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21. 发明授权

US07402131B2 Multiple laminar flow-based particle and cellular separation with laser steering 有权
标题翻译：多层次流动粒子与细胞分离与激光转向
公开(公告)号：US07402131B2
公开(公告)日：2008-07-22
申请号：US11543773
申请日：2006-10-06
申请人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
发明人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
IPC分类号： B04B7/08
CPC分类号： A61M1/3681 , A61M1/36 , A61M1/3693 , A61M1/38 , A61M2206/11 , B01L3/502761 , B03C1/28 , B03C5/005 , B03C2201/02 , B03C2201/18 , G01N30/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , Y10T436/25375
摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
摘要翻译：本发明提供了一种用于分离血液和其他类型的细胞组分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

22. 发明申请

US20080144037A1 Method and apparatus for sorting cells 有权
标题翻译：用于分选细胞的方法和装置
公开(公告)号：US20080144037A1
公开(公告)日：2008-06-19
申请号：US12071020
申请日：2008-02-14
申请人： Daniel Mueth , Amy L. Anderson , Christopher R. Knutson , Joseph Plewa
发明人： Daniel Mueth , Amy L. Anderson , Christopher R. Knutson , Joseph Plewa
IPC分类号： G01N21/47
CPC分类号： G01N21/6428 , C12M47/04 , G01N15/1404 , G01N15/1459 , G01N2015/1409 , G01N2015/1411 , G01N2015/149
摘要： Apparatus for sorting and orienting sperm cells has a pair or walls in confronting relationship forming a flow chamber having inlet, a downstream outlet, and intermediate detector region. The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid containing the cells to be sorted. The first and second streams have respective flow rates relative to third stream, such that the third stream is constricted forming a relatively narrow sample stream, so that the cells are oriented parallel to the walls. A detector detects desired cells and a sorter downstream of the detector for sorting the desired cells from the stream.
摘要翻译：用于分选和定向精子细胞的装置具有一对或多个相对关系的壁，形成具有入口，下游出口和中间检测器区域的流动室。入口接收第一和第二间隔开的输入流体流和含有待分选细胞的第三流样品流体。第一和第二流相对于第三流具有相应的流速，使得第三流收缩形成相对窄的样品流，使得电池平行于壁取向。检测器检测期望的细胞和检测器下游的分选器，用于从流中分选所需的细胞。

23. 发明授权

US08158927B2 Multiple laminar flow-based particle and cellular separation with laser steering 有权
标题翻译：多层次流动粒子与细胞分离与激光转向
公开(公告)号：US08158927B2
公开(公告)日：2012-04-17
申请号：US12659277
申请日：2010-03-02
申请人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
发明人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
IPC分类号： B01D21/01
CPC分类号： G03H1/0005 , A61L2/08 , B01D21/0009 , B01D21/01 , B01D21/262 , B01L3/502761 , B01L2200/0652 , B01L2200/0668 , B01L2300/0864 , B01L2400/0454 , B03C1/00 , B03C1/002 , B03C1/288 , B03C5/005 , B04B13/00 , G01N15/0205 , G01N21/6486 , G01N27/447 , G01N27/44756 , G01N33/487 , G01N33/5091 , G01N2015/0053 , G01N2201/061 , G01N2458/00 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , G21K5/08 , H05H3/04
摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.
摘要翻译：本发明提供了一种用于分离血液和其他类型的细胞组分的方法，装置和系统，并且可以与全息光学捕获操作或其他形式的光学镊子组合。示例性方法之一包括提供具有多个血液成分的第一流; 提供第二流; 使第一流与第二流接触以提供第一分离区; 以及将所述多个血液成分的第一血细胞成分差异沉积到所述第二流中，同时在所述第一流中同时维持所述多个血液成分的第二血细胞成分。然后，具有第一血细胞成分的第二流与具有第二血细胞成分的第一流有差别地移除。全息光学捕集器也可以与各种流动结合使用，以将选定的组分从一个流移动到另一个流，作为分离阶段的一部分或除了分离阶段之外。

24. 发明授权

US07118676B2 Multiple laminar flow-based particle and cellular separation with laser steering 有权
公开(公告)号：US07118676B2
公开(公告)日：2006-10-10
申请号：US10934597
申请日：2004-09-03
申请人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
发明人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Harris Rosenbaum
IPC分类号： B01D21/01
CPC分类号： A61M1/3681 , A61M1/36 , A61M1/3693 , A61M1/38 , A61M2206/11 , B01L3/502761 , B03C1/28 , B03C5/005 , B03C2201/02 , B03C2201/18 , G01N30/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , Y10T436/25375
摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

25. 发明申请

US20090002790A1 System and method for manipulating and processing materials using holographic optical trapping 审中-公开
标题翻译：使用全息光学捕获来操纵和处理材料的系统和方法
公开(公告)号：US20090002790A1
公开(公告)日：2009-01-01
申请号：US12230430
申请日：2008-08-28
申请人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
发明人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
IPC分类号： G03H1/04 , G02F1/29 , G02B27/40
CPC分类号： B82Y10/00 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： An apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the at least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
摘要翻译：一种用于通过用衍射光学元件（DOE）调制激光束而形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的装置。选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。根据材料的至少一个所选特征计算DOE的值。光束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱; 陷阱聚焦到光束焦点或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。

26. 发明申请

US20060174385A1 Method and apparatus for detecting targets 审中-公开
标题翻译：检测目标的方法和装置
公开(公告)号：US20060174385A1
公开(公告)日：2006-08-03
申请号：US11048059
申请日：2005-02-02
申请人： Lewis Gruber , Joseph Plewa , Misty Gruber
发明人： Lewis Gruber , Joseph Plewa , Misty Gruber
IPC分类号： G01N23/00
CPC分类号： G01N21/41 , B82Y15/00
摘要： A nano-sensor for sensing one or more targets has a plurality of sensor units, each including a nano-structure and an encapsulating sensible medium surrounding the nano-structure. Each nano-sensor unit being positioned by holographic optical trapping and operative to produce a signal output indicative of the presence of a particular target. A substrate has a sensor location for each sensor unit, each operative to produce an output in response to the signal from the corresponding sensor unit indicative of the presence of a particular target. The sensor may employ a disposable support for the sensor units adapted to be positioned in registration with the sensor locations and disposed of after use.
摘要翻译：用于感测一个或多个靶的纳米传感器具有多个传感器单元，每个传感器单元包括纳米结构和围绕纳米结构的封装敏感介质。每个纳米传感器单元通过全息光学捕获定位并且可操作以产生指示特定目标的存在的信号输出。衬底具有用于每个传感器单元的传感器位置，每个传感器单元响应于来自相应传感器单元的指示存在特定目标的信号而产生输出。传感器可以采用一次性支撑件，用于适于定位成与传感器位置对准的传感器单元并在使用后进行处理。

27. 发明授权

US06247603B1 Container coating for increasing product outage 有权
标题翻译：容器涂层增加产品中断
公开(公告)号：US06247603B1
公开(公告)日：2001-06-19
申请号：US09377848
申请日：1999-08-20
申请人： Christopher J. Farrell , Joseph Plewa
发明人： Christopher J. Farrell , Joseph Plewa
IPC分类号： B65D2300
CPC分类号： B65D23/0814
摘要： A dispensing apparatus and method for increasing product removal utilizing a coating. The apparatus includes a container having an outlet, a wall and a chamber. The chamber houses the coating and a product. The coating substantially covers the container wall. The product is dispensed through the container outlet without substantially removing all the coating applied to the container wall.
摘要翻译：一种用于使用涂层增加产品去除的分配装置和方法。该装置包括具有出口，壁和室的容器。房间内装有涂层和产品。涂层基本上覆盖容器壁。通过容器出口分配产品，而基本上不除去施加到容器壁上的所有涂层。

28. 发明授权

US07482577B2 System and method of sorting materials using holographic laser steering 有权
标题翻译：使用全息激光转向分选材料的系统和方法
公开(公告)号：US07482577B2
公开(公告)日：2009-01-27
申请号：US11808677
申请日：2007-06-12
申请人： Lewis Gruber , Kenneth Bradley , Ward Lopes , Robert Lancelot , Joseph Plewa , David Grier
发明人： Lewis Gruber , Kenneth Bradley , Ward Lopes , Robert Lancelot , Joseph Plewa , David Grier
IPC分类号： H01S1/00 , B01D21/01
CPC分类号： G01N15/1459 , B01L3/5027 , G01N2015/149 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , H05H3/04
摘要： The present invention employs a beam steering apparatus to isolate valuable cells from other cells, tissues, and contaminants. In one embodiment, the system balances optical trapping against biasing flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation.
摘要翻译：本发明采用光束转向装置来将有价值的细胞与其它细胞，组织和污染物分离。在一个实施例中，系统平衡光学捕获与偏置流平衡，以在计算机程序导向的陷阱的灵活控制下平行化细胞分选，其基于它们的组成或标签差异地操纵细胞以引导分离。

29. 发明申请

US20080285099A1 Method and apparatus for forming multi-dimensional colloidal structures using holographic optical tweezers 审中-公开
标题翻译：使用全息光学镊子形成多维胶体结构的方法和装置
公开(公告)号：US20080285099A1
公开(公告)日：2008-11-20
申请号：US11484598
申请日：2006-07-12
申请人： Christopher Knutson , Joseph Plewa
发明人： Christopher Knutson , Joseph Plewa
IPC分类号： G02B5/32
CPC分类号： B01L3/502761 , B01L2400/0454 , G03H1/0005 , G03H2001/0077
摘要： Holographic optical tweezers are used to position charge stabilized colloidal particles within a flow cell. Once the particles are positioned, fixation is accomplished by pumping an electrolyte solution or pH adjusted solution (or a combination of the two) into the sample cell. In the former, the Debye length is reduced and aggregation caused by the van der Waals attraction takes place. In the latter, the surface charge density of the suspension is reduced and aggregation caused by the van der Waals attraction takes place. This technique can be applied multiple times, and allows for the formation of two and three dimensional structures composed of multi-colloid types to be formed on or away from a substrate. The technique relies upon forces acting on virtually all colloidal dispersions making it applicable to a wide variety of colloid types and compositions, such as formation of photonic crystals, colloidal electronics, and bioengineered materials.
摘要翻译：全息光学镊子用于将电荷稳定的胶体颗粒定位在流动池内。一旦颗粒定位，通过将电解质溶液或pH调节的溶液（或两者的组合）泵送到样品池中来实现固定。在前者中，德拜长度减小，范德华力引起的聚集发生。在后者中，悬浮液的表面电荷密度降低，并且由范德华力引起的聚集发生。该技术可以多次施加，并且允许形成由多个胶体类型组成的二维和三维结构形成在基底上或离开基底。该技术依赖于几乎所有胶体分散体上的作用力，使其适用于各种胶体类型和组合物，例如形成光子晶体，胶体电子学和生物工程材料。

30. 发明申请

US20070235640A1 Systems and method of sorting materials using holographic laser steering 有权
标题翻译：使用全息激光转向分选材料的系统和方法
公开(公告)号：US20070235640A1
公开(公告)日：2007-10-11
申请号：US11808677
申请日：2007-06-12
申请人： Lewis Gruber , Kenneth Bradley , Ward Lopes , Robert Lancelot , Joseph Plewa , David Grier
发明人： Lewis Gruber , Kenneth Bradley , Ward Lopes , Robert Lancelot , Joseph Plewa , David Grier
IPC分类号： H05H3/04
CPC分类号： G01N15/1459 , B01L3/5027 , G01N2015/149 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , H05H3/04
摘要： The present invention employs a beam steering apparatus to isolate valuable cells from other cells, tissues, and contaminants. In one embodiment, the system balances optical trapping against biasing flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation.
摘要翻译：本发明采用光束转向装置来将有价值的细胞与其它细胞，组织和污染物分离。在一个实施例中，系统平衡光学捕获与偏置流平衡，以在计算机程序导向的陷阱的灵活控制下平行化细胞分选，其基于它们的组成或标签差异地操纵细胞以引导分离。

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