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21. 发明申请

US20120093723A1 NANOCARRIER COMPOSITIONS AND METHODS 有权
标题翻译： NANOCARRIER组合物和方法
公开(公告)号：US20120093723A1
公开(公告)日：2012-04-19
申请号：US13255635
申请日：2010-03-16
申请人： Patrick J. Sinko , Stanley Stein , Simi Gunaseelan , Shahrair Pooyan , Matthew S. Palombo , Xiaoping Zhang
发明人： Patrick J. Sinko , Stanley Stein , Simi Gunaseelan , Shahrair Pooyan , Matthew S. Palombo , Xiaoping Zhang
IPC分类号： A61K51/00 , A61K39/00 , C12N9/96 , A61K38/00 , C07K16/00 , A61K49/00 , A61K38/54 , B82Y5/00
CPC分类号： A61K47/42 , A61K9/5169
摘要： This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable difunctional moiety, as well as methods of using this nanocarrier.
摘要翻译：本发明提供用于体内递送生物活性剂的多聚体纳米载体，其包含与一种或多种所述生物活性剂可逆地或不可逆地连接的至少两种肽单体，其中所述两种或多种所述肽单体通过可生物降解的双官能部分共价连接，以及使用该纳米载体的方法。

22. 发明申请

US20110087004A1 ENHANCED ORAL TRANSCOMPARTMENTAL DELIVERY OF THERAPEUTIC OR DIAGNOSTIC AGENTS 审中-公开
标题翻译：治疗或诊断药物的加强口服转运
公开(公告)号：US20110087004A1
公开(公告)日：2011-04-14
申请号：US12818955
申请日：2010-06-18
申请人： Srinivasan Ramanathan , Stanley Stein , Michael Leibowitz , Patrick J. Sinko , Tamara Minko , Gregory C. Williams , Goubao Zhang , Xiaoping Zhang , Shahrair Pooyan , Seong Hee Park , Bo Qiu , Pankaj Paranjpe
发明人： Srinivasan Ramanathan , Stanley Stein , Michael Leibowitz , Patrick J. Sinko , Tamara Minko , Gregory C. Williams , Goubao Zhang , Xiaoping Zhang , Shahrair Pooyan , Seong Hee Park , Bo Qiu , Pankaj Paranjpe
IPC分类号： C07K7/06
CPC分类号： A61K38/08 , A61K47/60 , A61K47/62 , A61K47/665 , B82Y5/00
摘要： The invention is directed to pharmaceutical compositions and methods for delivery of a therapeutic or diagnostic agent from one bodily compartment to one or more other bodily compartment by administering one of the following conjugates: a polymer having multiple functional groups at least one of which is covalently bound to a therapeutic or diagnostic agent, and at least one cell uptake promoter covalently bound to the therapeutic or diagnostic agent; or a polymer and at least one cell uptake promoter bound thereto; the polymer further comprising multiple functional groups at least one of which is covalently bound a therapeutic or diagnostic agent.
摘要翻译：本发明涉及通过施用以下缀合物之一将治疗剂或诊断剂从一个身体隔室递送至一个或多个其它身体隔室的药物组合物和方法：具有多个官能团的聚合物，其中至少一个共价结合至少一种与治疗剂或诊断剂共价结合的细胞摄取促进剂; 或与其结合的聚合物和至少一种细胞摄取促进剂; 所述聚合物还包含多个官能团，其中至少一个与治疗剂或诊断剂共价结合。

23. 发明授权

US07846893B2 Drug-polymer conjugates coupled to a peptidic carrier 有权
标题翻译：与肽载体偶联的药物 - 聚合物共轭物
公开(公告)号：US07846893B2
公开(公告)日：2010-12-07
申请号：US11816317
申请日：2006-02-16
申请人： Patrick J. Sinko , Stanley Stein , Simi Gunaseelan , Shahriar Pooyan , Li Wan , Xiaoping Zhang
发明人： Patrick J. Sinko , Stanley Stein , Simi Gunaseelan , Shahriar Pooyan , Li Wan , Xiaoping Zhang
IPC分类号： A61K38/00 , A61K38/06 , A61K38/08 , A01N25/34
CPC分类号： A61K47/64 , A61K47/60
摘要： Monodisperse macromolecular conjugate compositions of a peptidic carrier irreversibly or reversibly conjugated with one or more effectors and one or more therapeutic agents, wherein at least one effector or therapeutic agent is attached to a pendant reactive group on said peptidic carrier via a water-soluble polymer. Monodispersity is obtained through the use of orthogonal and separate conjugation reactions.
摘要翻译：肽载体的单分散大分子缀合物组合物与一种或多种效应物和一种或多种治疗剂不可逆地或可逆地缀合，其中至少一种效应物或治疗剂通过水溶性聚合物连接到所述肽载体上的侧链反应性基团上。通过使用正交和分离的共轭反应获得单分散性。

24. 发明申请

US20060078910A1 Polygonal nanostructures of polynucleic acid multi-crossover molecules and assembly of lattices based on double crossover cohesion 有权
公开(公告)号：US20060078910A1
公开(公告)日：2006-04-13
申请号：US11148423
申请日：2005-06-09
申请人： Nadrian Seeman , Baoquan Ding , Pamela Constantinou , Tong Wang , Jens Kopatsch , Xiaoping Zhang , Ruojie Sha , Lisa Israel
发明人： Nadrian Seeman , Baoquan Ding , Pamela Constantinou , Tong Wang , Jens Kopatsch , Xiaoping Zhang , Ruojie Sha , Lisa Israel
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12N15/1031 , B82Y5/00 , B82Y40/00 , C07H21/02 , C12N15/10 , C12N15/1027
摘要： Robust nucleic acid arrays and lattices are assembled based on double crossover cohesion of polygonal units whose edges are composed of nucleic acid multi-crossover domains.

25. 发明授权

US08930247B1 System and methods for content-based financial decision making support 有权
标题翻译：基于内容的财务决策支持系统和方法
公开(公告)号：US08930247B1
公开(公告)日：2015-01-06
申请号：US12023934
申请日：2008-01-31
申请人： Xiaoping Zhang , David Kedmey , Fang Wang
发明人： Xiaoping Zhang , David Kedmey , Fang Wang
IPC分类号： G06Q30/00 , G06Q10/06 , G06F17/18
CPC分类号： G06Q10/0639 , G06F17/18 , G06Q40/04 , G06Q40/06
摘要： Robust content-based decision-making support is enabled by software with a customizable knowledge base. Utilizing proprietary information contained within a knowledge base, the software enables users to search the indexed database by feature, example firm, or pattern and update the knowledge base based on the results. The information contained in the knowledge base enables results to be ranked by relevance and enables other feedback to be provided. The system and methods provide process support by helping financial professionals identify, analyze, and construct data analysis patterns based on individual domain knowledge and preferences. The system and methods automatically detect abnormal patterns and automatically analyze their correlations to market events to provide further process support to financial professionals. Using the results of any searching, analysis, and processing, the system and methods provide a neural network or other learning algorithm to provide content-based decision-making support.
摘要翻译：基于内容的稳定的决策支持由具有可定制知识库的软件实现。利用知识库中包含的专有信息，该软件使用户能够通过特征，示例公司或模式搜索索引数据库，并根据结果更新知识库。知识库中包含的信息可使结果按照相关性进行排名，并提供其他反馈信息。系统和方法通过帮助金融专业人员根据个人领域知识和偏好来识别，分析和构建数据分析模式来提供流程支持。系统和方法自动检测异常模式，并自动分析其与市场事件的相关性，为财务专业人员提供进一步的流程支持。使用任何搜索，分析和处理的结果，系统和方法提供神经网络或其他学习算法来提供基于内容的决策支持。

26. 发明授权

US08458065B1 System and methods for content-based financial database indexing, searching, analysis, and processing 失效
标题翻译：基于内容的财务数据库索引，搜索，分析和处理的系统和方法
公开(公告)号：US08458065B1
公开(公告)日：2013-06-04
申请号：US12023908
申请日：2008-01-31
申请人： Xiaoping Zhang , David Kedmey , Fang Wang
发明人： Xiaoping Zhang , David Kedmey , Fang Wang
IPC分类号： G06Q40/00
CPC分类号： G06Q10/0639 , G06F17/18 , G06Q40/04 , G06Q40/06
摘要： Robust content-based financial data processing is enabled by software with a customizable knowledge base. The software indexes a publicly or privately available financial database based on the content of the database records. Utilizing proprietary information contained within a knowledge base, the software enables users to search the indexed database by feature, example firm, or pattern. The information contained in the knowledge base enables results to be ranked by relevance. Moreover, users provide feedback about search results to enhance the knowledge base. Software analyzes data by using adaptive signal processing to remove market trends or noise and enable complicated market research.
摘要翻译：可靠的基于内容的财务数据处理由具有可定制知识库的软件启用。该软件根据数据库记录的内容对公开或私有的财务数据库进行索引。利用知识库中包含的专有信息，该软件使用户能够通过特征，示例公司或模式搜索索引数据库。知识库中包含的信息可使结果按相关性排名。此外，用户提供关于搜索结果的反馈以增强知识库。软件通过使用自适应信号处理来分析数据，以消除市场趋势或噪音，并实现复杂的市场调研

27. 发明申请

US20130008966A1 INTELLIGENT TRAY AND METHOD OF MAKING THE SAME 审中-公开
标题翻译：智能托盘及其制作方法
公开(公告)号：US20130008966A1
公开(公告)日：2013-01-10
申请号：US13402832
申请日：2012-02-22
申请人： Ming Wa TAM , Huimin Wang , Yee Ping Chan , Xiaoping Zhang , Zhiguang Jiang
发明人： Ming Wa TAM , Huimin Wang , Yee Ping Chan , Xiaoping Zhang , Zhiguang Jiang
IPC分类号： G06K19/077 , B32B37/16
CPC分类号： H05K13/0084 , H01L21/67333
摘要： An intelligent tray for chips includes a main body having a readable and writable memory unit thereon. The readable and writable memory unit has parameters related to the intelligent tray written therein. The parameters written in the readable and writable memory unit can be read out automatically by a machine, and no need to be manually checked one by one. This helps to automate production, improve production efficiency and shorten production cycle.
摘要翻译：用于芯片的智能托盘包括其上具有可读写的存储单元的主体。可读写的存储单元具有与其中写入的智能盘相关的参数。写入可读写的存储单元中的参数可以由机器自动读出，不需要逐个手动检查。这有助于生产自动化，提高生产效率，缩短生产周期。

28. 发明授权

US09421272B2 Nanocarrier compositions and methods 有权
标题翻译：纳米载体组成和方法
公开(公告)号：US09421272B2
公开(公告)日：2016-08-23
申请号：US13255635
申请日：2010-03-16
申请人： Patrick J. Sinko , Stanley Stein , Simi Gunaseelan , Shahriar Pooyan , Matthew Sean Palombo , Xiaoping Zhang
发明人： Patrick J. Sinko , Stanley Stein , Simi Gunaseelan , Shahriar Pooyan , Matthew Sean Palombo , Xiaoping Zhang
IPC分类号： A61K51/00 , A61K39/00 , C12N9/96 , A61K38/00 , C07K16/00 , A61K49/00 , A61K38/54 , A61K47/42 , A61K9/51 , B82Y5/00
CPC分类号： A61K47/42 , A61K9/5169
摘要： This invention provides multimeric nanocarrier for in vivo delivery of a bioactive agent, comprising at least two peptide monomers reversibly or irreversibly linked with one or more of said bioactive agents, wherein said two or more of said peptide monomers are covalently linked by a biodegradable difunctional moiety, as well as methods of using this nanocarrier.
摘要翻译：本发明提供用于体内递送生物活性剂的多聚体纳米载体，其包含与一种或多种所述生物活性剂可逆地或不可逆地连接的至少两种肽单体，其中所述两种或多种所述肽单体通过可生物降解的双官能部分共价连接，以及使用该纳米载体的方法。

29. 发明授权

US09384780B2 System and method for video summarization and navigation based on statistical models 有权
标题翻译：基于统计模型的视频摘要和导航系统和方法
公开(公告)号：US09384780B2
公开(公告)日：2016-07-05
申请号：US14246869
申请日：2014-04-07
申请人： Xiaoping Zhang , Junfeng Jiang
发明人： Xiaoping Zhang , Junfeng Jiang
IPC分类号： H04N5/783 , H04N9/80 , G11B27/00 , H04N5/14 , H04N5/93 , H04N21/44 , H04N21/472 , H04N21/845 , G06F17/30 , H04N9/82
CPC分类号： G11B27/005 , G06F17/30846 , H04N5/147 , H04N5/783 , H04N5/93 , H04N9/8227 , H04N21/44008 , H04N21/47217 , H04N21/8456
摘要： The disclosed method calculates video time density functions based on inter-frame mutual information or other similarity measures. The method includes acquiring a video sequence from memory, computing mutual information or other similarity measures between two consecutive frames of the video sequence, and constructing a video temporal density function based on the mutual information or similarity measures. The method enables fast navigation of the video sequence by performing a temporal quantization of the video time density function to determine a set of quanta. The video sequence can be navigated using the nearest neighbor video frames to the set of quanta. The method enables thumbnail extraction of a video sequence using statistical modeling by performing a temporal quantization of the video time density function to segment video sequence in time domain and using mixture (such as Gaussian mixture and ICA mixture) vector quantization to find the sample frames for each temporal segment.
摘要翻译：所公开的方法基于帧间相互信息或其他相似性度量来计算视频时间密度函数。该方法包括从存储器获取视频序列，计算视频序列的两个连续帧之间的相互信息或其他相似性度量，以及基于相互信息或相似性度量构建视频时间密度函数。该方法通过执行视频时间密度函数的时间量化来确定一组量子，从而能够快速导航视频序列。视频序列可以使用最近邻视频帧导航到量子集。该方法通过使用视频时间密度函数的时间量化来在时域中分割视频序列并使用混合（诸如高斯混合和ICA混合）矢量量化来使用统计建模缩略图提取视频序列，以找到用于每个时间段。

30. 发明申请

US20160019218A1 SYSTEM AND METHOD FOR USING DATA INCIDENT BASED MODELING AND PREDICTION 审中-公开
标题翻译：使用基于数据事件的建模和预测的系统和方法
公开(公告)号：US20160019218A1
公开(公告)日：2016-01-21
申请号：US14750669
申请日：2015-06-25
申请人： Xiaoping Zhang , David Kedmey , Fang Wang
发明人： Xiaoping Zhang , David Kedmey , Fang Wang
IPC分类号： G06F17/30
CPC分类号： G06F16/2457 , G06F16/2428 , G06F2216/03 , G06Q40/04
摘要： A system and method for enabling information extraction from large data sets (so-called “big data”) according to a new paradigm is disclosed. This system does not generate functions describing why certain inputs result in certain outputs. Instead, it creates incident mappings of inputs to outputs without regard to why inputs result in outputs. These mappings can be distributions or other data sets representative of different outcomes occurring. This enables several useful operations. For example, by providing a data set indicative of outputs that have historically occurred following a particular input, the disclosed system can be used to predict future outcomes with probabilities. For example, if a particular stock price pattern is provided as an input, the system generates an output data set indicating the probabilities of certain price behaviors following that input pattern. This data set can thus be used to predict future behavior. Other useful operations are disclosed herein.
摘要翻译：公开了一种用于根据新范例从大数据集（所谓的“大数据”）提取信息的系统和方法。该系统不会产生描述为什么某些输入导致某些输出的功能。相反，它会创建对输出的输入的事件映射，而不考虑为什么输入会导致输出。这些映射可以是代表不同结果发生的分布或其他数据集。这样可以进行几个有用的操作。例如，通过提供指示在特定输入之后历史地发生的输出的数据集，所公开的系统可以用于以概率来预测未来的结果。例如，如果提供特定股票价格模式作为输入，则系统生成指示在该输入模式之后的某些价格行为的概率的输出数据集。因此，该数据集可用于预测将来的行为。本文公开了其它有用的操作。

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