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1. 发明申请

US20080182247A1 Methods And Kits For Diagnosing Or Monitoring Autoimmune And Chronic Inflammatory Disease 有权
标题翻译：用于诊断或监测自身免疫性和慢性炎性疾病的方法和试剂盒
公开(公告)号：US20080182247A1
公开(公告)日：2008-07-31
申请号：US11850897
申请日：2007-09-06
申请人： Bruce Richardson , Qianjin Lu
发明人： Bruce Richardson , Qianjin Lu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6858 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2523/125
摘要： The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases.
摘要翻译：本发明涉及用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的组合物和方法。特别地，本发明提供了用于诊断，监测和治疗自身免疫性疾病（例如类风湿性关节炎）或慢性炎性疾病（例如，系统性红斑狼疮）的方法，其基于检测或改变（例如，改变自身免疫的表达或甲基化状态）或慢性炎性疾病蛋白（例如，CD70和CD40L）。本发明还提供用于检测自身免疫性或慢性炎性疾病蛋白（例如CD70和CD40L）的甲基化状态并用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的试剂盒。

2. 发明申请

US20070031863A1 Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases 有权
公开(公告)号：US20070031863A1
公开(公告)日：2007-02-08
申请号：US11445415
申请日：2006-06-01
申请人： Bruce Richardson , Qianjin Lu
发明人： Bruce Richardson , Qianjin Lu
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases.

3. 发明申请

US20090123929A1 Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases 有权
标题翻译：用于诊断或监测自身免疫性和慢性炎性疾病的方法和试剂盒
公开(公告)号：US20090123929A1
公开(公告)日：2009-05-14
申请号：US12254550
申请日：2008-10-20
申请人： Bruce Richardson , Qianjin Lu
发明人： Bruce Richardson , Qianjin Lu
IPC分类号： C12Q1/68 , C40B30/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases.
摘要翻译：本发明涉及用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的组合物和方法。特别地，本发明提供了用于诊断，监测和治疗自身免疫性疾病（例如类风湿性关节炎）或慢性炎性疾病（例如，系统性红斑狼疮）的方法，其基于检测或改变（例如，改变自身免疫的表达或甲基化状态）或慢性炎性疾病蛋白（例如，CD70和CD40L）。本发明还提供用于检测自身免疫性或慢性炎性疾病蛋白（例如CD70和CD40L）的甲基化状态并用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的试剂盒。

4. 发明授权

US07807374B2 Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases 有权
标题翻译：用于诊断或监测自身免疫性和慢性炎性疾病的方法和试剂盒
公开(公告)号：US07807374B2
公开(公告)日：2010-10-05
申请号：US12254550
申请日：2008-10-20
申请人： Bruce Richardson , Qianjin Lu
发明人： Bruce Richardson , Qianjin Lu
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases.
摘要翻译：本发明涉及用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的组合物和方法。特别地，本发明提供了用于诊断，监测和治疗自身免疫性疾病（例如类风湿性关节炎）或慢性炎性疾病（例如，系统性红斑狼疮）的方法，其基于检测或改变（例如，改变自身免疫的表达或甲基化状态）或慢性炎性疾病蛋白（例如，CD70和CD40L）。本发明还提供用于检测自身免疫性或慢性炎性疾病蛋白（例如CD70和CD40L）的甲基化状态并用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的试剂盒。

5. 发明授权

US07439024B2 Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases 有权
标题翻译：用于诊断或监测自身免疫性和慢性炎性疾病的方法和试剂盒
公开(公告)号：US07439024B2
公开(公告)日：2008-10-21
申请号：US11445415
申请日：2006-06-01
申请人： Bruce Richardson , Qianjin Lu
发明人： Bruce Richardson , Qianjin Lu
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases.
摘要翻译：本发明涉及用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的组合物和方法。特别地，本发明提供了用于诊断，监测和治疗自身免疫性疾病（例如类风湿性关节炎）或慢性炎性疾病（例如，系统性红斑狼疮）的方法，其基于检测或改变（例如，改变自身免疫的表达或甲基化状态）或慢性炎性疾病蛋白（例如，CD70和CD40L）。本发明还提供用于检测自身免疫性或慢性炎性疾病蛋白（例如CD70和CD40L）的甲基化状态并用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的试剂盒。

6. 发明申请

US20060040288A1 Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases 有权
公开(公告)号：US20060040288A1
公开(公告)日：2006-02-23
申请号：US11142123
申请日：2005-06-01
申请人： Bruce Richardson , Qianjin Lu
发明人： Bruce Richardson , Qianjin Lu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6858 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2523/125
摘要： The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases.

7. 发明授权

US07723037B2 Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory disease 有权
标题翻译：用于诊断或监测自身免疫性和慢性炎性疾病的方法和试剂盒
公开(公告)号：US07723037B2
公开(公告)日：2010-05-25
申请号：US11850897
申请日：2007-09-06
申请人： Bruce Richardson , Qianjin Lu
发明人： Bruce Richardson , Qianjin Lu
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q1/6858 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2523/125
摘要： The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases.
摘要翻译：本发明涉及用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的组合物和方法。特别地，本发明提供了用于诊断，监测和治疗自身免疫性疾病（例如类风湿性关节炎）或慢性炎性疾病（例如，系统性红斑狼疮）的方法，其基于检测或改变（例如，改变自身免疫的表达或甲基化状态）或慢性炎性疾病蛋白（例如，CD70和CD40L）。本发明还提供用于检测自身免疫性或慢性炎性疾病蛋白（例如CD70和CD40L）的甲基化状态并用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的试剂盒。

8. 发明授权

US07279281B2 Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases 有权
标题翻译：用于诊断或监测自身免疫性和慢性炎性疾病的方法和试剂盒
公开(公告)号：US07279281B2
公开(公告)日：2007-10-09
申请号：US11142123
申请日：2005-06-01
申请人： Bruce Richardson , Qianjin Lu
发明人： Bruce Richardson , Qianjin Lu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6858 , C12Q2600/136 , C12Q2600/154 , C12Q2600/156 , C12Q2600/158 , C12Q2523/125
摘要： The present invention relates to compositions and methods for diagnosing, monitoring and/or treating an autoimmune or chronic inflammatory disease. In particular, the present invention provides methods for diagnosing, monitoring and treating an autoimmune disease (e.g., rheumatoid arthritis) or chronic inflammatory disease (e.g., systemic lupus erythematosus) based on detecting or altering (e.g., altering expression or methylation status of) autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L). The present invention also provides kits for detecting methylation status of autoimmune or chronic inflammatory disease proteins (e.g., CD70 and CD40L) and for diagnosing, monitoring and/or treating autoimmune or chronic inflammatory diseases.
摘要翻译：本发明涉及用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的组合物和方法。特别地，本发明提供了用于诊断，监测和治疗自身免疫性疾病（例如类风湿性关节炎）或慢性炎性疾病（例如，系统性红斑狼疮）的方法，其基于检测或改变（例如，改变自身免疫的表达或甲基化状态）或慢性炎性疾病蛋白（例如，CD70和CD40L）。本发明还提供用于检测自身免疫性或慢性炎性疾病蛋白（例如CD70和CD40L）的甲基化状态并用于诊断，监测和/或治疗自身免疫性或慢性炎性疾病的试剂盒。

9. 发明申请

US20190102312A1 LAZY INCREMENT FOR HIGH FREQUENCY COUNTERS 审中-公开
公开(公告)号：US20190102312A1
公开(公告)日：2019-04-04
申请号：US15721800
申请日：2017-09-30
申请人： Niall D. McDonnell , Christopher MacNamara , John J. Browne , Andrew Cunningham , Brendan Ryan , Patrick Fleming , Namakkal N. Venkatesan , Bruce Richardson , Tomasz Kantecki , Sean Harte , Pierre Laurent
发明人： Niall D. McDonnell , Christopher MacNamara , John J. Browne , Andrew Cunningham , Brendan Ryan , Patrick Fleming , Namakkal N. Venkatesan , Bruce Richardson , Tomasz Kantecki , Sean Harte , Pierre Laurent
IPC分类号： G06F12/0888 , G06F12/0806 , G06F12/0837 , G06F12/0817
摘要： A computing apparatus, including: a processor; a pointer to a counter memory location; and a lazy increment counter engine to: receive a stimulus to update the counter; and lazy increment the counter including issuing a weakly-ordered increment directive to the pointer.

10. 发明授权

US09555523B2 Socket coupling receptacle 有权
标题翻译：插座联接插座
公开(公告)号：US09555523B2
公开(公告)日：2017-01-31
申请号：US13467788
申请日：2012-05-09
申请人： Perry J. Richardson , Bruce Richardson
发明人： Perry J. Richardson , Bruce Richardson
IPC分类号： B25B13/06
CPC分类号： B25B13/06
摘要： An interchangeable socket for a socket wrench or other tool is disclosed. The socket has a fastener-receiving end, dimensioned to receive and fit a specified fastener. The socket has a post-receiving end dimensioned to receive and fit a square cross-section drive post. The post-receiving end has a square cross-section hollow bounded by four walls intersecting at corners of the hollow. The post-receiving end has guide surfaces that intersect with the four walls and each other. The guide surfaces cooperate with the drive post to rotate and align the drive post with the square cross-section hollow. The guide surfaces are symmetric with respect to the four walls. The guide surfaces are symmetric with respect to the corners of the square cross-section hollow.
摘要翻译：公开了用于套筒扳手或其他工具的可互换插座。插座具有紧固件接收端，其尺寸适于接收和装配指定的紧固件。插座具有接收端，其尺寸适于接收并安装正方形横截面的驱动柱。后接收端具有由在空心的角部相交的四个壁限定的正方形横截面中空。后接收端具有与四个壁和彼此相交的引导表面。引导表面与驱动柱配合以使驱动柱与正方形横截面中空旋转并对齐。引导表面相对于四个壁对称。引导表面相对于正方形横截面中空的角是对称的。

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