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21. 发明授权

US09063066B2 Method for analysis using X-ray fluorescence 有权
标题翻译：使用X射线荧光分析的方法
公开(公告)号：US09063066B2
公开(公告)日：2015-06-23
申请号：US13317341
申请日：2011-10-14
申请人： Lori J. Peterson , Cameron A. Mortillaro , Benjamin P. Warner , Nathan H. Zahler , Pratima Bharti , Chang-Tai Hsieh , Emilia A. Solomon
发明人： Lori J. Peterson , Cameron A. Mortillaro , Benjamin P. Warner , Nathan H. Zahler , Pratima Bharti , Chang-Tai Hsieh , Emilia A. Solomon
IPC分类号： G01N23/223 , A61B6/00
CPC分类号： G01N23/223 , A61B6/485 , G01N33/4833 , G01N33/487 , G01N2223/076 , G01N2223/0766 , G01N2223/612 , G01N2223/6126
摘要： The present invention is a method to quantify biomarkers. The method uses an X-ray fluorescence spectrometer to perform an X-ray fluorescence analysis on the sample to obtain spectral features derived from the biomarker; and quantifying the X-ray fluorescence signal of the biomarker.
摘要翻译：本发明是一种量化生物标志物的方法。该方法使用X射线荧光光谱仪对样品进行X射线荧光分析，以获得源自生物标志物的光谱特征; 并量化生物标志物的X射线荧光信号。

22. 发明授权

US08873707B2 Well plate 有权
标题翻译：井盘
公开(公告)号：US08873707B2
公开(公告)日：2014-10-28
申请号：US13567613
申请日：2012-08-06
申请人： Eva R. Birnbaum , Benjamin P. Warner , Sharon M. Baldwin , Jennifer A. Berger , Rebecca L. E. Miller
发明人： Eva R. Birnbaum , Benjamin P. Warner , Sharon M. Baldwin , Jennifer A. Berger , Rebecca L. E. Miller
IPC分类号： G01N1/28
CPC分类号： G01N23/2202 , G01N23/2204 , G01N23/223 , G01N2223/074 , G01N2223/076 , G01N2223/309 , G01N2223/64 , G03B42/02
摘要： An apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. A plate has one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays.
摘要翻译：通过X射线荧光光谱法制备用于测量的样品的装置。板有一个或多个孔穿过板。孔被板的一侧的薄膜覆盖。在膜覆盖孔的一个维度上，孔小于500微米。这部电影对于x射线是半透明的。

23. 发明授权

US08431357B2 Method and apparatus for measuring analyte transport across barriers using x-ray fluorescence 有权
标题翻译：使用X射线荧光测量跨屏障的分析物传输的方法和装置
公开(公告)号：US08431357B2
公开(公告)日：2013-04-30
申请号：US12496532
申请日：2009-07-01
申请人： Eva R. Birnbaum , Rebecca L. E. Miller , Lori J. Peterson , Jennifer A. Berger , Benjamin P. Warner
发明人： Eva R. Birnbaum , Rebecca L. E. Miller , Lori J. Peterson , Jennifer A. Berger , Benjamin P. Warner
IPC分类号： C12Q1/02 , G01N21/76 , G01N23/223
CPC分类号： G01N33/6872 , G01N23/2076 , G01N23/223 , G01N33/502 , G01N2223/076
摘要： The present invention includes a method and apparatus for measuring the removal of analyte from a cell. One or more cells are provided, comprising at least 10 picograms of an analyte within a volume defined by the area of an x-ray excitation beam and a depth of a depth of five times the 1/e attenuation depth for at least one characteristic x-ray signal of the analyte as attenuated by water. At least a of portion of the analyte is removed from the cells; and the analyte is measured using x-ray fluorescence.
摘要翻译：本发明包括用于测量从细胞中去除分析物的方法和装置。提供了一个或多个细胞，其包括由X射线激发束的区域限定的体积内的至少10皮克分析物和对于至少一个特征x的1 / e衰减深度的深度的5倍分析物的射线信号被水减弱。从细胞中去除至少一部分分析物; 并使用x射线荧光测量分析物。

24. 发明授权

US08238515B2 Well plate 有权
标题翻译：井盘
公开(公告)号：US08238515B2
公开(公告)日：2012-08-07
申请号：US12192762
申请日：2008-08-15
申请人： Eva R. Birnbaum , Benjamin P. Warner , Sharon M. Baldwin , Jennifer A. Berger , Rebecca L. E. Miller
发明人： Eva R. Birnbaum , Benjamin P. Warner , Sharon M. Baldwin , Jennifer A. Berger , Rebecca L. E. Miller
IPC分类号： G01N23/223
CPC分类号： G01N23/2202 , G01N23/2204 , G01N23/223 , G01N2223/074 , G01N2223/076 , G01N2223/309 , G01N2223/64 , G03B42/02
摘要： The present invention includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered by a film on one side of the plate. The holes are less than 500 micrometers across in one dimension where the film covers the holes. The film is translucent to x-rays. The present invention also includes an apparatus for preparing samples for measurement by x-ray fluorescence spectrometry. The apparatus comprises a plate having one or more holes passing through the plate. The holes are covered on one side of the plate by a detachable cover forming a water-tight seal against the plate. The cover is substantially free of the elements osmium, yttrium, iridium, phosphorus, zirconium, platinum, gold, niobium, mercury, thallium, molybdenum, sulfur, lead, bismuth, technetium, ruthenium, chlorine, rhodium, palladium, argon, silver, and thorium. The holes are less than about 500 micrometers across in one dimension where the cover covers the holes. The present invention also includes a method for preparing samples for measurement by x-ray fluorescence spectrometry. The method comprises providing a solution of with less than 10 micromolar solute and a volume of between about 2 microliters and about 2 milliliters. The solution is concentrated and analyzed using x-ray fluorescence spectrometry.
摘要翻译：本发明包括通过X射线荧光光谱法制备用于测量的样品的装置。该装置包括具有穿过板的一个或多个孔的板。孔被板的一侧的薄膜覆盖。在膜覆盖孔的一个维度上，孔小于500微米。这部电影对于x射线是半透明的。本发明还包括通过X射线荧光光谱法制备用于测量的样品的装置。该装置包括具有穿过板的一个或多个孔的板。孔通过可拆卸的盖子覆盖在板的一侧上，该盖子形成对板的防水密封。该盖基本上不含锇，钇，铱，磷，锆，铂，金，铌，汞，铊，钼，硫，铅，铋，锝，钌，氯，铑，钯，氩，和钍。这些孔在一个尺寸上小于约500微米，其中盖覆盖孔。本发明还包括通过X射线荧光光谱法制备用于测量的样品的方法。该方法包括提供小于10微摩尔溶质的溶液和约2微升至约2毫升的体积。使用x射线荧光光谱法浓缩溶液并进行分析。

25. 发明申请

US20120093286A1 Method for analysis using x-ray fluorescence 有权
标题翻译：使用X射线荧光分析的方法
公开(公告)号：US20120093286A1
公开(公告)日：2012-04-19
申请号：US13317341
申请日：2011-10-14
申请人： Lori J. Peterson , Camaron A. Mortillaro , Benjamin P. Warner , Nathan H. Zahler , Pratima Bharti , Chang-Tai Hsieh , Emilia A. Solomon
发明人： Lori J. Peterson , Camaron A. Mortillaro , Benjamin P. Warner , Nathan H. Zahler , Pratima Bharti , Chang-Tai Hsieh , Emilia A. Solomon
IPC分类号： G01N23/223
CPC分类号： G01N23/223 , A61B6/485 , G01N33/4833 , G01N33/487 , G01N2223/076 , G01N2223/0766 , G01N2223/612 , G01N2223/6126
摘要： The present invention is a method to quantify biomarkers. The method uses an X-ray fluorescence spectrometer to perform an X-ray fluorescence analysis on the sample to obtain spectral features derived from the biomarker; and quantifying the X-ray fluorescence signal of the biomarker.
摘要翻译：本发明是一种量化生物标志物的方法。该方法使用X射线荧光光谱仪对样品进行X射线荧光分析，以获得源自生物标志物的光谱特征; 并量化生物标志物的X射线荧光信号。

26. 发明授权

US07633669B2 Durable electrooptic devices comprising ionic liquids 有权
标题翻译：包含离子液体的耐用电光装置
公开(公告)号：US07633669B2
公开(公告)日：2009-12-15
申请号：US12291381
申请日：2008-11-06
申请人： Anthony K. Burrell , Anoop Agrawal , John P. Cronin , Juan C. L. Tonazzi , Benjamin P. Warner , T. Mark McCleskey
发明人： Anthony K. Burrell , Anoop Agrawal , John P. Cronin , Juan C. L. Tonazzi , Benjamin P. Warner , T. Mark McCleskey
IPC分类号： G02F1/153 , G02F1/15
CPC分类号： C09K9/02 , B60R1/088 , B82Y20/00 , C09K2211/1029 , G02F1/1521 , G02F1/155 , G02F1/157 , G02F2202/022 , G02F2202/36
摘要： Electrolyte solutions for electrochromic devices such as rear view mirrors and displays with low leakage currents are prepared using inexpensive, low conductivity conductors. Preferred electrolytes include bifunctional redox dyes and molten salt solvents with enhanced stability toward ultraviolet radiation. The solvents include lithium or quaternary ammonium cations, and perfluorinated sulfonylimide anions selected from trifluoromethylsulfonate (CF3SO3−), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N−), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N−) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C−). Electroluminescent, electrochromic and photoelectrochromic devices with nanostructured electrodes include ionic liquids with bifunctional redox dyes. Some of the electrolyte solutions color to red when devices employing the solutions are powered, leading to red or neutral electrooptic devices.
摘要翻译：使用廉价，低导电性的导体制备电致变色器件如后视镜和低漏电流的显示器的电解液。优选的电解质包括双功能氧化还原染料和熔融盐溶剂，对紫外线辐射具有增强的稳定性。溶剂包括锂或季铵阳离子，和选自三氟甲基磺酸盐（CF 3 SO 3 - ），双（三氟甲磺酰基）酰亚胺（（CF 3 SO 2）2 N）），双（全氟乙基磺酰基）酰亚胺（（CF 3 CF 2 SO 2）2 N-）和三）甲基化（（CF 3 SO 2）3 C-）。具有纳米结构电极的电致发光，电致变色和光电致变色装置包括具有双功能氧化还原染料的离子液体。当使用解决方案的设备供电时，一些电解液颜色变红，导致红色或中性电光设备。

27. 发明授权

US07615267B2 Radiofrequency attenuator and method 有权
标题翻译：射频衰减器及方法
公开(公告)号：US07615267B2
公开(公告)日：2009-11-10
申请号：US11101666
申请日：2005-03-28
申请人： Benjamin P. Warner , T. Mark McCleskey , Anthony K. Burrell , Anoop Agrawal , Simon B. Hall
发明人： Benjamin P. Warner , T. Mark McCleskey , Anthony K. Burrell , Anoop Agrawal , Simon B. Hall
IPC分类号： B32B1/00 , B32B1/02
CPC分类号： H05K9/0005 , B32B17/06 , C03C17/23 , C03C17/42 , C03C27/06 , C03C2217/231 , E06B5/18 , Y10T428/13 , Y10T428/1303 , Y10T428/131 , Y10T428/1314 , Y10T428/1352 , Y10T428/1359
摘要： Radiofrequency attenuator and method. The attenuator includes a pair of transparent windows. A chamber between the windows is filled with molten salt. Preferred molten salts include quarternary ammonium cations and fluorine-containing anions such as tetrafluoroborate (BF4−), hexafluorophosphate (PF6−), hexafluoroarsenate (AsF6−), trifluoromethylsulfonate (CF3SO3−), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N−), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N−) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3 C−). Radicals or radical cations may be added to or electrochemically generated in the molten salt to enhance the RF attenuation.
摘要翻译：射频衰减器及方法。衰减器包括一对透明窗口。窗户之间的一个房间里充满了熔盐。优选的熔盐包括季铵阳离子和含氟阴离子如四氟硼酸盐（BF4-），六氟磷酸盐（PF6-），六氟砷酸盐（AsF6-），三氟甲磺酸盐（CF3SO3-），双（三氟甲基磺酰基）酰亚胺（（CF 3 SO 2）2 N），（全氟乙基磺酰基）酰亚胺（（CF 3 CF 2 SO 2）2 N）和三（三氟甲基磺酰基）甲基化物（（CF 3 SO 2）3 C-）。可以在熔融盐中添加或电化学产生自由基或自由基阳离子以增强RF衰减。

28. 发明授权

US07450292B1 Durable electrooptic devices comprising ionic liquids 有权
标题翻译：包含离子液体的耐用电光装置
公开(公告)号：US07450292B1
公开(公告)日：2008-11-11
申请号：US11526416
申请日：2006-09-22
申请人： Anthony K. Burrell , Anoop Agrawal , John P. Cronin , Juan C. L. Tonazzi , Benjamin P. Warner , T. Mark McCleskey
发明人： Anthony K. Burrell , Anoop Agrawal , John P. Cronin , Juan C. L. Tonazzi , Benjamin P. Warner , T. Mark McCleskey
IPC分类号： G02F1/153 , G02F1/15 , G02F1/00
CPC分类号： C09K9/02 , B60R1/088 , B82Y20/00 , C09K2211/1029 , G02F1/1521 , G02F1/155 , G02F1/157 , G02F2202/022 , G02F2202/36
摘要： Electrolyte solutions for electrochromic devices such as rear view mirrors and displays with low leakage currents are prepared using inexpensive, low conductivity conductors. Preferred electrolytes include bifunctional redox dyes and molten salt solvents with enhanced stability toward ultraviolet radiation. The solvents include lithium or quaternary ammonium cations, and perfluorinated sulfonylimide anions selected from trifluoromethylsulfonate (CF3SO3−), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N−), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N−) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C−). Electroluminescent, electrochromic and photoelectrochromic devices with nanostructured electrodes include ionic liquids with bifunctional redox dyes. Some of the electrolyte solutions color to red when devices employing the solutions are powered, leading to red or neutral electrooptic devices.
摘要翻译：使用廉价，低导电性的导体制备电致变色器件如后视镜和低漏电流的显示器的电解液。优选的电解质包括双功能氧化还原染料和熔融盐溶剂，对紫外线辐射具有增强的稳定性。溶剂包括锂或季铵阳离子，和全氟磺酰亚胺阴离子，选自三氟甲基磺酸酯（CF 3 SO 3 SO 2），双（三氟甲基磺酰基）酰亚胺（（CF 3 SO 2）2 N - ），双（全氟乙基磺酰基）酰亚胺（（CF _{3（三氟甲基磺酰基）甲基化（（3,3-二甲基-2- （CF 3 SO 2）3） - （CH 3）3）。具有纳米结构电极的电致发光，电致变色和光电致变色装置包括具有双功能氧化还原染料的离子液体。当使用解决方案的设备供电时，一些电解液颜色变红，导致红色或中性电光设备。}

29. 发明授权

US07129093B2 Quantitative method of determining beryllium or a compound thereof in a sample 有权
标题翻译：测定样品中铍或其化合物的定量方法
公开(公告)号：US07129093B2
公开(公告)日：2006-10-31
申请号：US10812444
申请日：2004-03-30
申请人： T. Mark McCleskey , Deborah S. Ehler , Kevin D. John , Anthony K. Burrell , Gavin E. Collis , Edel M. Minogue , Benjamin P. Warner
发明人： T. Mark McCleskey , Deborah S. Ehler , Kevin D. John , Anthony K. Burrell , Gavin E. Collis , Edel M. Minogue , Benjamin P. Warner
IPC分类号： G01N33/20
CPC分类号： G01N21/643 , G01N31/22 , G01N2021/7786 , Y10T436/25125 , Y10T436/25875
摘要： A method of determining beryllium or a beryllium compound thereof in a sample, includes providing a sample suspected of comprising beryllium or a compound thereof, extracting beryllium or a compound thereof from the sample by dissolving in a solution, adding a fluorescent indicator to the solution to thereby bind any beryllium or a compound thereof to the fluorescent indicator, and determining the presence or amount of any beryllium or a compound thereof in the sample by measuring fluorescence.
摘要翻译：一种测定样品中铍或其铍化合物的方法，包括提供疑似含有铍或其化合物的样品，通过溶解于溶液中，从样品中提取铍或其化合物，向溶液中加入荧光指示剂从而将任何铍或其化合物与荧光指示剂结合，并通过测量荧光来确定样品中任何铍或其化合物的存在或量。

30. 发明授权

US06961168B2 Durable electrooptic devices comprising ionic liquids 失效
公开(公告)号：US06961168B2
公开(公告)日：2005-11-01
申请号：US10741903
申请日：2003-12-19
申请人： Anoop Agrawal , John P. Cronin , Juan C. L. Tonazzi , Benjamin P. Warner , T. Mark McCleskey , Anthony K. Burrell
发明人： Anoop Agrawal , John P. Cronin , Juan C. L. Tonazzi , Benjamin P. Warner , T. Mark McCleskey , Anthony K. Burrell
IPC分类号： C25B1/00 , G02B5/23 , G02F20060101 , G02F1/00 , G02F1/15 , G02F1/153 , G02F1/155
CPC分类号： C09K9/02 , B60R1/088 , C09K2211/1029 , G02F1/1521 , G02F1/157 , G02F2202/36
摘要： Electrolyte solutions for electrochromic devices such as rear view mirrors and displays with low leakage currents are prepared using inexpensive, low conductivity conductors. Preferred electrolytes include bifunctional redox dyes and molten salt solvents with enhanced stability toward ultraviolet radiation. The solvents include lithium or quaternary ammonium cations, and perfluorinated sulfonylimide anions selected from trifluoromethylsulfonate (CF3SO3−), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N−), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N−) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C−). Electroluminescent, electrochromic and photoelectrochromic devices with nanostructured electrodes include ionic liquids with bifunctional redox dyes.

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