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21. 发明授权

US6110188A Anastomosis method 失效
标题翻译：吻合方法
公开(公告)号：US6110188A
公开(公告)日：2000-08-29
申请号：US37216
申请日：1998-03-09
申请人： Hugh L. Narciso, Jr.
发明人： Hugh L. Narciso, Jr.
IPC分类号： A61B17/00 , A61B17/11
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/1135
摘要： A method for sealingly joining a graft vessel to a target vessel at an anastomosis site, the target vessel having an opening formed therein. The method includes positioning a fastener made from a deformable material radially adjacent to a free end portion of the graft vessel. The material is transformable between a non-fluent state and a fluent state, upon application of energy to the material. The method further includes inserting at least the free end portion of the graft vessel in the target vessel through the opening in the target vessel. Energy is then supplied to the deformable material at an intensity sufficient to transform the material into the fluent state. The free end portion of the graft is radially expanded to expand the graft vessel into intimate contact with an inner wall of the target vessel. The energy supply is discontinued so that the material returns to its non-fluent state to sealingly secure the graft vessel to the target vessel.
摘要翻译：一种在吻合部位将移植脉管密封地连接到靶容器的方法，其中形成有开口的靶容器。该方法包括将由可变形材料制成的紧固件定位成邻近移植物容器的自由端部分。在材料上施加能量之后，材料可以在非流动状态和流动状态之间转变。该方法还包括至少将移植物容器的自由端部分穿过靶容器中的开口。然后将能量以足以将材料转化成流动状态的强度提供给可变形材料。移植物的自由端部径向膨胀，以使移植物容器膨胀成与目标血管的内壁紧密接触。能量供应停止，使得材料返回到其非流动状态以将移植容器密封地固定到靶容器。

22. 发明授权

US06054449A Compounds and method for PDT of intimal hyperplasia and other diseases 失效
标题翻译： PDT内膜增生等疾病的化合物和方法
公开(公告)号：US06054449A
公开(公告)日：2000-04-25
申请号：US801829
申请日：1997-02-14
申请人： Byron Robinson , Alan R. Morgan , Hugh L. Narciso, Jr.
发明人： Byron Robinson , Alan R. Morgan , Hugh L. Narciso, Jr.
IPC分类号： A61K31/366 , A61K31/407 , A61K31/409 , A61K31/4375 , A61K41/00 , A61P9/10 , A61P17/06 , A61P27/06 , A61P35/00 , C07D487/22 , C07D493/04 , C07D519/00 , A61K31/41 , C09B47/00 , C07D478/22
CPC分类号： C07D493/04 , A61K41/0066 , A61K41/0071
摘要： A broad class of photosensitive compounds having enhanced in vivo target tissue selectivity and versatility in photodynamic therapy. Many furocoumarin compounds, such as psoralens, exhibit cytostatic activity when photoactivated but exhibit little in vivo specificity for selectively accumulating in any particular target tissue such as atheromatous plaques. Reactive Oxygen Producing Photosensitizers ("ROPPs") are photoactivatable compounds having an affinity for hyperproliferating cells (such as atheromatous plaque cells), which when photoactivated, produce cytotoxic reaction products. The photoactivity of a ROPP, such as a porphyrin, may be reduced by metalating the porphyrin while the selective affinity of the metalized ROPP for hyperproliferating tissue remains substantially unchanged. By linking a furocoumarin compound to a ROPP to form a F-ROPP, the cytostatic properties of the furocoumarin portion of the F-ROPP can be exploited while the selective affinity of the ROPP portion of the compound for hyperproliferating cells such as atheromatous plaque provides enhanced tissue selectivity without cytotoxicity. In vivo, certain F-ROPPs may be forced to selectively accumulate in a target tissue by illuminating only the target tissue with light having a wavelength operable for photoactivating the F portion of the F-ROPP thereby causing the F-ROPP to either form a monoadduct with or crosslink the cellular DNA in the target tissue. Light of a second wavelength can then be delivered to the target tissue to photoactivate the ROPP portion causing further interference with cellular activity.
摘要翻译：广泛的光敏化合物具有增强的体内靶组织选择性和光动力疗法的多功能性。许多呋喃香豆素化合物，如补骨脂素，当光活化时表现出细胞抑制活性，但是在任何特定靶组织如动脉粥样硬化斑块中选择性积累，但体内特异性较小。活性氧生产光敏剂（“ROPP”）是具有对过度增殖细胞（如动脉粥样硬化斑块细胞）的亲和力的光活化化合物，其在光活化时产生细胞毒性反应产物。可以通过金属化卟啉来减少ROPP如卟啉的光活性，同时金属化ROPP对过度增殖组织的选择性亲和性基本上保持不变。通过将呋喃香豆素化合物与ROPP连接以形成F-ROPP，可以利用F-ROPP的呋喃香豆素部分的细胞生长抑制性能，而化合物的ROPP部分对过度增殖细胞如动脉粥样硬化斑块的选择性亲和力提高组织选择性没有细胞毒性。在体内，某些F-ROPP可能被迫通过用具有可激活F-ROPP的F部分的光波长的光照射目标组织而选择性地累积在靶组织中，从而使F-ROPP形成单加合物与目标组织中的细胞DNA交联或交联。然后可以将第二波长的光递送到目标组织以激活ROPP部分，导致进一步干扰细胞活性。

23. 发明授权

US5773609A Photoactivatable compositions and to methods for the diagnosis and treating medical conditions 失效
标题翻译：与用于进行PDT的DNA形成和加合的组合物
公开(公告)号：US5773609A
公开(公告)日：1998-06-30
申请号：US801831
申请日：1997-02-14
申请人： Byron Robinson , Alan R. Morgan , Hugh L. Narciso, Jr.
发明人： Byron Robinson , Alan R. Morgan , Hugh L. Narciso, Jr.
IPC分类号： A61K31/366 , A61K31/407 , A61K31/409 , A61K31/4375 , A61K41/00 , A61P9/10 , A61P17/06 , A61P27/06 , A61P35/00 , C07D487/22 , C07D493/04 , C07D519/00 , A61K31/35
CPC分类号： C07D493/04 , A61K41/0066 , A61K41/0071
摘要： A broad class of photosensitive compounds having enhanced in vivo target tissue selectivity and versatility in photodynamic therapy. Many furocoumarin compounds, such as psoralens, exhibit cytostatic activity when photoactivated but exhibit little in vivo specificity for selectively accumulating in any particular target tissue such as atheromatous plaques. Reactive Oxygen Producing Photosensitizers ("ROPPs") are photoactivatable compounds having an affinity for hyperproliferating cells (such as atheromatous plaque cells), which when photoactivated, produce cytotoxic reaction products. The photoactivity of a ROPP, such as a porphyrin, may be reduced by metalating the porphyrin while the selective affinity of the metalized ROPP for hyperproliferating tissue remains substantially unchanged. By linking a furocoumarin compound to a ROPP to form a F-ROPP, the cytostatic properties of the furocoumarin portion of the F-ROPP can be exploited while the selective affinity of the ROPP portion of the compound for hyperproliferating cells such as atheromatous plaque provides enhanced tissue selectivity without cytotoxicity. In vivo, certain F-ROPPs may be forced to selectively accumulate in a target tissue by illuminating only the target tissue with light having a wavelength operable for photoactivating the F portion of the F-ROPP thereby causing the F-ROPP to either form a monoadduct with or crosslink the cellular DNA in the target tissue. Light of a second wavelength can then be delivered to the target tissue to photoactivate the ROPP portion causing further interference with cellular activity.
摘要翻译：广泛的光敏化合物具有增强的体内靶组织选择性和光动力疗法的多功能性。许多呋喃香豆素化合物，如补骨脂素，当光活化时表现出细胞抑制活性，但是在任何特定靶组织如动脉粥样硬化斑块中选择性积累，但体内特异性较小。活性氧生产光敏剂（“ROPP”）是具有对过度增殖细胞（如动脉粥样硬化斑块细胞）的亲和力的光活化化合物，其在光活化时产生细胞毒性反应产物。可以通过金属化卟啉来减少ROPP如卟啉的光活性，同时金属化ROPP对过度增殖组织的选择性亲和性基本上保持不变。通过将呋喃香豆素化合物与ROPP连接以形成F-ROPP，可以利用F-ROPP的呋喃香豆素部分的细胞生长抑制性能，而化合物的ROPP部分对过度增殖细胞如动脉粥样硬化斑块的选择性亲和力提高组织选择性没有细胞毒性。在体内，某些F-ROPP可能被迫通过用具有可激活F-ROPP的F部分的光波长的光照射目标组织而选择性地累积在靶组织中，从而使F-ROPP形成单加合物与目标组织中的细胞DNA交联或交联。然后可以将第二波长的光递送到目标组织以激活ROPP部分，导致进一步干扰细胞活性。

24. 发明授权

US5700243A Balloon perfusion catheter 失效
标题翻译：气球灌注导管
公开(公告)号：US5700243A
公开(公告)日：1997-12-23
申请号：US653461
申请日：1996-05-24
申请人： Hugh L. Narciso, Jr.
发明人： Hugh L. Narciso, Jr.
IPC分类号： A61B18/22 , A61M29/02 , A61N5/06 , A61M29/00
CPC分类号： A61M25/104 , A61N5/0601 , A61B2018/2261 , A61M2025/1097 , A61M2205/052
摘要： The present invention is an improved balloon-type catheter with an integral fiber optic assembly for delivering light to a intraluminal target wherein the improvement comprises the use of a perfusion channel to bypass the balloon near the tip of the catheter. The bypass channel enables a fluid material such as oxygen or blood to flow around the inflated balloon during photo-irradiation. A preferred embodiment of the balloon-type perfusion includes a body portion comprising an elongated, flexible, tubular sheath having proximal and distal ends. The body portion is internally partitioned into three longitudinal lumens. The first lumen contains the illuminating fiber optics that include a cylindrical light diffuser tip. The second lumen is an inflation passage for conducting inflation fluid to a balloon which coaxially surrounds the sheath overlying the diffuser tip terminus of the fiber optics near the distal end of the catheter. The third lumen, usually larger in cross-sectional area than the other two, serves as both a portion of a perfusion channel and as a conduit for a guidewire or other ancillary device. A portion of the perfusion channel exits the body portion proximal to the balloon providing fluid communication between the external surface of the sheath and the third lumen. The perfusion channel enables a fluid to flow from the proximal side of the inflated balloon to the distal side of the balloon while the balloon is inflated.
摘要翻译：本发明是一种改进的球囊型导管，其具有用于将光输送到腔内靶的整体光纤组件，其中改进包括使用灌注通道绕过导管末端附近的球囊。旁路通道使得诸如氧气或血液的流体材料在光照射期间能够在充气气囊周围流动。球囊型灌注的优选实施例包括主体部分，其包括具有近端和远端的细长柔性管状护套。主体部分内部分为三个纵向腔。第一个管腔包含一个照明光纤，它包括一个圆柱形光扩散器尖端。第二内腔是用于将膨胀流体传导到气囊的充气通道，其同轴地围绕护套，覆盖在导管远端附近的光纤的扩散器末端。第三腔通常比其他两侧的横截面面积更大，用作灌注通道的一部分和用于导丝或其它辅助装置的导管。灌注通道的一部分离开靠近球囊的主体部分，提供护套的外表面和第三腔之间的流体连通。灌注通道使得当球囊膨胀时，流体从充气球囊的近侧流动到球囊的远侧。

25. 发明授权

US5169395A Laser delivery system 失效
标题翻译：激光输送系统
公开(公告)号：US5169395A
公开(公告)日：1992-12-08
申请号：US691696
申请日：1991-04-26
申请人： Hugh L. Narciso, Jr.
发明人： Hugh L. Narciso, Jr.
IPC分类号： A61B17/22 , A61B18/22 , A61F7/12 , A61M29/02 , A61N5/06
CPC分类号： A61N5/062 , A61N5/0601 , A61B2017/22038 , A61B2017/22087 , A61B2018/2261 , A61F7/12 , A61M25/104
摘要： A system is described for the delivery of light to, and/or the receiving of light from, a target located on the wall of a tortuous tube such as a blood vessel. The delivery system is generally useful for laterally delivering and receiving light for the detection and photodynamic therapy of target tissue and is particularly useful for the treatment of atherosclerosis. When certain biocompatible photoreactive molecules such as hematoporphyrin or the like are injected into a patient the molecules are selectively taken up by target tissue such as tumors or atheromatous plaque. Subsequent illumination of the target tissue activates the photoreactive molecules causing fluorescence emission from, and destruction of, the host target tissue. The preferred embodiments comprise a hollow optical waveguide terminating in a supple diffuser tip which may be inserted over an intravascular flexible guide wire. The optical delivery catheter is advanced along the guidewire until the diffuser tip reaches the target tissue. Light of a wavelength suitable to activate previously injected photoreactive molecules is delivered to the target causing selective cell lysis and/or target tissue destruction. The disclosed system is also capable of delivering laser energy for simultaneous hyperthermic generation and photodynamic therapy.
摘要翻译：描述了一种系统，用于从位于诸如血管的弯曲管的壁上的靶递送光和/或接收光。递送系统通常用于侧向递送和接收用于靶组织的检测和光动力治疗的光，并且对于治疗动脉粥样硬化特别有用。当将某些生物相容的光反应性分子如血卟啉等注入患者时，分子被靶组织如肿瘤或动脉粥样硬化斑块选择性地摄取。靶组织的随后照射激活导致主体靶组织的荧光发射和破坏的光反应分子。优选实施例包括端接在柔性扩散器末端中的中空光波导，其可插入血管内柔性引导线上。光学输送导管沿着导丝前进，直到扩散器尖端到达靶组织。适用于激活先前注射的光反应性分子的波长的光被传递到靶，导致选择性细胞裂解和/或靶组织破坏。所公开的系统还能够提供用于同时发热和光动力疗法的激光能量。

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