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21. 发明申请

US20060111226A1 Methods of making reclosable packages for vacuum, pressure and/or liquid containment 有权
公开(公告)号：US20060111226A1
公开(公告)日：2006-05-25
申请号：US11257682
申请日：2005-10-25
申请人： David Anzini , Rusty Koenigkramer , David Matthews , Lars Wihlborg , Glyn Russell
发明人： David Anzini , Rusty Koenigkramer , David Matthews , Lars Wihlborg , Glyn Russell
IPC分类号： B31B1/90
CPC分类号： B65D33/2533 , A44B19/16 , A44B19/36 , A44B19/60 , B31B70/8131 , B31B70/8132 , B65D33/2508 , B65D33/2583 , B65D33/2591
摘要： A method of manufacturing flexible containers that are hermetically resealable. Each resealable container comprises a receptacle and a pair of plastic zipper strips. The zipper strips are flattened at the ends within the side seal regions and are joined to each other, without substantial deformation of the closure profiles, in respective transition areas substantially contiguous with the side seals. These transition areas of zipper strip joinder assist in providing a leakproof transition from the openable section of the zipper to the side seals, where the closure profiles are fused and flattened (i.e., crushed).

22. 发明申请

US20060083909A1 Easy-open dough packages and related methods of manufacture 审中-公开
标题翻译：易开口面团包装及相关制造方法
公开(公告)号：US20060083909A1
公开(公告)日：2006-04-20
申请号：US10968620
申请日：2004-10-19
申请人： David Matthews , Eric Plourde , Brian Daniels
发明人： David Matthews , Eric Plourde , Brian Daniels
IPC分类号： B31B45/00 , B65D85/00
CPC分类号： B65D75/66 , B65B61/02 , B65D85/36 , Y10T428/249923
摘要： A generally tube-shaped package that has a tear strip joined to a web of packaging film, the tear strip incorporating an encapsulated tear notch. The package is filled with cookie or bread dough. In accordance with one embodiment, the tear strip is part of a tape that is joined to a web of packaging film. Preferably, the tear strip has a tear bead. Optionally, tearing off of the tear strip provides access to a peel seal, which in turn must be sundered to gain access to the dough. In accordance with another embodiment, the tear strip comprises a portion of a web of packaging film, which portion is bounded by a pair of mutually parallel capped tear lines. A tear bead is disposed between the tear lines. Methods of manufacturing such packages are disclosed.
摘要翻译：一种通常为管状的包装，其具有连接到包装膜的幅材的撕裂条，所述撕裂条包括封装的撕裂缺口。包装充满了饼干或面包面团。根据一个实施例，撕条是连接到包装薄膜网的带的一部分。优选地，撕条具有泪珠。任选地，撕裂撕条可以进入剥离密封件，剥离密封件又必须被清洗以便进入面团。根据另一个实施例，撕条包括一部分包装膜的腹板，该部分由一对相互平行的覆盖撕裂线限定。泪珠设置在撕裂线之间。公开了制造这种包装的方法。

23. 发明申请

US20060013231A1 Consolidated ethernet optical network and apparatus 审中-公开
标题翻译：综合以太网光网络和设备
公开(公告)号：US20060013231A1
公开(公告)日：2006-01-19
申请号：US10874154
申请日：2004-06-22
申请人： David Matthews , Rodolfo Montelongo , Chin Yuan , Orestis Manthoulis , Laxman Sahasrabuddhe
发明人： David Matthews , Rodolfo Montelongo , Chin Yuan , Orestis Manthoulis , Laxman Sahasrabuddhe
IPC分类号： H04L12/56
CPC分类号： H04L69/32
摘要： A consolidated optical Ethernet network and apparatus are disclosed. In one form a network device includes an aggregation layer access interface operable to access an aggregation layer and a core layer access interface provided in combination with the aggregation layer access interface and operable to access a core layer. The device may be provided within a Multiprotocol Label Switching based Ethernet Optical Network (EON) as a network switch and may allow for efficient access to multiple layers of a network communicating information within the EON.
摘要翻译：公开了一种整合的光以太网网络和装置。在一种形式中，网络设备包括可操作以访问聚合层的聚合层访问接口和与聚合层访问接口组合提供并可操作以访问核心层的核心层访问接口。该设备可以设置在作为网络交换机的基于多协议标签交换的以太网光网络（EON）中，并且可以允许有效地访问在EON内传送信息的网络的多个层。

24. 发明申请

US20050150186A1 Methods of making slide-zippered reclosable packages on horizontal form-fill-seal machines 审中-公开
公开(公告)号：US20050150186A1
公开(公告)日：2005-07-14
申请号：US11074132
申请日：2005-03-07
申请人： David Matthews , Charles Thorpe
发明人： David Matthews , Charles Thorpe
IPC分类号： B65B1/02 , B31B1/90 , B31B19/90 , B65B9/04 , B65B9/093 , B65B61/18 , B65B9/02
CPC分类号： B65B43/50 , B31B50/81 , B31B70/8132 , B65B9/04 , B65B9/093 , B65B61/188 , Y10T24/45168 , Y10T428/1303
摘要： Methods of making slide-zippered reclosable packages are provided. In one embodiment, a pair of opposing film extensions are provided on each package between which a zipper and slider are attached. In another embodiment, sliders are inserted on to zippered packages output from a form-fill-seal machine or the like. In yet another embodiment, during package formation a reclosable zipper is sealed to each package and then a slider is inserted on to the zipper. In yet another embodiment, during package formation a reclosable zipper is sealed to each package and a slider is inserted on to each zipper, either before or after zipper sealing.

25. 发明申请

US20050146900A1 Method and apparatus for trimming current limit and frequency to maintain a constant maximum power 失效
标题翻译：用于调整电流限制和频率以保持恒定最大功率的方法和装置
公开(公告)号：US20050146900A1
公开(公告)日：2005-07-07
申请号：US11071380
申请日：2005-03-02
申请人： Balu Balakrishnan , Alex Djenguerian , David Matthews
发明人： Balu Balakrishnan , Alex Djenguerian , David Matthews
IPC分类号： H02M3/28 , H02M1/00 , H02M1/32 , H02M3/155 , H02M3/156 , H02M3/335 , H02M3/00
CPC分类号： H02M1/32 , G05F3/262 , H02M3/156 , H02M3/33507 , H02M7/003 , H02M2001/0093 , H03K17/0822
摘要： Methods and apparatuses to trim current limit (Ip) and frequency (f) to maintain a constant maximum power. In one aspect of the invention, a power supply regulator having a peak current limit detection threshold and an operating frequency is disclosed. The peak current limit threshold or the operating frequency are adjusted specifically to maintain the Ipm·fn product substantially constant from one power supply controller to another where m is substantially equal to 2 and n is substantially equal to 1. In another aspect of the invention, the power supply regulator has a control circuit having a control threshold current. The peak current limit threshold or the operating frequency are adjusted specifically to maintain the product of Ipm·fn divided by the control threshold current substantially constant from one power supply controller to another where m is substantially equal to 2 and n is substantially equal to 1.
摘要翻译：限制电流极限（I SUB）和频率（f）的方法和装置以维持恒定的最大功率。在本发明的一个方面，公开了具有峰值电流限制检测阈值和工作频率的电源调节器。峰值电流限制阈值或工作频率被特别地调整，以保持从一个电源控制器基本上恒定的电压I n 到另一个，其中m基本上等于2，并且n基本上等于1.在本发明的另一方面，电源调节器具有具有控制阈值电流的控制电路。对峰值电流限制阈值或工作频率进行特殊调整，以保持I / O的乘积除以控制阈值电流从一个电源控制器基本上恒定到另一个，其中m基本上等于2，并且n基本上等于1。

26. 发明申请

US20050066202A1 Methods and arrangements for providing multiple concurrent desktops and workspaces in a shared computing environment 有权
标题翻译：在共享计算环境中提供多个并发桌面和工作区的方法和安排
公开(公告)号：US20050066202A1
公开(公告)日：2005-03-24
申请号：US10966571
申请日：2004-10-15
申请人： Christopher Evans , Giampiero Sierra , Victor Tan , Praerit Garg , David Matthews , Reiner Fink , Paul Hellyar
发明人： Christopher Evans , Giampiero Sierra , Victor Tan , Praerit Garg , David Matthews , Reiner Fink , Paul Hellyar
IPC分类号： G06F21/20 , G06F9/44 , G06F9/46 , H04L9/00
CPC分类号： G06F9/451
摘要： Methods and arrangements are provided for use in multiple user computing environments. These methods and arrangements can be configured to allow for a plurality of separate and concurrent desktops and workspaces within the shared computing environment. One method includes creating a separate desktop thread for each user that is authenticated during a logon process, creating a separate desktop associated with each desktop thread, and maintaining a list of desktop threads that are created. In this manner, several users can be logged on simultaneously. In certain implementations, the method further includes establishing a separate user environment associated with each desktop and launching a separate user shell associated with each desktop. The list of desktop threads allows for selective and/or automatic switching from a first desktop to a second desktop without terminating a desktop thread associated with the first desktop. The methods and arrangements are also applicable to remote process logon and switching.
摘要翻译：提供了在多个用户计算环境中使用的方法和布置。这些方法和布置可以被配置为允许在共享计算环境内的多个单独的和并发的桌面和工作空间。一种方法包括为登录过程中进行身份验证的每个用户创建单独的桌面线程，创建与每个桌面线程相关联的单独桌面，以及维护创建的桌面线程列表。以这种方式，几个用户可以同时登录。在某些实现中，该方法还包括建立与每个桌面相关联的单独的用户环境并且启动与每个桌面相关联的单独的用户外壳。桌面线程列表允许从第一桌面到第二桌面的选择性和/或自动切换，而不终止与第一台桌面相关联的桌面线程。方法和布置也适用于远程进程登录和切换。

27. 发明授权

US09041660B2 Soft keyboard control 有权
标题翻译：软键盘控制
公开(公告)号：US09041660B2
公开(公告)日：2015-05-26
申请号：US12330529
申请日：2008-12-09
申请人： Jan-Kristian Markiewicz , Reed Townsend , David Matthews , Vishnu Sivaji
发明人： Jan-Kristian Markiewicz , Reed Townsend , David Matthews , Vishnu Sivaji
IPC分类号： G06F3/041 , G06F3/0488 , G06F3/042
CPC分类号： G06F3/0488 , G06F3/0426 , G06F2203/04804 , G06F2203/04808
摘要： This document describes tools associated with soft keyboard control functions. In some implementations, the tools recognize a keyboard launch gesture on a touch sensitive screen and present a preview of a keyboard on the touch sensitive screen responsive to the launch gesture. The tools can also display the keyboard on the touch sensitive screen responsive to cessation of the launch gesture.
摘要翻译：本文档介绍与软键盘控制功能相关的工具。在一些实施方式中，工具识别触敏屏幕上的键盘启动手势，并且响应于发射手势呈现触敏屏幕上的键盘的预览。响应于停止启动手势，这些工具还可以在触摸屏上显示键盘。

28. 发明授权

US08802692B2 Synergistic effects between sphingosine-1-phosphate receptor antagonists and antimicrotubule agents 有权
标题翻译：鞘氨醇-1-磷酸受体拮抗剂和抗微管剂之间的协同作用
公开(公告)号：US08802692B2
公开(公告)日：2014-08-12
申请号：US13124586
申请日：2009-10-16
申请人： Geetha Shankar , Frauke Bentzien , Peter Lamb , David Matthews
发明人： Geetha Shankar , Frauke Bentzien , Peter Lamb , David Matthews
IPC分类号： A61K31/44 , A01N43/36 , A61K31/40
CPC分类号： A61K31/4196 , A61K31/16 , A61K31/337 , A61K31/34 , A61K31/4192 , A61K31/435 , A61K2300/00
摘要： This invention is based on the discovery that the administration of a sphingosine-1-phosphate receptor antagonist (S1P) and at least one chemotherapeutic agent selected from the the group of antimicrotubule agents provides an unexpectedly superior treatment for cancer. Antimicrobial agents such as the taxane compounds are known in the art, for example, paclitaxel (available as TAXOL® from Bristol-Myers Squibb, Princeton, N.J.), docetaxel (available as TAXOTERE® from Sanofi-aventis, Bridgewater, N.J.) and the like and other compounds that act as antimicrotubule agents, such as Vincristine (ONCOVIN®, VINCASAR PFS®, VCR), Vinblastin (VELBAN®, VELSAR®) and Vinorelbine, and similar compounds. The present invention also provides methods of modulating the growth of selected cell populations, such as cancer cells, by administering a therapeutically effective amount of at least one sphingosine-1-phosphate 1 (S1P1R) receptor antagonists, and at least one antimicrotubule agent.
摘要翻译：本发明基于以下发现：施用鞘氨醇-1-磷酸受体拮抗剂（S1P）和选自抗微管剂组的至少一种化学治疗剂提供了对于癌症的意想不到的优异治疗。抗菌剂如紫杉烷化合物是本领域已知的，例如紫杉醇（可从Bristol-Myers Squibb，Princeton，NJ获得），多西紫杉醇（可从Sanofi-aventis，Bridgewater，NJ获得）和类似物和其它作为抗微管剂的化合物，如长春新碱（ONCVIN®，VINCASARPFS®，VCR），长春花碱（VELBAN®，VELSAR）和长春瑞滨等）和类似化合物。本发明还提供了通过施用治疗有效量的至少一种鞘氨醇-1-磷酸1（S1P1R）受体拮抗剂和至少一种抗微管剂来调节所选细胞群体如癌细胞的生长的方法。

29. 发明申请

US20140221374A1 RAF KINASE INHIBITORS 审中-公开
标题翻译： RAF激酶抑制剂
公开(公告)号：US20140221374A1
公开(公告)日：2014-08-07
申请号：US14005720
申请日：2012-03-16
申请人： Jean-Michel Vernier , Stephanie Hopkins , Pierre-Yves Bounaud , Patrick O'Connor , David Matthews , Steve Bender
发明人： Jean-Michel Vernier , Stephanie Hopkins , Pierre-Yves Bounaud , Patrick O'Connor , David Matthews , Steve Bender
IPC分类号： C07D417/14 , C07D403/14 , C07D401/14 , C07D401/04 , C07D403/04 , C07D417/04
CPC分类号： C07D417/14 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D471/04
摘要： Described herein are compounds, pharmaceutical compositions and methods for the inhibition of RAF kinase mediated signaling. Said compounds, pharmaceutical compositions and methods have utility in the treatment of human disease and disorders.
摘要翻译：本文描述了用于抑制RAF激酶介导的信号传导的化合物，药物组合物和方法。所述化合物，药物组合物和方法可用于治疗人类疾病和病症。

30. 发明授权

US08750161B1 Metropolitan IP aggregation network design tool 失效
标题翻译：大都会IP聚合网络设计工具
公开(公告)号：US08750161B1
公开(公告)日：2014-06-10
申请号：US12972651
申请日：2010-12-20
申请人： David Matthews , Promod Kumar Bhagat , Robert Duncan Doverspike , John Gregory Klincewicz , Jian Li , Guangzhi Li , David Frederick Lynch , Moshe Segal , Dongmei Wang
发明人： David Matthews , Promod Kumar Bhagat , Robert Duncan Doverspike , John Gregory Klincewicz , Jian Li , Guangzhi Li , David Frederick Lynch , Moshe Segal , Dongmei Wang
IPC分类号： H04L12/28
CPC分类号： H04W40/02 , H04L45/12 , H04L45/64
摘要： In a tool for use by network planners in designing metropolitan IP aggregation networks, several optimization methods are integrated into a tool. A k-means algorithm is used to choose access packet switch locations. A dual-k-means algorithm is used to choose the backbone switch locations. Each access packet switch is dual homed to two backbone packet switches using two diverse paths. The diverse path configuration is found using a maxflow-mincost algorithm on a modified fiber map topology. The link topology connecting the backbone packet switches to each other is designed using a heuristic that creates a skeleton network topology and then adds express links one by one, testing each link to assure reduced overall network cost. The resulting network topology is then improved upon by local search.
摘要翻译：在网络规划者用于设计城域IP聚合网络的工具中，将几种优化方法集成到工具中。 k-means算法用于选择接入分组交换机的位置。双k均值算法用于选择主干交换机的位置。每个接入分组交换机被双重归属到两个主干分组交换机，使用两个不同的路径。在修改的光纤映射拓扑上使用maxflow-mincost算法找到不同的路径配置。将骨干分组交换机连接到彼此的链路拓扑结构使用启发式设计，创建骨架网络拓扑，然后逐个添加快速链接，测试每个链路以确保降低整体网络成本。然后通过本地搜索来改进所得到的网络拓扑。

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