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21. 发明授权

US06834461B2 Method to modulate plant growth by injecting a plug at lift 失效
标题翻译：通过在电梯上注入塞来调节植物生长的方法
公开(公告)号：US06834461B2
公开(公告)日：2004-12-28
申请号：US10244902
申请日：2002-09-16
申请人： Marc Poirier , John Kitchen , Steven Kiiskila , Troy Lucyshyn , Mark Ingram , Andrew Jackson , Kyle Krushelniski , Philip Leduc
发明人： Marc Poirier , John Kitchen , Steven Kiiskila , Troy Lucyshyn , Mark Ingram , Andrew Jackson , Kyle Krushelniski , Philip Leduc
IPC分类号： A01G908
CPC分类号： A01G9/081 , A01C21/00 , A01C23/023 , A01G29/00
摘要： A method for modulating plant growth is provided whereby seedlings that are grown in containers such as blocks are fertilized at lift. Prior to fertilization, the block, which has numerous plug cavities, is restrained. The seedlings, which are grown in plugs formed in plug cavities, are supported and a bore is drilled into the bottom of the plug. The bore extends to the top of the plug to produce a small port, which serves as a port for expulsion of air during the injection operation. The fertilizer is measured in a metering roller and is then pneumatically injected into the bore in the plug. Upon completion of the injection, the bore is closed to reduce the loss of fertilizer from the plug. The various operations may be automated or performed manually.
摘要翻译：提供了调节植物生长的方法，其中生长在诸如块的容器中的幼苗在提升时受精。在受精之前，具有许多塞孔的块受到限制。在形成在塞孔中的塞子中生长的幼苗被支撑并且在塞子的底部钻出孔。孔延伸到塞的顶部以产生小的端口，其用作在注射操作期间排出空气的端口。肥料在计量辊中测量，然后气动地注入塞子的孔中。注射完成后，关闭孔以减少栓塞中肥料的损失。各种操作可以是自动的或手动执行的。

22. 发明申请

US20160009681A1 COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY 有权
标题翻译：化合物抑制富含重复激素激酶活性
公开(公告)号：US20160009681A1
公开(公告)日：2016-01-14
申请号：US14772525
申请日：2014-02-27
申请人： Michael MILLER , Kallol BASU , Duane MONG , Jack SCOTT , Hong LIU , Xing DAI , Andrew STAMFORD , Marc POIRIER , Paul TEMPEST , MERCK SHARP & DOHME CORP.
发明人： Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Hong Liu , Xing Dai , Andrew Stamford , Marc Poirier , Paul Tempest
IPC分类号： C07D401/04 , C07D498/08 , C07D401/14 , C07D495/08 , C07D498/04 , C07D487/04 , C07D413/14 , C07D405/14 , C07D417/14
CPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/08 , C07D495/08 , C07D498/04 , C07D498/08
摘要： The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK2 kinase is involved.
摘要翻译：本发明涉及作为LRRK2激酶的有效抑制剂的吲唑化合物，可用于治疗或预防其中涉及LRRK2激酶的疾病，例如帕金森病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及LRRK2激酶的疾病中的用途。

23. 发明授权

US08680294B2 Enantio- and stereo specific synthesis of β-amino-α-hydroxy amides 有权
标题翻译：氨基-α-羟基酰胺的对映体和立体特异性合成
公开(公告)号：US08680294B2
公开(公告)日：2014-03-25
申请号：US13387619
申请日：2010-07-27
申请人： John Traverse , William M. Leong , Steven P. Miller , Jennifer Albaneze-Walker , Thomas J. Hunter , Lijun Wang , Hongbiao Liao , Ashok Arasappan , Scott T. Trzaska , Randi M. Smith , Azzeddine Lekhal , Stephane L. Bogen , Jianshe Kong , Frank Bennett , F. George Njoroge , Marc Poirier , Shen-Chun Kuo , Yonggang Chen , Kenneth S. Matthews , Patrice Demonchaux , Amadeo Ferreira
发明人： John Traverse , William M. Leong , Steven P. Miller , Jennifer Albaneze-Walker , Thomas J. Hunter , Lijun Wang , Hongbiao Liao , Ashok Arasappan , Scott T. Trzaska , Randi M. Smith , Azzeddine Lekhal , Stephane L. Bogen , Jianshe Kong , Frank Bennett , F. George Njoroge , Marc Poirier , Shen-Chun Kuo , Yonggang Chen , Kenneth S. Matthews , Patrice Demonchaux , Amadeo Ferreira
IPC分类号： C07D207/06
CPC分类号： C07D209/52 , C07C51/353 , C07C67/04 , C07C237/04 , C07C315/02 , C07C315/04 , C07C317/28 , C07C319/14 , C07C319/20 , C07C2601/02 , C07C2601/14 , C07K5/0202 , C07K5/06034 , C07C323/53 , C07C317/44 , C07C57/03 , C07C69/533
摘要： Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.
摘要翻译：用于制备式I化合物的方法：式（I）。公开了可用于制备式I化合物的中间体和用于制备所述中间体的方法。

24. 发明申请

US20140058116A1 PROCESS FOR PREPARING INHIBITORS OF THE HEPATITIS C VIRUS 审中-公开
标题翻译：制备丙型肝炎病毒的抑制剂的方法
公开(公告)号：US20140058116A1
公开(公告)日：2014-02-27
申请号：US14114251
申请日：2012-05-02
申请人： Ji Xie , George Wu , Joseph Lamberson , Marc Poirier , Frank Chen
发明人： Ji Xie , George Wu , Joseph Lamberson , Marc Poirier , Frank Chen
IPC分类号： C07D209/52
CPC分类号： A61K9/00 , A61K38/005 , A61K38/06 , C07D209/52 , C07K1/36
摘要： The present invention relates to synthetic processes useful in the preparation of compounds of Formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease and have application in the treatment of conditions caused by HCV. In particular, the present invention relates to novel oxidation processes useful for preparing compounds of Formula (I) and related compounds, including pharmaceutically acceptable salts, hydrates and solvates thereof, and including stereoisomers thereof.
摘要翻译：本发明涉及用于制备式（I）化合物的合成方法，其可用作丙型肝炎病毒（HCV）NS3蛋白酶的抑制剂，并且可用于治疗由HCV引起的病症。特别地，本发明涉及可用于制备式（I）化合物和相关化合物的新型氧化方法，包括其药学上可接受的盐，水合物和溶剂合物，并包括它们的立体异构体。

25. 发明申请

US20070149459A1 Oxidation process for the preparation of N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-{N-[(tert-butylamino)carbonyl]-3-methyl-L-valyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide and related compounds 失效
标题翻译：制备N- [3-氨基-1-（环丁基甲基）-2,3-二氧代丙基] -3- {N - [（叔丁基氨基）羰基] -3-甲基-L-缬氨酰基} -6的氧化方法，6-二甲基-3-氮杂双环[3.1.0]己烷-2-甲酰胺及相关化合物
公开(公告)号：US20070149459A1
公开(公告)日：2007-06-28
申请号：US11598528
申请日：2006-11-13
申请人： George Wu , Ji Xie , Paitoon Rashatasakhon , Frank Chen , Marc Poirier , Victoria Sprague
发明人： George Wu , Ji Xie , Paitoon Rashatasakhon , Frank Chen , Marc Poirier , Victoria Sprague
IPC分类号： A61K38/05 , C07K5/08
CPC分类号： C07D209/52 , A61K38/00 , C07K5/0202
摘要： The present application relates to a process for preparing a compound of formula I: wherein R1 is alkyl; R2 is alkyl; and R3 is optionally substituted cycloalklylalkyl which comprises oxidizing a compound of the formula wherein R1, R2 and R3 are defined above to yield a compound of formula I.
摘要翻译：本申请涉及制备式I化合物的方法：其中R 1是烷基; R 2是烷基; 和R 3是任选取代的环烷基烷基，其包括将下式化合物其中R 1，R 2和R 3， SUP>如上定义，得到式I化合物。

26. 发明授权

US06495689B2 Synthesis of intermediates useful in preparing tricyclic compounds 有权
标题翻译：可用于制备三环化合物的中间体的合成
公开(公告)号：US06495689B2
公开(公告)日：2002-12-17
申请号：US09886845
申请日：2001-06-21
申请人： Charles F. Bernard , Michael Casey , Frank Xing Chen , Denise C. Grogan , Marc Poirier , Robert P. Williams , Yee-Shing Wong , George G. Wu
发明人： Charles F. Bernard , Michael Casey , Frank Xing Chen , Denise C. Grogan , Marc Poirier , Robert P. Williams , Yee-Shing Wong , George G. Wu
IPC分类号： C07D22116
CPC分类号： C07D221/16
摘要： Disclosed is a process for preparing a compound having the formula: wherein R, R1, R2, R3, and R4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy.
摘要翻译：公开了一种制备具有下式的化合物的方法：其中R，R 1，R 2，R 3和R 4独立地选自H，Br，Cl，F，烷基或烷氧基。

27. 发明授权

US5998620A Synthesis of intermediates useful in preparing tricyclic compounds 失效
标题翻译：可用于制备三环化合物的中间体的合成
公开(公告)号：US5998620A
公开(公告)日：1999-12-07
申请号：US45803
申请日：1998-03-23
申请人： Xing Chen , Marc Poirier , Yee-Shing Wong , Guang-Zhong Wu
发明人： Xing Chen , Marc Poirier , Yee-Shing Wong , Guang-Zhong Wu
IPC分类号： C07D221/16 , C07D401/04 , C07D221/06
CPC分类号： C07D401/04 , C07D221/16
摘要： The invention relates to a process for preparing a compound of the formula ##STR1## comprising reacting a bromo-substituted pyridine with an amine of the formula NHR.sup.5 R.sup.6, reacting the resulting amide with an iodo-halomethyl-substituted compound and cyclizing the resultant product, wherein R, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in the specification; also claimed are a compound of the formula ##STR2## and a process for preparing it from the corresponding halo-substituted benzoic acid.
摘要翻译：本发明涉及一种制备下式化合物的方法，其中包括使溴取代的吡啶与式NHR 5 R 6的胺反应，使得到的酰胺与碘代卤代甲基取代的化合物反应，并使得到的产物环化，其中R，R 1 R2，R3和R4如说明书中所定义; 还要求的是下式的化合物及其由相应的卤代取代的苯甲酸制备的方法。

28. 发明授权

US5760232A Synthesis of intermediates useful in preparing bromo-substituted tricyclic compounds 失效
标题翻译：可用于制备溴代三环化合物的中间体的合成
公开(公告)号：US5760232A
公开(公告)日：1998-06-02
申请号：US882753
申请日：1997-06-16
申请人： Xing Chen , Marc Poirier , Yee-Shing Wong , Guang-Zhong Wu
发明人： Xing Chen , Marc Poirier , Yee-Shing Wong , Guang-Zhong Wu
IPC分类号： C07D401/04 , C07D221/16
CPC分类号： C07D401/04
摘要： The invention relates to a process for preparing a compound of the formula ##STR1## comprising: (a) reacting 2,5-dibromo-3-methylpyridine with an amine of the formula NHR.sup.5 R.sup.6 to obtain an amide; (b) reacting the amide with a compound of formula 3 ##STR2## in the presence of a strong base to obtain a compound of formula 4 ##STR3## (c) converting a compound of formula 4 to the corresponding cyano compound or aldehyde; (d) reacting the cyano compound or aldehyde with a piperidine derivative to obtain an aldehyde or alcohol of formula 7a or 7b, respectively: ##STR4## (e) cyclizing a compound of formula 7a or 7b; wherein R.sup.1 -R.sup.7 are as defined in the specification.
摘要翻译：本发明涉及制备式I化合物的方法，其包括：（a）使2,5-二溴-3-甲基吡啶与式NHR 5 R 6的胺反应，得到酰胺; （b）在强碱存在下使酰胺与式3化合物反应，得到式4化合物（c）将式4的化合物转化成相应的氰基化合物或醛 ; （d）使氰基化合物或醛与哌啶衍生物反应，分别得到式7a或7b的醛或醇：（e）使式7a或7b的化合物环化; 其中R1-R7如说明书中所定义。

29. 发明申请

US20120178942A1 ENANTIO- AND STEREO-SPECIFIC SYNTHESES OF BETA-AMINO-ALPHA- HYDROXY AMIDES 有权
标题翻译：氨基 - 氨基 - 羟丙基氨基酸的纯化和立体特异性合成
公开(公告)号：US20120178942A1
公开(公告)日：2012-07-12
申请号：US13387619
申请日：2010-07-27
申请人： John Traverse , William M. Leong , Steven P. Miller , Jennifer Albaneze-Walker , Thomas J. Hunter , Lijun Wang , Hongbiao Liao , Ashok Arasappan , Scott T. Trzaska , Randi M. Smith , Azzeddine Lekhal , Stephane L. Bogen , Jianshe Kong , Frank Bennett , F. George Njoroge , Marc Poirier , Shen-Chun Kuo , Yonggang Chen , Kenneth S. Matthews , Patrice Demonchaux , Amadeo Ferreira
发明人： John Traverse , William M. Leong , Steven P. Miller , Jennifer Albaneze-Walker , Thomas J. Hunter , Lijun Wang , Hongbiao Liao , Ashok Arasappan , Scott T. Trzaska , Randi M. Smith , Azzeddine Lekhal , Stephane L. Bogen , Jianshe Kong , Frank Bennett , F. George Njoroge , Marc Poirier , Shen-Chun Kuo , Yonggang Chen , Kenneth S. Matthews , Patrice Demonchaux , Amadeo Ferreira
IPC分类号： C07D209/52 , C07C237/14 , C07C317/44 , C07C315/02 , C07C271/56 , C07C231/02 , C07C263/00 , C07C265/10 , C07C313/12 , C07C211/35 , C07C275/26 , C07C273/18
CPC分类号： C07D209/52 , C07C51/353 , C07C67/04 , C07C237/04 , C07C315/02 , C07C315/04 , C07C317/28 , C07C319/14 , C07C319/20 , C07C2601/02 , C07C2601/14 , C07K5/0202 , C07K5/06034 , C07C323/53 , C07C317/44 , C07C57/03 , C07C69/533
摘要： Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.
摘要翻译：用于制备式I化合物的方法：式（I）。公开了可用于制备式I化合物的中间体和用于制备所述中间体的方法。

30. 发明申请

US20110191182A1 System and Method for Managing and Optimizing Advertising Networks 有权
标题翻译：管理和优化广告网络的系统和方法
公开(公告)号：US20110191182A1
公开(公告)日：2011-08-04
申请号：US12628492
申请日：2009-12-01
申请人： Marc Poirier , Richard Couture
发明人： Marc Poirier , Richard Couture
IPC分类号： G06Q30/00
CPC分类号： G06Q90/00 , G06Q30/02 , G06Q30/0256 , G06Q30/0275
摘要： The system of the present invention is used to execute data consolidation to combine data from Google, MSN and Yahoo, at least. The user does not need anymore to combine by himself data in spreadsheets. The system allows creating consolidated campaigns that span across search providers, letting the user effortlessly build reports that previously took hours to create each month. The system of the present invention is particularly suited for agencies. A tool designed for agencies needs to allow for management at the client level as well as the agency level. The system client center gives each member of the team a summary view of the client accounts that they're responsible for, along with emerging trend indicators for every major metric.
摘要翻译：本发明的系统至少用于执行数据整合以组合Google，MSN和Yahoo的数据。用户不需要自己将数据合并在电子表格中。该系统允许创建跨越搜索提供商的合并广告系列，让用户轻松构建以前每个月创建几个小时的报告。本发明的系统特别适用于机构。为机构设计的工具需要在客户层面和机构层面进行管理。系统客户中心为团队的每个成员提供他们负责的客户帐户的摘要视图，以及每个主要指标的新兴趋势指标。

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