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21. 发明申请

US20050208615A1 Product removal process for use in a biofermentation system 失效
标题翻译：用于生物发酵系统的产品去除过程
公开(公告)号：US20050208615A1
公开(公告)日：2005-09-22
申请号：US10860221
申请日：2004-06-03
申请人： Antoinette Wilkins , David Lowe
发明人： Antoinette Wilkins , David Lowe
IPC分类号： C12M1/00 , B01D15/08 , C12M1/12 , C12M1/26 , C12N1/38 , C12P7/18 , C12P1/00 , C12P21/06
CPC分类号： C12M47/12 , B01D15/1814 , B01D15/426 , C12M29/02 , C12M33/14 , C12M47/10 , C12N1/38 , C12P7/18
摘要： This invention relates to a bioprocess engineering solution for a product removal process for use in a biofermentation. The invention discloses a process for withdrawing an aliquot of broth from a biofermentation vessel during at least a portion of the biofermentation, removing biocatalyst and water, chromatographically separating biofermentation products from the withdrawn broth using water as an eluent, and returning the remaining components of the broth back to the biofermentation vessel. Process chromatography permits highly selective separation of the target molecule, preventing feedback inhibition of the biofermentation.
摘要翻译：本发明涉及用于在生物发酵中使用的产品去除方法的生物过程工程解决方案。本发明公开了一种在至少一部分生物发酵过程中从生物发酵容器中取出等份的肉汤的方法，除去生物催化剂和水，使用水作为洗脱剂，使生物发酵产物与取出的肉汤色谱分离，并返回剩余组分肉汤回到生物发酵罐。过程色谱法允许目标分子的高度选择性分离，防止反应抑制生物发酵。

22. 发明申请

US20050132425A1 Transgenic flies expressing Abeta42-Italian 审中-公开
公开(公告)号：US20050132425A1
公开(公告)日：2005-06-16
申请号：US10970189
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/033
CPC分类号： A01K67/0333 , A01K67/0339 , A01K2267/0312
摘要： The present invention discloses a transgenic fly that expresses the Italian mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Italian peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.

23. 发明申请

US20050132423A1 Transgenic flies expressing Abeta42-Flemish 审中-公开
标题翻译：表达Abeta42-Flemish的转基因苍蝇
公开(公告)号：US20050132423A1
公开(公告)日：2005-06-16
申请号：US10969895
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/033 , C12N15/85
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C12N15/8509
摘要： The present invention discloses a transgenic fly that expresses the Flemish mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Flemish peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译：本发明公开了一种表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的佛兰芒突变体型的转基因飞行物，以及表达Tau蛋白和人类Abeta42前体蛋白（APP）的双转基因飞行物，人淀粉样蛋白-β前体蛋白质（APP）的肽。本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。

24. 发明申请

US20050132421A1 Transgenic flies expressing Abeta42-Arctic 审中-公开
标题翻译：表达Abeta42-北极的转基因苍蝇
公开(公告)号：US20050132421A1
公开(公告)日：2005-06-16
申请号：US10969893
申请日：2004-10-21
申请人： David Lowe , Gerhard Koenig , Christopher Cummings
发明人： David Lowe , Gerhard Koenig , Christopher Cummings
IPC分类号： A01K67/00 , A01K67/033 , C12N15/85 , G01N33/00
CPC分类号： A01K67/0339 , A01K2217/05 , A01K2227/706 , A01K2267/0312 , C12N15/8509
摘要： The present invention discloses a transgenic fly that expresses the Arctic mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Arctic peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.
摘要翻译：本发明公开了表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的北极突变体版本的转基因飞行物，以及表达Tau蛋白质和人Abeta42二极体的双重转基因飞行物，人淀粉样蛋白-β前体蛋白质（APP）的肽。本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。

25. 发明申请

US20050107865A1 Endoprosthesis having foot extensions 有权
标题翻译：具有脚伸展的内假体
公开(公告)号：US20050107865A1
公开(公告)日：2005-05-19
申请号：US10992976
申请日：2004-11-19
申请人： Anton Clifford , Kevin Kang , David Lowe , Jeff Pappas , Erik Eli , Howard Huang , Lisa Weldon , Ketan Muni , Eugene Young
发明人： Anton Clifford , Kevin Kang , David Lowe , Jeff Pappas , Erik Eli , Howard Huang , Lisa Weldon , Ketan Muni , Eugene Young
IPC分类号： A61F2/00 , A61F2/06 , A61F2/90
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2220/0008 , A61F2230/0054 , A61F2250/0098 , Y10T29/49826 , Y10T29/49908
摘要： Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration. The annular elements are longitudinally aligned and connected at connection locations. Preferably, each connection location includes a foot extension, such as by an overlapping pattern between the longitudinally-adjacent annular elements or by a connector extending therebetween.
摘要翻译：内置假体，例如支架，包括至少一个环形元件，所述至少一个环形元件由第一组支柱构件限定，所述第一组撑杆构件互相连接以限定靠近所述环形元件相对侧的顶点。环形元件还包括在至少一对周向相邻的支柱构件之间延伸的脚延伸部。脚部延伸部具有从周向相邻的支柱构件的对应端部周向延伸的第一和第二脚部，并且具有轮廓以提供至少两个弯曲区域。第一和第二脚部在脚延伸部的脚趾部分处连接，并且在一对周向相邻的支柱构件之间限定圆周方向的顶点。优选地，提供至少一个或多个另外的环形元件，每个环形元件由互连的支柱构件限定。环形元件通常在输送配置和展开配置之间可扩展。环形元件在连接位置处纵向对齐并连接。优选地，每个连接位置包括脚部延伸部，例如通过在纵向相邻的环形元件之间的重叠图案，或者通过在它们之间延伸的连接器。

26. 发明申请

US20140335961A1 METHODOLOGY FOR EQUALIZING SYSTEMIC LATENCIES IN TELEVISION RECEPTION IN CONNECTION WITH GAMES OF SKILL PLAYED IN CONNECTION WITH LIVE TELEVISION PROGRAMMING 有权
公开(公告)号：US20140335961A1
公开(公告)日：2014-11-13
申请号：US14338298
申请日：2014-07-22
申请人： David B. Lockton , Mark K. Berner , Mark J. Micheli , David Lowe
发明人： David B. Lockton , Mark K. Berner , Mark J. Micheli , David Lowe
IPC分类号： A63F13/30
CPC分类号： A63F13/358 , A63F13/12 , A63F13/216 , A63F13/22 , A63F13/285 , A63F13/32 , A63F13/332 , A63F13/335 , A63F13/338 , A63F13/50 , A63F13/795 , A63F13/92 , A63F2300/406 , A63F2300/407 , A63F2300/409 , A63F2300/534 , H04N5/04 , H04N21/2385 , H04N21/25866 , H04N21/27 , H04N21/4302 , H04N21/435 , H04N21/43615 , H04N21/44209 , H04N21/4508 , H04N21/47217 , H04N21/4781 , H04N21/6131
摘要： A method of and system for handling latency issues encountered in producing real-time entertainment such as games of skill synchronized with live or taped televised events is described herein. There are multiple situations that are dealt with regarding latencies in receiving a television signal with respect to real-time entertainment based on the unfolding games played along with the telecasts. Systemic delays, arbitrarily imposed delays of a broadcast signal and variances in the precise broadcast times of taped television programs have to be equalized so as to provide fair entertainment.

27. 发明申请

US20130047025A1 SYSTEM AND METHOD FOR STREAM PROCESSING UTILIZING MULTIPOTENT MORPHOGENIC STEM CELLS 有权
标题翻译：利用多元多态干细胞进行流程处理的系统和方法
公开(公告)号：US20130047025A1
公开(公告)日：2013-02-21
申请号：US13212392
申请日：2011-08-18
申请人： Kenneth Sabir , David Lowe
发明人： Kenneth Sabir , David Lowe
IPC分类号： G06F11/20
CPC分类号： G06F11/2035
摘要： A method, computer program product, and system for de-centralized stream processing is provided. The method may include providing a plurality of processing nodes in a hierarchical genome having a plurality of levels, wherein each of said processing nodes is configured to transmit and receive a stream of data. The method may further include restricting a subset of the plurality of processing nodes from differentiating into a role within each level of the hierarchical genome. The method may also include identifying a failure at one of the processing nodes and replacing the failed node with one of the processing nodes from the restricted subset.
摘要翻译：提供了一种用于去集中式流处理的方法，计算机程序产品和系统。该方法可以包括在具有多个级别的分层基因组中提供多个处理节点，其中每个所述处理节点被配置为发送和接收数据流。该方法还可以包括将多个处理节点的子集限制为在分级基因组的每个级别内的角色。该方法还可以包括在处理节点之一处识别出故障，并且从受限子集中用处理节点之一替换故障节点。

28. 发明申请

US20130046858A1 SYSTEM AND METHOD FOR HIERARCHICAL STREAM PROCESSING 失效
标题翻译：用于分层流程处理的系统和方法
公开(公告)号：US20130046858A1
公开(公告)日：2013-02-21
申请号：US13212449
申请日：2011-08-18
申请人： Kenneth Sabir , David Lowe
发明人： Kenneth Sabir , David Lowe
IPC分类号： G06F15/16
CPC分类号： G06F9/5072 , G06F19/28
摘要： A method, computer program product, and system for de-centralized stream processing is provided. The method may include providing a plurality of processing nodes each of said processing nodes configured to transmit and receive a stream of data. The method may also include providing a genome including a hierarchical set of tasks that represent a hierarchical functional decomposition of one or more problem scenarios. The method may further include identifying, at each of the processing nodes, one or more tasks for a first genome level. The method may additionally include differentiating, at one or more of the plurality of processing nodes, into one or more tasks, based upon, at least in part, the first genome level. The method may further include grouping a plurality of the processing nodes together to achieve a power level. The method may also include activating a second genome level once the power level has been reached. The method may further include repeating until one or more of the nodes differentiates into a further genome level.
摘要翻译：提供了一种用于去集中式流处理的方法，计算机程序产品和系统。该方法可以包括提供多个处理节点，每个处理节点被配置成发送和接收数据流。该方法还可以包括提供基因组，其包括表示一个或多个问题场景的分层功能分解的任务的分层组。该方法还可以包括在每个处理节点处识别用于第一基因组水平的一个或多个任务。该方法可以另外包括在至少部分地基于第一基因组水平的基础上将多个处理节点中的一个或多个处理区分成一个或多个任务。该方法还可以包括将多个处理节点分组在一起以实现功率水平。一旦达到功率水平，该方法还可以包括激活第二基因组水平。该方法可以进一步包括重复，直到一个或多个节点区分为进一步的基因组水平。

29. 发明申请

US20120157178A1 METHODOLOGY FOR EQUALIZING SYSTEMIC LATENCIES IN TELEVISION RECEPTION IN CONNECTION WITH GAMES OF SKILL PLAYED IN CONNECTION WITH LIVE TELEVISION PROGRAMMING 有权
标题翻译：在与电视节目编排相关的技能游戏相关电视接收中的系统播放的均衡化方法
公开(公告)号：US20120157178A1
公开(公告)日：2012-06-21
申请号：US13403845
申请日：2012-02-23
申请人： David B. Lockton , Mark K. Berner , Mark J. Micheli , David Lowe
发明人： David B. Lockton , Mark K. Berner , Mark J. Micheli , David Lowe
IPC分类号： A63F9/24
CPC分类号： A63F13/358 , A63F13/12 , A63F13/216 , A63F13/22 , A63F13/285 , A63F13/32 , A63F13/332 , A63F13/335 , A63F13/338 , A63F13/50 , A63F13/795 , A63F13/92 , A63F2300/406 , A63F2300/407 , A63F2300/409 , A63F2300/534 , H04N5/04 , H04N21/2385 , H04N21/25866 , H04N21/27 , H04N21/4302 , H04N21/435 , H04N21/43615 , H04N21/44209 , H04N21/4508 , H04N21/47217 , H04N21/4781 , H04N21/6131
摘要： A method of and system for handling latency issues encountered in producing real-time entertainment such as games of skill synchronized with live or taped televised events is described herein. There are multiple situations that are dealt with regarding latencies in receiving a television signal with respect to real-time entertainment based on the unfolding games played along with the telecasts. Systemic delays, arbitrarily imposed delays of a broadcast signal and variances in the precise broadcast times of taped television programs have to be equalized so as to provide fair entertainment.
摘要翻译：这里描述了一种用于处理在生产实时娱乐中遇到的延迟问题的方法和系统，例如与实况或录音电视事件同步的技能游戏。基于与电视广播一起播放的展开游戏，关于实时娱乐接收电视信号的延迟有多种情况。系统延误，任意施加的广播信号的延迟和录像电视节目的精确广播时间的差异必须相等，以提供公平的娱乐。

30. 发明授权

US08163884B2 Interleukin-21 receptor binding proteins 失效
标题翻译：白细胞介素-21受体结合蛋白
公开(公告)号：US08163884B2
公开(公告)日：2012-04-24
申请号：US12472209
申请日：2009-05-26
申请人： Laird Bloom , Davinder Gill , Yulia Vugmeyster , Deborah A. Young , David Lowe , Viia Valge-Archer
发明人： Laird Bloom , Davinder Gill , Yulia Vugmeyster , Deborah A. Young , David Lowe , Viia Valge-Archer
IPC分类号： C07K16/28 , A61K39/00 , A61K39/395 , C12P21/02
CPC分类号： C07K14/54 , C07K16/2866 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要： The present invention provides binding proteins and antigen-binding fragments thereof that specifically bind to the human interleukin-21 receptor (IL-21R). The binding proteins can act as, e.g., antagonists of IL-21R activity, thereby modulating immune responses in general, and those mediated by IL-21R in particular. The disclosed compositions and methods may be used, e.g., in diagnosing and/or treating IL-21R-associated disorders, e.g., inflammatory disorders, autoimmune diseases, allergies, transplant rejection, cancer, and other immune system disorders.
摘要翻译：本发明提供与人白细胞介素-21受体（IL-21R）特异性结合的结合蛋白及其抗原结合片段。结合蛋白可以作为例如IL-21R活性的拮抗剂，从而调节一般的免疫应答，特别是由IL-21R介导的那些。所公开的组合物和方法可用于例如诊断和/或治疗IL-21R相关疾病，例如炎症性疾病，自身免疫疾病，过敏反应，移植排斥反应，癌症和其他免疫系统疾病。

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