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21. 发明授权

US08173808B2 Substituted naphthalenyl-pyrimidine compounds 有权
标题翻译：取代的萘基 - 嘧啶化合物
公开(公告)号：US08173808B2
公开(公告)日：2012-05-08
申请号：US12981113
申请日：2010-12-29
申请人： Mark A. Ashwell , Chris Brassard , Audra Dalton , Jason Hill , Robert Nicewonger , David Vensel
发明人： Mark A. Ashwell , Chris Brassard , Audra Dalton , Jason Hill , Robert Nicewonger , David Vensel
IPC分类号： C07D401/00
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/10 , C07D473/16 , C07D473/34 , C07D487/04 , C07D495/04 , Y02A50/401 , Y02A50/409 , Y02A50/411 , A61K2300/00
摘要： The present invention relates to substituted naphthalenyl-pyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted naphthalenyl-pyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译：本发明涉及取代的萘基 - 嘧啶化合物和合成这些化合物的方法。本发明还涉及含有取代的萘基 - 嘧啶化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

22. 发明申请

US20100311754A1 1,4-Disubstituted Naphthalenes as Inhibitors of P38 Map Kinase 有权
标题翻译： 1,4-二取代萘作为P38映射激酶的抑制剂
公开(公告)号：US20100311754A1
公开(公告)日：2010-12-09
申请号：US12854687
申请日：2010-08-11
申请人： Mark A. Ashwell , Yanbin Liu , Syed Ali , Jason Hill , Woj Wrona
发明人： Mark A. Ashwell , Yanbin Liu , Syed Ali , Jason Hill , Woj Wrona
IPC分类号： A61K31/54 , C07D295/088 , C07D417/12 , C07D413/12 , C07D403/12 , A61P19/02 , A61P1/04 , A61P1/00 , A61P37/00 , A61P29/00 , A61P17/06 , C12N5/071
CPC分类号： C07D295/185 , C07D207/27 , C07D207/327 , C07D207/404 , C07D209/12 , C07D209/42 , C07D209/44 , C07D209/48 , C07D211/22 , C07D211/46 , C07D211/58 , C07D211/60 , C07D213/30 , C07D213/56 , C07D213/61 , C07D213/81 , C07D213/82 , C07D215/38 , C07D217/04 , C07D217/26 , C07D231/12 , C07D231/14 , C07D239/38 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/56 , C07D241/08 , C07D249/12 , C07D257/04 , C07D261/08 , C07D263/14 , C07D277/24 , C07D285/14 , C07D295/088 , C07D295/155 , C07D307/42 , C07D317/60 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D491/10
摘要： Naphthalene-based compounds having linked heterocyclic and aromatic rings capable of inhibiting P38, methods for inhibiting P38 in vivo or in vitro, diagnostics for determining activity in the treatment of P38 and/or cytokine-associated conditions and methods for treating conditions associated with P38 activity or cytokine activity; more particularly naphthalene-based compounds of Formula (I) having a morpholine heterocyclic ring, and methods of use thereof.
摘要翻译：具有能够抑制P38的连接的杂环和芳环的萘基化合物，体内或体外抑制P38的方法，用于确定治疗P38和/或细胞因子相关病症的活性的诊断和用于治疗与P38活性相关的病症的方法或细胞因子活性; 更具体地，具有吗啉杂环的式（I）的萘系化合物及其使用方法。

23. 发明授权

US10177804B2 Portable electronic device assembly 有权
公开(公告)号：US10177804B2
公开(公告)日：2019-01-08
申请号：US15942940
申请日：2018-04-02
申请人： Jason Hill
发明人： Jason Hill
IPC分类号： H04M1/00 , H04B1/3888 , A45C11/00 , H04M1/02 , A45C1/06
摘要： Apparatus and associated methods relate to an electronic device protection module configured with a casing adapted to cushion and removably retain the electronic device, a bi-fold component mechanically coupled with the casing, and a releasable electronic device accessory pouch attaching receptacle disposed in the bi-fold component. In an illustrative example, the electronic device may be a smartphone. The casing may be, for example, elastically deformable, cushioning the smartphone against impact. In some examples, the casing may be configured with openings or buttons to enable device operation. In some designs, the bi-fold component may be configured with pockets adapted to secure currency or cards. In some embodiments, the attaching receptacle may releasably attach an accessory pouch to the bi-fold component. Various examples may advantageously provide portable device protection and enhanced access to the user's device accessories, for example, protecting the user's device and storing the user's accessories in the accessory pouch.

24. 发明授权

US08906928B2 Substituted pyrazolo-pyrrolo-pyridine-dione compounds 有权
标题翻译：取代的吡唑并吡啶 - 二酮化合物
公开(公告)号：US08906928B2
公开(公告)日：2014-12-09
申请号：US12751396
申请日：2010-03-31
申请人： Jason Hill , Manish Tandon , Nivedita Namdev , Rocio Palma , Neil Westlund , Anton Filikov
发明人： Jason Hill , Manish Tandon , Nivedita Namdev , Rocio Palma , Neil Westlund , Anton Filikov
IPC分类号： C07D471/04 , C07D471/14
CPC分类号： C07D471/14
摘要： The present invention relates to substituted pyrazolo-pyrrolo-pyridine-dione compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrazolo-pyrrolo-pyridine-dione compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
摘要翻译：本发明涉及取代的吡唑并吡啶 - 二酮化合物和合成这些化合物的方法。本发明还涉及含有取代的吡唑并吡啶 - 二酮化合物的药物组合物和通过将这些化合物或药物组合物给予有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

25. 发明授权

US07862995B2 Methods and materials for predicting responsiveness to treatment with dual tyrosine kinase inhibitor 有权
标题翻译：用于预测双重酪氨酸激酶抑制剂治疗反应的方法和材料
公开(公告)号：US07862995B2
公开(公告)日：2011-01-04
申请号：US11223700
申请日：2005-09-09
申请人： Sarah S. Bacus , Jason Hill
发明人： Sarah S. Bacus , Jason Hill
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/48 , A01N37/18
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/57415 , G01N2333/4712 , G01N2333/4756 , G01N2333/71 , G01N2333/72 , G01N2800/52
摘要： The present invention relates to a panel of targeted therapy markers that can be used in assessing a particular subject's sensitivity to various therapeutic agents and cancer treatments as a means of prognosticating whether a treatment or use of a particular therapeutic agent will result in a clinically positive outcome. Cellular receptors, ligands to those receptors and molecules involved in the programmed cell death pathway are examples of targeted therapy markers that might be used in the present invention.
摘要翻译：本发明涉及一组靶向治疗标志物，其可用于评估特定受试者对各种治疗剂和癌症治疗的敏感性，作为预测特定治疗剂的治疗或使用是否将导致临床阳性结果的手段。细胞受体，参与程序性细胞死亡途径的那些受体和分子的配体是可用于本发明的靶向治疗标志物的实例。

26. 发明授权

US07483403B2 Protocol for reliable, self-organizing, low-power wireless network for security and building automation systems 有权
标题翻译：用于安全和楼宇自动化系统的可靠，自组织，低功耗无线网络的协议
公开(公告)号：US07483403B2
公开(公告)日：2009-01-27
申请号：US10301478
申请日：2002-11-21
申请人： Falk Herrmann , Arati Manjeshwar , Jason Hill
发明人： Falk Herrmann , Arati Manjeshwar , Jason Hill
IPC分类号： H04B7/00 , H04Q7/00 , H04L12/28
CPC分类号： H04L12/2827 , H04L12/12 , H04L12/2803 , H04W52/0216 , H04W52/0219 , H04W52/0229 , H04W52/0245 , H04W84/18 , Y02D70/22
摘要： A method to wirelessly network a sensor/actuator node is described. The sensor/actuator node is installed in a sensor/actuator node network and arranged in a hierarchical manner with a plurality of node levels and a cluster head network. A unique node identifier is assigned to the sensor node and the sensor node network is initialized. The sensor node is woken-up to perform a task and then set to an active low power mode.
摘要翻译：描述了一种无线网络传感器/致动器节点的方法。传感器/致动器节点安装在传感器/致动器节点网络中，并且以多个节点级别和簇头网络以分层方式布置。传感器节点分配唯一的节点标识符，并初始化传感器节点网络。唤醒传感器节点执行任务，然后设置为活动低功耗模式。

27. 发明申请

US20060248147A1 System and method for automatically sending messages to service personnel 审中-公开
标题翻译：自动向服务人员发送消息的系统和方法
公开(公告)号：US20060248147A1
公开(公告)日：2006-11-02
申请号：US11115680
申请日：2005-04-27
申请人： Jason Hill , Michael Wolford
发明人： Jason Hill , Michael Wolford
IPC分类号： G06F15/16
CPC分类号： G06Q30/02 , G06Q10/107
摘要： Communications with service personnel involve receiving a service request and assigning the service request to a first mobile messaging device. A first electronic message indicative of the service request is generated and communicated to the first mobile messaging device. When it is determined that a responsive answer is not received from the first mobile messaging device, another mobile messaging device assigned to respond to the service request is automatically determined. A second electronic message indicative of the service request is generated and communicated to the other mobile messaging device.
摘要翻译：与服务人员的通信涉及接收服务请求并将服务请求分配给第一移动消息收发设备。产生指示服务请求的第一电子消息并将其传送到第一移动消息收发设备。当确定没有从第一移动消息收发设备接收到响应答案时，自动确定被分配以响应服务请求的另一个移动消息收发设备。产生指示服务请求的第二电子消息并将其传送到另一个移动消息收发设备。

28. 发明申请

US20060190074A1 Valve apparatus, system and method 有权
标题翻译：阀门装置，系统及方法
公开(公告)号：US20060190074A1
公开(公告)日：2006-08-24
申请号：US11063681
申请日：2005-02-23
申请人： Jason Hill , Susan Shoemaker , William Drasler
发明人： Jason Hill , Susan Shoemaker , William Drasler
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2475 , A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2220/0016 , A61F2220/005 , A61F2220/0066 , A61F2230/0013 , A61F2230/008 , A61F2250/0036 , Y10T29/49405 , Y10T137/0402
摘要： A venous valve with a frame and a cover on the frame for unidirectional flow of a liquid through the valve.
摘要翻译：具有框架的静脉瓣和框架上的盖子，用于通过阀门单向流动液体。

29. 发明申请

US20050042402A1 Apparatus and method for extrusion of thin-walled tubes 失效
标题翻译：用于挤出薄壁管的装置和方法
公开(公告)号：US20050042402A1
公开(公告)日：2005-02-24
申请号：US10946875
申请日：2004-09-22
申请人： James Venditti , Howard Wolek , Alice Wong , David Sogard , Jason Hill , Timothy Girton , Christopher Brodeur
发明人： James Venditti , Howard Wolek , Alice Wong , David Sogard , Jason Hill , Timothy Girton , Christopher Brodeur
IPC分类号： B29C47/20 , B29C45/53 , B29C47/00 , B29C47/54 , B29L23/00 , B32B1/08
CPC分类号： B29C47/54 , B29C45/531 , B29C47/0004 , B29C47/0023 , B29C47/003 , B29C47/0042 , B29K2027/18 , B29K2105/04 , B29L2023/007 , Y10T428/1352 , Y10T428/139
摘要： The present invention provides an apparatus and method for manufacturing polymeric thin-walled tubular members, which are well-suited for use as vascular grafts. The apparatus of the present invention enables extrusion of a tubular member having an extremely thin wall thickness so as to facilitate passage through tortuous vascular passageways. The apparatus achieves uniform wall thickness in a tubular member by establishing and maintaining axial alignment of a ram having a concentrically disposed guide rod therein with a die supported in concentric relation to the guide rod.
摘要翻译：本发明提供一种用于制造聚合物薄壁管状构件的装置和方法，其非常适合用作血管移植物。本发明的装置能够挤出具有非常薄的壁厚的管状构件，以便于通过曲折的血管通道。该装置通过建立并保持其中具有同心设置的导杆的冲头的轴向对准，并且与导向件同心地支撑模具，在管状构件中实现均匀的壁厚。

30. 发明授权

US06545015B2 Catechols as antimicrobial agents 失效
公开(公告)号：US06545015B2
公开(公告)日：2003-04-08
申请号：US09934743
申请日：2001-08-22
申请人： Milton L. Hammond , Aaron H. Leeman , Milana Maletic , Gina M. Santorelli , Sherman T. Waddell , John Finn , Michael Morytko , Jason Hill , Dennis Keith
发明人： Milton L. Hammond , Aaron H. Leeman , Milana Maletic , Gina M. Santorelli , Sherman T. Waddell , John Finn , Michael Morytko , Jason Hill , Dennis Keith
IPC分类号： C07D21500
CPC分类号： C07D233/64 , C07D215/14 , C07D231/12 , C07D233/56 , C07D235/12 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12
摘要： Compounds, pharmaceutically acceptable salts, and compositions thereof of the general formula: wherein Ar is aryl and heteroaryl; R1, R2, R3, and R4 are hydrido, alkyl, cyano, heteroaryl, hydroxy, amino, acylamino, halo, alkoxy, aryloxy, carboxyamido, alkenyl, cycloalkyl, heterocyclyl, acyl, acyloxy, carboalkoxy, carboxy, thio, sulfinyl, sulfonyl and sulfoxy, R5, R6, R7, and R8 are hydrido and lower alkyl; and Het is a nitrogen-containing heterocyclic ring.

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