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21. 发明申请

US20140310835A1 SOYBEAN EVENT SYHT04R AND COMPOSITIONS AND METHODS FOR DETECTION THEREOF 有权
标题翻译：大豆事件SYHT04R及其检测方法及其检测方法
公开(公告)号：US20140310835A1
公开(公告)日：2014-10-16
申请号：US13994166
申请日：2011-12-09
申请人： John Daniel Hipskind , Kristina Burgin , Rakesh Jain , Karolyn Terpstra , John Dawson , Annick Jeanne De Framond , Becky Breitinger
发明人： John Daniel Hipskind , Kristina Burgin , Rakesh Jain , Karolyn Terpstra , John Dawson , Annick Jeanne De Framond , Becky Breitinger
IPC分类号： C12N15/82
CPC分类号： C12N15/8274 , A01H5/10 , A01N37/40 , A01N39/04 , A01N57/20 , C12N9/0069 , C12N15/8275 , C12N15/8278 , C12N15/8281 , C12N15/8282 , C12N15/8283 , C12N15/8286 , C12Q1/6895 , C12Q2600/13 , C12Q2600/156 , C12Q2600/158 , C12Y113/11027 , A01N41/10 , A01N43/40 , A01N43/56 , A01N43/80 , A01N2300/00
摘要： Soybean plants comprising event SYHT04R, methods of detecting and using the same, and soybean plants comprising a heterologous insert at the same site as SYHT04R.
摘要翻译：包含事件SYHT04R的大豆植物，检测和使用其的方法，以及包含与SYHT04R相同位点的异源插入物的大豆植物。

22. 发明授权

US07335513B2 Apparatus and methods for parallel processing of multiple reaction mixtures 有权
标题翻译：用于并行处理多种反应混合物的装置和方法
公开(公告)号：US07335513B2
公开(公告)日：2008-02-26
申请号：US10060075
申请日：2002-01-28
申请人： Matthew F. Smith , John F. Varni , G. Cameron Dales , Trevor G. Frank , Rakesh Jain , Lynn Van Erden
发明人： Matthew F. Smith , John F. Varni , G. Cameron Dales , Trevor G. Frank , Rakesh Jain , Lynn Van Erden
IPC分类号： G01N1/10
CPC分类号： B01J19/0046 , B01J2219/00283 , B01J2219/00308 , B01J2219/00313 , B01J2219/00335 , B01J2219/00337 , B01J2219/00373 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/00601 , B01J2219/00689 , B01J2219/00691 , B01J2219/00722 , C40B40/14 , C40B60/14 , Y10T436/2575 , Y10T436/25875
摘要： A parallel reactor system including a reactor and vessels in the reactor for holding reaction mixtures, and a cannula for introducing fluid reaction material into the vessels. A robot system is operable to insert the cannula into cannula passages in the reactor for delivery of reaction materials, including condensed gases, to respective vessels, and to withdraw the cannula from the cannula passages after delivery. Related methods are also disclosed.
摘要翻译：一种并联反应器系统，包括用于保持反应混合物的反应器中的反应器和容器，以及用于将流体反应材料引入容器的插管。机器人系统可操作以将插管插入反应器中的插管通道中，用于将反应材料（包括冷凝气体）输送到相应的容器，并且在输送后从插管通道中抽出插管。还公开了相关方法。

23. 发明申请

US20060088882A1 Methods for the treatment or prevention of obesity 审中-公开
标题翻译：治疗或预防肥胖症的方法
公开(公告)号：US20060088882A1
公开(公告)日：2006-04-27
申请号：US10519248
申请日：2003-06-27
申请人： Rakesh Jain , Dai Fukumura
发明人： Rakesh Jain , Dai Fukumura
IPC分类号： C40B40/10 , A61K39/395
CPC分类号： G01N33/74 , A61K2039/505 , C07K16/2863 , G01N2333/71 , G01N2500/04 , G01N2800/044
摘要： The invention provides methods for the treatment or prevention of obesity. The invention also provides screening methods for determining whether a compound is useful for the treatment or prevention of obesity.
摘要翻译：本发明提供了治疗或预防肥胖症的方法。本发明还提供了用于确定化合物是否可用于治疗或预防肥胖症的筛选方法。

24. 发明申请

US20060036086A1 Use of signal transduction inhibitors and combination therapies for the prevention or treatment of cancer and angiogenesis related diseases 审中-公开
标题翻译：使用信号转导抑制剂和联合疗法预防或治疗癌症和血管生成相关疾病
公开(公告)号：US20060036086A1
公开(公告)日：2006-02-16
申请号：US10507352
申请日：2003-03-05
申请人： Rakesh Jain , Yotaro Izumi , Lei Xu , Dai Fukumura
发明人： Rakesh Jain , Yotaro Izumi , Lei Xu , Dai Fukumura
IPC分类号： C12Q1/68 , C07H21/02
CPC分类号： G01N33/574 , A61K39/39533 , A61K45/06 , C12Q1/6886 , C12Q2600/158 , A61K2300/00
摘要： The invention provides improved compositions (e.g., combinations of signal transduction inhibitors) and methods for the prevention, stabilization, or treatment of cancer or other angiogenesis related diseases. In particular, the present methods use combination therapies to modulate the expression or activity of multiple mRNA molecules or proteins associated with angiogenesis or cancer in a mammal (e.g., a human)
摘要翻译：本发明提供改进的组合物（例如，信号转导抑制剂的组合）以及用于预防，稳定或治疗癌症或其它血管生成相关疾病的方法。特别地，本发明的方法使用组合疗法来调节哺乳动物（例如人）中与血管生成或癌症相关的多种mRNA分子或蛋白质的表达或活性，

25. 发明授权

US06797820B2 Succinate compounds, compositions and methods of use and preparation 失效
标题翻译：琥珀酸盐化合物，组合物和使用方法和制备
公开(公告)号：US06797820B2
公开(公告)日：2004-09-28
申请号：US09738859
申请日：2000-12-13
申请人： Dinesh Patel , Jeffrey W. Jacobs , Rakesh Jain , Zhi-Jie Ni , Zhengyu Yuan
发明人： Dinesh Patel , Jeffrey W. Jacobs , Rakesh Jain , Zhi-Jie Ni , Zhengyu Yuan
IPC分类号： A61K315377
CPC分类号： C07D295/185 , C07D207/09 , C07D207/14 , C07D207/16 , C07D211/60 , C07D217/26 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.
摘要翻译：公开了新的异羟肟酸化合物。这些异羟肟酸盐抑制肽原甲酰酶（PDF），一种存在于原核生物中的酶。羟基聚糖可用作抗微生物剂和抗生素。本发明的化合物显示出对其他金属蛋白酶如基质金属蛋白酶（MMPs）的肽基变性酶的选择性抑制。还公开了化合物的合成和使用方法。

26. 发明授权

US6071684A Photographic element containing specific magenta coupler 失效
标题翻译：含有特定品红色耦合器的摄影元件
公开(公告)号：US6071684A
公开(公告)日：2000-06-06
申请号：US134053
申请日：1998-08-14
申请人： Leslie Shuttleworth , Rakesh Jain , Stanley W. Cowan
发明人： Leslie Shuttleworth , Rakesh Jain , Stanley W. Cowan
IPC分类号： G03C7/30 , G03C7/38 , G03C7/392 , G03C1/08
CPC分类号： G03C7/383 , G03C7/301 , G03C1/34 , G03C7/39224 , Y10S430/158
摘要： Disclosed is a photographic element comprising a support on which is coated at least one layer containing a light sensitive silver halide emulsion having associated therewith a dye-forming coupler of Formula (1a). wherein R.sub.1 is an alkyl group of not more than 8 carbon atoms; R.sub.5, R.sub.6, R.sub.7, and R.sub.8 each independently represent a hydrogen atom or a substituent; and A is an alkylene group. The element has improved post-process keeping.
摘要翻译：公开了一种照相元件，其包含载体，其上涂覆有至少一层含有光敏卤化银乳剂的层，其具有式（1a）的染料形成成色剂。其中R1是不大于8个碳原子的烷基; R5，R6，R7和R8各自独立地表示氢原子或取代基; A是亚烷基。该元素改进了后处理保持。

27. 发明授权

US5484696A Photographic elements containing 2-equivalent pyrazolone magenta dye forming couplers and fade reducing compounds 失效
标题翻译：含有2-当量吡唑啉酮品红色染料形成成色剂和褪色还原化合物的照相元件
公开(公告)号：US5484696A
公开(公告)日：1996-01-16
申请号：US362635
申请日：1994-12-22
申请人： Rakesh Jain , William R. Schleigh , Robert C. Stewart
发明人： Rakesh Jain , William R. Schleigh , Robert C. Stewart
IPC分类号： G03C7/00 , G03C7/30 , G03C7/384 , G03C7/392 , G03C7/38
CPC分类号： G03C7/3012 , G03C7/39296 , G03C7/384 , G03C7/39216 , G03C7/39276
摘要： A silver halide photographic element having a light sensitive silver halide which layer also contains a 2-equivalent pyrazolone magenta coupler, a compound of formula (S) below, and a hydroquinone compound of formula (R) below: ##STR1## wherein: R.sub.1 is an alkyl group; and R.sub.2, R.sub.3 and R.sub.4 are independently an alkyl group or H.The presence of the compound (S) when used with the two-equivalent pyrazolone magenta coupler and compound (R), can result in low magenta dye fade, increased wavelength of maximum absorption of the magenta dye and increased magenta dye bandwidth.
摘要翻译：一种具有感光卤化银的卤化银照相元件，该层还含有2-当量的吡唑啉酮品红成色剂，下式（S）的化合物和下式（R）的氢醌化合物：其中：R1是烷基; 并且R2，R3和R4独立地是烷基或H.当与双当量吡唑啉酮品红成色剂和化合物（R）一起使用时，化合物（S）的存在可导致低品红色染料褪色，增加最大波长品红染料的吸收和品红色染料带宽的增加。

28. 发明授权

US5437962A Photographic elements containing particular color couplers in combination with particular stabilizers 失效
标题翻译：包含特定色耦合器的特定稳定器的照相元件
公开(公告)号：US5437962A
公开(公告)日：1995-08-01
申请号：US42194
申请日：1993-04-02
申请人： Rakesh Jain , Thomas H. Jozefiak , Hugh M. Williamson
发明人： Rakesh Jain , Thomas H. Jozefiak , Hugh M. Williamson
IPC分类号： G03C7/30 , G03C7/36 , G03C7/392 , G03C7/32
CPC分类号： G03C7/36 , G03C7/3013
摘要： A photographic element having at least one photosensitive silver halide layer and associated therewith both a particular type of color coupler and a particular type of stabilizer. The color coupler is of the general formula (1) or (2): ##STR1## wherein A and B represent the same or different electron-withdrawing group,X is H or a group which splits off on coupling with oxidized color developer,R is an alkyl, cycloalkyl, aryl or heterocyclic which may be substituted, --COR.sup.1, --CSR.sup.1, SOR.sup.1, SO.sub.2 R.sup.1, --NHCOR.sup.1, --CONHR.sup.1, --COOR.sup.1, --COSR.sup.1, --NHSO.sub.2 R.sup.1 wherein R.sup.1 is an alkyl, cycloalkyl, or aryl group any of which are optionally substituted, and wherein two or more of A, B, R, and X optionally form part of a ring,Link is a linking group andn is 0, 1 or 2.The stabilizer is of the general formula (II), (III) or (IV): ##STR2## wherein the substituents of (II), (III) and (IV) are as defined in the specification.
摘要翻译：具有至少一个光敏卤化银层并与其相关联的特定类型的彩色耦合器和特定类型的稳定器的照相元件。彩色成色剂具有通式（1）或（2）：其中A和B表示相同或不同的吸电子基团，X为H或与氧化显色剂偶联时分裂的基团R 是可以被取代的烷基，环烷基，芳基或杂环，-COR1，-CSR1，SOR1，SO2R1，-NHCOR1，-CONHR1，-COOR1，-COSR1，-NHSO2R1，其中R1是烷基，环烷基或芳基，其中任选被取代，并且其中两个或多个A，B，R和X任选地形成环的一部分，Link是连接基团，n是0,1或2.稳定剂具有通式（II （II），（III）和（IV）的取代基如说明书中所定义。

29. 发明授权

US5434040A Photographic elements containing particular color couplers in combination with metal complex stabilizers 失效
标题翻译：含有特定颜色耦合器与金属络合物稳定剂组合的照相元件
公开(公告)号：US5434040A
公开(公告)日：1995-07-18
申请号：US42197
申请日：1993-04-02
申请人： Rakesh Jain , Thomas H. Jozefiak , Sundaram Krishnamurthy , John L. Pawlak , Hugh M. Williamson
发明人： Rakesh Jain , Thomas H. Jozefiak , Sundaram Krishnamurthy , John L. Pawlak , Hugh M. Williamson
IPC分类号： G03C7/30 , G03C7/36 , G03C7/392 , G03C7/32
CPC分类号： G03C7/36 , G03C7/3013
摘要： A photographic element having at least one photosensitive silver halide layer and associated therewith both a particular type of color coupler and a particular type of stabilizer. The color coupler is of the general formula (1) or (2): ##STR1## wherein A and B represent the same or different electron-withdrawing group,X is H or a group which splits off on coupling with oxidized color developer,R is an alkyl, cycloalkyl, aryl or heterocyclic which may be substituted, --COR.sup.1, --CSR.sup.1, SOR.sup.1, SO.sub.2 R.sup.1, --NHCOR.sup.1, --CONHR.sup.1, --COOR.sup.1, --COSR.sup.1, --NHSO.sub.2 R.sup.1 wherein R.sup.1 is an alkyl, cycloalkyl, or aryl group any of which are optionally substituted, and wherein two or more of A, B, R, and X optionally form part of a ring,Link is a linking group andn is 0, 1 or 2.The stabilizer is of the general formula (I) below: ##STR2## wherein: M is Cu, Co, Ni, Pd or Pt;W.sup.2, W.sup.3, W.sup.4 and W.sup.5 are defined in the specification.
摘要翻译：具有至少一个光敏卤化银层并与其相关联的特定类型的彩色耦合器和特定类型的稳定器的照相元件。（1）或（2）的成色剂：其中A和B表示相同或不同的吸电子基团，X是H或分开的基团与氧化显色剂偶联时，R为可被取代的烷基，环烷基，芳基或杂环，-COR1，-CSR1，SOR1，SO2R1，-NHCOR1，-CONHR1，-COOR1，-COSR1，-NHSO2R1，其中R1为任何一个烷基，环烷基或芳基任选被取代，并且其中A，B，R和X中的两个或更多个任选地形成环的一部分，Link是连接基团，n是0,1或2。稳定剂具有以下通式（I）：其中：M为Cu，Co，Ni，Pd或Pt; W2，W3，W4和W5在说明书中定义。

30. 发明授权

US5426021A Liquid or low melting bis-phenol stabilizers for yellow image dye stabilization in ektacolor paper 失效
标题翻译：液体或低熔点双酚稳定剂，用于在ektacolor纸中稳定黄色图像
公开(公告)号：US5426021A
公开(公告)日：1995-06-20
申请号：US86977
申请日：1993-07-02
申请人： Sundaram Krishnamurthy , Rakesh Jain , Paul P. Spara , Thomas A. Rosiek
发明人： Sundaram Krishnamurthy , Rakesh Jain , Paul P. Spara , Thomas A. Rosiek
IPC分类号： C07C69/017 , C07C315/04 , C07C317/22 , C07F9/12 , G03C7/392 , G03C7/36
CPC分类号： G03C7/39216 , C07C315/04 , C07C69/017 , C07F9/12
摘要： A photographic element containing a silver halide emulsion layer having associated therewith, a dye-forming coupler and a dye stabilizer which has a melting point of less than 150.degree. C. (and preferably less than 100.degree. C.) and is of the formula: ##STR1## wherein R, m, q, X, Y, r, and (R.sup.7).sub.n are defined in the specification.The element particularly contains a coupler which forms a yellow dye upon reaction with oxidized developer. A method of making stabilizers of the above type using particular solvents and a non-aqueous workup, is also provided.
摘要翻译：含有与其相关的卤化银乳剂层的照相元件，染料成色剂和染料稳定剂，其熔点低于150℃（优选小于100℃），并具有下式：）n在规范中定义。元素特别包含与氧化显影剂反应形成黄色染料的成色剂。还提供了使用特定溶剂和非水处理制备上述类型的稳定剂的方法。

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