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    • 21. 发明授权
    • Transdermal systems for the delivery of ionic agents directly to open wounds and surgically repaired incisions
    • 用于将离子剂直接递送至开放性伤口和手术修复的切口的透皮系统
    • US08295924B2
    • 2012-10-23
    • US13009999
    • 2011-01-20
    • Carter R. AndersonRussell L. MorrisRobert Cohen
    • Carter R. AndersonRussell L. MorrisRobert Cohen
    • A61N1/30A61M31/00A61F13/00
    • A61N1/0448
    • A transdermal system for the delivery of an anesthetic or other active therapeutic agent directly to a selected site of injured skin tissue by iontophoresis is disclosed, which utilizes a transdermal skin-worn patch including a donor electrode chamber containing a donor electrode and an amount of an active agent in a form suitable for transdermal delivery in electrical communication with the donor electrode and a return electrode. The patch also contains a source of electric current connected in a circuit with the donor and return electrode, a current regulating device is optionally provided in the circuit for controlling the electrical output of the patch and at least the donor electrode chamber includes a provision for absorbing a quantity of fluid associated with weepage from adjacent injured skin tissue.
    • 公开了一种用于通过离子电渗法将麻醉剂或其它活性治疗剂直接递送至受损皮肤组织的选定部位的透皮系统,其利用透皮的皮肤佩戴的贴片,其包括供体电极室,其包含施主电极和 活性剂,其形式适合于与供体电极和返回电极电连通的透皮递送。 贴片还包含与供体和返回电极在电路中连接的电流源,电路中可选地提供电流调节装置,用于控制贴片的电输出,并且至少供体电极室包括用于吸收 与来自相邻受伤皮肤组织的渗漏相关的一定量的流体。
    • 24. 发明申请
    • Dosage Control Electrode for Iontophoresis Device
    • 离子电渗装置用量控制电极
    • US20100324470A1
    • 2010-12-23
    • US12868123
    • 2010-08-25
    • Carter R. AndersonRussell L. Morris
    • Carter R. AndersonRussell L. Morris
    • A61N1/30A61N1/00
    • A61N1/0436A61N1/044
    • An electrode assembly for use in an iontophoresis device for the transcutaneous administration of an active therapeutic species has a base layer of including a linking conductive base material which is consumed (oxidizes or reduces) preferentially to water, a first upper layer of sacrificial material coated on a first portion of the base layer wherein the sacrificial material is consumed preferentially to the linking conductive base material of the base layer. A second upper layer of non-conducting material is coated on a second portion of the base layer, the second upper layer being spaced from the first upper layer, connected by a narrow exposed linking area of the base layer material remaining exposed therebetween. During operation of an associated iontophoresis device, the sacrificial material will be sequentially consumed; the first upper layer will be fully consumed followed by the linking conductive base material of the exposed linking area of the base layer which severs the base layer thereby breaking circuit continuity disabling activity in the device. A visual indicator may be provided allowing a wearer to monitor the state of reaction of the linking area.
    • 用于经皮给药活性治疗物种的离子电渗疗法装置的电极组件具有包含优先吸收(氧化或还原)水的连接导电基材的基层,涂覆在第一上层的牺牲材料 基底层的第一部分,其中牺牲材料优先地消耗到基底层的连接导电基底材料。 第二上层非导电材料被涂覆在基层的第二部分上,第二上层与第一上层隔开,第二上层由保留在其间的基层材料的窄暴露的连接区连接。 在相关联的离子电渗装置的操作期间,牺牲材料将被顺序消耗; 第一上层将被完全消耗,之后是基底层的暴露的连接区域的连接导电基底材料,其切断基底层,从而破坏器件中的电路连续性失效活动。 可以提供视觉指示器,允许佩戴者监视连接区域的反应状态。