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    • 22. 发明申请
    • Dispenser and Apparatus and Method of Filling a Dispenser
    • 分配器和装置以及灌装分配器的方法
    • US20080142112A1
    • 2008-06-19
    • US12025362
    • 2008-02-04
    • Daniel PyJulian V. Chan
    • Daniel PyJulian V. Chan
    • B65B1/04
    • B65D83/62A61J1/00A61J1/1443B65B3/30B65B31/044B65D83/425
    • A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.
    • 用于保持多个剂量的流体或其它物质并用于分配物质的分配器具有小瓶,容纳在小瓶内的柔性囊,以及形成在膀胱和小瓶之间的可变体积存储室。 填充阀与储存室流体连通地联接并且限定(1)将储存室与环境大气密封的常闭密封的流体密封位置,和(2)允许流体通过阀门的打开位置 两者都抽真空储存室并引入流体通过阀门填充储存室。 泵与储存室流体连通地联接,用于将流体泵出储存室。 分配阀与泵流体连通地联接并限定(1)常闭的,流体密封的位置,防止流体从分配器通过,以及(2)用于分配泵送的流体通过的打开位置。 密封的空分配器被灭菌,例如通过对其施加γ射线。 然后,通过使填充阀与排气/分配构件接合以消除储存室,并且通过将来自填充构件的流体通过打开的填充阀引入并进入储存室,灭菌的密封的空分配器充满流体。 填充构件从阀中取出,并且弹簧将阀移动到关闭位置以将分配器内的流体气密地密封。
    • 28. 发明授权
    • Intradermal delivery device and method
    • 皮内输送装置及方法
    • US06971999B2
    • 2005-12-06
    • US10294926
    • 2002-11-14
    • Daniel PyJulian V. Chan
    • Daniel PyJulian V. Chan
    • A61M20060101A61M5/00A61M5/24A61M5/315A61M5/32A61M5/42A61M5/46
    • A61M5/425A61M5/24A61M5/3158A61M5/31591A61M5/3287A61M5/46
    • The subject intradermal delivery device provides for penetration to a fixed depth without requiring special expertise by the user. The device consists of a syringe nested inside an inner shell and an outer shell. An elongated annular channel is formed between the inner shell and the outer shell. A housing receives the syringe and concentric shells in a sliding engagement. A first seal on the distal end of the housing forms a variable length channel in communication with the elongated annular channel via a port formed in the outer shell. When the device is applied to the skin, the housing and syringe are slid towards the skin, and the variable length channel generates a vacuum which forces the skin to bulge into the elongated annular channel. As a result, the skin is tensioned across the inner shell to form a substantially planar, taut target area of skin. The taut target area of skin in combination with a stop on the housing determines the insertion depth of the syringe.
    • 受试者皮内递送装置提供穿透至固定深度,而不需要用户的专门知识。 该装置由嵌套在内壳和外壳内的注射器组成。 在内壳和外壳之间形成细长的环形通道。 壳体以滑动接合的方式接收注射器和同心壳体。 在壳体的远端上的第一密封件通过形成在外壳中的端口形成与细长环形通道连通的可变长度通道。 当将该装置应用于皮肤时,壳体和注射器朝向皮肤滑动,并且可变长度通道产生迫使皮肤凸起进入细长环形通道的真空。 结果,皮肤被横跨内壳张紧,以形成基本上平坦的,拉紧的皮肤目标区域。 与壳体上的止动件组合的皮肤的拉紧目标区域决定了注射器的插入深度。