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21. 发明申请

US20110278475A1 MULTIPLEX ILLUMINATION SYSTEM AND METHOD 审中-公开
标题翻译：多重照明系统和方法
公开(公告)号：US20110278475A1
公开(公告)日：2011-11-17
申请号：US13191279
申请日：2011-07-26
申请人： Paul Lundquist , Cheng Frank Zhong , Pegian Zhao , Stephen Tumer
发明人： Paul Lundquist , Cheng Frank Zhong , Pegian Zhao , Stephen Tumer
IPC分类号： G01J1/58
CPC分类号： G01N27/44721
摘要： Systems and methods for analyzing highly multiplexed sample arrays using highly multiplexed, high density optical systems to illuminate high density sample arrays and/or provide detection from such high density arrays. Systems and methods comprise substrates having an array of discrete signal sources having a pitch P2, and an optical system that divided illumination light into an array of illumination spots, the illumination spots having a pitch P1 that is less than P2.
摘要翻译：使用高度多路复用的高密度光学系统来分析高度复用的样本阵列以照亮高密度样本阵列和/或从这样的高密度阵列提供检测的系统和方法。系统和方法包括具有间距P2的离散信号源阵列的基板和将照明光分成照明点阵列的光学系统，照明点具有小于P2的间距P1。

22. 发明授权

US08053742B2 Substrates, systems and methods for analyzing materials 有权
标题翻译：基材，分析材料的系统和方法
公开(公告)号：US08053742B2
公开(公告)日：2011-11-08
申请号：US12896515
申请日：2010-10-01
申请人： Paul Lundquist , Stephen Turner
发明人： Paul Lundquist , Stephen Turner
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N2021/7786 , G02B6/43
摘要： Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.
摘要翻译：用于分析材料的衬底，系统和方法，其包括设置在衬底上或衬底内的波导阵列，使得从波导发出的消逝场照射设置在衬底表面上或其附近的材料，从而允许分析这些材料。底物，系统和方法用于各种分析操作，包括核酸分析，包括杂交和测序分析，细胞分析和其他分子分析。

23. 发明申请

US20090181396A1 METHODS AND SYSTEMS FOR ANALYSIS OF FLUORESCENT REACTIONS WITH MODULATED EXCITATION 有权
标题翻译：用调制激发荧光反应分析的方法与系统
公开(公告)号：US20090181396A1
公开(公告)日：2009-07-16
申请号：US12351173
申请日：2009-01-09
申请人： Khai Luong , Paul Lundquist , Ravi Dalal , John Lyle , Stephen Turner
发明人： Khai Luong , Paul Lundquist , Ravi Dalal , John Lyle , Stephen Turner
IPC分类号： C12Q1/68 , G01N21/76 , C12M1/34
CPC分类号： C12M1/34 , G01N21/6428 , G01N21/645 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/7786 , Y10T436/2525
摘要： Methods, systems and their components for monitoring fluorescent signals and particularly transient fluorescent signals from reaction mixtures of interest, which methods and systems employ modulated excitation light sources to reduce impacts of excessive illumination on the reaction components or the data obtained therefrom.
摘要翻译：用于监测来自感兴趣的反应混合物的荧光信号和特别是瞬时荧光信号的方法，系统及其组件，该方法和系统采用调制的激发光源以减少过度照明对反应组分的影响或由其获得的数据。

24. 发明申请

US20080080059A1 MODULAR OPTICAL COMPONENTS AND SYSTEMS INCORPORATING SAME 审中-公开
标题翻译：模块化的光学组件和系统
公开(公告)号：US20080080059A1
公开(公告)日：2008-04-03
申请号：US11863058
申请日：2007-09-27
申请人： John Dixon , Paul Lundquist
发明人： John Dixon , Paul Lundquist
IPC分类号： G02B27/14
CPC分类号： G02B27/1006 , G01N21/6452 , G02B27/106 , G02B27/126 , G02B27/144 , G02B27/148
摘要： Modular optical systems employing integrated optical plates, prisms, reflective and semireflective layers that provide less complex, more robust optical systems. The modular systems provide single, or double component optical modules for the redirection, deflection and separation of optical energy for use in optical systems, and particularly optical detection systems for, e.g., fluorescence analysis tools used in the biochemical and chemical analysis industries.
摘要翻译：使用集成光学板，棱镜，反射和半反射层的模块化光学系统，其提供较不复杂，更坚固的光学系统。模块化系统提供用于光学系统的光能的重定向，偏转和分离的单组件或双组分光学模块，并且特别是用于例如用于生物化学和化学分析工业中的荧光分析工具的光学检测系统。

25. 发明授权

US08802424B2 Methods and systems for analysis of fluorescent reactions with modulated excitation 有权
标题翻译：用调制激发分析荧光反应的方法和系统
公开(公告)号：US08802424B2
公开(公告)日：2014-08-12
申请号：US12351173
申请日：2009-01-09
申请人： Khai Luong , Paul Lundquist , Ravi Dalal , John Lyle , Stephen Turner
发明人： Khai Luong , Paul Lundquist , Ravi Dalal , John Lyle , Stephen Turner
IPC分类号： C12M1/00 , C12Q1/68 , C12M1/34 , G01N21/64 , G01N1/00
CPC分类号： C12M1/34 , G01N21/6428 , G01N21/645 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/7786 , Y10T436/2525
摘要： Methods, systems and their components for monitoring fluorescent signals and particularly transient fluorescent signals from reaction mixtures of interest, which methods and systems employ modulated excitation light sources to reduce impacts of excessive illumination on the reaction components or the data obtained therefrom.
摘要翻译：用于监测来自感兴趣的反应混合物的荧光信号和特别是瞬时荧光信号的方法，系统及其组件，该方法和系统采用调制的激发光源以减少过度照明对反应组分的影响或从其获得的数据。

26. 发明授权

US08471219B2 Substrates, systems and methods for analyzing materials 有权
公开(公告)号：US08471219B2
公开(公告)日：2013-06-25
申请号：US13477865
申请日：2012-05-22
申请人： Paul Lundquist , Stephen Turner
发明人： Paul Lundquist , Stephen Turner
IPC分类号： G01N21/64
CPC分类号： C12Q1/6874 , B01L2300/0636 , C12Q1/6869 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N21/7703 , G01N21/7743 , G01N2021/6439 , G01N2021/7786 , G01N2201/08 , G02B6/10 , G02B6/43
摘要： Substrates, systems and methods for analyzing materials that include waveguide arrays disposed upon or within the substrate such that evanescent fields emanating from the waveguides illuminate materials disposed upon or proximal to the surface of the substrate, permitting analysis of such materials. The substrates, systems and methods are used in a variety of analytical operations, including, inter alia, nucleic acid analysis, including hybridization and sequencing analyses, cellular analyses and other molecular analyses.

27. 发明授权

US07961314B2 Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources 有权
标题翻译：用于同时实时监测来自多个来源的光信号的方法和系统
公开(公告)号：US07961314B2
公开(公告)日：2011-06-14
申请号：US11978211
申请日：2007-10-26
申请人： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Stephen Turner , John Dixon
发明人： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Stephen Turner , John Dixon
IPC分类号： G01J3/30
CPC分类号： G01J3/02 , G01J3/0224 , G01J3/10 , G01J3/14 , G01J3/2803 , G01N21/6445 , G01N21/6452 , G01N21/6456 , G01N21/648 , G01N2021/6417
摘要： Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.
摘要翻译：用于实时监测来自信号源阵列的光信号的方法和系统，特别是具有频谱不同信号分量的光信号源。系统包括与光学列车光学通信的信号源阵列，其将激发辐射引导到来自这种阵列的信号和从这些阵列发出的信号，并将信号映射到检测器阵列上，从而可以对这些信号进行额外的处理。

28. 发明授权

US07791792B2 Transient optical power suppressing apparatus, method, and network 有权
标题翻译：瞬态光功率抑制装置，方法和网络
公开(公告)号：US07791792B2
公开(公告)日：2010-09-07
申请号：US12174395
申请日：2008-07-16
申请人： Paul Lundquist , Marc Levesque , Denis Zaccarin
发明人： Paul Lundquist , Marc Levesque , Denis Zaccarin
IPC分类号： H04B10/17 , G02B6/26
CPC分类号： H04B10/296 , H01S5/042 , H01S5/06825
摘要： An apparatus for suppressing optical power transients includes a variable optical attenuator receiving an input optical signal and outputting an output optical signal; an optical power sensing element coupled to the input optical signal and sensing a portion of the input optical signal; and a feedforward loop controller coupled to the variable optical attenuator and to the optical power sensing element; the feedforward control loop providing feedforward control of the variable optical attenuator to reduce optical power transients of the input optical signal and maintain a substantially constant output power based on the input optical power and a reference value; the variable optical attenuator having a default opaque state in which the input optical signal is substantially attenuated when power is not being supplied to said variable optical attenuator. Variations include feedback loop controllers and a combination feedback and feedforward loop controllers.
摘要翻译：用于抑制光功率瞬变的装置包括：可变光衰减器，其接收输入光信号并输出输出光信号; 耦合到所述输入光信号并感测所述输入光信号的一部分的光功率感测元件; 以及耦合到所述可变光衰减器和所述光功率感测元件的前馈环路控制器; 所述前馈控制环路提供所述可变光衰减器的前馈控制以减少所述输入光信号的光功率瞬变，并且基于所述输入光功率和参考值保持基本上恒定的输出功率; 所述可变光衰减器具有默认不透明状态，其中当功率未被提供给所述可变光衰减器时，所述输入光信号基本衰减。变化包括反馈回路控制器和组合反馈和前馈回路控制器。

29. 发明申请

US20070188750A1 Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources 有权
公开(公告)号：US20070188750A1
公开(公告)日：2007-08-16
申请号：US11483413
申请日：2006-07-07
申请人： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Stephen Turner , John Dixon
发明人： Paul Lundquist , Denis Zaccarin , Yves Lacroix , Stephen Turner , John Dixon
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01J3/02 , G01J3/0224 , G01J3/10 , G01J3/14 , G01J3/2803 , G01N21/6445 , G01N21/6456 , G01N21/648 , G01N2021/6417 , G01N2021/6441
摘要： Methods and systems for real-time monitoring of optical signals from arrays of signal sources, and particularly optical signal sources that have spectrally different signal components. Systems include signal source arrays in optical communication with optical trains that direct excitation radiation to and emitted signals from such arrays and image the signals onto detector arrays, from which such signals may be subjected to additional processing.

30. 发明申请

US20070063992A1 Finger-keyed human-machine interface device 审中-公开
标题翻译：手指键盘人机界面装置
公开(公告)号：US20070063992A1
公开(公告)日：2007-03-22
申请号：US11228647
申请日：2005-09-17
申请人： Paul Lundquist
发明人： Paul Lundquist
IPC分类号： G09G5/00
CPC分类号： G06F3/0219 , G06F1/163 , G06F3/014
摘要： A finger-keyed human-machine interface device and methods provide outputs suitable for entering keyed data into a computer, cash register, musical device or other machines. Varying relative positions or orientations of body-attached electrodes generates data. Combinations of connections between electrodes are translated into output signals corresponding to keyed outputs. Levels of connections are used for predictive provisional inputs allowing a user to retract outputs before they are made final and for other applications. Mappings of electrodes attached to fingers and hands are presented for entering keyed data or selecting musical notes.
摘要翻译：手指键控人机接口设备和方法提供适合于将键控数据输入到计算机，收银机，音乐设备或其他机器中的输出。身体附着电极的相对位置或方向的变化产生数据。电极之间的连接的组合被转换成对应于键控输出的输出信号。连接级别用于预测临时输入，允许用户在最终产品和其他应用程序之前缩回输出。呈现用于输入键入数据或选择音符的电极附着在手指和手上的贴图。

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