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21. 发明申请

US20050279917A1 Cooperative optical-imaging sensor array 有权
标题翻译：协同光学成像传感器阵列
公开(公告)号：US20050279917A1
公开(公告)日：2005-12-22
申请号：US11150478
申请日：2005-06-11
申请人： Steven Barrett , Michael Wilcox , Donald Thelen , David Cox
发明人： Steven Barrett , Michael Wilcox , Donald Thelen , David Cox
IPC分类号： G06K9/58 , G06K9/60 , G06T5/00 , H01L27/00 , H01L27/146
CPC分类号： H04N5/23296 , G06K9/58 , G06K9/60 , G06T7/44 , G06T2200/28 , H01L27/14601
摘要： An apparatus and method for providing image primitives, such as edge polarity, edge magnitude, edge orientation, and edge displacement, and derivatives thereof, for an object are described. The data are obtained substantially simultaneously and processed in parallel such that multiple objects can be distinguished from one another in real time.
摘要翻译：描述了一种用于为物体提供诸如边缘极性，边缘幅度，边缘取向和边缘位移及其派生的图像原语的装置和方法。基本上同时获得数据并且并行处理，使得可以实时地将多个对象彼此区分开。

22. 发明申请

US20050273691A1 Metadata system for tracking quality processes 审中-公开
标题翻译：跟踪质量流程的元数据系统
公开(公告)号：US20050273691A1
公开(公告)日：2005-12-08
申请号：US10858893
申请日：2004-06-02
申请人： David Cox , Gerald Lee , Paul Brackett , Paul Upson , Ting Yen
发明人： David Cox , Gerald Lee , Paul Brackett , Paul Upson , Ting Yen
IPC分类号： G06F17/21 , G06F17/30
CPC分类号： G06F16/93
摘要： Systems and methods for using metadata to describe quality management documents. Each quality management document is broken into sections, with each section describing the processes and checklists for a particular step in the manufacturing process. The metadata allows a system to automatically display a correctly formatted document and to guide users in the correct completion of the document. The metadata provides for error checking and condition checking to ensure the accuracy of the document.
摘要翻译：使用元数据描述质量管理文件的系统和方法。每个质量管理文件分为几个部分，每个部分描述制造过程中特定步骤的过程和清单。元数据允许系统自动显示正确格式的文档，并指导用户正确完成文档。元数据提供错误检查和条件检查，以确保文档的准确性。

23. 发明申请

US20050239080A1 Mismatch repair detection 审中-公开
标题翻译：不匹配修复检测
公开(公告)号：US20050239080A1
公开(公告)日：2005-10-27
申请号：US10728122
申请日：2003-12-03
申请人： David Cox , Malek Faham , Siamak Baharloo
发明人： David Cox , Malek Faham , Siamak Baharloo
IPC分类号： C12N1/21 , C12N15/74 , C12Q1/68
CPC分类号： C12Q1/6827 , C12Q1/6897 , C12Q2600/156
摘要： Mismatch Repair Detection (MRD), a novel method for DNA-variation detection, utilizes bacteria to detect mismatches by a change in expression of a marker gene. DNA fragments to be screened for variation are cloned into two MRD plasmids, and bacteria are transformed with heteroduplexes of these constructs. Resulting colonies express the marker gene in the absence of a mismatch, and lack expression in the presence of a mismatch. MRD is capable of detecting a single mismatch within 10 kb of DNA. In addition, MRD can analyze many fragments simultaneously, offering a powerful method for high-throughput genotyping and mutation detection.
摘要翻译：用于DNA变异检测的新方法的不匹配修复检测（MRD）利用细菌通过标记基因的表达变化来检测错配。将待筛选的DNA片段克隆到两个MRD质粒中，并用这些构建体的异源双链体转化细菌。得到的菌落在不存在错配的情况下表达标记基因，并且在存在失配的情况下缺乏表达。 MRD能够检测DNA的10 kb内的单一错配。此外，MRD可以同时分析许多片段，为高通量基因分型和突变检测提供了强大的方法。

24. 发明授权

US06953797B2 Use of phenylheteroalkylamine derivatives 失效
标题翻译：苯基杂烷基胺衍生物的用途
公开(公告)号：US06953797B2
公开(公告)日：2005-10-11
申请号：US10204808
申请日：2001-02-20
申请人： David Cheshire , Stephen Connolly , David Cox , Ian Millichip
发明人： David Cheshire , Stephen Connolly , David Cox , Ian Millichip
IPC分类号： C07D295/12 , A61K31/137 , A61K31/145 , A61K31/275 , A61K31/277 , A61K31/365 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/5375 , A61K31/695 , A61K45/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/06 , A61P1/18 , A61P3/10 , A61P9/02 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/06 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/28 , A61P25/30 , A61P27/06 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/02 , A61P43/00 , C07C211/48 , C07C211/52 , C07C253/30 , C07C255/58 , C07C315/02 , C07C317/28 , C07C319/14 , C07C323/29 , C07C323/62 , C07D263/32 , C07D277/28 , C07D295/125 , A61K31/535 , A61K31/42 , C07C255/50 , C07D263/30 , C07D295/06
CPC分类号： C07D295/125 , A61K31/137 , A61K31/277 , A61K31/421 , A61K31/426 , A61K31/5375 , A61K31/695 , C07C211/48 , C07C255/58 , C07C317/28 , C07C323/29 , C07C323/62
摘要： There is disclosed the use of a compound of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of nitric oxide synthase activity is beneficial. Certain novel compounds of formula (Ia) and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof are disclosed; together with processes for their preparation, compositions containing them and their use in therapy. The compounds of formulae (I) and (Ia) are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment or prohylaxis of inflammatory disease
摘要翻译：公开了式（I）化合物的用途，其中R 1，R 2，X，Y，V，W和Z如说明书中所定义，及其药学上可接受的盐，对映异构体或外消旋物在制备药物中的用途，用于治疗或预防一氧化氮合成酶活性抑制是有益的疾病或病症。公开了某些新的式（Ia）化合物及其药学上可接受的盐及其对映异构体和外消旋体; 以及其制备方法，含有它们的组合物及其在治疗中的用途。式（I）和（Ia）的化合物是一氧化氮合酶的抑制剂，因此特别可用于炎性疾病的治疗或预防

25. 发明申请

US20050156600A1 Single and multi-trace omnidirectional sonde and line locators and transmitter used therewith 有权
标题翻译：单和多迹线全向探头和线定位器和发射机
公开(公告)号：US20050156600A1
公开(公告)日：2005-07-21
申请号：US11077947
申请日：2005-03-11
申请人： Mark Olsson , Jeffrey Prsha , Dawn Shaffer , Ray Merewether , Michael Martin , Bradley Barnicoat , David Cox , Thomas Kolb
发明人： Mark Olsson , Jeffrey Prsha , Dawn Shaffer , Ray Merewether , Michael Martin , Bradley Barnicoat , David Cox , Thomas Kolb
IPC分类号： G01S7/03 , G01S13/88 , G01V3/15 , G01V3/10
CPC分类号： G01S7/03 , G01S13/88 , G01S13/885 , G01V3/15 , G06F3/016 , G06F3/0346
摘要： At least one antenna array including three mutually orthogonal antennas each sharing a common center point senses an electromagnetic signal emitted by a buried object such as a utility line, pipe or sonde. A circuit at least partially mounted in a housing is connected to the array and determines a location of the buried object by measuring signal strength and field angles in three dimensions without having to align the antenna array relative to the buried object while eliminating nulls and false peaks. A graphical user interface (GUI) has user-friendly icons, symbols, menus, numbers and graphical and auditory representation of signal strength. A plurality of different underground objects can be simultaneously detected and their different locations can be simultaneously indicated to a user via audible sounds and/or visual images on a display.
摘要翻译：每个共享公共中心点的包括三个相互正交的天线的至少一个天线阵列感测由诸如公用事业线，管道或探测器的掩埋物体发射的电磁信号。至少部分地安装在壳体中的电路连接到阵列并且通过在三维中测量信号强度和场角来确定掩埋物体的位置，而不必相对于掩埋物体对准天线阵列，同时消除零峰和假峰。图形用户界面（GUI）具有用户友好的图标，符号，菜单，数字以及信号强度的图形和听觉表示。可以同时检测多个不同的地下物体，并且可以通过显示器上的可听见的声音和/或视觉图像同时向用户指示其不同的位置。

26. 发明申请

US20050100911A1 Methods for enriching populations of nucleic acid samples 审中-公开
标题翻译：富集核酸样品群体的方法
公开(公告)号：US20050100911A1
公开(公告)日：2005-05-12
申请号：US10635175
申请日：2003-08-06
申请人： Nila Patil , David Cox , Charit Pethiyagoda , Andrew Sparks , Huang-Tsu Chen
发明人： Nila Patil , David Cox , Charit Pethiyagoda , Andrew Sparks , Huang-Tsu Chen
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6806 , C12Q1/6855 , C12Q2531/113 , C12Q2565/501 , C12Q2521/313 , C12Q2525/191 , C12Q2525/313 , C12Q2533/101
摘要： The invention provides several methods for reducing the complexity of a population of nucleic acids prior to performing an analysis of the nucleic acids on a nucleic acid probe array. The methods result in a subset of the initial population enriched for a desired property, or lacking nucleic acids having an undesired properly. The resulting nucleic acids in the subset are then applied to the array for various types of analysis. The methods are particularly useful for analyzing populations having a high decree of complexity, for example, chromosomal-derived DNA, or whole genomic DNA, or mRNA population. In addition, such methods allow for analysis of pooled samples.
摘要翻译：本发明提供了在对核酸探针阵列上的核酸进行分析之前降低核酸群体的复杂性的几种方法。该方法导致富集所需性质的初始群体的子集，或缺少具有不理想的核酸。然后将该子集中得到的核酸应用于阵列进行各种类型的分析。该方法对于分析具有高复杂度的群体特别有用，例如染色体衍生的DNA或全基因组DNA或mRNA群体。此外，这种方法允许对合并的样品进行分析。

27. 发明申请

US20050097134A1 Method for evaluating a transformer design 失效
标题翻译：变压器设计评估方法
公开(公告)号：US20050097134A1
公开(公告)日：2005-05-05
申请号：US10699468
申请日：2003-10-31
申请人： Karen Smiley , Thomas Long , David Cox
发明人： Karen Smiley , Thomas Long , David Cox
IPC分类号： G06F20060101 , G06F7/00
CPC分类号： G06F17/50 , G06F2217/10 , G06F2217/78 , Y10S707/99933 , Y10S707/99936 , Y10S707/99942 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945
摘要： A preferred method for evaluating a transformer design using data representing test results from a plurality of transformers and stored in a data base includes comparing the data representing test results to predetermined criteria for the test results to determine whether the test results satisfy the predetermined criteria. The preferred method also includes counting the number of the test results that do not satisfy the predetermined criteria, and generating an indication that a predetermined quantity of the test results do not satisfy the predetermined criteria if at least the predetermined quantity of the test results do not satisfy the predetermined criteria.
摘要翻译：使用表示来自多个变压器并存储在数据库中的测试结果的数据来评估变压器设计的优选方法包括将表示测试结果的数据与测试结果的预定标准进行比较，以确定测试结果是否满足预定标准。优选方法还包括计数不满足预定标准的测试结果的数量，并且如果至少预定量的测试结果不是，则产生预定量的测试结果不满足预定标准的指示满足预定标准。

28. 发明申请

US20050069589A1 Tissue adhesive sealant 失效
标题翻译：组织胶粘剂
公开(公告)号：US20050069589A1
公开(公告)日：2005-03-31
申请号：US10894609
申请日：2004-07-20
申请人： Johan Lowinger , Bruno Lowinger , Frank DeLustro , David Cox , David Browdie
发明人： Johan Lowinger , Bruno Lowinger , Frank DeLustro , David Cox , David Browdie
IPC分类号： A01N37/18 , A61B20060101 , A61K9/14 , A61K38/00 , A61K38/17 , A61K39/00 , A61L24/10 , C07K1/00 , G01N33/567
CPC分类号： A61L24/102 , A61L24/108
摘要： A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.
摘要翻译：组织粘合剂密封剂包括在与包含醛和氨基酸的交联剂溶液组合的溶液中的可交联蛋白质，所述交联剂溶液含有与醛交联反应的物质以形成密封。密封剂非常适合单独粘合组织或与贴片组合。醛和含氨基酸的物质之间的比例在醛部分上为20:1和1:1之间：氨基酸或肽亚基摩尔数。当蛋白质和交联剂以15:1至1:1的摩尔比存在时，形成特别强的密封。

29. 发明申请

US20050040854A1 Low voltage to high voltage level shifter and related methods 失效
标题翻译：低电压至高电平电平转换器及相关方法
公开(公告)号：US20050040854A1
公开(公告)日：2005-02-24
申请号：US10920639
申请日：2004-08-18
申请人： Erik Mentze , Herbert Hess , Kevin Buck , David Cox
发明人： Erik Mentze , Herbert Hess , Kevin Buck , David Cox
IPC分类号： H03K19/0185 , H03K19/0175
CPC分类号： H03K19/018521
摘要： A shifter circuit comprises a high and low voltage buffer stages and an output buffer stage. The high voltage buffer stage comprises multiple transistors arranged in a transistor stack having a plurality of intermediate nodes connecting individual transistors along the stack. The transistor stack is connected between a voltage level being shifted to and an input voltage. An inverter of this stage comprises multiple inputs and an output. Inverter inputs are connected to a respective intermediate node of the transistor stack. The low voltage buffer stage has an input connected to the input voltage and an output, and is operably connected to the high voltage buffer stage. The low voltage buffer stage is connected between a voltage level being shifted away from and a lower voltage. The output buffer stage is driven by the outputs of the high voltage buffer stage inverter and the low voltage buffer stage.
摘要翻译：移位电路包括高低电压缓冲级和输出缓冲级。高电压缓冲级包括布置在晶体管堆叠中的多个晶体管，其具有沿堆叠连接各个晶体管的多个中间节点。晶体管堆叠被连接在被移位的电压电平和输入电压之间。该级的逆变器包括多个输入和一个输出。逆变器输入端连接到晶体管堆叠的相应中间节点。低电压缓冲级具有连接到输入电压和输出的输入，并且可操作地连接到高电压缓冲级。低电压缓冲级连接在远离电压和较低电压的电压电平之间。输出缓冲级由高压缓冲级反相器和低电压缓冲级的输出驱动。

30. 发明授权

US4419352A Pyranoquinolinones and analogs thereof 失效
标题翻译：吡喃喹啉酮及其类似物
公开(公告)号：US4419352A
公开(公告)日：1983-12-06
申请号：US236329
申请日：1981-02-20
申请人： David Cox , Hugh Cairns , Nigel Chadwick , John L. Suschitzky
发明人： David Cox , Hugh Cairns , Nigel Chadwick , John L. Suschitzky
IPC分类号： A61K31/435 , A61K31/495 , A61P11/06 , A61P37/08 , C07D215/00 , C07D215/48 , C07D239/72 , C07D239/90 , C07D311/24 , C07D335/06 , C07D491/04 , C07D491/052 , C07D495/04 , A61K31/47 , A61K31/535 , C07D413/14
CPC分类号： C07D491/04 , C07D215/48 , C07D239/90 , C07D311/24 , C07D335/06 , C07D495/04 , Y10S514/826 , Y10S514/914 , Y10S514/925 , Y10S514/926 , Y10S514/927 , Y10S514/934
摘要： There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --CZC(G.sub.1).dbd.(G.sub.2)--Z--,R.sub.4, R.sub.9 and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, alkyl, halogen, alkenyl, --NO.sub.2, --NR.sub.1 R.sub.2, --OR.sub.3, --S(O).sub.n R.sub.3 ; or alkyl substituted by hydroxy, amino, alkoxy or carbonyl oxygen,n is 0, 1 or 2,R.sub.1 and R.sub.2, which may be the same or different, each represent hydrogen, alkyl, --CONHR.sub.3, phenyl or phenyl substituted by alkyl or halogen, or R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a 5 or 6 membered heterocyclic ring,R.sub.3 represents hydrogen, alkyl, alkenyl or phenyl,one of G.sub.1 and G.sub.2 is hydrogen and the other is a group E,each E, which may be the same or different, is --COOH, a 5-tetrazolyl group, or a carboxamidotetrazole group,each Z, which may be the same or different, is oxygen or sulphur, andone or two of the atoms, a, b, c and d are nitrogen atoms and the remainder are carbon atoms, R.sup.9 having no significance when two of a, b, c and d are nitrogen,(with certain exclusions)and pharmaceutically acceptable derivatives thereof.There are also described methods for making the compounds and pharmaceutical, e.g. anti-allergic, compositions and mixtures containing them.
摘要翻译：描述了式I，其中相邻的一对R 5，R 6，R 7和R 8形成链-CZC（G1）=（G2）-Z-，R4，R9和R5的其余部分的式I化合物， R 6，R 7和R 8可以相同或不同，各自表示氢，烷基，卤素，烯基，-NO 2，-NR 1 R 2，-OR 3，-S（O）n R 3; 或被羟基，氨基，烷氧基或羰基氧取代的烷基，n为0,1或2，可以相同或不同的R 1和R 2各自表示氢，烷基，-CONHR 3，苯基或被烷基或卤素取代的苯基，或R1和R2与它们所连接的氮原子一起形成5或6元杂环，R 3表示氢，烷基，链烯基或苯基，G1和G2之一是氢，另一个是基团E，每个 E可以相同或不同，为-COOH，5-四唑基或羧酰胺基四唑基，各Z可以相同或不同，为氧或硫，一个或两个原子为 b，c和d为氮原子，其余为碳原子，当a，b，c和d中的两个为氮时，R 9为无意义（具有某些排除）及其药学上可接受的衍生物。还描述了制备化合物和药物的方法。抗过敏剂，组合物和含有它们的混合物。

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