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21. 发明申请

US20130266948A1 Apparatus and Methods for Integrated Sample PReparation, Reaction and Detection 审中-公开
标题翻译：综合样本检测，反应和检测的装置和方法
公开(公告)号：US20130266948A1
公开(公告)日：2013-10-10
申请号：US13759557
申请日：2013-02-05
申请人： Dylan Hilmer Bird , Jesus Ching , Bruce A. Johnson , Keith E. Moravick , Bruce Richardson
发明人： Dylan Hilmer Bird , Jesus Ching , Bruce A. Johnson , Keith E. Moravick , Bruce Richardson
IPC分类号： C12Q1/68
CPC分类号： B01L7/52 , B01F5/12 , B01F11/0071 , B01F15/0203 , B01F15/0237 , B01F2015/0221 , B01F2215/0037 , B01L3/502 , B01L3/502715 , B01L3/50851 , B01L3/523 , B01L3/527 , B01L7/00 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/044 , B01L2300/0627 , B01L2300/0654 , B01L2300/0672 , B01L2300/0829 , B01L2300/0867 , B01L2300/087 , B01L2300/1805 , B01L2400/0406 , B01L2400/043 , B01L2400/0478 , B01L2400/0481 , B01L2400/0622 , B01L2400/0633 , B01L2400/0644 , B01L2400/0683 , C12Q1/6806 , C12Q1/686 , G01N1/38 , G01N35/1079 , G01N2035/0436 , Y10T436/118339 , Y10T436/25375 , Y10T436/255
摘要： Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided, as are methods for using such cartridges. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.
摘要翻译：还提供了用于分离生物样品和样品上的下游生物测定的柱，以及使用这种盒的方法。在一个实施方案中，从生物样品中分离核酸样品，并且例如通过聚合酶链式反应扩增核酸样品。本文提供的盒还可用于分离非核酸样品，例如蛋白质，并对蛋白质进行下游反应，例如结合测定。还提供了用于进行下游生物测定和检测测定结果的仪器。

22. 发明授权

US08372340B2 Apparatus and methods for integrated sample preparation, reaction and detection 有权
标题翻译：综合样品制备，反应和检测的装置和方法
公开(公告)号：US08372340B2
公开(公告)日：2013-02-12
申请号：US13033129
申请日：2011-02-23
申请人： Dylan Hilmer Bird , Jesus Ching , Bruce A. Johnson , Keith E. Moravick , Bruce Richardson
发明人： Dylan Hilmer Bird , Jesus Ching , Bruce A. Johnson , Keith E. Moravick , Bruce Richardson
IPC分类号： B01J19/00
CPC分类号： B01L7/52 , B01F5/12 , B01F11/0071 , B01F15/0203 , B01F15/0237 , B01F2015/0221 , B01F2215/0037 , B01L3/502 , B01L3/502715 , B01L3/50851 , B01L3/523 , B01L3/527 , B01L7/00 , B01L2200/025 , B01L2200/026 , B01L2200/028 , B01L2200/0647 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/044 , B01L2300/0627 , B01L2300/0654 , B01L2300/0672 , B01L2300/0829 , B01L2300/0867 , B01L2300/087 , B01L2300/1805 , B01L2400/0406 , B01L2400/043 , B01L2400/0478 , B01L2400/0481 , B01L2400/0622 , B01L2400/0633 , B01L2400/0644 , B01L2400/0683 , C12Q1/6806 , C12Q1/686 , G01N1/38 , G01N35/1079 , G01N2035/0436 , Y10T436/118339 , Y10T436/25375 , Y10T436/255
摘要： Cartridges for the isolation of a biological sample and downstream biological assays on the sample are provided. In one embodiment, a nucleic acid sample is isolated from a biological sample and the nucleic acid sample is amplified, for example by the polymerase chain reaction. The cartridges provided herein can also be used for the isolation of non-nucleic acid samples, for example proteins, and to perform downstream reactions on the proteins, for example, binding assays. Instruments for carrying out the downstream biological assays and for detecting the results of the assays are also provided.
摘要翻译：提供用于分离生物样品的柱和样品上的下游生物测定。在一个实施方案中，从生物样品中分离核酸样品，并且例如通过聚合酶链式反应扩增核酸样品。本文提供的盒还可用于分离非核酸样品，例如蛋白质，并对蛋白质进行下游反应，例如结合测定。还提供了用于进行下游生物测定和检测测定结果的仪器。

23. 发明授权

US07723037B2 Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory disease 有权
标题翻译：用于诊断或监测自身免疫性和慢性炎性疾病的方法和试剂盒
公开(公告)号：US07723037B2
公开(公告)日：2010-05-25
申请号：US11850897
申请日：2007-09-06
申请人： Bruce Richardson , Qianjin Lu
发明人： Bruce Richardson , Qianjin Lu
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q1/6858 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2523/125
摘要： The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases.
摘要翻译：本发明涉及用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的组合物和方法。特别地，本发明提供了用于诊断，监测和治疗自身免疫性疾病（例如类风湿性关节炎）或慢性炎性疾病（例如，系统性红斑狼疮）的方法，其基于检测或改变（例如，改变自身免疫的表达或甲基化状态）或慢性炎性疾病蛋白（例如，CD70和CD40L）。本发明还提供用于检测自身免疫性或慢性炎性疾病蛋白（例如CD70和CD40L）的甲基化状态并用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的试剂盒。

24. 发明授权

US07279281B2 Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases 有权
标题翻译：用于诊断或监测自身免疫性和慢性炎性疾病的方法和试剂盒
公开(公告)号：US07279281B2
公开(公告)日：2007-10-09
申请号：US11142123
申请日：2005-06-01
申请人： Bruce Richardson , Qianjin Lu
发明人： Bruce Richardson , Qianjin Lu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6858 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2523/125
摘要： The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases.
摘要翻译：本发明涉及用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的组合物和方法。特别地，本发明提供了用于诊断，监测和治疗自身免疫性疾病（例如类风湿性关节炎）或慢性炎性疾病（例如，系统性红斑狼疮）的方法，其基于检测或改变（例如，改变自身免疫的表达或甲基化状态）或慢性炎性疾病蛋白（例如，CD70和CD40L）。本发明还提供用于检测自身免疫性或慢性炎性疾病蛋白（例如CD70和CD40L）的甲基化状态并用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的试剂盒。

25. 发明申请

US20170286337A1 TECHNOLOGIES FOR A DISTRIBUTED HARDWARE QUEUE MANAGER 审中-公开
公开(公告)号：US20170286337A1
公开(公告)日：2017-10-05
申请号：US15087154
申请日：2016-03-31
申请人： Ren Wang , Yipeng Wang , Jr-Shian Tsai , Andrew Herdrich , Tsung-Yuan Tai , Niall McDonnell , Stephen Van Doren , David Sonnier , Debra Bernstein , Hugh Wilkinson , Narender Vangati , Stephen Miller , Gage Eads , Andrew Cunningham , Jonathan Kenny , Bruce Richardson , William Burroughs , Joseph Hasting , An Yan , James Clee , Te Ma , Jerry Pirog , Jamison Whitesell
发明人： Ren Wang , Yipeng Wang , Jr-Shian Tsai , Andrew Herdrich , Tsung-Yuan Tai , Niall McDonnell , Stephen Van Doren , David Sonnier , Debra Bernstein , Hugh Wilkinson , Narender Vangati , Stephen Miller , Gage Eads , Andrew Cunningham , Jonathan Kenny , Bruce Richardson , William Burroughs , Joseph Hasting , An Yan , James Clee , Te Ma , Jerry Pirog , Jamison Whitesell
IPC分类号： G06F13/36 , G06F13/40 , G06F12/10 , G06F13/24
CPC分类号： G06F13/36 , G06F12/1027 , G06F13/24 , G06F13/4004 , G06F2212/1021 , G06F2212/50 , G06F2212/68
摘要： Technologies for a distributed hardware queue manager include a compute device having a procesor. The processor includes two or more hardware queue managers as well as two or more processor cores. Each processor core can enqueue or dequeue data from the hardware queue manager. Each hardware queue manager can be configured to contain several queue data structures. In some embodiments, the queues are addressed by the processor cores using virtual queue addresses, which are translated into physical queue addresses for accessing the corresponding hardware queue manager. The virtual queues can be moved from one physical queue in one hardware queue manager to a different physical queue in a different physical queue manager without changing the virtual address of the virtual queue.

26. 发明申请

US20170028594A1 METHOD OF FABRICATING CYLINDRICAL POLYMER MASK 有权
标题翻译：制备圆柱聚合物掩模的方法
公开(公告)号：US20170028594A1
公开(公告)日：2017-02-02
申请号：US15236240
申请日：2016-08-12
申请人： Boris Kobrin , Oliver Seitz , Bruce Richardson , Ian McMackin , Mukti Aryal , Bryant Grigsby
发明人： Boris Kobrin , Oliver Seitz , Bruce Richardson , Ian McMackin , Mukti Aryal , Bryant Grigsby
IPC分类号： B29C39/10 , B29C33/42 , G03F1/72 , B29C53/34 , B29C35/02 , B29C33/38 , B29C39/02
CPC分类号： B29C39/10 , B29C33/3857 , B29C33/424 , B29C35/02 , B29C39/026 , B29C39/148 , B29C53/34 , B29K2083/00 , B29L2031/757 , G03F1/72 , G03F7/0002 , Y10T428/24802
摘要： A cylindrical mask may be fabricated using a hollow casting cylinder and a mask cylinder. The casting cylinder has an inner diameter that is larger than the outer diameter of the mask cylinder. The casting and mask cylinders are coaxially assembled and a liquid polymer inserted in a space surrounding the mask cylinder between the inner surface of the casting cylinder and the outer surface of the mask cylinder. After curing the liquid polymer, the casting cylinder is removed. A surface of the cured polymer can be patterned. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.
摘要翻译：可以使用中空铸造圆筒和掩模筒来制造圆柱形掩模。铸造圆筒的内径大于荫罩圆筒的外径。铸造和掩模气缸同轴组装，并且液体聚合物插入在铸塑缸的内表面和掩模缸的外表面之间围绕掩模缸的空间中。在固化液体聚合物之后，移去铸造圆筒。固化的聚合物的表面可以被图案化。要强调的是，该摘要被提供以符合要求抽象的规则，允许搜索者或其他读者快速确定技术公开内容的主题。提交它的理解是，它不会用于解释或限制权利要求的范围或含义。

27. 发明申请

US20120152050A1 THREE-AXIS ROBOTIC SYSTEM WITH LINEAR BEARING SUPPORTS 有权
标题翻译：具有直线轴承支持的三轴机器人系统
公开(公告)号：US20120152050A1
公开(公告)日：2012-06-21
申请号：US13324640
申请日：2011-12-13
申请人： Bruce Richardson
发明人： Bruce Richardson
IPC分类号： B25J18/00
CPC分类号： B25J9/023 , Y10S901/16 , Y10S901/23 , Y10T74/20305 , Y10T74/20311 , Y10T74/20317
摘要： A three-axis robotic system. On the first and second axes, respective linear bearings have movable carriages, and backbone-free linear bases acting as exclusive support or linear bearing supports. A first motor is mounted to the first linear bearing support and coupled to the first carriage. The second linear bearing support is attached at one end to the first carriage and may be orthogonal to the first linear bearing support. A second motor is mounted to the second linear bearing support and coupled to the second carriage. A third axis member is attached to the second carriage. The third axis member may be orthogonal to the first and second linear bearing supports. A third carriage is slidable on the third axis member. A third motor is mounted to the third axis member and coupled to the third carriage. Each respective motor and carriage may be coupled by a belt or leadscrew.
摘要翻译：三轴机器人系统。在第一和第二轴上，相应的直线轴承具有可移动的支架，并且无骨架的线性底座用作专用支撑件或直线轴承支架。第一马达安装到第一直线轴承座并联接到第一托架。第二线性轴承支撑件的一端附接到第一滑架，并且可以与第一直线轴承支撑件正交。第二电动机安装到第二线性轴承支撑件并联接到第二支架。第三轴构件附接到第二托架。第三轴构件可以与第一和第二直线轴承支撑件正交。第三滑架可在第三轴构件上滑动。第三马达安装到第三轴构件并联接到第三托架。每个相应的马达和托架可以通过皮带或丝杠连接。

28. 发明申请

US20110256121A1 METHODS AND KITS FOR DIAGNOSING OR MONITORING AUTOIMMUNE AND CHRONIC INFLAMMATORY DISEASES 审中-公开
标题翻译：用于诊断或监测自身免疫性疾病和慢性炎症性疾病的方法和工具
公开(公告)号：US20110256121A1
公开(公告)日：2011-10-20
申请号：US13125779
申请日：2009-10-22
申请人： Bruce Richardson
发明人： Bruce Richardson
IPC分类号： A61K39/395 , C40B30/04 , A61P25/00 , A61P29/00 , A61P33/06 , A61P37/06 , C12Q1/68 , A61P9/00
CPC分类号： G01N33/5308 , C12Q1/6883 , C12Q2600/154 , G01N2800/102 , G01N2800/104
摘要： The present invention relates to compositions and methods for diagnosing, monitoring and/or treating disease (e.g., autoimmune or chronic inflammatory disease, heart disease and/or stroke). In particular, the present invention provides methods for diagnosing, monitoring and treating disease based upon detecting or altering (e.g., altering expression or methylation status of) disease proteins (e.g., CD70, CD40L, and/or KIR). The present invention also provides kits for detecting methylation status of disease proteins (e.g., CD70, CD40L, and/or KIR) and for diagnosing, monitoring and/or treating diseases (e.g., autoimmune or chronic inflammatory disease, heart disease and/or stroke).
摘要翻译：本发明涉及用于诊断，监测和/或治疗疾病（例如自身免疫性或慢性炎症性疾病，心脏病和/或中风）的组合物和方法。特别地，本发明提供了用于基于疾病蛋白质（例如CD70，CD40L和/或KIR）的检测或改变（例如改变表达或甲基化状态）来诊断，监测和治疗疾病的方法。本发明还提供用于检测疾病蛋白（例如CD70，CD40L和/或KIR）的甲基化状态并用于诊断，监测和/或治疗疾病（例如自身免疫性或慢性炎性疾病，心脏病和/或中风）的试剂盒）。

29. 发明授权

US07439024B2 Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases 有权
标题翻译：用于诊断或监测自身免疫性和慢性炎性疾病的方法和试剂盒
公开(公告)号：US07439024B2
公开(公告)日：2008-10-21
申请号：US11445415
申请日：2006-06-01
申请人： Bruce Richardson , Qianjin Lu
发明人： Bruce Richardson , Qianjin Lu
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases.
摘要翻译：本发明涉及用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的组合物和方法。特别地，本发明提供了用于诊断，监测和治疗自身免疫性疾病（例如类风湿性关节炎）或慢性炎性疾病（例如，系统性红斑狼疮）的方法，其基于检测或改变（例如，改变自身免疫的表达或甲基化状态）或慢性炎性疾病蛋白（例如，CD70和CD40L）。本发明还提供用于检测自身免疫性或慢性炎性疾病蛋白（例如CD70和CD40L）的甲基化状态并用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的试剂盒。

30. 发明申请

US20070015125A1 Automated updating of job assessments 审中-公开
标题翻译：自动更新工作评估
公开(公告)号：US20070015125A1
公开(公告)日：2007-01-18
申请号：US11268256
申请日：2005-11-07
申请人： Tommie Mobbs , Juan Benavidez , James Robinson , Bruce Richardson
发明人： Tommie Mobbs , Juan Benavidez , James Robinson , Bruce Richardson
IPC分类号： G09B19/00
CPC分类号： G09B7/00 , G06Q10/1053
摘要： The results of a performance appraisal are correlated with data collected from a job assessment process. Questions from the assessment that relate to high employee performance, and low employee performance are desirably identified. Questions that have no relation to performance are also desirably identified, as well as any additional questions such as those that show gender, age, or racial bias, for example. For those questions that are shown to predict high or low performance, the relative weights of those questions in the job assessment can be adjusted upwards so that they will have a greater bearing on whether an employee is hired. Those questions that show little or no relation to employee performance can be weighted downward, or removed entirely, resulting in a more streamlined and efficient job assessment process.
摘要翻译：绩效评估的结果与从工作评估过程收集的数据相关联。理想地确定评估中与员工绩效高，员工绩效低的问题。与性能无关的问题也被期望地识别，以及任何其他问题，例如显示性别，年龄或种族偏见的问题。对于那些可以预测高绩效或低绩效的问题，工作评估中的这些问题的相对权重可以向上调整，以便对员工是否被雇用有更大的影响。那些与员工绩效几乎没有关系的问题可以向下权衡，或者完全被删除，从而导致更加精简和有效的工作评估过程。

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