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21. 发明申请

US20160213258A1 METHODS FOR GENERATING MULTIPLE MISMATCHED CODED EXCITATION SIGNALS 审中-公开
标题翻译：用于产生多个不匹配的编码激励信号的方法
公开(公告)号：US20160213258A1
公开(公告)日：2016-07-28
申请号：US14979797
申请日：2015-12-28
申请人： Bahman Lashkari , Andreas Mandelis , Kaicheng Zhang
发明人： Bahman Lashkari , Andreas Mandelis , Kaicheng Zhang
IPC分类号： A61B5/00 , A61B1/04
CPC分类号： A61B5/0095 , A61B5/0033 , A61B5/0507 , A61B5/055 , A61B5/7228 , A61B5/7246 , A61B8/12 , A61B8/4494 , A61B8/5207 , A61B2576/00 , G01S15/8913 , G01S15/8915 , G01S15/8922 , G01S15/8961
摘要： The present disclosure provides systems and methods for imaging based on the generation and use of mismatched coded excitation signals. Cross-correlation properties of the received signal reveal the location and/or timing and/or properties of the source. The use of mismatched signals enables spatial and/or temporal and/or functional encoding of the transmitted signals. In some embodiments, high-speed imaging may be performed by employing mismatched codes for spatial and/or temporal encoding, and by employing a subset of transducer elements as transmitters, and another subset of elements as receivers. Various example embodiments of different types of mismatched codes are provided, including codes that employ multiple frequency chirps, codes that employ concatenated multi-frequency binary phase-coded waveforms, and chirped binary phase-coded waveforms.
摘要翻译：本公开提供了基于错配编码激励信号的生成和使用的用于成像的系统和方法。接收信号的互相关属性显示源的位置和/或时序和/或属性。使用不匹配的信号可以实现发射信号的空间和/或时间和/或功能编码。在一些实施例中，可以通过对空间和/或时间编码采用不匹配的代码，并且通过使用换能器元件的子集作为发射机，以及将元素的另一子集作为接收机来执行高速成像。提供了不同类型的不匹配代码的各种示例实施例，包括采用多频率啁啾的代码，采用级联的多频二进制相位编码波形的代码和啁啾的二进制相位编码波形。

22. 发明授权

US09220415B2 Systems and methods for frequency-domain photoacoustic phased array imaging 有权
标题翻译：用于频域光声相控阵成像的系统和方法
公开(公告)号：US09220415B2
公开(公告)日：2015-12-29
申请号：US13660771
申请日：2012-10-25
申请人： Andreas Mandelis , Sergey Telenkov , Bahman Lashkari
发明人： Andreas Mandelis , Sergey Telenkov , Bahman Lashkari
IPC分类号： A61B5/00 , A61B5/1455 , G01N21/17 , G01N21/31 , G01N21/39 , G01N21/47 , G03B42/06
CPC分类号： A61B5/0095 , A61B5/14551 , A61B5/14552 , A61B5/7235 , A61B5/7257 , G01N21/1702 , G01N21/314 , G01N21/39 , G01N21/4795 , G03B42/06
摘要： Systems and methods of frequency-domain photoacoustic imaging are provided utilizing an ultrasonic phased array probe and intensity modulated optical excitation with coding to improve signal-to-noise ratio. Embodiments employ frequency-domain photoacoustic imaging methodologies such as the photoacoustic radar, coupled with a multi-element ultrasonic sensor array to deliver spatially-resolved correlation images of photoacoustic sources, which may be employed to image optical heterogeneities within tissue-like scattering media.
摘要翻译：利用超声波相控阵探头和具有编码的强度调制光激励来提供频域光声成像的系统和方法，以提高信噪比。实施例采用频域光声成像方法，例如光声雷达，与多元超声波传感器阵列耦合，以提供光声源的空间分辨相关图像，其可用于在组织样散射介质内成像光学异质性。

23. 发明授权

US08649835B2 Method of performing wavelength modulated differential laser photothermal radiometry with high sensitivity 有权
标题翻译：高灵敏度进行波长调制差分激光光热辐射测量的方法
公开(公告)号：US08649835B2
公开(公告)日：2014-02-11
申请号：US12948525
申请日：2010-11-17
申请人： Andreas Mandelis , Xinxin Guo
发明人： Andreas Mandelis , Xinxin Guo
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/0093 , A61B5/1455 , A61B5/7228 , G01D3/022 , G01D5/32 , G01D18/008 , G01T1/1603
摘要： Methods are provided for the detection of an analyte in a sample using wavelength modulated differential photothermal radiometry with enhanced sensitivity. A wavelength modulated differential photothermal radiometry system, comprising two optical modulated beams, where each beam experiences different absorption by the analyte, is calibrated by controlling the relative phase difference between the modulated beams so that individual photothermal signals corresponding to each modulated beam are 180° out of phase, corresponding to peak sensitivity to analyte concentration. The system may be further calibrated by varying the relative intensities of the two modulated beams and measuring standards containing known analyte concentration in order to determine an optimal relative intensity for a given concentration range of interest.
摘要翻译：提供了使用具有增强的灵敏度的波长调制差分光热辐射测量来检测样品中分析物的方法。波长调制的差分光热辐射测量系统包括两个光调制光束，其中每个光束经受分析物的不同吸收，通过控制调制光束之间的相对相位来校准，使得对应于每个调制光束的各个光热信号为180° 的相位，对应于对分析物浓度的峰值敏感性。可以通过改变两个调制束的相对强度和包含已知分析物浓度的测量标准来进一步校准系统，以便确定给定的感兴趣浓度范围的最佳相对强度。

24. 发明申请

US20130122468A1 METHOD OF PROCESSING AND DISPLAYING ORAL HEALTH DIAGNOSTIC DATA 审中-公开
标题翻译：加工和显示口腔健康诊断数据的方法
公开(公告)号：US20130122468A1
公开(公告)日：2013-05-16
申请号：US13697758
申请日：2011-05-13
申请人： Stephen Abrams , Koneswaran Sivagurunathan , Josh Silvertown , Jin-Seok Jeon , Andreas Mandelis
发明人： Stephen Abrams , Koneswaran Sivagurunathan , Josh Silvertown , Jin-Seok Jeon , Andreas Mandelis
IPC分类号： A61B5/00
CPC分类号： A61B5/4547 , A61B6/14 , A61B6/4488 , A61B6/463 , A61B6/468 , A61B6/5217 , A61C19/00 , G06Q50/22
摘要： A method is provided for analyzing and displaying an oral health status of a tooth or an entire dentition based on a measurement with a diagnostic device. Diagnostic data pertaining to a selected tooth, tooth surface, section of tooth surface or numbers of teeth in a mouth is recorded from an oral health diagnostic device, optionally along with an image of the particular tooth or tooth surface examined. The diagnostic data is processed and compared with reference data to determine an oral health status of the tooth. The oral health status of the tooth is then displayed on an odontogram shown in a user interface. The user interface may also provide reports comparing changes in the measured data and/or images along with the therapies used, thereby enabling the measurement and tracking of outcomes from various therapies over time.
摘要翻译：提供了一种用于基于使用诊断装置的测量来分析和显示牙齿或整个牙列的口腔健康状况的方法。从口腔健康诊断装置记录与选定的牙齿，牙齿表面，牙齿表面或牙齿数量有关的诊断数据，可选地与被检查的特定牙齿或牙齿表面的图像一起记录。处理诊断数据并与参考数据进行比较以确定牙齿的口腔健康状况。然后将牙齿的口腔健康状况显示在用户界面中显示的odontogram上。用户界面还可以提供比较所测量的数据和/或图像的变化以及所使用的疗法的报告，从而使得能够随着时间的推移来测量和跟踪各种疗法的结果。

25. 发明授权

US08306608B2 Method and apparatus using infrared photothermal radiometry (PTR) and modulated laser luminescence (LUM) for diagnostics of defects in teeth 有权
标题翻译：使用红外光热辐射测量（PTR）和调制激光发光（LUM）进行牙齿缺陷诊断的方法和设备
公开(公告)号：US08306608B2
公开(公告)日：2012-11-06
申请号：US11488194
申请日：2006-07-18
申请人： Andreas Mandelis , Stephen Abrams , Jin-Seok Jeon , Kiran Kulkarni , Anna Matvienko
发明人： Andreas Mandelis , Stephen Abrams , Jin-Seok Jeon , Kiran Kulkarni , Anna Matvienko
IPC分类号： A61B6/00 , G01N21/00 , A61C1/00
CPC分类号： A61B5/417 , A61B5/0088 , A61B5/0452 , A61B5/7228
摘要： There is provided a high-spatial-resolution dynamic diagnostic instrument which can provide simultaneous measurements of laser-induced frequency-domain infrared photothermal radiometric and alternating-current (ac) modulated luminescence signals from defects, demineralization, remineralization and caries in teeth intraorally. The emphasis is on the abilities of this instrument to approach important problems such as the detection, diagnosis and ongoing monitoring of carious lesions and or defects on the occlusal pits and fissures, smooth surfaces and interproximal areas between teeth which normally go undetected by x-ray radiographs or visual examination. The instrument is also able to detect early areas of demineralized tooth and or areas of remineralized tooth as well as defects along the margins of restorations. This capability of inspecting a local spot can be extended to a modulated imaging of sub-surface of target tooth by using a multi-array infrared camera. Two configurations of the instrument are presented.
摘要翻译：提供了一种高空间分辨率动态诊断仪器，可以同时测量激光诱导的频域红外光热辐射和交流（ac）调制的发光信号，从缺陷，软化，再矿化和齿内牙龋。重点在于该仪器能够处理重要问题，例如龋齿病变的检测，诊断和持续监测，以及咬合凹陷和裂缝，牙齿之间的平滑表面和间隙之间的缺陷，这些区域通常未被x射线检测放射照片或视觉检查。该仪器还能够检测到软化牙齿的早期区域或再矿化区域，以及沿修复边缘的缺陷。通过使用多阵列红外摄像机，可以将局部斑点检测能力扩展到目标牙齿的子表面的调制成像。介绍了仪器的两种配置。

26. 发明申请

US20070021670A1 Method and apparatus using infrared photothermal radiometry (PTR) and modulated laser luminescence (LUM) for diagnostics of defects in teeth 有权
标题翻译：使用红外光热辐射测量（PTR）和调制激光发光（LUM）进行牙齿缺陷诊断的方法和设备
公开(公告)号：US20070021670A1
公开(公告)日：2007-01-25
申请号：US11488194
申请日：2006-07-18
申请人： Andreas Mandelis , Stephen Abrams , Jin-Seok Jeon , Kiran Kulkarni , Anna Mativenko
发明人： Andreas Mandelis , Stephen Abrams , Jin-Seok Jeon , Kiran Kulkarni , Anna Mativenko
IPC分类号： A61B6/00
CPC分类号： A61B5/417 , A61B5/0088 , A61B5/0452 , A61B5/7228
摘要： There is provided a high-spatial-resolution dynamic diagnostic instrument which can provide simultaneous measurements of laser-induced frequency-domain infrared photothermal radiometric and alternating-current (ac) modulated luminescence signals from defects, demineralization, remineralization and caries in teeth intraorally. The emphasis is on the abilities of this instrument to approach important problems such as the detection, diagnosis and ongoing monitoring of carious lesions and or defects on the occlusal pits and fissures, smooth surfaces and interproximal areas between teeth which normally go undetected by x-ray radiographs or visual examination. The instrument is also able to detect early areas of demineralized tooth and or areas of remineralized tooth as well as defects along the margins of restorations. This capability of inspecting a local spot can be extended to a modulated imaging of sub-surface of target tooth by using a multi-array infrared camera. Two configurations of the instrument are presented.
摘要翻译：提供了一种高空间分辨率动态诊断仪器，可以同时测量激光诱导的频域红外光热辐射和交流（ac）调制的发光信号，从缺陷，软化，再矿化和齿内牙龋。重点在于该仪器能够处理重要问题，例如龋齿病变的检测，诊断和持续监测，以及咬合凹陷和裂缝，牙齿之间的平滑表面和间隙之间的缺陷，这些区域通常未被x射线检测放射照片或视觉检查。该仪器还能够检测到软化牙齿的早期区域或再矿化区域，以及沿修复边缘的缺陷。通过使用多阵列红外摄像机，可以将局部斑点检测能力扩展到目标牙齿的子表面的调制成像。介绍了仪器的两种配置。

27. 发明授权

US07116421B2 Device and method for differential sensing of hydrogen gas using thermoabsorptance or thermoreflectance 失效
标题翻译：使用热吸收或热敏电阻差分感应氢气的装置和方法
公开(公告)号：US07116421B2
公开(公告)日：2006-10-03
申请号：US10384598
申请日：2003-03-11
申请人： Jose Agustin Garcia , Andreas Mandelis , Chinhua Wang
发明人： Jose Agustin Garcia , Andreas Mandelis , Chinhua Wang
IPC分类号： G01N21/00
CPC分类号： G01N21/783 , G01N21/171 , G01N33/005
摘要： A hydrogen sensor, useful for trace hydrogen gas detection. The sensor involves providing a gas sample, generating modulated optical excitation sources, bringing the optical excitation source to the side of a metalized thin pyroelectric film, and detecting via a lock-in amplifier circuit the coherent differential signal resulting from thermoreflectance and thermoabsorptance changes in the film when exposed to hydrogen gas.
摘要翻译：氢传感器，用于痕量氢气检测。该传感器包括提供气体样品，产生调制的光学激发源，将光学激发源带到金属化的薄热电薄膜的侧面，以及通过锁定放大器电路检测由于热反射和热吸收变化引起的相干差分信号当暴露于氢气时胶片。

28. 发明申请

US20050234319A1 Laser photo-thermo-acoustic (PTA) frequency swept heterodyned lock-in depth profilometry imaging system 有权
标题翻译：激光光热声（PTA）频率扫描外差锁定深度轮廓测量成像系统
公开(公告)号：US20050234319A1
公开(公告)日：2005-10-20
申请号：US11058233
申请日：2005-02-16
申请人： Andreas Mandelis , Alex Vitkin , Sergey Telenkov , Ying Fan
发明人： Andreas Mandelis , Alex Vitkin , Sergey Telenkov , Ying Fan
IPC分类号： A61B5/05 , G01B21/08 , G01N21/17 , G01N21/47 , G01N29/06 , G01N29/07 , G01N29/11 , G01N29/46
CPC分类号： G01N21/1702 , G01B21/085 , G01N21/4795 , G01N29/0609 , G01N29/07 , G01N29/11 , G01N29/46 , G01N2291/02475 , G01N2291/02872 , G01N2291/0421
摘要： A method and apparatus for biomedical subsurface imaging and measurement of thickness, elastic and optical properties of industrial and biomedical materials based on laser Photo-Thermo-Acoustic (PTA) frequency-swept heterodyne depth profilometry, In particular, the invention relates to biomedical imaging and measure of tissue and tumour thickness, L, speed of sound, cs, acoustic attenuation coefficient, γ, optical absorption coefficient, μa, and optical scattering coefficient, μs. The method and apparatus involves providing for a sample of the material to be characterized; irradiating the material for a selected period of time with an excitation waveform from a modulated optical excitation source wherein a photo-thermo-acoustic emission is responsively emitted from said solid; detecting said emitted photo-thermo-acoustic emission; processing the electronic signal to convert the frequency-domain signal into time-domain and perform depth profilometric imaging and determining thermoelastic and optical properties of the material sample;
摘要翻译：基于激光光热声（PTA）频扫外差深度轮廓测量法的工业和生物医学材料的厚度，弹性和光学性质的生物医学地下成像和测量的方法和装置，特别地，本发明涉及生物医学成像和组织和肿瘤厚度的测量，L，声速，声衰减系数，γ，光吸收系数，μλα和光散射系数，μ< SUB> s 。该方法和装置包括提供要表征的材料的样品; 用来自调制光激发源的激发波形照射材料一段选定的时间，其中从所述固体响应地发射光热声发射; 检测所述发射的光热声发射; 处理电子信号以将频域信号转换成时域并执行深度轮廓测量成像并确定材料样品的热弹性和光学性质;

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