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21. 发明申请

US20060241742A1 Stent comprising a coating system 审中-公开
标题翻译：支架包括涂层系统
公开(公告)号：US20060241742A1
公开(公告)日：2006-10-26
申请号：US10562376
申请日：2004-06-14
申请人： Claus Harder , Stephane Delaloye , Bernd Heublein
发明人： Claus Harder , Stephane Delaloye , Bernd Heublein
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2250/0035 , A61F2250/0067 , A61L31/10 , A61L31/16 , A61L2300/602
摘要： A stent comprises a tubular base body which is open on the front sides thereof and has a peripheral wall that is at least partially covered with a coating system consisting of at least one polymer carrier and at least one pharmacologically active substance, which is released into the surrounding tissue once the stent has been implanted in the human or animal body. The invention creates a coating system which enables an optimum local application of the active ingredient. A concentration of the substance, a morphological structure of the carrier(s), a material modification of the carrier(s), and/or a layer thickness of the carrier(s), are predetermined in the longitudinal direction of the stent, in such a way that the elution varies locally in the longitudinal direction of the stent and is determined according to the pathophysiological and/or rheological conditions to be expected during the application.
摘要翻译：支架包括在其前侧开口的管状基体，并且具有至少部分地覆盖有由至少一种聚合物载体和至少一种药理活性物质组成的涂层系统的周壁，其被释放到一旦将支架植入人体或动物体内，就会围绕组织。本发明产生一种涂覆系统，其能够最佳地局部施用活性成分。物质的浓度，载体的形态结构，载体的材料改性和/或载体的层厚度在支架的纵向上是预定的，在这样一种方式使得洗脱在支架的纵向上局部变化，并且根据在施用期间预期的病理生理学和/或流变学条件来确定。

22. 发明授权

US6165167A Rapid exchange catheter system 失效
标题翻译：快速交换导管系统
公开(公告)号：US6165167A
公开(公告)日：2000-12-26
申请号：US990174
申请日：1997-12-15
申请人： Stephane Delaloye
发明人： Stephane Delaloye
IPC分类号： A61M25/00 , A61F2/958 , A61M25/01 , A61M29/02 , A61M25/098
CPC分类号： A61M25/0169 , A61M25/10 , A61M2025/0063 , A61M2025/0183
摘要： In a catheter system for rapid exchange via a guidewire with a flexible, elongated inner catheter, which has a proximal end and a distal end as well as a guidewire lumen, which extends from an insertion port on the distal end to a lateral through port distally from the proximal end, and a flexible, tubular outer catheter, in which the inner catheter is disposed axially displaceably, and which has a lateral exit port for the guidewire, retaining means are provided on the inner catheter and the outer catheter, which retaining means prevent twisting of the outer catheter relative to the inner catheter. Thus, the through port and the exit port remain aligned with each other and the catheter system can be displaced simply along the guidewire. In addition, the outer catheter can be readily displaced relative to the inner catheter.
摘要翻译：在用于通过具有柔性细长的内导管的导丝器的导管系统中进行快速交换的导管，所述内导管具有近端和远端以及从远端的插入端口向远端延伸到侧向通孔的导丝管腔从该近端和一个柔性的管状外导管，其中内导管轴向位移地布置，并且其具有用于导丝的侧向出口，保持装置设置在内导管和外导管上，该保持装置防止外导管相对于内导管扭转。因此，通孔和出口保持彼此对准，并且导管系统可以简单地沿导丝移位。此外，外导管可以容易地相对于内导管移位。

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