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21. 发明申请

US20080141739A1 LOCKING DEVICE AND METHOD FOR UNLOCKING THE LOCKING DEVICE 有权
标题翻译：用于解锁锁定装置的锁定装置和方法
公开(公告)号：US20080141739A1
公开(公告)日：2008-06-19
申请号：US12036442
申请日：2008-02-25
申请人： Kevin Houlihan , Patrick E. Wind , Michael Gallo
发明人： Kevin Houlihan , Patrick E. Wind , Michael Gallo
IPC分类号： E05B63/00 , E05B65/06
CPC分类号： E05B65/025 , E05B1/0053 , E05B63/0065 , E05C9/026 , Y10T70/5124 , Y10T70/5345 , Y10T70/5363 , Y10T70/8459
摘要： A locking device and a method for unlocking the locking device are provided. The locking device includes a stationary plug having a first aperture extending therein configured to receive a key. The stationary plug further includes an outer surface, an inner surface defined by the first aperture, and at least a second aperture extending from the outer surface to the inner surface. The locking device further includes a housing having an outer wall disposed around at least a portion of the stationary plug. The outer wall has at least a third aperture extending therethrough. The locking device further includes a bolt member operably coupled to the outer wall of the housing. The locking device further includes a locking mechanism disposed in the third aperture of the housing and extending into the second aperture of the stationary plug. The locking mechanism is configured to allow rotation of the housing about the stationary plug when the key is inserted into the first aperture. The housing is configured to rotate from a first operational position to a second operational position in response to a force being applied to the bolt member.
摘要翻译：提供了锁定装置和用于解锁锁定装置的方法。锁定装置包括具有在其中延伸的第一孔的固定塞，其构造成接收钥匙。固定塞还包括外表面，由第一孔限定的内表面和至少一个从外表面延伸到内表面的第二孔。锁定装置还包括具有围绕固定塞的至少一部分设置的外壁的壳体。外壁具有至少延伸穿过其中的第三孔。锁定装置还包括可操作地联接到壳体的外壁的螺栓构件。锁定装置还包括设置在壳体的第三孔中并延伸到固定塞的第二孔中的锁定机构。锁定机构构造成当钥匙插入第一孔口时允许壳体围绕固定塞旋转。壳体构造成响应于施加到螺栓构件的力而从第一操作位置旋转到第二操作位置。

22. 发明申请

US20060150693A1 Locking device and method for unlocking the locking device 有权
公开(公告)号：US20060150693A1
公开(公告)日：2006-07-13
申请号：US11322171
申请日：2005-12-29
申请人： Kevin Houlihan , Patrick Wind , Michael Gallo
发明人： Kevin Houlihan , Patrick Wind , Michael Gallo
IPC分类号： E05B65/06
CPC分类号： E05B65/025 , E05B1/0053 , E05B63/0065 , E05C9/026 , Y10T70/5124 , Y10T70/5345 , Y10T70/5363 , Y10T70/8459
摘要： A locking device and a method for unlocking the locking device are provided. The locking device includes a stationary plug having a first aperture extending therein configured to receive a key. The stationary plug further includes an outer surface, an inner surface defined by the first aperture, and at least a second aperture extending from the outer surface to the inner surface. The locking device further includes a housing having an outer wall disposed around at least a portion of the stationary plug. The outer wall has at least a third aperture extending therethrough. The locking device further includes a bolt member operably coupled to the outer wall of the housing. The locking device further includes a locking mechanism disposed in the third aperture of the housing and extending into the second aperture of the stationary plug. The locking mechanism is configured to allow rotation of the housing about the stationary plug when the key is inserted into the first aperture. The housing is configured to rotate from a first operational position to a second operational position in response to a force being applied to the bolt member.

23. 发明授权

US09315577B2 Anti-hepcidin antibodies and methods of use 有权
标题翻译：抗铁调素抗体及使用方法
公开(公告)号：US09315577B2
公开(公告)日：2016-04-19
申请号：US12990137
申请日：2009-04-28
申请人： Ian Foltz , Michael Gallo , Keegan Cooke , Randal R. Ketchem , Christopher Mehlin
发明人： Ian Foltz , Michael Gallo , Keegan Cooke , Randal R. Ketchem , Christopher Mehlin
IPC分类号： C07K16/26 , A61K38/18 , A61K39/395 , A61K39/00 , C07K19/00
CPC分类号： C07K16/26 , A61K38/1816 , A61K39/3955 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K2300/00
摘要： The invention relates to monoclonal antibodies that bind hepcidin and methods of making and using such antibodies. Also provided are methods of treating hepcidin-related disorders.
摘要翻译：本发明涉及结合铁调素的单克隆抗体以及制备和使用这些抗体的方法。还提供了治疗铁调素相关病症的方法。

24. 发明授权

US09200475B2 Apparatus and method for vending securely stored products to consumers 有权
标题翻译：将安全存储的产品售卖给消费者的装置和方法
公开(公告)号：US09200475B2
公开(公告)日：2015-12-01
申请号：US13291500
申请日：2011-11-08
申请人： Michael Gallo , Steve Sanelli
发明人： Michael Gallo , Steve Sanelli
IPC分类号： E05B11/00 , E05B35/12 , E05B47/02 , G07F7/06 , E05B13/00 , E05C3/24
CPC分类号： E05B15/0046 , E05B13/004 , E05B15/101 , E05B35/12 , E05B47/023 , E05C3/24 , G07F7/0609 , Y10S70/62 , Y10S70/63 , Y10T70/625 , Y10T70/7441 , Y10T70/7768 , Y10T292/1047 , Y10T292/1062 , Y10T292/1078 , Y10T403/602
摘要： A lock mechanism is disclosed, the lock mechanism having a rotary latch configured for rotation between a locked position and an unlocked position, the rotary latch rotating in a first plane and the rotary latch is retained in the locked position after it has been rotated into the locked position from the unlocked position, the rotary latch being spring biased into the unlocked position by a biasing member; and a first lock mechanism for retaining the rotary latch in the locked position after rotation of the rotary latch into the locked position, the rotary latch being capable of being manipulated back into the unlocked position from the locked position after actuation of the first locking mechanism into a release position, wherein actuation of the first lock mechanism is in a second plane that is not parallel to the first plane.
摘要翻译：公开了一种锁定机构，该锁定机构具有构造成在锁定位置和解锁位置之间旋转的旋转闩锁，所述旋转闩锁在第一平面中旋转，并且所述旋转闩锁在已经旋转到所述锁定位置之后被保持在所述锁定位置锁定位置从解锁位置，旋转闩锁通过偏置构件弹簧偏置到解锁位置; 以及第一锁定机构，用于在旋转闩锁旋转到锁定位置之后将旋转闩锁保持在锁定位置，旋转闩锁能够在致动第一锁定机构之后从锁定位置被操纵回到解锁位置，进入释放位置，其中所述第一锁定机构的致动处于不平行于所述第一平面的第二平面中。

25. 发明申请

US20150315813A1 APPARATUS AND METHOD FOR VENDING SECURELY STORED PRODUCTS TO CONSUMERS 审中-公开
标题翻译：用于向消费者发放安全存储产品的装置和方法
公开(公告)号：US20150315813A1
公开(公告)日：2015-11-05
申请号：US14797774
申请日：2015-07-13
申请人： Michael Gallo , Steve Sanelli
发明人： Michael Gallo , Steve Sanelli
IPC分类号： E05B15/00 , E05B15/10
CPC分类号： E05B15/0046 , E05B13/004 , E05B15/101 , E05B35/12 , E05B47/023 , E05C3/24 , G07F7/0609 , Y10S70/62 , Y10S70/63 , Y10T70/625 , Y10T70/7441 , Y10T70/7768 , Y10T292/1047 , Y10T292/1062 , Y10T292/1078 , Y10T403/602
摘要： A lock mechanism is disclosed, the lock mechanism having a rotary latch configured for rotation between a locked position and an unlocked position, the rotary latch rotating in a first plane and the rotary latch is retained in the locked position after it has been rotated into the locked position from the unlocked position, the rotary latch being spring biased into the unlocked position by a biasing member; and a first lock mechanism for retaining the rotary latch in the locked position after rotation of the rotary latch into the locked position, the rotary latch being capable of being manipulated back into the unlocked position from the locked position after actuation of the first locking mechanism into a release position, wherein actuation of the first lock mechanism is in a second plane that is not parallel to the first plane.
摘要翻译：公开了一种锁定机构，该锁定机构具有构造成在锁定位置和解锁位置之间旋转的旋转闩锁，所述旋转闩锁在第一平面中旋转，并且所述旋转闩锁在已经旋转到所述锁定位置之后被保持在所述锁定位置锁定位置从解锁位置，旋转闩锁通过偏置构件弹簧偏压到解锁位置; 以及第一锁定机构，用于在旋转闩锁旋转到锁定位置之后将旋转闩锁保持在锁定位置，旋转闩锁能够在致动第一锁定机构之后从锁定位置被操纵回到解锁位置，进入释放位置，其中所述第一锁定机构的致动处于不平行于所述第一平面的第二平面中。

26. 发明申请

US20140086482A1 Automatically Matching Colors in Stereoscopic Image Pairs 有权
标题翻译：自动匹配立体图像对中的颜色
公开(公告)号：US20140086482A1
公开(公告)日：2014-03-27
申请号：US13625535
申请日：2012-09-24
申请人： Michael Gallo
发明人： Michael Gallo
IPC分类号： G06K9/62
CPC分类号： H04N13/133 , H04N13/15
摘要： A method, system, and computer-readable storage medium are disclosed for automatically matching colors in stereoscopic image pairs. A stereoscopic image pair is converted from a first color space to a second color space, comprising mapping color values in the first color space to color values in the second color space. The second color space is more perceptually uniform than the first color space. A color-matched stereoscopic image pair is generated in the second color space, comprising applying a respective transformation for each of a plurality of luminance ranges in each image of the stereoscopic image pair. The transformations are applied to the color values in the second color space dependent upon a contribution of each of the color values to each of the luminance ranges. The color-matched stereoscopic image pair is converted from the second color space to the first color space.
摘要翻译：公开了用于自动匹配立体图像对中的颜色的方法，系统和计算机可读存储介质。立体图像对从第一颜色空间转换为第二颜色空间，包括将第一颜色空间中的颜色值映射到第二颜色空间中的颜色值。第二个颜色空间比第一个颜色空间更加感知统一。在第二颜色空间中产生颜色匹配的立体图像对，包括对立体图像对的每个图像中的多个亮度范围中的每一个应用各自的变换。根据每个颜色值对每个亮度范围的贡献，将变换应用于第二颜色空间中的颜色值。颜色匹配的立体图像对从第二颜色空间转换为第一颜色空间。

27. 发明授权

US08227580B2 Human monoclonal antibodies to epidermal growth factor receptor 有权
标题翻译：人表皮生长因子受体单克隆抗体
公开(公告)号：US08227580B2
公开(公告)日：2012-07-24
申请号：US12767086
申请日：2010-04-26
申请人： Aya Jakobovits , Xiao-Dong Yang , Michael Gallo , Xiao-Chi Jia
发明人： Aya Jakobovits , Xiao-Dong Yang , Michael Gallo , Xiao-Chi Jia
IPC分类号： C07K16/28 , C07K16/00
CPC分类号： C07K16/2863 , A61K38/00 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/77
摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided. Also provided in accordance with the invention are antibodies that possess one or more of the following functional characteristics: (i) inhibit tyrosine phosphorylation of EGF-r, (ii) do not inhibit EGF-r internalization, (ii) inhibit EGF-r degradation, (iii) inhibition of EGF induced EGF-r degradation, (iv) protect threonine phosphorylation of EGF-r, (v) protect threonine phosphorylation of other molecules, particularly a 62 KD molecule identified by immunoprecipitation, and (vi) inhibit vascular endothelial cell growth factor signal by tumor cells by greater than 50% and endothelial cells by greater than 40% relative to control.
摘要翻译：根据本发明，提供了针对人表皮生长因子受体（EGF-r）的完全人单克隆抗体。提供了编码核酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于CDR1至CDR3的连续重链和轻链序列的序列。还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤。根据本发明还提供了具有一个或多个以下功能特征的抗体：（i）抑制EGF-r的酪氨酸磷酸化，（ii）不抑制EGF-r内化，（ii）抑制EGF-r降解，（iii）抑制EGF诱导的EGF-r降解，（iv）保护EGF-r的苏氨酸磷酸化，（v）保护其他分子，特别是通过免疫沉淀鉴定的62KD分子的苏氨酸磷酸化，和（vi）抑制血管内皮肿瘤细胞的细胞生长因子信号大于50％，内皮细胞相对于对照组大于40％。

28. 发明申请

US20100305307A1 HUMAN MONOCLONAL ANTIBODIES TO EPIDERMAL GROWTH FACTOR RECEPTOR 有权
标题翻译：人类单克隆抗体对人类生长因子受体的影响
公开(公告)号：US20100305307A1
公开(公告)日：2010-12-02
申请号：US12767086
申请日：2010-04-26
申请人： Aya Jakobovits , Xiao-Dong Yang , Michael Gallo , Xiao-Chi Jia
发明人： Aya Jakobovits , Xiao-Dong Yang , Michael Gallo , Xiao-Chi Jia
IPC分类号： C07K16/00
CPC分类号： C07K16/2863 , A61K38/00 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/77
摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided. Also provided in accordance with the invention are antibodies that possess one or more of the following functional characteristics: (i) inhibit tyrosine phosphorylation of EGF-r, (ii) do not inhibit EGF-r internalization, (ii) inhibit EGF-r degradation, (iii) inhibition of EGF induced EGF-r degradation, (iv) protect threonine phosphorylation of EGF-r, (v) protect threonine phosphorylation of other molecules, particularly a 62 KD molecule identified by immunoprecipitation, and (vi) inhibit vascular endothelial cell growth factor signal by tumor cells by greater than 50% and endothelial cells by greater than 40% relative to control.
摘要翻译：根据本发明，提供了针对人表皮生长因子受体（EGF-r）的完全人单克隆抗体。提供了编码核酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于CDR1至CDR3的连续重链和轻链序列的序列。还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤。根据本发明还提供了具有一个或多个以下功能特征的抗体：（i）抑制EGF-r的酪氨酸磷酸化，（ii）不抑制EGF-r内化，（ii）抑制EGF-r降解（iii）抑制EGF诱导的EGF-r降解，（iv）保护EGF-r的苏氨酸磷酸化，（v）保护其他分子，特别是通过免疫沉淀鉴定的62KD分子的苏氨酸磷酸化，和（vi）抑制血管内皮肿瘤细胞的细胞生长因子信号大于50％，内皮细胞相对于对照组大于40％。

29. 发明申请

US20090258392A1 SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS 有权
标题翻译：免疫球蛋白中的序列多样性生成
公开(公告)号：US20090258392A1
公开(公告)日：2009-10-15
申请号：US12423594
申请日：2009-04-14
申请人： Michael Gallo , Jaspal Singh Kang , Craig Robin Pigott
发明人： Michael Gallo , Jaspal Singh Kang , Craig Robin Pigott
IPC分类号： C12P21/08 , C12N15/11 , C12N15/00 , C12N5/06
CPC分类号： C07K16/00 , C07K2317/56 , C12N15/113 , C12N2310/14
摘要： Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations of immunoglobulin gene elements, including introduction of artificial diversity (D) segment genes and optimization of recombination signal sequence (RSS) efficiency, are disclosed.
摘要翻译：公开了用于在体外产生免疫球蛋白结构多样性的组合物和方法，特别是用于减少V区和J区段基因利用中的偏差，并且以不需要DJ重组在V-DJ之前产生免疫球蛋白VDJ重组事件重组。公开了选择免疫球蛋白基因元件的有利组合，包括引入人工多样性（D）片段基因和优化重组信号序列（RSS）效率。

30. 发明申请

US20050107596A1 Anti-alpha3(IV)nc1 monoclonal antibodies and animal model for human anti-glomerular basement membrane autoantibody disease 审中-公开
标题翻译：抗α3（IV）nc1单克隆抗体和人类抗肾小球基底膜自身抗体疾病的动物模型
公开(公告)号：US20050107596A1
公开(公告)日：2005-05-19
申请号：US10475764
申请日：2002-04-23
申请人： Michael Madaio , Michael Gallo
发明人： Michael Madaio , Michael Gallo
IPC分类号： C07K16/18 , C07K16/42 , C12P21/08 , C12N5/06
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/4241 , C07K2317/21
摘要： The present invention relates to methods of making a mouse model of human anti-GBM disease, to mice produced by such methods, and to human antibodies and antigen-binding portions thereof that specifically bind to α3(IV) NC1 collagen. The present invention also relates to compositions comprising the above antibodies or portions thereof and methods of using such compositions for diagnosis, and to nucleic acid molecules encoding the above antibodies or portions thereof. The present invention further relates to methods of isolating compounds/peptides that specifically binds anti-α3(IV) NC1 antibodies, pharmaceutical compositions comprising these compounds/peptides and methods of using such compositions for diagnosis and treatment.
摘要翻译：本发明涉及制备人抗-GBM疾病小鼠模型，通过这些方法制备的小鼠以及特异性结合α3（IV）NC1胶原的人抗体及其抗原结合部分的方法。本发明还涉及包含上述抗体或其部分的组合物和使用该组合物进行诊断的方法，以及编码上述抗体或其部分的核酸分子。本发明还涉及分离特异性结合抗α3（IV）NC1抗体的化合物/肽的方法，包含这些化合物/肽的药物组合物和使用这种组合物进行诊断和治疗的方法。

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