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1. 发明申请

US20080134735A1 APPARATUS AND METHOD FOR VENDING SECURELY STORED PRODUCTS TO CONSUMERS 有权
标题翻译：用于向消费者发放安全存储产品的装置和方法
公开(公告)号：US20080134735A1
公开(公告)日：2008-06-12
申请号：US11938002
申请日：2007-11-09
申请人： Michael Gallo , Steve Sanelli
发明人： Michael Gallo , Steve Sanelli
IPC分类号： E05B63/14
CPC分类号： E05B15/0046 , E05B13/004 , E05B15/101 , E05B35/12 , E05B47/023 , E05C3/24 , G07F7/0609 , Y10S70/62 , Y10S70/63 , Y10T70/625 , Y10T70/7441 , Y10T70/7768 , Y10T292/1047 , Y10T292/1062 , Y10T292/1078 , Y10T403/602
摘要： A lock mechanism is disclosed, the lock mechanism having a rotary latch configured for rotation between a locked position and an unlocked position, the rotary latch rotating in a first plane and the rotary latch is retained in the locked position after it has been rotated into the locked position from the unlocked position, the rotary latch being spring biased into the unlocked position by a biasing member; and a first lock mechanism for releasing the rotary latch from the locked position after actuation of the first lock mechanism, the biasing member rotating the rotary latch into the unlocked position, the rotary latch being capable of being manipulated back into the locked position from the unlocked position after release by the first locking mechanism and the first locking mechanism must be reset in order to once again release the rotary latch.
摘要翻译：公开了一种锁定机构，该锁定机构具有构造成在锁定位置和解锁位置之间旋转的旋转闩锁，所述旋转闩锁在第一平面中旋转，并且所述旋转闩锁在已经旋转到所述锁定位置之后被保持在所述锁定位置锁定位置从解锁位置，旋转闩锁通过偏置构件弹簧偏压到解锁位置; 以及第一锁定机构，用于在所述第一锁定机构致动之后将所述旋转闩锁从所述锁定位置释放，所述偏置构件将所述旋转闩锁旋转到所述解锁位置，所述旋转闩锁能够被解锁回锁定位置必须复位通过第一锁定机构释放的位置和第一锁定机构以再次释放旋转闩锁。

2. 发明授权

US09200475B2 Apparatus and method for vending securely stored products to consumers 有权
标题翻译：将安全存储的产品售卖给消费者的装置和方法
公开(公告)号：US09200475B2
公开(公告)日：2015-12-01
申请号：US13291500
申请日：2011-11-08
申请人： Michael Gallo , Steve Sanelli
发明人： Michael Gallo , Steve Sanelli
IPC分类号： E05B11/00 , E05B35/12 , E05B47/02 , G07F7/06 , E05B13/00 , E05C3/24
CPC分类号： E05B15/0046 , E05B13/004 , E05B15/101 , E05B35/12 , E05B47/023 , E05C3/24 , G07F7/0609 , Y10S70/62 , Y10S70/63 , Y10T70/625 , Y10T70/7441 , Y10T70/7768 , Y10T292/1047 , Y10T292/1062 , Y10T292/1078 , Y10T403/602
摘要： A lock mechanism is disclosed, the lock mechanism having a rotary latch configured for rotation between a locked position and an unlocked position, the rotary latch rotating in a first plane and the rotary latch is retained in the locked position after it has been rotated into the locked position from the unlocked position, the rotary latch being spring biased into the unlocked position by a biasing member; and a first lock mechanism for retaining the rotary latch in the locked position after rotation of the rotary latch into the locked position, the rotary latch being capable of being manipulated back into the unlocked position from the locked position after actuation of the first locking mechanism into a release position, wherein actuation of the first lock mechanism is in a second plane that is not parallel to the first plane.
摘要翻译：公开了一种锁定机构，该锁定机构具有构造成在锁定位置和解锁位置之间旋转的旋转闩锁，所述旋转闩锁在第一平面中旋转，并且所述旋转闩锁在已经旋转到所述锁定位置之后被保持在所述锁定位置锁定位置从解锁位置，旋转闩锁通过偏置构件弹簧偏置到解锁位置; 以及第一锁定机构，用于在旋转闩锁旋转到锁定位置之后将旋转闩锁保持在锁定位置，旋转闩锁能够在致动第一锁定机构之后从锁定位置被操纵回到解锁位置，进入释放位置，其中所述第一锁定机构的致动处于不平行于所述第一平面的第二平面中。

3. 发明申请

US20150315813A1 APPARATUS AND METHOD FOR VENDING SECURELY STORED PRODUCTS TO CONSUMERS 审中-公开
标题翻译：用于向消费者发放安全存储产品的装置和方法
公开(公告)号：US20150315813A1
公开(公告)日：2015-11-05
申请号：US14797774
申请日：2015-07-13
申请人： Michael Gallo , Steve Sanelli
发明人： Michael Gallo , Steve Sanelli
IPC分类号： E05B15/00 , E05B15/10
CPC分类号： E05B15/0046 , E05B13/004 , E05B15/101 , E05B35/12 , E05B47/023 , E05C3/24 , G07F7/0609 , Y10S70/62 , Y10S70/63 , Y10T70/625 , Y10T70/7441 , Y10T70/7768 , Y10T292/1047 , Y10T292/1062 , Y10T292/1078 , Y10T403/602
摘要： A lock mechanism is disclosed, the lock mechanism having a rotary latch configured for rotation between a locked position and an unlocked position, the rotary latch rotating in a first plane and the rotary latch is retained in the locked position after it has been rotated into the locked position from the unlocked position, the rotary latch being spring biased into the unlocked position by a biasing member; and a first lock mechanism for retaining the rotary latch in the locked position after rotation of the rotary latch into the locked position, the rotary latch being capable of being manipulated back into the unlocked position from the locked position after actuation of the first locking mechanism into a release position, wherein actuation of the first lock mechanism is in a second plane that is not parallel to the first plane.
摘要翻译：公开了一种锁定机构，该锁定机构具有构造成在锁定位置和解锁位置之间旋转的旋转闩锁，所述旋转闩锁在第一平面中旋转，并且所述旋转闩锁在已经旋转到所述锁定位置之后被保持在所述锁定位置锁定位置从解锁位置，旋转闩锁通过偏置构件弹簧偏压到解锁位置; 以及第一锁定机构，用于在旋转闩锁旋转到锁定位置之后将旋转闩锁保持在锁定位置，旋转闩锁能够在致动第一锁定机构之后从锁定位置被操纵回到解锁位置，进入释放位置，其中所述第一锁定机构的致动处于不平行于所述第一平面的第二平面中。

4. 发明授权

US09080350B2 Apparatus and method for vending securely stored products to consumers 有权
公开(公告)号：US09080350B2
公开(公告)日：2015-07-14
申请号：US13291500
申请日：2011-11-08
申请人： Michael Gallo , Steve Sanelli
发明人： Michael Gallo , Steve Sanelli
IPC分类号： E05B11/00 , E05B35/12 , E05B47/02 , G07F7/06 , E05B13/00 , E05C3/24
摘要： A lock mechanism is disclosed, the lock mechanism having a rotary latch configured for rotation between a locked position and an unlocked position, the rotary latch rotating in a first plane and the rotary latch is retained in the locked position after it has been rotated into the locked position from the unlocked position, the rotary latch being spring biased into the unlocked position by a biasing member; and a first lock mechanism for retaining the rotary latch in the locked position after rotation of the rotary latch into the locked position, the rotary latch being capable of being manipulated back into the unlocked position from the locked position after actuation of the first locking mechanism into a release position, wherein actuation of the first lock mechanism is in a second plane that is not parallel to the first plane.

5. 发明申请

US20120125060A1 APPARATUS AND METHOD FOR VENDING SECURELY STORED PRODUCTS TO CONSUMERS 有权
标题翻译：用于向消费者发放安全存储产品的装置和方法
公开(公告)号：US20120125060A1
公开(公告)日：2012-05-24
申请号：US13291500
申请日：2011-11-08
申请人： Michael Gallo , Steve Sanelli
发明人： Michael Gallo , Steve Sanelli
IPC分类号： E05B35/00 , F16B1/00
CPC分类号： E05B15/0046 , E05B13/004 , E05B15/101 , E05B35/12 , E05B47/023 , E05C3/24 , G07F7/0609 , Y10S70/62 , Y10S70/63 , Y10T70/625 , Y10T70/7441 , Y10T70/7768 , Y10T292/1047 , Y10T292/1062 , Y10T292/1078 , Y10T403/602
摘要： A lock mechanism is disclosed, the lock mechanism having a rotary latch configured for rotation between a locked position and an unlocked position, the rotary latch rotating in a first plane and the rotary latch is retained in the locked position after it has been rotated into the locked position from the unlocked position, the rotary latch being spring biased into the unlocked position by a biasing member; and a first lock mechanism for retaining the rotary latch in the locked position after rotation of the rotary latch into the locked position, the rotary latch being capable of being manipulated back into the unlocked position from the locked position after actuation of the first locking mechanism into a release position, wherein actuation of the first lock mechanism is in a second plane that is not parallel to the first plane and wherein the first lock mechanism must be reset in order to subsequently release the rotary latch from the locked position.
摘要翻译：公开了一种锁定机构，该锁定机构具有构造成在锁定位置和解锁位置之间旋转的旋转闩锁，所述旋转闩锁在第一平面中旋转，并且所述旋转闩锁在已经旋转到所述锁定位置之后被保持在所述锁定位置锁定位置从解锁位置，旋转闩锁通过偏置构件弹簧偏置到解锁位置; 以及第一锁定机构，用于在将旋转闩锁旋转到锁定位置之后将旋转闩锁保持在锁定位置，所述旋转闩锁能够在致动第一锁定机构之后被从锁定位置操作回到解锁位置，进入释放位置，其中所述第一锁定机构的致动处于不平行于所述第一平面的第二平面中，并且其中所述第一锁定机构必须被复位，以便随后将所述旋转闩锁从所述锁定位置释放。

6. 发明授权

US08051691B2 Apparatus and method for vending securely stored products to consumers 有权
标题翻译：将安全存储的产品售卖给消费者的装置和方法
公开(公告)号：US08051691B2
公开(公告)日：2011-11-08
申请号：US11938002
申请日：2007-11-09
申请人： Michael Gallo , Steve Sanelli
发明人： Michael Gallo , Steve Sanelli
IPC分类号： E05B11/00
CPC分类号： E05B15/0046 , E05B13/004 , E05B15/101 , E05B35/12 , E05B47/023 , E05C3/24 , G07F7/0609 , Y10S70/62 , Y10S70/63 , Y10T70/625 , Y10T70/7441 , Y10T70/7768 , Y10T292/1047 , Y10T292/1062 , Y10T292/1078 , Y10T403/602
摘要： A lock mechanism is disclosed, the lock mechanism having a rotary latch configured for rotation between a locked position and an unlocked position, the rotary latch rotating in a first plane and the rotary latch is retained in the locked position after it has been rotated into the locked position from the unlocked position, the rotary latch being spring biased into the unlocked position by a biasing member; and a first lock mechanism for releasing the rotary latch from the locked position after actuation of the first lock mechanism, the biasing member rotating the rotary latch into the unlocked position, the rotary latch being capable of being manipulated back into the locked position from the unlocked position after release by the first locking mechanism and the first locking mechanism must be reset in order to once again release the rotary latch.
摘要翻译：公开了一种锁定机构，该锁定机构具有构造成在锁定位置和解锁位置之间旋转的旋转闩锁，所述旋转闩锁在第一平面中旋转，并且所述旋转闩锁在已经旋转到所述锁定位置之后被保持在所述锁定位置锁定位置从解锁位置，旋转闩锁通过偏置构件弹簧偏压到解锁位置; 以及第一锁定机构，用于在所述第一锁定机构致动之后将所述旋转闩锁从所述锁定位置释放，所述偏置构件使所述旋转闩锁旋转到所述解锁位置，所述旋转闩锁能够被解锁回锁定位置必须复位通过第一锁定机构释放的位置和第一锁定机构以再次释放旋转闩锁。

7. 发明申请

US20130236931A1 SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS AND OTHER PROTEINS 审中-公开
标题翻译：免疫球蛋白和其他蛋白质的序列多样性生成
公开(公告)号：US20130236931A1
公开(公告)日：2013-09-12
申请号：US13765484
申请日：2013-02-12
申请人： Michael Gallo , Jaspal Singh Kang , Craig Robin Pigott
发明人： Michael Gallo , Jaspal Singh Kang , Craig Robin Pigott
IPC分类号： C12P21/00
CPC分类号： C12P21/00 , C07K16/00 , C07K2317/56 , C12N15/102 , C12N15/113 , C12N2310/14
摘要： An in vitro system for generating sequence, and thus structural, diversity in proteins is described. The system can be constructed using appropriately selected nucleic acid molecules that encode regions of a selected protein or proteins and recombination signal sequences (RSS). The selected protein(s) can be, for example, immunoglobulin (Ig) V, D, J and/or C regions, regions of a non-immunoglobulin (non-Ig) protein, or a combination of Ig regions and non-Ig regions. Assembly of such appropriately selected components and their introduction into suitable recombination-competent host cells allows for recombination between the RSS sequences and introduction of sequence and structural diversity into the protein(s).
摘要翻译：描述了用于产生序列的体外系统，因此蛋白质的结构多样性。可以使用适当选择的编码所选蛋白质或蛋白质区域的重组信号序列（RSS）的核酸分子来构建该系统。所选择的蛋白可以是例如免疫球蛋白（Ig）V，D，J和/或C区，非免疫球蛋白（非Ig）蛋白的区域，或Ig区和非Ig的组合地区。组装这些适当选择的组分并将其引入合适的可重组的宿主细胞中允许RSS序列之间的重组，并将序列和结构多样性引入到蛋白质中。

8. 发明申请

US20050100546A1 Human monoclonal antibodies to epidermal growth factor receptor 审中-公开
标题翻译：人表皮生长因子受体单克隆抗体
公开(公告)号：US20050100546A1
公开(公告)日：2005-05-12
申请号：US11021795
申请日：2004-12-22
申请人： Aya Jakobovits , Xiao-Dong Yang , Michael Gallo , Xiao-Chi Jia
发明人： Aya Jakobovits , Xiao-Dong Yang , Michael Gallo , Xiao-Chi Jia
IPC分类号： A61K38/00 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2863 , A61K38/00 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/77
摘要： In accordance with the present invention, there are provided fully human monoclonal antibodies against human epidermal growth factor receptor (EGF-r). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences from CDR1 through CDR3, are provided. Hybridomas expressing such immunoglobulin molecules and monoclonal antibodies are also provided. Also provided in accordance with the invention are antibodies that possess one or more of the following functional characteristics: (i) inhibit tyrosine phosphorylation of EGF-r, (ii) do not inhibit EGF-r internalization, (ii) inhibit EGF-r degradation, (iii) inhibition of EGF induced EGF-r degradation, (iv) protect threonine phosphorylation of EGF-r, (v) protect threonine phosphorylation of other molecules, particularly a 62 KD molecule identified by immunoprecipitation, and (vi) inhibit vascular endothelial cell growth factor signal by tumor cells by greater than 50% and endothelial cells by greater than 40% relative to control.
摘要翻译：根据本发明，提供了针对人表皮生长因子受体（EGF-r）的完全人单克隆抗体。提供了含有重链和轻链免疫球蛋白分子的Nuclotide序列编码和氨基酸序列，特别是对应于CDR1至CDR3的连续重链和轻链序列的序列。还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤。根据本发明还提供了具有一个或多个以下功能特征的抗体：（i）抑制EGF-r的酪氨酸磷酸化，（ii）不抑制EGF-r内化，（ii）抑制EGF-r降解，（iii）抑制EGF诱导的EGF-r降解，（iv）保护EGF-r的苏氨酸磷酸化，（v）保护其他分子，特别是通过免疫沉淀鉴定的62KD分子的苏氨酸磷酸化，和（vi）抑制血管内皮肿瘤细胞的细胞生长因子信号大于50％，内皮细胞相对于对照组大于40％。

9. 发明申请

US20120258495A1 SEQUENCE DIVERSITY GENERATION IN IMMUNOGLOBULINS 有权
标题翻译：免疫球蛋白中的序列多样性生成
公开(公告)号：US20120258495A1
公开(公告)日：2012-10-11
申请号：US13205218
申请日：2011-08-08
申请人： Michael Gallo , Jaspal Singh Kang , Craig Robin Pigott
发明人： Michael Gallo , Jaspal Singh Kang , Craig Robin Pigott
IPC分类号： C12N5/10 , C12P21/00
CPC分类号： C07K16/00 , C07K2317/56 , C12N15/113 , C12N2310/14
摘要： Compositions and methods are disclosed for generating immunoglobulin structural diversity in vitro, and in particular, for reducing biases in V region and J segment gene utilization, and for generating immunoglobulin V-D-J recombination events in a manner that does not require D-J recombination to precede V-DJ recombination. Selection of advantageous combinations of immunoglobulin gene elements, including introduction of artificial diversity (D) segment genes and optimization of recombination signal sequence (RSS) efficiency, are disclosed.
摘要翻译：公开了用于在体外产生免疫球蛋白结构多样性的组合物和方法，特别是用于减少V区和J区段基因利用中的偏差，并且以不需要DJ重组在V-DJ之前产生免疫球蛋白VDJ重组事件重组。公开了选择免疫球蛋白基因元件的有利组合，包括引入人工多样性（D）片段基因和优化重组信号序列（RSS）效率。

10. 发明授权

US07982024B2 Antibodies to insulin-like growth factor I receptor 有权
标题翻译：胰岛素样生长因子I受体的抗体
公开(公告)号：US07982024B2
公开(公告)日：2011-07-19
申请号：US12756417
申请日：2010-04-08
申请人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose Ramon Corvalan , Michael Gallo
发明人： Bruce D. Cohen , Jean Beebe , Penelope E. Miller , James D. Moyer , Jose Ramon Corvalan , Michael Gallo
IPC分类号： C07H21/04 , C12N15/00 , C12N5/07 , C12N5/16 , A61K39/395 , C07K16/00
CPC分类号： C07K16/2863 , A01K2217/05 , A61K31/138 , A61K31/513 , A61K31/517 , A61K31/704 , A61K39/39541 , A61K39/39558 , A61K48/00 , A61K2039/505 , C07K14/72 , C07K16/30 , C07K16/40 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N33/57492 , G01N2333/65 , G01N2333/71 , A61K2300/00
摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The invention also relates to human anti-IGF-IR antibodies, including chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulin molecules derived from anti-IGF-IR antibodies and nucleic acid molecules encoding such molecules. The present invention also relates to methods of making anti-IGF-IR antibodies, pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-IGF-IR antibodies. The invention also relates to gene therapy methods and transgenic animals comprising nucleic acid molecules of the present invention.
摘要翻译：本发明涉及特异性结合胰岛素样生长因子I受体（IGF-1R）的抗体及其抗原结合部分，其优选为人IGF-1R。本发明还涉及人抗IGF-1R抗体，包括嵌合，双特异性，衍生的单链抗体或融合蛋白的部分。本发明还涉及衍生自抗IGF-1R抗体和编码这种分子的核酸分子的分离的重链和轻链免疫球蛋白分子。本发明还涉及制备抗IGF-1R抗体的方法，包含这些抗体的药物组合物和使用抗体及其组合物进行诊断和治疗的方法。本发明还提供使用编码包含人抗IGF-1R抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。本发明还涉及包含本发明的核酸分子的基因治疗方法和转基因动物。

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