包括用于生物识别的第一数据 ; 第三成像系统，其根据第二光子捕获第二生物特征的第二图像，其中所述第二生物特征位于小于所述第一和第二视场的第三视场中，并且所述第二图像包括第二图像生物识别数据。至少一个有源照明源发射第二光子。

22. 发明授权

US08460278B2 Eye therapy system 失效
标题翻译：眼科治疗系统
公开(公告)号：US08460278B2
公开(公告)日：2013-06-11
申请号：US12572019
申请日：2009-10-01
申请人： David Muller
发明人： David Muller
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B2018/00005 , A61B2018/00755 , A61B2018/00875 , A61F9/0079 , A61F9/013
摘要： A system includes a conducting element that conducts energy from an energy source to apply therapy to an eye. The system includes a covering configured to be removably attached to the conducting element. The covering has an interface surface that is positionable at an eye. At least a portion of the interface surface includes one or more dielectric materials. Energy is deliverable to the eye through the interface surface. In one aspect, the covering provides an electrical insulator to minimize the concentration of electrical current in the area of contact with the eye. In another aspect, the covering allows the eye to be cooled during the application of energy without directly applying coolant to the eye. In another aspect, the covering includes a dielectric layer that may provide varying impedances that allow different patterns for energy delivery. In another aspect, the sheath promotes hygienic use of the conducting element.
摘要翻译：一种系统包括从能量源传导能量以将治疗应用于眼睛的导电元件。该系统包括构造成可移除地附接到导电元件的覆盖物。覆盖物具有可在眼睛处定位的界面。界面表面的至少一部分包括一种或多种介电材料。能量通过界面可传递给眼睛。在一个方面，覆盖物提供电绝缘体以最小化与眼睛接触的区域中的电流的浓度。另一方面，覆盖物允许眼睛在施加能量期间被冷却，而不直接将冷却剂施加到眼睛。在另一方面，覆盖物包括可提供允许不同图案用于能量输送的变化阻抗的介电层。另一方面，护套促进卫生使用导电元件。

23. 发明申请

US20100256705A1 EYE THERAPY SYSTEM 失效
标题翻译：眼睛治疗系统
公开(公告)号：US20100256705A1
公开(公告)日：2010-10-07
申请号：US12753523
申请日：2010-04-02
申请人： David Muller , Thomas Ryan , Ronald Scharf
发明人： David Muller , Thomas Ryan , Ronald Scharf
IPC分类号： A61N1/00 , A61F9/007
CPC分类号： A61B18/18 , A61B18/1815 , A61F9/007 , A61F9/0079 , A61F9/013 , A61F2009/00872 , A61N1/403
摘要： An electrical energy applicator in one embodiment extends from a proximal end to a distal end. The energy conducting applicator includes, at the proximal end, a connection to one or more electrical energy sources. The energy conducting applicator directs electrical energy from the one or more electrical energy sources to the distal end. The energy conducting applicator includes an outer conductor and an inner conductor extending to the distal end. The outer conductor and the inner conductor are separated by a gap. The outer conductor includes a plurality of moveable outer segments and the inner conductor includes a plurality of moveable inner segments. The plurality of outer segments and the plurality of inner segments form a total contact surface at the distal end. The total contact surface is positionable at a surface of an eye. The electrical energy is applied to the eye according to the total contact surface.
摘要翻译：一个实施例中的电能施加器从近端延伸到远端。能量传导施加器在近端处包括与一个或多个电能源的连接。能量传导施加器将电能从一个或多个电能源引导到远端。能量传导施加器包括外导体和延伸到远端的内导体。外导体和内导体间隔开。外导体包括多个可移动外部段，并且内部导体包括多个可移动的内部段。多个外部段和多个内部段在远端处形成总接触表面。总接触表面可定位在眼睛的表面。电能根据总接触面施加到眼睛。

24. 发明申请

US20090275936A1 SYSTEM AND METHOD FOR APPLYING THERAPY TO AN EYE USING ENERGY CONDUCTION 审中-公开
标题翻译：使用能量诱导将眼部应用于眼睛的系统和方法
公开(公告)号：US20090275936A1
公开(公告)日：2009-11-05
申请号：US12113672
申请日：2008-05-01
申请人： David Muller
发明人： David Muller
IPC分类号： A61F9/007 , A61B18/18
CPC分类号： A61F9/00 , A61B18/18 , A61B18/1815 , A61F9/0079 , A61F9/013
摘要： Thermokeratoplasty is applied to achieve a customized reshaping of a cornea, especially, for the treatment of astigmatism. Energy is applied to the cornea in a customized pattern using a specific configuration of two conductors. In one embodiment, an outer conductor and an outer conductor are separated by a gap. When a conducting element is applied to the corneal surface the area of the cornea at the periphery of the inner conductor is subject to an energy pattern with substantially the same shape and dimension as the gap between the inner and outer conductors. The inner and outer conductors may be positioned and shaped to form a gap having any desirable size and/or shape, including non-annular and asymmetrical shapes. The gap may be configured by altering the spatial relationships between the inner conductor and the outer conductor, by altering the size, shape, and/or position of the inner and/or outer conductors, or by forming one or more indentations or protrusions in or on the inner conductor and/or the outer conductor. Additionally or alternatively, energy is applied to the cornea in a customized pattern defined by a specific arrangement of one or more dielectric materials providing varying impedance.
摘要翻译： Thermokeratoplasty应用于实现角膜的定制重塑，特别是用于治疗散光。使用两个导体的特定配置，以定制的模式将角能量施加到角膜。在一个实施例中，外部导体和外部导体被间隙隔开。当将导电元件施加到角膜表面时，内导体周围的角膜的区域经受与内导体和外导体之间的间隙基本相同的形状和尺寸的能量图案。内导体和外导体可以定位和成形以形成具有任何期望的尺寸和/或形状的间隙，包括非环形和非对称形状。可以通过改变内导体和/或外导体的尺寸，形状和/或位置，或者通过在内导体和/或外导体中形成一个或多个凹陷或突起来改变内导体和外导体之间的空间关系来构造间隙在内部导体和/或外部导体上。附加地或替代地，以由提供变化的阻抗的一个或多个介电材料的特定布置限定的定制图案将能量施加到角膜。

25. 发明授权

US10449090B2 Corneal implant systems and methods 有权
公开(公告)号：US10449090B2
公开(公告)日：2019-10-22
申请号：US15055614
申请日：2016-02-28
申请人： David Muller
发明人： David Muller
IPC分类号： A61F9/008 , B23K26/00 , B23K26/361 , B23K26/12 , B23K26/38 , B23K26/402 , A61F2/14 , B23K103/00
摘要： A system for forming a corneal implant includes a cutting apparatus, which includes a laser source that emits a laser and optical elements that direct the laser. The system includes a controller implemented with at least one processor and at least one data storage device. The controller generates a sculpting plan for modifying a first shape of a lenticule formed from corneal tissue and achieving a second shape for the lenticule to produce a corneal implant with a refractive profile to reshape a recipient eye. The sculpting plan is determined from measurements relating to the lenticule having the first shape and information relating to a refractive profile for a corneal implant. The controller controls the cutting apparatus to direct, via the one or more optical elements, the laser from the laser source to sculpt the lenticule according to the sculpting plan to produce the corneal implant with the refractive profile.

26. 发明授权

US09044308B2 Systems and methods for reshaping an eye feature 有权
标题翻译：重塑眼睛特征的系统和方法
公开(公告)号：US09044308B2
公开(公告)日：2015-06-02
申请号：US13480127
申请日：2012-05-24
申请人： David Muller , Vance Thompson
发明人： David Muller , Vance Thompson
IPC分类号： A61B18/18 , A61F9/013 , A61F9/008
CPC分类号： A61F9/013 , A61F9/00804 , A61F9/00836 , A61F2009/00853 , A61F2009/00872
摘要： Systems and methods include a cutting instrument that creates incisions in selected areas of the cornea; an eye therapy system that applies reshaping forces to the cornea; and a controller that determines the selected areas of the cornea for the incisions and the reshaping forces from the eye therapy system, such that the reshaping forces and the incisions combine to achieve corrective reshaping of the cornea. Other systems and methods include measuring an eye to determine a required amount of reshaping of a cornea; determining one or more doses of cross-linking agent and one or more corresponding doses of photoactivating light according to the required amount of reshaping; applying the cross-linking agent to the cornea; and delivering, from a light source, the photoactivating light to the area of the eye, the photoactivating light combining with the cross-linking agent to induce the corrective reshaping of the cornea.
摘要翻译：系统和方法包括在角膜的选定区域中产生切口的切割工具; 一种将矫正力应用于角膜的眼科治疗系统; 以及控制器，其确定角膜的选择区域用于切口和来自眼部治疗系统的重塑力，使得重塑力和切口结合以实现角膜的矫正重塑。其他系统和方法包括测量眼睛以确定角膜重塑的所需量; 根据所需的重塑量确定一种或多种剂量的交联剂和一种或多种相应剂量的光活化光; 将交联剂施用于角膜; 以及从光源将光活化光输送到眼睛的区域，所述光活化光与交联剂结合以引起角膜的矫正重塑。

27. 发明授权

US08652131B2 Eye therapy system 失效
标题翻译：眼科治疗系统
公开(公告)号：US08652131B2
公开(公告)日：2014-02-18
申请号：US13470975
申请日：2012-05-14
申请人： David Muller , Ronald Scharf , Thomas Ryan , Neal Marshall , Radha Pertaub , Artie Wu
发明人： David Muller , Ronald Scharf , Thomas Ryan , Neal Marshall , Radha Pertaub , Artie Wu
IPC分类号： A61B18/18
CPC分类号： A61F9/007 , A61B18/1477 , A61B18/18 , A61B18/22 , A61B2018/00702 , A61B2018/00791 , A61B2018/1425 , A61B2018/1807 , A61F9/0079 , A61F9/009 , A61F2009/00853 , A61F2009/00872 , A61H35/02 , A61H2201/0207 , A61H2201/0214 , A61H2201/0242 , A61H2201/0292 , A61H2201/10 , A61H2201/5007 , A61H2230/50
摘要： A system for applying therapy to an eye selectively applies coolant to the corneal surface to minimize heat-related damage to the corneal surface during thermokeratoplasty. Embodiments may include an energy source, a conducting element, a coolant supply, and a coolant delivery system. The conducting element is operably connected to the energy source and extends from a proximal end to a distal end. The conducting element directs energy from the energy source to the distal end, which is positionable at the eye. The coolant delivery system is in communication with the coolant supply and is operable to deliver a micro-controlled pulse of coolant to the distal end.
摘要翻译：用于向眼睛施加治疗的系统选择性地将冷却剂施加到角膜表面，以在热机器人成形期间最小化对角膜表面的热损伤。实施例可以包括能量源，导电元件，冷却剂供应和冷却剂输送系统。导电元件可操作地连接到能量源并且从近端延伸到远端。导电元件将能量从能量源引导到可在眼睛处定位的远端。冷却剂输送系统与冷却剂供应源连通并且可操作以将冷却剂的微控制脉冲输送到远端。

28. 发明授权

US08409189B2 System and method for reshaping an eye feature 失效
标题翻译：用于重塑眼睛特征的系统和方法
公开(公告)号：US08409189B2
公开(公告)日：2013-04-02
申请号：US12018457
申请日：2008-01-23
申请人： David Muller
发明人： David Muller
IPC分类号： A61B18/14
CPC分类号： A61B18/14 , A61B18/18 , A61B18/1815 , A61B2018/00017 , A61B2018/00035 , A61B2090/065 , A61F9/0079 , A61F9/009 , A61F9/013 , A61F2009/00853 , A61F2009/00872
摘要： A system for applying therapy to an eye includes an applicator having a conducting element configured to direct energy from an energy source to an application end of the conducting element, where the application end has an eye contact portion. A positioning system receives the applicator and positions the eye contact portion in stable engagement with the surface of an eye. In some embodiments, the conducting element is disposed within a housing for the applicator and an adjustment system is employed to move the conducting element relative to the housing. The adjustment system enables controlled movement of the conducting element and the eye contact portion against the corneal surface. In particular embodiments, sufficient contact between the applicator and the cornea is determined by causing applanation of the cornea. In other embodiments, a physical measurement device, such as a strain gauge, is employed to determine when sufficient contact has been established.
摘要翻译：用于对眼睛施加治疗的系统包括具有导电元件的施加器，该导电元件被配置为将能量从能量源引导到导电元件的施加端，其中施加端具有眼睛接触部分。定位系统接收施加器并将眼睛接触部分定位成与眼睛的表面稳定接合。在一些实施例中，导电元件设置在用于施用器的壳体内，并且使用调节系统相对于壳体移动导电元件。调节系统使得导电元件和眼睛接触部分能够相对于角膜表面受控地运动。在特定实施例中，施加器和角膜之间的充分接触是通过引起角膜的扁平化来确定的。在其它实施例中，使用诸如应变计的物理测量装置来确定何时建立了足够的接触。

29. 发明授权

US08202272B2 Eye therapy system 失效
标题翻译：眼科治疗系统
公开(公告)号：US08202272B2
公开(公告)日：2012-06-19
申请号：US12208963
申请日：2008-09-11
申请人： David Muller , Ronald Scharf , Thomas Ryan , Neal Marshall , Radha Pertaub , Artie Wu
发明人： David Muller , Ronald Scharf , Thomas Ryan , Neal Marshall , Radha Pertaub , Artie Wu
IPC分类号： A61B18/18
CPC分类号： A61F9/007 , A61B18/1477 , A61B18/18 , A61B18/22 , A61B2018/00702 , A61B2018/00791 , A61B2018/1425 , A61B2018/1807 , A61F9/0079 , A61F9/009 , A61F2009/00853 , A61F2009/00872 , A61H35/02 , A61H2201/0207 , A61H2201/0214 , A61H2201/0242 , A61H2201/0292 , A61H2201/10 , A61H2201/5007 , A61H2230/50
摘要： A system for applying therapy to an eye selectively applies coolant to the corneal surface to minimize heat-related damage to the corneal surface during thermokeratoplasty. Embodiments may include an energy source, a conducting element, a coolant supply, and a coolant delivery system. The conducting element is operably connected to the energy source and extends from a proximal end to a distal end. The conducting element directs energy from the energy source to the distal end, which is positionable at the eye. The coolant delivery system is in communication with the coolant supply and is operable to deliver a micro-controlled pulse of coolant to the distal end.
摘要翻译：用于向眼睛施加治疗的系统选择性地将冷却剂施加到角膜表面，以在热机器人成形期间最小化对角膜表面的热损伤。实施例可以包括能量源，导电元件，冷却剂供应和冷却剂输送系统。导电元件可操作地连接到能量源并且从近端延伸到远端。导电元件将能量从能量源引导到可在眼睛处定位的远端。冷却剂输送系统与冷却剂供应源连通并且可操作以将冷却剂的微控制脉冲输送到远端。

30. 发明授权

US07761160B2 System and method for determining atrioventicular pacing delay based on atrial repolarization 有权
标题翻译：基于心房复极化的心房起搏延迟的系统和方法
公开(公告)号：US07761160B2
公开(公告)日：2010-07-20
申请号：US12622139
申请日：2009-11-19
申请人： David Muller , Xiaoyi Min
发明人： David Muller , Xiaoyi Min
IPC分类号： A61N1/00
CPC分类号： A61N1/368 , A61N1/3682
摘要： Techniques are provided for estimating optimal atrioventricular pacing delay values for use in pacing the ventricles based on features of an intracardiac electrogram (IEGM) signal. Briefly, atrioventricular pacing delay pacing values are set based upon the location of atrial repolarization events within the IEGM. In one example, the end of an atrial repolarization is identified, then the interval from the atrial depolarization to the end of the atrial repolarization is measured. The atrioventricular pacing delay is then set by subtracting an offset value from that interval so as to time delivery of V-pulses prior the end of atrial repolarization. In this manner, atrioventricular pacing delay values are set based only IEGM signals and hence can be set to optimal/preferred values by the device itself without requiring surface electrocardiogram (EKG) signals and Doppler echocardiography or other cardiac performance monitoring techniques.
摘要翻译：提供技术用于基于心内电描记图（IEGM）信号的特征来估计用于起搏心室的最佳房室起搏延迟值。简而言之，房室起搏延迟起搏值是根据IEGM内心房复极化事件的位置设定的。在一个实例中，确定了心房复极化的终点，然后测量从心房去极化到心房复极末期的间隔。然后通过从该间隔减去偏移值来设置房室起搏延迟，以便在心房复极化结束前的时间递送V脉冲。以这种方式，房室起搏延迟值仅基于IEGM信号设置，因此可以通过装置本身设置为最佳/优选值，而不需要表面心电图（EKG）信号和多普勒超声心动图或其他心脏性能监测技术。

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