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21. 发明申请

US20140295575A1 ZWITTERION-CONTAINING ACRIDINIUM COMPOUNDS 审中-公开
标题翻译：含ZWITTERION的含有化合物
公开(公告)号：US20140295575A1
公开(公告)日：2014-10-02
申请号：US14302341
申请日：2014-06-11
申请人： Anand Natrajan , David Sharpe , Qingping Jiang
发明人： Anand Natrajan , David Sharpe , Qingping Jiang
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , C07D219/04 , C07D219/14 , C07D401/12 , C09B15/00 , Y10T436/13
摘要： Hydrophilic, chemiluminescent acridinium compounds containing zwitterions are disclosed. These acridinium compounds, when used as chemiluminescent labels in immunochemistry assays and the like, exhibit decreased non-specific binding to solid phases and provide increased assay sensitivity.
摘要翻译：公开了含有两性离子的亲水的，化学发光的吖啶鎓化合物。当这些吖啶鎓化合物在免疫化学测定等中用作化学发光标记时，表现出与固相的非特异性结合降低并提供增加的测定灵敏度。

22. 发明授权

US08778624B2 Zwitterion-containing acridinium compounds 有权
标题翻译：含两性离子的吖啶鎓化合物
公开(公告)号：US08778624B2
公开(公告)日：2014-07-15
申请号：US13510158
申请日：2010-11-12
申请人： Anand Natrajan , David Sharpe , Qingping Jiang
发明人： Anand Natrajan , David Sharpe , Qingping Jiang
IPC分类号： G01N33/53 , G01N33/533 , G01N21/76
CPC分类号： G01N33/54393 , C07D219/04 , C07D219/14 , C07D401/12 , C09B15/00 , Y10T436/13
摘要： Hydrophilic, chemiluminescent acridinium compounds containing zwitterions are disclosed. These acridinium compounds, when used as chemiluminescent labels in immunochemistry assays and the like, exhibit decreased non-specific binding to solid phases and provide increased assay sensitivity.
摘要翻译：公开了含有两性离子的亲水的，化学发光的吖啶鎓化合物。当这些吖啶鎓化合物在免疫化学测定等中用作化学发光标记时，表现出与固相的非特异性结合降低并提供增加的测定灵敏度。

23. 发明授权

US08119422B2 Stable acridinium esters with fast light emission 有权
标题翻译：具有快速发光的稳定的吖啶酯
公开(公告)号：US08119422B2
公开(公告)日：2012-02-21
申请号：US12445304
申请日：2007-10-15
申请人： Anand Natrajan , Qingping Jiang , David Sharpe
发明人： Anand Natrajan , Qingping Jiang , David Sharpe
IPC分类号： G01N33/533 , G01N21/76 , C07D219/00
CPC分类号： C07D219/04 , Y10T436/13 , Y10T436/143333 , Y10T436/21
摘要： Chemiluminescent acridinium esters are provided which are fast light emitting and hydrolytically stable. The chemiluminescent acridinium esters are useful labels in assays for detecting or quantifying analytes.
摘要翻译：提供化学发光的吖啶酯，其具有快速发光和水解稳定性。化学发光吖啶酯是用于检测或定量分析物的测定中的有用标签。

24. 发明授权

US06664043B2 Acridinium ester labels having hydrophilic modifiers 有权
标题翻译：具有亲水改性剂的吖啶酯标签
公开(公告)号：US06664043B2
公开(公告)日：2003-12-16
申请号：US09898381
申请日：2001-07-03
申请人： Anand Natrajan , David Sharpe , Qingping Jiang
发明人： Anand Natrajan , David Sharpe , Qingping Jiang
IPC分类号： C12Q100
CPC分类号： G01N33/533
摘要： The present invention is generally directed to detectable chemiluminescent acridinium ester labels having hydrophilic modifiers; to compositions, complexes and/or conjugates which include such labels; and to processes for performing bioanalytical assays for target analytes which use such labels. Assays for folate, theophylline, and tobramycin (using such labels with hydrophilic modifiers such as nonionic polyethylene glycol and polyionic spermine disulfonate and polyionic spermine dicarboxylate) are described in detail.
摘要翻译：本发明一般涉及具有亲水改性剂的可检测化学发光吖啶酯标记物; 包括这些标签的组合物，复合物和/或共轭物; 以及用于对使用这种标记的靶分析物进行生物分析测定的方法。叶酸，茶碱和妥布霉素的测定（使用亲水性改性剂，如非离子聚乙二醇和聚偏二精胺二磺酸盐等）的标记。

25. 发明授权

US06355803B1 Near infrared chemiluminescent acridinium compounds and uses thereof 有权
标题翻译：近红外化学发光吖啶化合物及其用途
公开(公告)号：US06355803B1
公开(公告)日：2002-03-12
申请号：US09371489
申请日：1999-08-10
申请人： Anand Natrajan , Qingping Jiang , David Sharpe , Say-Jong Law
发明人： Anand Natrajan , Qingping Jiang , David Sharpe , Say-Jong Law
IPC分类号： C07D21904
CPC分类号： G01N33/582 , C07D219/04 , Y10S436/80 , Y10S436/815 , Y10S436/817 , Y10S530/812 , Y10T436/13
摘要： This application relates to long-wavelength acridinium compounds having electron-donating groups, which may either be: (a) Part of an extended conjugation system attached by appropriate functional groups to the acridinium nucleus, with coplanarity of the attached functional group and the acridone moiety during light emission (geometry requirement), said functional group consisting of at least one aromatic ring and one electron-donating atom or group with an extra pair of electrons which can readily delocalize into the extended &pgr; system to which the heteroatom is directly attached or built into, and establish stable extended resonance with the electron-withdrawing carbonyl moiety of the light emitting acridone. Such electron-donating atom or group that exists in the form of an anion has particularly strong effect to further the bathochromic shift of the emission wavelength; or (b) directly attached at one or more of positions C-2, C-4, C-5, or C-7 of the acridinium nucleus, of electron-donating atoms or groups having extra pair(s) of electrons. The electron-donating entities can be the same or different if more than one electron-donating entity is used. An electron-donating atom or group that exists in the form of an anion has particularly strong effect to further the bathochromic shift of the emission wavelength.
摘要翻译：本申请涉及具有给电子基团的长波长吖啶鎓化合物，其可以是：（a）通过适当的官能团与吖啶核连接的部分扩展共轭体系，具有连接的官能团和吖啶酮部分的共面性在发光（几何要求）期间，所述官能团由至少一个芳族环和一个给电子原子或一个具有额外的电子对的基团组成，其可以容易地定位到直接连接或构建杂原子的延伸的π系统并与发光吖啶酮的吸电子羰基部分建立稳定的扩展共振。以阴离子形式存在的这种给电子原子或基团对于进一步发射波长的红移具有特别强的作用; 或（b）直接连接在吖啶核的C-2，C-4，C-5，或C-7的一个或多个位置上，具有给电子的原子或具有额外的电子对的基团。如果使用多于一个给电子实体，电子给体实体可以相同或不同。以阴离子形式存在的给电子原子或基团对进一步发射波长的红移具有特别强的作用。

26. 发明授权

US07097995B2 Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes 有权
标题翻译：化学发光吖啶鎓化合物及其类似物作为水解酶的底物
公开(公告)号：US07097995B2
公开(公告)日：2006-08-29
申请号：US10928300
申请日：2004-08-27
申请人： Qingping Jiang , Anand Natrajan , David J. Sharpe , Wen-Jee Wong , Say-Jong Law
发明人： Qingping Jiang , Anand Natrajan , David J. Sharpe , Wen-Jee Wong , Say-Jong Law
IPC分类号： C12Q1/34
CPC分类号： C07D491/10 , C07D219/04 , C07F9/64 , C12Q1/42 , C12Q2334/00 , G01N33/533 , G01N33/582
摘要： A chemiluminescent substrate of a hydrolytic enzyme having the following general Formula I is disclosed, as follows: Lumi-M-PFormula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P is a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following: where HE is a hydrolytic enzyme. Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.
摘要翻译：公开了具有以下通式I的水解酶的化学发光底物，如下：<？在线公式描述=“在线公式”末端=“铅”→> Lumi-M-PFormula I < -line-formula description =“In-line Formulas”end =“tail”？>其中“Lumi”是能够自身产生光的化学发光部分（a），（b）MP附着和（c）M附着。 Lumi的实例包括化学发光吖啶鎓化合物，苯并吖啶鎓化合物，喹啉鎓化合物，异喹啉鎓化合物，菲啶鎓化合物和光合精化合物，螺吡啶化合物，鲁米诺化合物和异鲁米诺化合物。 M是具有至少一个选自氧，氮和硫的孤对电子的多价杂原子，其一端直接连接到Lumi的发光部分，另一端直接附着于P。 P是可以通过水解酶容易地除去的基团。使用上述化合物的酶反应如下：其中HE是水解酶。 Lumi-M是具有与Lumi-M-P不同的物理和/或化学性质的化学发光产物。

27. 发明授权

US06783948B1 Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes 有权
标题翻译：化学发光吖啶鎓化合物及其类似物作为水解酶的底物
公开(公告)号：US06783948B1
公开(公告)日：2004-08-31
申请号：US09626566
申请日：2000-07-27
申请人： Qingping Jiang , Anand Natrajan , David J. Sharpe , Wen-Jee Wong , Say-Jong Law
发明人： Qingping Jiang , Anand Natrajan , David J. Sharpe , Wen-Jee Wong , Say-Jong Law
IPC分类号： C12Q134
CPC分类号： C07D491/10 , C07D219/04 , C07F9/64 , C12Q1/42 , C12Q2334/00 , G01N33/533 , G01N33/582
摘要： A chemiluminescent substrate of hydrolytic enzyme having the following general Formula I, as follows: Lumi-M-P Formula I where “Lumi” is a chemiluminescent moiety capable of producing light (a) by itself, (b) with MP attached and (c) with M attached. Examples of Lumi include chemiluminescent acridinium compounds, benzacridinium compounds, quinolinium compounds, isoquinolinium compounds, phenanthridinium compounds, and lucigenin compounds, spiroacridan compounds, luminol compounds and isoluminol compounds. M is a multivalent heteroatom having at least one lone pair of electrons selected from oxygen, nitrogen and sulfur, directly attached to the light emitting moiety of Lumi at one end and to P at the other end. P it a group that can be readily removed by hydrolytic enzymes. An enzymatic reaction utilizing the above compound is the following: where HE is a hydrolytic enzyme Lumi-M is a chemiluminescent product having physical and/or chemical properties different from those of Lumi-M-P.
摘要翻译：具有以下通式I的水解酶的化学发光底物如下：其中“Lumi”是能够自身产生光的化学发光部分（a），（b）MP附着的（c）和M连接的化合物发光部分。 Lumi的实例包括化学发光吖啶鎓化合物，苯并吖啶鎓化合物，喹啉鎓化合物，异喹啉鎓化合物，菲啶鎓化合物和光合精化合物，螺吡啶化合物，鲁米诺化合物和异鲁米诺化合物。 M是具有至少一个选自氧，氮和硫的孤对电子的多价杂原子，其一端直接连接到Lumi的发光部分，另一端直接附着于P。 P是可以通过水解酶容易地除去的基团。使用上述化合物的酶反应如下：其中HE是水解酶，Lumi-M是具有与Lumi-M-P不同的物理和/或化学性质的化学发光产物。

28. 发明授权

US5656426A Functionaized hydrophilic acridinium esters 失效
标题翻译：功能性亲水吖啶酯
公开(公告)号：US5656426A
公开(公告)日：1997-08-12
申请号：US225165
申请日：1994-04-08
申请人： Say-Jong Law , Chariklia Sotiriou-Leventis , Anand Natrajan , Qingping Jiang , Peter B. Connolly , John P. Kilroy , Constance R. McCudden , Stephen M. Tirrell
发明人： Say-Jong Law , Chariklia Sotiriou-Leventis , Anand Natrajan , Qingping Jiang , Peter B. Connolly , John P. Kilroy , Constance R. McCudden , Stephen M. Tirrell
IPC分类号： G01N33/53 , C07D219/04 , C07D401/12 , C07F9/64 , C07J1/00 , C07J21/00 , C07J43/00 , C12Q1/68 , G01N33/532 , G01N33/533 , G01N33/569 , G01N33/58
CPC分类号： C07D401/12 , C07D219/04 , C07F9/64 , C07J1/0011 , C07J1/0022 , C07J21/006 , C07J43/003 , C12Q1/6816 , G01N33/533 , G01N33/586
摘要： Novel acridinium esters that are useful, either alone or when incorporated into liposomes, as chemiluminescent agents in binding assays (e.g., immunoassays and gene probe assays) with improved-sensitivity are disclosed. In addition, the synthesis of these esters and their use in assays for detecting an analyte is described. In particular, assays for testosterone and the Rubella virus are disclosed.
摘要翻译：公开了在改进的灵敏度的结合测定（例如，免疫测定和基因探针测定）中单独使用或当掺入脂质体中时作为化学发光剂的新型吖啶酯。此外，描述了这些酯的合成及其在用于检测分析物的测定中的用途。特别地，公开了睾酮和风疹病毒的测定。

29. 发明授权

US08293908B2 Facile N-alkylation of acridine compounds in ionic liquids 有权
标题翻译：吖啶化合物在离子液体中的简便N-烷基化
公开(公告)号：US08293908B2
公开(公告)日：2012-10-23
申请号：US12743622
申请日：2008-11-18
申请人： Anand Natrajan , David Wen
发明人： Anand Natrajan , David Wen
IPC分类号： C07D219/00
CPC分类号： C07D219/04
摘要： A method is provided for N-alkylation of acridine compounds, typically with a 1,3- propane sultone alkylating reagent, in ionic liquid solvents to provide the corresponding acridinium compounds in high yield.
摘要翻译：提供了一种在离子液体溶剂中将吖啶化合物（通常与1,3-丙磺酸烷基化试剂）进行N-烷基化以提供高产率的相应的吖啶鎓化合物的方法。

30. 发明申请

US20100256380A1 FACILE N-ALKYLATION OF ACRIDINE COMPOUNDS IN IONIC LIQUIDS 有权
标题翻译：酸性化合物在离子液体中的N-烷基化
公开(公告)号：US20100256380A1
公开(公告)日：2010-10-07
申请号：US12743622
申请日：2008-11-18
申请人： Anand Natrajan , David Wen
发明人： Anand Natrajan , David Wen
IPC分类号： C07D219/04
CPC分类号： C07D219/04
摘要： A method is provided for N-alkylation of acridine compounds, typically with a 1,3-propane sultone alkylating reagent, in ionic liquid solvents to provide the corresponding acridinium compounds in high yield.
摘要翻译：提供了用于在离子液体溶剂中将吖啶化合物（通常与1,3-丙磺酸内酯烷基化试剂）进行N-烷基化的方法，以高产率提供相应的吖啶鎓化合物。

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