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21. 发明授权

US06410325B1 Antisense modulation of phospholipase A2, group VI (Ca2+-independent) expression 有权
标题翻译：磷脂酶A2，VI（Ca2 + - 独立）表达的反义调节
公开(公告)号：US06410325B1
公开(公告)日：2002-06-25
申请号：US09851896
申请日：2001-05-09
申请人： C. Frank Bennett , Susan M. Freier , Andrew T. Watt
发明人： C. Frank Bennett , Susan M. Freier , Andrew T. Watt
IPC分类号： C12Q168
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/01004 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Phospholipase A2, group VI (Ca2+-independent). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Phospholipase A2, group VI (Ca2+-independent). Methods of using these compounds for modulation of Phospholipase A2, group VI (Ca2+-independent) expression and for treatment of diseases associated with expression of Phospholipase A2, group VI (Ca2+-independent) are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节磷脂酶A2，VI（Ca 2+独立）的表达。组合物包含靶向编码磷脂酶A2，组VI（Ca 2+独立）的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节磷脂酶A2，VI（Ca2 + - 独立）表达和治疗与磷脂酶A2，VI（Ca2 + - 独立型）表达相关的疾病的方法。

22. 发明授权

US06300491B1 Oligonucleotide inhibition of cell adhesion 失效
标题翻译：寡核苷酸抑制细胞粘附
公开(公告)号：US06300491B1
公开(公告)日：2001-10-09
申请号：US09009490
申请日：1998-01-20
申请人： C. Frank Bennett , Christopher K. Mirabelli
发明人： C. Frank Bennett , Christopher K. Mirabelli
IPC分类号： C07H2102
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/70525 , C07K14/70542 , C07K14/70564 , C12N15/1138 , C12N2310/315 , C12N2310/322 , C12N2310/352 , C12N2310/3533
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to treatment through modulation of the synthesis or metabolism of intercellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, 5′-untranslated sequences, 3′-untranslated sequences, and intervening sequences. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating cell adhesion proteins with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation cell adhesion molecules are disclosed.
摘要翻译：提供组合物和方法，用于治疗和诊断适于通过调节细胞间粘附分子的合成或代谢来治疗的疾病。根据优选实施方案，提供了与编码细胞间粘附分子-1，血管细胞粘附分子-1和内皮细胞粘附分子-1的核酸特异性杂交的寡核苷酸。所述寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。在其它优选实施方案中，寡核苷酸与转录起始位点，翻译起始位点，5'-非翻译序列，3'非翻译序列和插入序列特异性杂交。公开了通过用与上述蛋白质之一相对应的RNA或DNA特异性杂交的寡核苷酸调节细胞粘附蛋白来治疗患有治疗性干预的疾病的方法。公开了治疗响应于调节细胞粘附分子的疾病的方法。

23. 发明授权

US06294382B1 Antisense modulation of SRC-1 expression 有权
标题翻译： SRC-1表达的反义调制
公开(公告)号：US06294382B1
公开(公告)日：2001-09-25
申请号：US09723534
申请日：2000-11-27
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/00 , C07K14/4705 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q1/689 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of SRC-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding SRC-1. Methods of using these compounds for modulation of SRC-1 expression and for treatment of diseases associated with expression of SRC-1 are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节SRC-1的表达。组合物包含靶向编码SRC-1的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节SRC-1表达和治疗与SRC-1表达相关的疾病的方法。

24. 发明授权

US06190869B1 Antisense inhibition of protein kinase C-theta expression 有权
标题翻译：蛋白激酶C-θ表达的反义抑制
公开(公告)号：US06190869B1
公开(公告)日：2001-02-20
申请号：US09429322
申请日：1999-10-26
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C07H2104
CPC分类号： C12N15/1137 , A61K38/00 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Q1/6883 , C12Y207/11013 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Protein kinase C-theta. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Protein kinase C-theta. Methods of using these compounds for modulation of Protein kinase C-theta expression and for treatment of diseases associated with expression of Protein kinase C-theta are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节蛋白激酶C-θ的表达。组合物包含靶向编码蛋白激酶C-θ的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节蛋白激酶C-θ表达和治疗与蛋白激酶C-θ表达相关的疾病的方法。

25. 发明授权

US06177273B1 Antisense modulation of integrin-linked kinase expression 有权
标题翻译：整合素连接激酶表达的反义调控
公开(公告)号：US06177273B1
公开(公告)日：2001-01-23
申请号：US09428219
申请日：1999-10-26
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C07H2104
CPC分类号： C12Q1/6883 , A61K48/00 , C07B2200/11 , C07H21/00 , C12N9/1205 , C12N15/1137 , C12N2310/321 , C12N2310/3341 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Integrin-linked kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Integrin-linked kinase. Methods of using these compounds for modulation of Integrin-linked kinase expression and for treatment of diseases associated with expression of Integrin-linked kinase are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节整联蛋白连接的激酶的表达。组合物包含针对编码整联蛋白连接的激酶的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节整联蛋白连接的激酶表达和治疗与整联蛋白连接的激酶表达相关的疾病的方法。

26. 发明授权

US6165788A Antisense modulation of Survivin expression 失效
公开(公告)号：US6165788A
公开(公告)日：2000-12-26
申请号：US286407
申请日：1999-04-05
申请人： C. Frank Bennett , Elizabeth J. Ackermann , Eric E. Swayze , Lex M. Cowsert
发明人： C. Frank Bennett , Elizabeth J. Ackermann , Eric E. Swayze , Lex M. Cowsert
IPC分类号： C07H21/04 , A61K31/7088 , A61K31/712 , A61K48/00 , A61P35/00 , C07H21/00 , C12P21/04 , C07H21/02 , C12Q1/68
CPC分类号： C07H21/00 , C07B2200/11
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.

27. 发明授权

US06150162A Antisense modulation of CD44 expression 有权
标题翻译： CD44表达的反义调制
公开(公告)号：US06150162A
公开(公告)日：2000-11-21
申请号：US213719
申请日：1998-12-17
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： A61K38/00 , C12N15/113 , C12Q1/68 , C07H21/00 , C07H21/02 , C07H21/04 , C12P13/34
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of CD44. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD44. Methods of using these compounds for modulation of CD44 expression and for treatment of diseases associated with expression of CD44 are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节CD44的表达。组合物包含靶向编码CD44的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节CD44表达和治疗与CD44表达相关的疾病的方法。

28. 发明授权

US6140126A Antisense modulation of Y-box binding protein 1 expression 失效
标题翻译： Y-box结合蛋白1表达的反义调制
公开(公告)号：US6140126A
公开(公告)日：2000-10-31
申请号：US429323
申请日：1999-10-26
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： A61K38/00 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N15/09
CPC分类号： C12N15/113 , C12Q1/6876 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Q2600/158 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Y-box binding protein 1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Y-box binding protein 1. Methods of using these compounds for modulation of Y-box binding protein 1 expression and for treatment of diseases associated with expression of Y-box binding protein 1 are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节Y盒结合蛋白1的表达。该组合物包含靶向编码Y盒结合蛋白1的核酸的反义化合物，特别是反义寡核苷酸1.使用这些化合物调节提供Y盒结合蛋白1表达和用于治疗与Y盒结合蛋白1的表达相关的疾病。

29. 发明授权

US6121047A Antisense modulation of SHP-1 expression 有权
标题翻译： SHP-1表达的反义调制
公开(公告)号：US6121047A
公开(公告)日：2000-09-19
申请号：US358685
申请日：1999-07-21
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P35/00 , A61P43/00 , C12N15/113 , C07H21/04 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/1137 , C12Y301/03048 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of SHP-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding SHP-1. Methods of using these compounds for modulation of SHP-1 expression and for treatment of diseases associated with expression of SHP-1 are provided.
摘要翻译：提供反义化合物，组合物和方法用于调节SHP-1的表达。组合物包含靶向编码SHP-1的核酸的反义化合物，特别是反义寡核苷酸。提供了使用这些化合物调节SHP-1表达和治疗与SHP-1表达相关的疾病的方法。

30. 发明授权

US6096722A Antisense modulation of cell adhesion molecule expression and treatment of cell adhesion molecule-associated diseases 失效
标题翻译：细胞粘附分子表达的反义调控和细胞粘附分子相关疾病的治疗
公开(公告)号：US6096722A
公开(公告)日：2000-08-01
申请号：US85759
申请日：1998-05-27
申请人： C. Frank Bennett , Christopher K. Mirabelli , Brenda Baker
发明人： C. Frank Bennett , Christopher K. Mirabelli , Brenda Baker
IPC分类号： A01N43/04 , A61K31/70 , A61K38/00 , A61K48/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346
摘要： Compositions and methods are provided for the modulation of expression of cellular adhesion molecules. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and endothelial leukocyte adhesion molecule-1. Methods of modulating expression of cellular adhesion molecules are provided, as are methods of treating conditions associated with cellular adhesion molecules. In a preferred embodiment, the cellular adhesion molecule is ICAM-1, and a preferred antisense sequence targeted to human ICAM-1 is demonstrated to have clinical utility in several disease indications.
摘要翻译：提供组合物和方法用于调节细胞粘附分子的表达。根据优选实施方案，提供了与编码细胞间粘附分子-1，血管细胞粘附分子-1和内皮细胞粘附分子-1的核酸特异性杂交的寡核苷酸。提供调节细胞粘附分子表达的方法，以及治疗与细胞粘附分子相关的病症的方法。在优选的实施方案中，细胞粘附分子是ICAM-1，并且针对人ICAM-1的优选反义序列证明在几种疾病适应症中具有临床效用。

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