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21. 发明授权

US07940969B2 System and method of characterizing vascular tissue 有权
标题翻译：表征血管组织的系统和方法
公开(公告)号：US07940969B2
公开(公告)日：2011-05-10
申请号：US11445782
申请日：2006-06-01
申请人： Anuja Nair , D. Geoffrey Vince , Jon D. Klingensmith , Barry D. Kuban
发明人： Anuja Nair , D. Geoffrey Vince , Jon D. Klingensmith , Barry D. Kuban
IPC分类号： G06K9/00 , A61B8/14
CPC分类号： A61B8/12 , A61B5/02007 , A61B5/7257 , A61B5/726 , A61B8/0833 , G06T7/0012 , G06T2207/30101
摘要： A system and method is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, in one embodiment of the present invention, an ultrasonic device is used to acquire RF backscattered data (i.e., IVUS data) from a blood vessel. The IVUS data is then transmitted to a computing device and used to create an IVUS image. The blood vessel is then cross-sectioned and used to identify its tissue type and to create a corresponding image (i.e., histology image). A region of interest (ROI), preferably corresponding to the identified tissue type, is then identified on the histology image. The computing device, or more particularly, a characterization application operating thereon, is then adapted to identify a corresponding region on the IVUS image. To accurately match the ROI, however, it may be necessary to warp or morph the histology image to substantially fit the contour of the IVUS image. After the corresponding region is identified, the IVUS data that corresponds to this region is identified. Signal processing is then performed and at least one parameter is identified. The identified parameter and the tissue type (e.g., characterization data) is stored in a database. In another embodiment of the present invention, the characterization application is adapted to receive IVUS data, determine parameters related thereto (either directly or indirectly), and use the parameters stored in the database to identify a tissue type or a characterization thereof.
摘要翻译：提供了一种使用背散射数据和已知参数来表征血管组织的系统和方法。具体地，在本发明的一个实施例中，使用超声波装置从血管获取RF背散射数据（即，IVUS数据）。然后将IVUS数据传输到计算设备并用于创建IVUS图像。然后将血管切片并用于识别其组织类型并产生相应的图像（即，组织学图像）。然后在组织学图像上识别优选对应于所识别的组织类型的感兴趣区域（ROI）。然后，计算设备，或更具体地，在其上操作的表征应用程序适用于识别IVUS图像上的对应区域。然而，为了精确地匹配ROI，可能需要使组织学图像变形或变形以基本上适合IVUS图像的轮廓。识别对应区域后，识别与该区域对应的IVUS数据。然后执行信号处理，并且识别至少一个参数。所识别的参数和组织类型（例如表征数据）被存储在数据库中。在本发明的另一个实施例中，表征应用适于接收IVUS数据，确定与其相关的参数（直接或间接），并且使用存储在数据库中的参数来识别组织类型或其表征。

22. 发明申请

US20070260141A1 AUTOMATED LESION ANALYSIS BASED UPON AUTOMATIC PLAQUE CHARACTERIZATION ACCORDING TO A CLASSIFICATION CRITERION 有权
标题翻译：根据分类标准自动分析自动分析
公开(公告)号：US20070260141A1
公开(公告)日：2007-11-08
申请号：US11689963
申请日：2007-03-22
申请人： Marja Margolis , D. Vince , Anuja Nair , Vincent Burgess
发明人： Marja Margolis , D. Vince , Anuja Nair , Vincent Burgess
IPC分类号： A61B8/00
CPC分类号： A61B8/12 , A61B5/02007 , A61B5/7264 , A61B8/0833 , G06F19/00 , G06T7/0012 , G06T2207/30101
摘要： A system and method are disclosed for automatically classifying plaque lesions. A plaque classification application applies a plaque classification criterion to at least one graphical image, comprising a map of spectrally-analyzed characterized tissue of a vessel cross-section, to render an overall plaque classification for the slice or set of slices, covering a 3D volume. The plaque classification is based upon the amount and location of each characterized tissue type (e.g., necrotic core—NC). In an exemplary embodiment the set of potential plaque classifications, not to be confused with characterized tissue types—from which the plaque classifications are derived—include, for example: adaptive intimal thickening (AIT), pathological intimal thickening (PIT), fibroatheroma (FA), thin-cap fibroatheroma (TCFA), and fibro-calcific (FC).
摘要翻译：公开了用于自动分类斑块损伤的系统和方法。斑块分类应用将斑块分类标准应用于至少一个图形图像，其包括血管横截面的光谱分析的特征性组织的图，以呈现切片或切片组的整体斑块分类，覆盖3D体积。斑块分类基于每个特征性组织类型（例如，坏死核 - NC）的量和位置。在一个示例性的实施方案中，不会与斑块分类来源的特征性组织类型混淆的一组潜在斑块分类包括例如：适应性内膜增厚（AIT），病理性内膜增厚（PIT），纤维变性（FA）），薄盖纤维性肝硬化（TCFA）和纤维钙化（FC）。

23. 发明申请

US20070100239A1 System and method for characterizing vascular tissue 有权
标题翻译：用于表征血管组织的系统和方法
公开(公告)号：US20070100239A1
公开(公告)日：2007-05-03
申请号：US11580342
申请日：2006-10-14
申请人： Anuja Nair , Barry Kuban , D. Vince , Jon Klingensmith
发明人： Anuja Nair , Barry Kuban , D. Vince , Jon Klingensmith
IPC分类号： A61B8/00
CPC分类号： A61B8/0891 , A61B5/02007 , A61B5/7203 , A61B5/726 , A61B8/0833 , A61B8/12 , A61B8/4461 , A61B8/4488 , A61B8/461 , A61B8/467 , A61B8/52 , A61B8/5238 , G01S7/5205 , G01S7/52087 , G01S15/8977 , G06F19/00
摘要： A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter and/or substantially synchronizing the acquisition of blood-vessel data to an identifiable portion of heartbeat data. Specifically, in accordance with a first embodiment of the present invention, a computing device is electrically connected to a catheter and used to acquire RF backscattered data from a vascular structure (e.g., a blood vessel, etc.). The backscattered ultrasound data is then used, together with an algorithm, to estimate at least one transfer function. The transfer function(s) can then be used (at least in a preferred embodiment) to calculate response data for the vascular tissue (i.e., the tissue component of the backscattered ultrasound data). In a second embodiment of the present invention, an IVUS console is electrically connected to a catheter and a computing device and is used to acquire RF backscattered data from a vascular structure. The backscattered data is then transmitted to the computing device, where it is used to estimate the catheter's transfer function and to calculate response data for the vascular tissue. The response data and histology data are then used to characterize at least a portion of the vascular tissue (e.g., identify tissue type, etc.). In a third embodiment of the present invention, a data-gathering device (e.g., an IVUS device, etc.) is electrically connected to a heart-monitoring device (e.g., an EKG device, etc.), which is used to gather heartbeat data from a patient. In accordance with this embodiment of the present invention, the backscattered data is acquired during a cyclical portion of the heartbeat data so that the blood vessel can be analyzed or imaged as if it were standing still, or not expanding and relaxing.
摘要翻译：提供了一种用于使用从血管组织反向散射的超声数据来估计导管的传递功能和/或使血管数据的获取基本上同步到心跳数据的可识别部分的系统和方法。具体地，根据本发明的第一实施例，计算设备电连接到导管并用于从血管结构（例如，血管等）获取RF背散射数据。然后将后向散射超声数据与算法一起用于估计至少一个传递函数。然后可以使用传递函数（至少在一个优选实施例中）来计算血管组织的反应数据（即反向散射超声数据的组织分量）。在本发明的第二实施例中，IVUS控制台电连接到导管和计算设备，并用于从血管结构获取RF背散射数据。然后将背散射数据传输到计算设备，其中其用于估计导管的传递函数并计算血管组织的反应数据。然后使用响应数据和组织学数据来表征血管组织的至少一部分（例如，识别组织类型等）。在本发明的第三实施例中，数据收集装置（例如，IVUS装置等）电连接到用于收集心跳的心脏监测装置（例如，EKG装置等）来自病人的资料根据本发明的该实施例，在心跳数据的循环部分期间获取背散射数据，使得血管可以被分析或成像，就好像静止不动，或者不扩张和放松。

24. 发明授权

US07175597B2 Non-invasive tissue characterization system and method 有权
标题翻译：非侵入性组织表征系统及方法
公开(公告)号：US07175597B2
公开(公告)日：2007-02-13
申请号：US10356812
申请日：2003-02-03
申请人： D. Geoffrey Vince , Anuja Nair , Jon D. Klingensmith
发明人： D. Geoffrey Vince , Anuja Nair , Jon D. Klingensmith
IPC分类号： A61B8/00
CPC分类号： A61B8/00 , A61B5/02007 , A61B5/7264 , A61B8/0825
摘要： One embodiment of the present system and method is directed to the identification of tissues within a vascular object by analyzing ultrasound data collected from the vascular object by non-invasive scans. By identifying and characterizing types of tissue from ultrasound data, an assessment can be made about the health condition of a patient without an invasive procedure. Other applications of the present system will also be appreciated including identifying other types of tissues.
摘要翻译：本系统和方法的一个实施例涉及通过非侵入性扫描分析从血管对象收集的超声数据来识别血管对象内的组织。通过从超声数据中识别和表征组织的类型，可以对没有侵入性程序的患者的健康状况进行评估。还将理解本系统的其它应用，包括识别其他类型的组织。

25. 发明申请

US20060253033A1 System and method of characterizing vascular tissue 有权
标题翻译：表征血管组织的系统和方法
公开(公告)号：US20060253033A1
公开(公告)日：2006-11-09
申请号：US11445591
申请日：2006-06-01
申请人： Anuja Nair , D. Vince , Jon Klingensmith , Barry Kuban
发明人： Anuja Nair , D. Vince , Jon Klingensmith , Barry Kuban
IPC分类号： A61B8/14
CPC分类号： A61B8/12 , A61B5/02007 , A61B5/7257 , A61B5/726 , A61B8/0833 , G06T7/0012 , G06T2207/30101
摘要： A system and method is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, in one embodiment of the present invention, an ultrasonic device is used to acquire RF backscattered data (i.e., IVUS data) from a blood vessel. The IVUS data is then transmitted to a computing device and used to create an IVUS image. The blood vessel is then cross-sectioned and used to identify its tissue type and to create a corresponding image (i.e., histology image). A region of interest (ROI), preferably corresponding to the identified tissue type, is then identified on the histology image. The computing device, or more particularly, a characterization application operating thereon, is then adapted to identify a corresponding region on the IVUS image. To accurately match the ROI, however, it may be necessary to warp or morph the histology image to substantially fit the contour of the IVUS image. After the corresponding region is identified, the IVUS data that corresponds to this region is identified. Signal processing is then performed and at least one parameter is identified. The identified parameter and the tissue type (e.g., characterization data) is stored in a database. In another embodiment of the present invention, the characterization application is adapted to receive IVUS data, determine parameters related thereto (either directly or indirectly), and use the parameters stored in the database to identify a tissue type or a characterization thereof.
摘要翻译：提供了一种使用背散射数据和已知参数来表征血管组织的系统和方法。具体地，在本发明的一个实施例中，使用超声波装置从血管获取RF背散射数据（即，IVUS数据）。然后将IVUS数据传输到计算设备并用于创建IVUS图像。然后将血管切片并用于识别其组织类型并产生相应的图像（即，组织学图像）。然后在组织学图像上识别优选对应于所识别的组织类型的感兴趣区域（ROI）。然后，计算设备，或更具体地，在其上操作的表征应用程序适用于识别IVUS图像上的对应区域。然而，为了精确地匹配ROI，可能需要使组织学图像变形或变形以基本上适合IVUS图像的轮廓。识别对应区域后，识别与该区域对应的IVUS数据。然后执行信号处理，并且识别至少一个参数。所识别的参数和组织类型（例如表征数据）被存储在数据库中。在本发明的另一个实施例中，表征应用适于接收IVUS数据，确定与其相关的参数（直接或间接），并且使用存储在数据库中的参数来识别组织类型或其表征。

26. 发明申请

US20220139561A1 Device and Method for Determining the Likelihood of a Patient Having a Clinical Event or a Clinically Silent Event Based on Ascertained Physiological Parameters 有权
公开(公告)号：US20220139561A1
公开(公告)日：2022-05-05
申请号：US12890633
申请日：2010-09-25
申请人： Marja Pauliina Margolis , Geoffrey Vince , Anuja Nair
发明人： Marja Pauliina Margolis , Geoffrey Vince , Anuja Nair
IPC分类号： G16H50/30 , A61B5/02 , A61B5/00 , A61B8/12 , A61B8/08
摘要： Using a patient's physiological parameters ascertained using standard intravascular ultrasound (IVUS) in combination with virtual histology (VH), these physiological parameters are evaluated to predict whether the patient's physiology has an increased risk of producing a Clinical Event or a Silent Clinical Event. In one embodiment the following three physiological parameters: the Plaque Burden; the Minimum Lumen Area; and whether a VH-TCFA or multiple VH-TCFAs are present are compared to target values and ranges. A concurrence of the values for the physiological parameters falling within the target ranges indicates that a patient's physiology has an increased risk of producing a Clinical Event or a Silent Clinical Event, respectively. In other embodiments, combinations of any two of the three physiological parameters listed above are compared to target values and ranges. A concurrence of the values for two of the physiological parameters falling within the target ranges indicates that a patient's physiology has an increased risk of producing a Clinical Event. In still other embodiments, any of the three physiological parameters listed above are compared to target values and ranges. Any of the values of the physiological parameters falling within the target ranges indicates that a patient's physiology has an increased risk of producing a Clinical Event.

27. 发明授权

US08233718B2 System and method for identifying a vascular border 有权
标题翻译：识别血管边界的系统和方法
公开(公告)号：US08233718B2
公开(公告)日：2012-07-31
申请号：US13155196
申请日：2011-06-07
申请人： Jon D. Klingensmith , D. Geoffrey Vince , Anuja Nair , Barry D. Kuban
发明人： Jon D. Klingensmith , D. Geoffrey Vince , Anuja Nair , Barry D. Kuban
IPC分类号： G06K9/48 , G06K9/00 , A61B6/00 , A61F11/00
CPC分类号： G06T7/0012 , A61B5/02007 , A61B8/12 , G06T7/12 , G06T2207/10132 , G06T2207/20101 , G06T2207/30101
摘要： A system and method is provided for using a first vascular image, or more particularly a plurality of control points located thereon, to identify a border on a second vascular image. Embodiments of the present invention operate in accordance with an intra-vascular ultrasound (IVUS) device and a computing device electrically connected thereto. Specifically, in one embodiment of the present invention, an IVUS console is electrically connected to a computing device and adapted to acquire IVUS data. The IVUS data (or multiple sets thereof) is then provided to (or acquired by) the computing device. In one embodiment of the present invention, the computing device includes a plurality of applications operating thereon—i.e., a border-detection application, an extrapolation application, and an active-contour application. These applications are used to (i) identify a border and control points on a first IVUS image (i.e., any IVUS image), (ii) extrapolate the control points to a second IVUS image (i.e., another IVUS image), (iii) identify a border on the second IVUS image, and (iv) adjust the border on the second IVUS image in accordance with at least one factor. In one embodiment of the present invention, the at least one factor is selected from a group consisting of gradient factor, continuity factor, and curvature factor.
摘要翻译：提供了一种系统和方法，用于使用位于其上的第一血管图像，或更具体地多个控制点来识别第二血管图像上的边界。本发明的实施例根据血管内超声（IVUS）装置和与其电连接的计算装置进行操作。具体地，在本发明的一个实施例中，IVUS控制台电连接到计算设备并适于获取IVUS数据。然后将IVUS数据（或其多组）提供给计算设备（或由其获取）。在本发明的一个实施例中，计算设备包括在其上操作的多个应用，即边界检测应用，外推应用和主动轮廓应用。这些应用用于（i）识别第一IVUS图像（即，任何IVUS图像）上的边界和控制点，（ii）将控制点外推到第二IVUS图像（即另一IVUS图像），（iii）识别第二IVUS图像上的边界，以及（iv）根据至少一个因素调整第二IVUS图像上的边界。在本发明的一个实施例中，至少一个因素选自由梯度因子，连续性因子和曲率因子组成的组。

28. 发明申请

US20110235892A1 System and Method for Identifying a Vascular Border 有权
标题翻译：识别血管边界的系统和方法
公开(公告)号：US20110235892A1
公开(公告)日：2011-09-29
申请号：US13155196
申请日：2011-06-07
申请人： Jon D. Klingensmith , D. Geoffrey Vince , Anuja Nair , Barry D. Kuban
发明人： Jon D. Klingensmith , D. Geoffrey Vince , Anuja Nair , Barry D. Kuban
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , A61B5/02007 , A61B8/12 , G06T7/12 , G06T2207/10132 , G06T2207/20101 , G06T2207/30101
摘要： A system and method is provided for using a first vascular image, or more particularly a plurality of control points located thereon, to identify a border on a second vascular image. Embodiments of the present invention operate in accordance with an intra-vascular ultrasound (IVUS) device and a computing device electrically connected thereto. Specifically, in one embodiment of the present invention, an IVUS console is electrically connected to a computing device and adapted to acquire IVUS data. The IVUS data (or multiple sets thereof) is then provided to (or acquired by) the computing device. In one embodiment of the present invention, the computing device includes a plurality of applications operating thereon—i.e., a border-detection application, an extrapolation application, and an active-contour application. These applications are used to (i) identify a border and control points on a first IVUS image (i.e., any IVUS image), (ii) extrapolate the control points to a second IVUS image (i.e., another IVUS image), (iii) identify a border on the second IVUS image, and (iv) adjust the border on the second IVUS image in accordance with at least one factor. In one embodiment of the present invention, the at least one factor is selected from a group consisting of gradient factor, continuity factor, and curvature factor.
摘要翻译：提供了一种系统和方法，用于使用位于其上的第一血管图像，或更具体地多个控制点来识别第二血管图像上的边界。本发明的实施例根据血管内超声（IVUS）装置和与其电连接的计算装置进行操作。具体地，在本发明的一个实施例中，IVUS控制台电连接到计算设备并适于获取IVUS数据。然后将IVUS数据（或其多组）提供给计算设备（或由其获取）。在本发明的一个实施例中，计算设备包括在其上操作的多个应用，即边界检测应用，外推应用和主动轮廓应用。这些应用用于（i）识别第一IVUS图像（即，任何IVUS图像）上的边界和控制点，（ii）将控制点外推到第二IVUS图像（即另一IVUS图像），（iii）识别第二IVUS图像上的边界，以及（iv）根据至少一个因素调整第二IVUS图像上的边界。在本发明的一个实施例中，至少一个因素选自由梯度因子，连续性因子和曲率因子组成的组。

29. 发明授权

US07927275B2 System and method of aquiring blood-vessel data 有权
标题翻译：获取血管数据的系统和方法
公开(公告)号：US07927275B2
公开(公告)日：2011-04-19
申请号：US10647977
申请日：2003-08-25
申请人： Barry D. Kuban , Jon D. Klingenamith , D. Geoffrey Vince , Anuja Nair
发明人： Barry D. Kuban , Jon D. Klingenamith , D. Geoffrey Vince , Anuja Nair
IPC分类号： A61B8/00
CPC分类号： A61B8/543 , A61B8/12 , A61B8/445 , G06T7/0012 , G06T2207/30101
摘要： A system and method is provided for substantially synchronizing the acquisition of blood-vessel data to an identifiable portion of heartbeat data. Specifically, a data-gathering device is adapted to acquire heartbeat data and blood-vessel data from a heart-monitoring device and a data-gathering probe, respectively. In a preferred embodiment of the present invention, the blood-vessel data is acquired during a cyclical portion of the heartbeat data. By identifying a cyclical (or commonly reoccurring) portion of the heartbeat data and acquiring blood-vessel data during this cyclical portion (or during an interval that substantially corresponds thereto), the blood vessel can be analyzed as if it were standing still—i.e., not expanding and relaxing. In one embodiment of the present invention, the heart-monitoring device includes an EKG device, the data-gathering device includes an intra-vascular ultrasound (IVUS) device and a computing device, and the data-gathering probe includes at least one transducer. In another embodiment of the present invention, the data-gathering system further includes a retraction device adapted to move the data-gathering probe though a blood vessel at a substantially steady speed.
摘要翻译：提供了一种用于将血管数据的获取基本上同步到心跳数据的可识别部分的系统和方法。具体地，数据收集装置适于分别从心脏监测装置和数据收集探针获取心跳数据和血管数据。在本发明的优选实施例中，在心跳数据的周期部分期间获取血管数据。通过在该循环部分（或在与其基本对应的间隔期间）识别心跳数据的周期性（或通常重复发生的）部分并获取血管数据，可以像静置时一样分析血管，不扩大和放松。在本发明的一个实施例中，所述心脏监测装置包括EKG装置，所述数据收集装置包括血管内超声（IVUS）装置和计算装置，并且所述数据收集探针包括至少一个换能器。在本发明的另一个实施例中，数据收集系统还包括一个缩回装置，其适于以基本上稳定的速度移动通过血管的数据收集探针。

30. 发明申请

US20110087101A1 System and Method for Determining a Transfer Function 有权
标题翻译：用于确定传递函数的系统和方法
公开(公告)号：US20110087101A1
公开(公告)日：2011-04-14
申请号：US12878770
申请日：2010-09-09
申请人： Anuja Nair , D. Geoffrey Vince , Jon D. Klingensmith , Barry D. Kuban
发明人： Anuja Nair , D. Geoffrey Vince , Jon D. Klingensmith , Barry D. Kuban
IPC分类号： A61B8/12
CPC分类号： A61B5/02007 , A61B5/726 , A61B8/12
摘要： A system and method is provided for using ultrasound data backscattered from vascular tissue to estimate the transfer function of a catheter (including components attached thereto—e.g., IVUS console, transducer, etc.). Specifically, in accordance with a first embodiment of the present invention, a computing device is electrically connected to a catheter and used to acquire RF backscattered data from a vascular structure (e.g., a blood vessel, etc.). The backscattered ultrasound data is then used, together with an algorithm, to estimate the transfer function. The transfer function can then be used (at least in a preferred embodiment) to calculate response data for the vascular tissue (i.e., the tissue component of the backscattered ultrasound data). In a second embodiment of the present invention, an IVUS console is electrically connected to a catheter and a computing device and is used to acquire RF backscattered data from a vascular structure. The backscattered data is then transmitted to the computing device, where it is used to estimate the catheter's transfer function and to calculate response data for the vascular tissue. The response data and histology data are then used to characterize at least a portion of the vascular tissue (e.g., identify tissue type, etc.).
摘要翻译：提供了一种系统和方法，用于使用从血管组织反向散射的超声数据来估计导管（包括与其连接的部件，例如，IVUS控制台，换能器等）的传递功能。具体地，根据本发明的第一实施例，计算设备电连接到导管并用于从血管结构（例如，血管等）获取RF背散射数据。然后将后向散射的超声数据与算法一起用于估计传递函数。然后可以使用传递函数（至少在一个优选实施例中）来计算血管组织的反应数据（即背散射超声数据的组织分量）。在本发明的第二实施例中，IVUS控制台电连接到导管和计算设备，并用于从血管结构获取RF背散射数据。然后将背散射数据传输到计算设备，其中其用于估计导管的传递函数并计算血管组织的反应数据。然后使用响应数据和组织学数据来表征血管组织的至少一部分（例如，识别组织类型等）。

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