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21. 发明申请

US20060199956A1 Bicyclic heterocycles as HIV integrase inhibitors 有权
公开(公告)号：US20060199956A1
公开(公告)日：2006-09-07
申请号：US11288533
申请日：2005-11-29
申请人： B. Naidu , Jacques Banville , Francis Beaulieu , Timothy Connolly , Mark Krystal , John Matiskella , Carl Ouellet , Serge Plamondon , Roger Remillard , Margaret Sorenson , Yasutsugu Ueda , Michael Walker
发明人： B. Naidu , Jacques Banville , Francis Beaulieu , Timothy Connolly , Mark Krystal , John Matiskella , Carl Ouellet , Serge Plamondon , Roger Remillard , Margaret Sorenson , Yasutsugu Ueda , Michael Walker
IPC分类号： C07D491/04
CPC分类号： C07D498/04 , A61K31/519 , A61K31/5383 , A61K31/541 , A61K31/675 , A61K31/683 , A61K45/06 , A61K2300/00
摘要： The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

22. 发明申请

US20050267105A1 Bicyclic heterocycles as HIV integrase inhibitors 有权
标题翻译：双环杂环作为HIV整合酶抑制剂
公开(公告)号：US20050267105A1
公开(公告)日：2005-12-01
申请号：US11126891
申请日：2005-05-11
申请人： B. Naidu , Jacques Banville , Francis Beaulieu , Timothy Connolly , Mark Krystal , John Matiskella , Carl Ouellet , Serge Plamondon , Roger Remillard , Margaret Sorenson , Yasutsugu Ueda , Michael Walker
发明人： B. Naidu , Jacques Banville , Francis Beaulieu , Timothy Connolly , Mark Krystal , John Matiskella , Carl Ouellet , Serge Plamondon , Roger Remillard , Margaret Sorenson , Yasutsugu Ueda , Michael Walker
IPC分类号： A61K31/519 , A61K31/538 , A61P31/18 , C07D491/04 , C07D498/04
CPC分类号： C07D498/04
摘要： The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.
摘要翻译：本发明包括抑制HIV整合酶并防止病毒整合入人DNA的式I的一系列环状双环嘧啶酮化合物。这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。本发明还包括用于治疗感染HIV的那些的药物组合物和方法。

23. 发明申请

US20050217209A1 Packaging apparatus 审中-公开
标题翻译：包装设备
公开(公告)号：US20050217209A1
公开(公告)日：2005-10-06
申请号：US11092981
申请日：2005-03-30
申请人： Paul Colwell , Francis Groom , Michael Walker
发明人： Paul Colwell , Francis Groom , Michael Walker
IPC分类号： B65B5/10 , B65B35/40 , B65B35/30
CPC分类号： B65B35/40 , B65B5/106 , B65B21/242
摘要： The invention provides a machine for packaging a product. The machine has a feed end for receiving products to be packaged, a delivery end from which packaged products are discharged, and a plurality of packaging lanes. Each packaging lane is adopted for packaging a row of products so that the machine can simultaneously package a plurality of rows of products.
摘要翻译：本发明提供一种用于包装产品的机器。机器具有用于接收要包装的产品的进料端，从其排出包装产品的输送端和多个包装通道。每个包装通道被用于包装一排产品，使机器可以同时包装多行产品。

24. 发明申请

US20050192208A2 ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF 有权
标题翻译：离子通道调节化合物及其用途
公开(公告)号：US20050192208A2
公开(公告)日：2005-09-01
申请号：US10674684
申请日：2003-09-29
申请人： Allen Bain , Gregory Beatch , Cindy Longley , Bertrand Plouvier , Tao Sheng , Michael Walker , Richard Wall , Sandro Yong , Jeff Zhu , Alexander Zolotoy
发明人： Allen Bain , Gregory Beatch , Cindy Longley , Bertrand Plouvier , Tao Sheng , Michael Walker , Richard Wall , Sandro Yong , Jeff Zhu , Alexander Zolotoy
IPC分类号： C07D295/08 , A61K20060101 , A61K31/13 , A61K31/133 , A61K31/135 , A61K31/40 , A61K31/4015 , A61K31/407 , A61K31/41 , A61K31/4162 , A61K31/426 , A61K31/495 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P3/10 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P15/00 , A61P15/10 , A61P17/14 , A61P21/00 , A61P21/04 , A61P23/00 , A61P25/00 , A61P25/06 , A61P25/28 , A61P27/02 , A61P29/00 , A61P37/06 , C07C20060101 , C07C217/52 , C07D20060101 , C07D207/04 , C07D207/12 , C07D207/24 , C07D207/26 , C07D207/27 , C07D277/04 , C07D295/096 , C07D295/15 , C07D295/18 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10 , C07D491/113 , A61K31/00
CPC分类号： C07D207/27 , C07C217/52 , C07C2601/14 , C07D207/12 , C07D277/04 , C07D295/08 , C07D295/096 , C07D295/14 , C07D295/15 , C07D295/185 , C07D333/54 , C07D333/56 , C07D491/10
摘要： Abstract of the DisclosureIon channel modulating compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses a variety of in vitro and in vivo uses for the compounds and compositions, including the treatment of arrhythmia and the production of analgesia and local anesthesia.
摘要翻译：公开的摘要公开了离子通道调节化合物。本发明的化合物可以掺入组合物和试剂盒中。本发明还公开了用于化合物和组合物的各种体外和体内用途，包括治疗心律失常和产生镇痛和局部麻醉。

25. 发明申请

US20050179585A1 ULTRA-WIDEBAND RADAR SYSTEM USING SUB-BAND CODED PULSES 有权
标题翻译：超声波雷达系统使用子带编码脉冲
公开(公告)号：US20050179585A1
公开(公告)日：2005-08-18
申请号：US10851635
申请日：2004-05-21
申请人： Michael Walker , David Furuno , Naiel Askar , Gerald Rogerson
发明人： Michael Walker , David Furuno , Naiel Askar , Gerald Rogerson
IPC分类号： G01S20060101 , G01S7/28 , G01S13/00 , G01S13/02 , G01S13/28
CPC分类号： G01S13/284 , G01S13/0209 , G01S13/282
摘要： Methods and apparatus are provided for radar systems using multiple pulses that are shorter than the expected range delay extent of the target to be imaged. In one implementation, a method for performing radar includes the steps of: transmitting a plurality of pulses, each pulse having a different center frequency and a time duration shorter than an expected range delay extent of a target, wherein a total bandwidth is defined by a bandwidth occupied by the plurality of pulses; receiving reflections of the plurality of pulses; and performing pulse compression on the received pulse reflections to generate a detection signal having a radar resolution approximately equivalent to the transmission and reception of a single pulse having the total bandwidth. In preferred form, the pulses comprise ultrawideband (UWB) pulses each occupying a sub-band of the overall system bandwidth.
摘要翻译：为使用比要成像的目标的预期范围延迟范围短的多个脉冲的雷达系统提供方法和装置。在一个实施方式中，执行雷达的方法包括以下步骤：发送多个脉冲，每个脉冲具有与目标的预期范围延迟范围不同的中心频率和持续时间，其中总带宽由多个脉冲占用的带宽; 接收多个脉冲的反射; 并对所接收的脉冲反射进行脉冲压缩，以生成雷达分辨率近似等于具有总带宽的单个脉冲的发送和接收的检测信号。在优选形式中，脉冲包括每个占据整个系统带宽的子带的超宽带（UWB）脉冲。

26. 发明申请

US20050020644A1 Bicyclic fused pyridinyl amides and advantagesous compositons thereof for use as fungicides 审中-公开
标题翻译：双环稠合吡啶基酰胺和其有用的组合物用作杀真菌剂
公开(公告)号：US20050020644A1
公开(公告)日：2005-01-27
申请号：US10501258
申请日：2003-02-20
申请人： John Bisaha , James Hay , Stephen Foor , Michael Walker , David Clark
发明人： John Bisaha , James Hay , Stephen Foor , Michael Walker , David Clark
IPC分类号： A01N37/44 , A01N43/42 , A01N43/76 , A01N47/04 , A01N47/14 , A01N47/34 , A01N55/02 , A01N57/18 , C07D401/12 , C07D491/04 , C07D495/04 , C07D213/56 , A01N43/40
CPC分类号： C07D401/12 , C07D491/04 , C07D495/04
摘要： Compounds of Formula I, including all geometric and stereoisomers, N-oxides, and agriculturally suitable salts thereof: (Formula I); wherein X and either Y or Z are a linking chain 3 or 4 atoms in length attached to contiguous carbon atoms and are taken together with said carbon atoms to form a fused phenyl ring, a fused 5- or 6-membered nonaromatic carbocyclic or heterocyclic ring optionally including one or two ring members selected from the group consisting of C(═O), SO or S(O)2, or a fused 5- or 6-membered heteroaromatic ring, each fused ring optionally substituted with one to three substituents independently selected from R7; and R1, R2, R5, R6R7, m and p are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and a method for controlling plant diseases caused by fungal plant pathogens that involves applying an effective amount of a compound of Formula I.
摘要翻译：式I的化合物，包括所有几何和立体异构体，N-氧化物及其农业上合适的盐：（式I）; 其中X和Y或Z是连接在连接碳原子上的长度为3或4个原子的连接链，并与所述碳原子一起形成稠合苯环，稠合的5或6元非芳族碳环或杂环任选地包括一个或两个选自C（= O），SO或S（O）2的环成员或稠合的5或6元杂芳环，每个稠环任选被一至三个取代基独立地取代选自R 7; 和R 1，R 2，R 5，R 6 R 7，m和p如本公开所定义。还公开了含有式I化合物的组合物和用于控制由真菌植物病原体引起的植物病害的方法，其涉及施用有效量的式I化合物。

27. 发明申请

US20050009889A1 Synergistic fungicide compositions containing at least one n-(2-pyridinyl) 1-3-pyridinecarboxamide derivative and one or more further fungicides useful for controlling fungal plant diseases 审中-公开
标题翻译：含有至少一种正（2-吡啶基）1-3-吡啶甲酰胺衍生物和一种或多种用于防治真菌植物病害的其它杀真菌剂的协同杀菌剂组合物
公开(公告)号：US20050009889A1
公开(公告)日：2005-01-13
申请号：US10501853
申请日：2003-03-18
申请人： Stephen Foor , Michael Walker
发明人： Stephen Foor , Michael Walker
IPC分类号： A01N43/40 , A01N25/04 , A01N25/12 , A01N25/14 , A01N43/54 , A01N43/76 , A01N43/84 , A01N47/10 , A01N47/14 , A01N47/34 , A01N55/02 , A01P3/00 , C07D20060101 , C07D401/12
CPC分类号： A01N43/40 , A01N43/76 , A01N47/14 , A01N47/34 , A01N57/12 , A01N2300/00
摘要： Compositions for controlling plant diseases caused by fungal plant pathogens are described, comprising: (a) at least one compound of Formula I, including all geometric and stereoisomers, N-oxides and agriculturally suitable salts thereof: I—wherein R1, R2, R5 and R6, m and n are as defined in the disclosure; and (b) at least one compound selected from the group consisting of (b1) alkylenebis(dithiocarbamate) fungicides; (b2) compounds acting at the bc1 complex of the fungal mitochondrial respiratory electron transfer site; (b3) cymoxanil; (b4) compounds acting at the demethylase enzyme of the sterol biosynthesis pathway; (b5) morpholine and piperidine compounds that act on the sterol biosynthesis pathway; (b6) phenylamide fungicides; (b7) pyrimidinone fungicides; (b8) phthalimides; and (b9) fosetyl-aluminum. Also disclosed are methods for controlling plant diseases caused by fungal plant pathogens that involves applying an effective amount of the combinations described.
摘要翻译：描述了用于控制由真菌植物病原体引起的植物疾病的组合物，其包含：（a）至少一种式I化合物，包括所有几何和立体异构体，N-氧化物及其农业上合适的盐：I-其中R1，R2，R5和 R6，m和n如本公开中所定义; 和（b）至少一种选自（b1）亚烷基双（二硫代氨基甲酸酯）杀真菌剂的化合物; （b2）在真菌线粒体呼吸电子转移位点的bc1复合物上起作用的化合物; （b3）cymoxanil; （b4）在甾醇生物合成途径的去甲基酶处作用的化合物; （b5）作用于甾醇生物合成途径的吗啉和哌啶化合物; （b6）苯酰胺类杀真菌剂; （b7）嘧啶酮类杀真菌剂; （b8）邻苯二甲酰亚胺; 和（b9）卵磷脂铝。还公开了用于控制由真菌植物病原体引起的植物疾病的方法，涉及应用有效量的所述组合。

28. 发明授权

US06539350B1 Method and circuit arrangement for speech level measurement in a speech signal processing system 失效
标题翻译：用于语音信号处理系统中语音电平测量的方法和电路装置
公开(公告)号：US06539350B1
公开(公告)日：2003-03-25
申请号：US09442392
申请日：1999-11-18
申请人： Michael Walker
发明人： Michael Walker
IPC分类号： G10L1520
CPC分类号： G10L25/48 , G10L2025/783
摘要： Speech level measurement is particularly significant for successful echo compensation in telecommunications systems, for noise suppression in a noisy environment, for example in military vehicles, or in speech recognition and in speech coding and decoding systems. A method is indicated which permits speech levels measurement only if features of speech are recognized and interferences and speech pauses are filtered out for the measurement. To this end, speech and pause detectors and a mean value generator are utilized, the time behavior of which is largely adapted to the perception capability of the human ear. Briefly spoken vowels thus are well detected, while nasal sounds or consonants are suppressed in the case of falling levels. A speech level measuring device is indicated which provides very accurate results in a short adaptation period.
摘要翻译：语音电平测量对于电信系统中成功的回波补偿，例如在嘈杂环境中的噪声抑制，例如在军用车辆中，或在语音识别和语音编码和解码系统中尤其重要。指示一种方法，其仅在语音特征被识别并且干扰和语音暂停被滤出用于测量时才允许语音水平测量。为此，利用语音和暂停检测器和平均值发生器，其时间行为很大程度上适应于人耳的感知能力。简单说出的元音因此被很好地发现，而鼻音或辅音在下降的情况下被压制。指示语音电平测量装置，其在短的适应期内提供非常精确的结果。

29. 发明授权

US06499629B1 Dispensing apparatus for viscous liquids 失效
标题翻译：粘性液体分配装置
公开(公告)号：US06499629B1
公开(公告)日：2002-12-31
申请号：US09578366
申请日：2000-05-25
申请人： Paul K. Colangelo , Peter J. Petrecca , Alan Ramspeck , Michael Walker
发明人： Paul K. Colangelo , Peter J. Petrecca , Alan Ramspeck , Michael Walker
IPC分类号： B67D562
CPC分类号： B05C11/1034 , B05C5/001 , B05C5/02 , B05C5/0225 , Y10T137/2196 , Y10T137/6525 , Y10T137/6606
摘要： Apparatus for dispensing viscous liquid, such as hot melt adhesive, includes a manifold, a dispensing module, a heater thermally coupled to the manifold, and thermally insulating cover structure secured around both the module and the manifold. Air gaps are formed between the cover structure and the heated components inside to further reduce heat transfer. The cover structure may also include heat dissipating fins. A supply connector associated with the manifold includes an interior flow passage, an exterior annular recess and at least one port communicating therebetween. A valve includes a valve seat having an orifice and a sealing surface located around the orifice. The valve further includes a valve stem movable between open and closed positions and having a recess in one end and a sealing edge located around the recess. A valve module includes an integrated heating element for providing localized heat to the adhesive immediately prior to dispensing.
摘要翻译：用于分配粘性液体（例如热熔粘合剂）的设备包括歧管，分配模块，热联接到歧管的加热器以及固定在模块和歧管两端的隔热盖结构。在盖结构和内部加热部件之间形成气隙，以进一步减少热传递。盖结构还可以包括散热翅片。与歧管相关联的供应连接器包括内部流动通道，外部环形凹部和在其间连通的至少一个端口。阀包括具有孔的阀座和位于孔周围的密封表面。阀还包括可在打开位置和关闭位置之间移动的阀杆，并且在一端具有凹部，以及位于凹部周围的密封边缘。阀模块包括集成的加热元件，用于在分配之前立即向粘合剂提供局部热量。

30. 发明授权

US5570423A Method of providing adaptive echo cancellation 失效
标题翻译：提供自适应回波消除的方法
公开(公告)号：US5570423A
公开(公告)日：1996-10-29
申请号：US519303
申请日：1995-08-25
申请人： Michael Walker , Hans-Jurgen Matt
发明人： Michael Walker , Hans-Jurgen Matt
IPC分类号： H04M9/08 , H04B3/20
CPC分类号： H04M9/082
摘要： A method of adaptive echo cancellation finds application for example in the hands-free facilities of telecommunications terminals, to compensate for disturbing echoes from the acoustic feedback between loudspeaker (1) and microphone (2). It is known to simulate these echoes (h(k)) with digital filters, and to subtract them from the echo-affected microphone signal (z(k)). The realization usually requires a signal processor with a high operating speed, a floating point logic and a large memory space. The task is to present a cost-effective method, which can be used under different acoustic conditions. The invention fulfills this task by using a known FIR filter (5), whose filter coefficients (c.sub.1 to c.sub.N) are determined according to the NLMS algorithm. The step width (.alpha.), which determines the changing speed of the filter coefficients (c.sub.1 to c.sub.N), can be made a function of one or more of various factors, including the current loudspeaker-microphone coupling (dlm), a quality criterion (Q) of the excitation, the existence of local speech signals (lokspk), the existence of briefly fluctuating local noises (lnoise), and the efficiency of the echo canceller. A special scaling of the coefficient values in conjunction with the adaptive step width control, advantageously permits the use of short FIR filters and cost-effective fixed-point computers.
摘要翻译：自适应回波消除的方法例如在电信终端的免提设施中应用，以补偿来自扬声器（1）和麦克风（2）之间的声反馈的干扰回波。已知用数字滤波器模拟这些回波（h（k）），并从回波影响的麦克风信号（z（k））中减去它们。该实现通常需要具有高操作速度，浮点逻辑和大的存储空间的信号处理器。任务是提供一种经济有效的方法，可以在不同的声学条件下使用。本发明通过使用已知的FIR滤波器（5）来实现该任务，其滤波器系数（c1至cN）根据NLMS算法确定。确定滤波器系数（c1至cN）的变化速度的步长（α）可以作为各种因素中的一种或多种的函数，包括当前的扬声器 - 麦克风耦合（dlm），质量标准（Q ），本地语音信号（lokspk）的存在，短暂波动的局部噪声（lnoise）的存在以及回声消除器的效率。结合自适应步长控制的系数值的特殊缩放有利地允许使用短FIR滤波器和成本有效的定点计算机。

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