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21. 发明申请

US20070093422A1 Drug comprising synthetic peptide analogs for the treatment of cancer 失效
标题翻译：包含用于治疗癌症的合成肽类似物的药物
公开(公告)号：US20070093422A1
公开(公告)日：2007-04-26
申请号：US11643342
申请日：2006-12-21
申请人： Rama Mukherjee , Anand Burman , Anu Singh , Manu Jaggi , Sudhanand Prasad , Sarjana Dutt
发明人： Rama Mukherjee , Anand Burman , Anu Singh , Manu Jaggi , Sudhanand Prasad , Sarjana Dutt
IPC分类号： A61K38/10 , C07K7/06
CPC分类号： A61K38/08 , A61K2300/00
摘要： The present invention relates to a combination of peptides that may be used for treatment of cancer. The peptide combination competes for the binding of specific neuropeptides at the plasma membrane and thereby alters the levels of key intracellular molecules implicated in cell proliferation, resulting in a broad spectrum of anticancer activity. The invention also relates to pharmaceutical compositions containing a combination of such peptide analogs.
摘要翻译：本发明涉及可用于治疗癌症的肽的组合。肽组合竞争在质膜上特异性神经肽的结合，从而改变涉及细胞增殖的关键细胞内分子的水平，导致广谱的抗癌活性。本发明还涉及含有这些肽类似物的组合的药物组合物。

22. 发明申请

US20060159783A1 Method for treating cancer using betulinic acid rich herbal extract 审中-公开
标题翻译：使用富含桦木酸的草药提取物治疗癌症的方法
公开(公告)号：US20060159783A1
公开(公告)日：2006-07-20
申请号：US11219482
申请日：2005-09-02
申请人： Rama Mukherjee , Dhiraj Khattar , Manu Jaggi , Anu Singh , Mukesh Kumar , Honey Bala
发明人： Rama Mukherjee , Dhiraj Khattar , Manu Jaggi , Anu Singh , Mukesh Kumar , Honey Bala
IPC分类号： A61K36/906
CPC分类号： A61K31/56 , A61K36/725
摘要： This invention relates to an orally effective herbal extract-based composition having broad-spectrum anticancer activity, more specifically a method of treating, inhibiting and/or preventing malignant tumors of the colon, intestine, stomach, breast, melanoma, glioblastoma, lung, cervix, ovary, prostate, oral cavity, larynx, liver, pancreas, kidney, bladder, endothelial cells, leukemia and myeloma using a herbal extract of Zizyphus, rich in betulinic acid. An advantage of the extract is that the betulinic acid has low systemic toxicity. The extract inhibits Protein Kinase C activity of cancer cells and induces apoptosis.
摘要翻译：本发明涉及具有广谱抗癌活性的口服有效的草药提取物组合物，更具体地，涉及治疗，抑制和/或预防结肠，肠，胃，乳腺，黑素瘤，成胶质细胞瘤，肺，子宫颈恶性肿瘤的方法，卵巢，前列腺，口腔，喉，肝，胰腺，肾，膀胱，内皮细胞，白血病和骨髓瘤，使用梓属的草药提取物，富含桦木酸。提取物的优点是桦木酸具有低的全身毒性。提取物抑制癌细胞的蛋白激酶C活性并诱导细胞凋亡。

23. 发明授权

US6156725A Drug for the treatment of cancer 失效
标题翻译：用于治疗癌症的药物
公开(公告)号：US6156725A
公开(公告)日：2000-12-05
申请号：US727679
申请日：1996-10-08
申请人： Rama Mukherjee , Manu Jaggi
发明人： Rama Mukherjee , Manu Jaggi
IPC分类号： A61K38/08 , A61K38/10 , C12N5/09 , A61K38/00
CPC分类号： C12N5/0693 , A61K38/08 , A61K38/10 , Y10S514/908
摘要： A pharmaceutical composition useful for killing or inhibiting multiplication of cancer cells. It is expected that the pharmaceutical composition will be useful in preventing, inhibiting, or modulating the hypersecretion of VIP, somatostatin, bombesin, Substance P, or a combination of VIP, somatostatin, bombesin, or Substance P. The composition may suitably comprise, consist of, or consist essentially of a therapeutically effective combination of peptide analogs of somatostatin, VIP, bombesin, and Substance P. Also provided is a method of treatment for humans or other animals suffering from cancer, the method comprising administering a therapeutically effective dose of the pharmaceutical composition so as to kill or inhibit the multiplication of cancer cells. The method of treatment may be particularly useful in the treatment of cancers of the colon and rectum. Also provided is a method of treatment for humans or animals having hypersecretion or modulation of VIP, somatostatin, bombesin, Substance P, or a combination of VIP, somatostatin, bombesin, or Substance P.
摘要翻译：用于杀死或抑制癌细胞增殖的药物组合物。预期药物组合物可用于预防，抑制或调节VIP，生长抑素，铃蟾肽，物质P或VIP，生长抑素，铃蟾肽或物质P的组合的高分泌。组合物可适当地包括，组成或基本上由生长抑素，VIP，铃蟾肽和物质P的肽类似物的治疗有效组合组成。还提供了治疗患有癌症的人或其他动物的方法，所述方法包括施用治疗有效剂量的药物组合物，以杀死或抑制癌细胞的增殖。治疗方法可能特别适用于结肠和直肠癌的治疗。还提供了对具有VIP，生长抑素，铃蟾肽，物质P或VIP，生长抑素，铃蟾肽或物质P的组合的过度分泌或调节的人或动物的治疗方法。

24. 发明授权

US5744363A Method for establishing a tumor-cell line by preparing single-cell suspension of tumor cells from tumor biopsies 失效
标题翻译：通过从肿瘤活检中制备肿瘤细胞的单细胞悬液来建立肿瘤细胞系的方法
公开(公告)号：US5744363A
公开(公告)日：1998-04-28
申请号：US764571
申请日：1996-12-13
申请人： Rama Mukherjee , Manu Jaggi
发明人： Rama Mukherjee , Manu Jaggi
IPC分类号： A61K38/08 , A61K38/10 , C12N5/09 , C12N5/00
CPC分类号： C12N5/0693 , A61K38/08 , A61K38/10
摘要： The present invention provides a novel method for the establishment of tumorigenic cell lines from biopsies of human or animal tumors. The method includes preparing a single-cell suspension of a tumor cells by injecting cell culture medium into an isolated tumor or a portion thereof to flush out the tumor cells. The tumor or portion thereof may be in a cell culture maintenance medium. The step of injecting cell culture medium into the isolated tumor or portion thereof involves piercing the tumor or portion thereof with a needle to inject the cell culture medium and flush out the tumor cells. The steps of piercing the tumor or portion thereof with a needle and injecting the cell culture medium to flush out the tumor cells preferably are repeated until the single-cell suspension has a particular cell density. The method also includes establishing a primary tumor cell culture by growing the cells from the single-cell suspension in a cell culture medium.
摘要翻译：本发明提供了一种用于从人或动物肿瘤的活检中建立致瘤细胞系的新方法。该方法包括通过将细胞培养基注入分离的肿瘤或其一部分来冲洗肿瘤细胞来制备肿瘤细胞的单细胞悬液。肿瘤或其部分可以在细胞培养维持培养基中。将细胞培养基注入分离的肿瘤或其部分的步骤包括用针刺穿肿瘤或其部分以注射细胞培养基并冲洗出肿瘤细胞。用针刺穿肿瘤或其部分并注射细胞培养基冲洗出肿瘤细胞的步骤最好重复进行，直到单细胞悬液具有特定的细胞密度。该方法还包括通过在细胞培养基中从单细胞悬浮液中培养细胞来建立原代肿瘤细胞培养物。

25. 发明授权

US6048847A Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this 失效
标题翻译：使用桦木酸及其衍生物抑制癌症生长及其监测方法
公开(公告)号：US6048847A
公开(公告)日：2000-04-11
申请号：US40856
申请日：1998-03-18
申请人： Sunder Ramadoss , Manu Jaggi , Mohammad Jamshed Ahmad Siddiqui
发明人： Sunder Ramadoss , Manu Jaggi , Mohammad Jamshed Ahmad Siddiqui
IPC分类号： A61K31/15 , A61K31/21 , A61K31/56 , C07J53/00 , C07J63/00
CPC分类号： C07J63/008 , A61K31/15 , A61K31/21 , A61K31/56 , C07J53/00 , Y10S514/908
摘要： The invention relates to use of betulinic acid and/or its derivatives for treating, inhibiting, and/or preventing tumors or cancer growth more particularly, to treating leukemia, lymphomas, lung, prostate and ovarian cancer. This invention also relates to novel betulinic acid derivatives and a composition containing betulinic acid derivatives with or without betulinic acid.
摘要翻译：本发明涉及桦木酸和/或其衍生物用于治疗，抑制和/或预防肿瘤或癌症生长，特别是治疗白血病，淋巴瘤，肺，前列腺和卵巢癌的用途。本发明还涉及新颖的桦木酸衍生物和含有或不含桦木酸的桦木酸衍生物的组合物。

26. 发明授权

US06228850B1 Antiangiogenic activity of betulinic acid and its derivatives 失效
标题翻译：桦木酸及其衍生物的抗血管生成活性
公开(公告)号：US06228850B1
公开(公告)日：2001-05-08
申请号：US09166809
申请日：1998-10-06
申请人： Manu Jaggi , Sunder Ramadoss , Praveen Rajendran , Mohammad Jamshed Ahmad Siddiqui
发明人： Manu Jaggi , Sunder Ramadoss , Praveen Rajendran , Mohammad Jamshed Ahmad Siddiqui
IPC分类号： A61K3115
CPC分类号： C07J63/008 , A61K31/15 , A61K31/21 , A61K31/56 , C07J53/00 , Y10S514/908 , A61K2300/00
摘要： Use of betulinic acid and/or its derivatives for inhibiting and/or preventing angiogenesis is described. Compositions containing betulinic acid derivatives with or without betulinic acid can be used for these purposed.
摘要翻译：描述了桦木酸和/或其衍生物用于抑制和/或预防血管生成的用途。含有或不含桦木酸的含桦木酸衍生物的组合物可用于这些用途。

27. 发明授权

US06670345B1 Betulinic acid derivatives for inhabiting cancer growth and process for the manufacture of betulinic acid 失效
标题翻译：用于抑制癌症生长的桦木酸衍生物和用于制备桦木酸的方法
公开(公告)号：US06670345B1
公开(公告)日：2003-12-30
申请号：US09431905
申请日：1999-11-02
申请人： Sunder Ramadoss , Manu Jaggi , Mohammad Jamshed Ahmad Siddiqui , Achla Behl Khanna
发明人： Sunder Ramadoss , Manu Jaggi , Mohammad Jamshed Ahmad Siddiqui , Achla Behl Khanna
IPC分类号： C07J5300
CPC分类号： C07J53/00 , C07J63/008
摘要： The invention relates to the use of betulinic acid derivatives for the inhibition and or prevention of cancer growth. The invention also relates to novel betulinic acid derivatives useful for inhibition of tumor cancer cells and a process for the preparation of the derivatives. The invention also relates to anti-leukemic and anti-lymphoma activity of the betulinic acid derivatives, and the use of the derivatives for the treatment of prostate, lung, laryngeal, colon and ovarian cancer.
摘要翻译：本发明涉及桦木酸衍生物用于抑制和/或预防癌症生长的用途。本发明还涉及可用于抑制肿瘤癌细胞的新型桦木酸衍生物和制备衍生物的方法。本发明还涉及桦木酸衍生物的抗白血病和抗淋巴瘤活性，以及该衍生物用于治疗前列腺，肺，喉，结肠和卵巢癌的用途。

28. 发明授权

US06403816B1 Betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis 失效
标题翻译：具有抗血管生成活性的桦木酸衍生物，制备这些衍生物的方法及其用于治疗肿瘤相关血管生成的用途
公开(公告)号：US06403816B1
公开(公告)日：2002-06-11
申请号：US09399617
申请日：1999-09-20
申请人： Manu Jaggi , Sunder Ramadoss , Praveen Rajendran , Mohammad Jamshed Ahmad Siddiqui
发明人： Manu Jaggi , Sunder Ramadoss , Praveen Rajendran , Mohammad Jamshed Ahmad Siddiqui
IPC分类号： C07J5300
CPC分类号： C07J63/008 , A61K31/15 , A61K31/21 , A61K31/56 , C07J53/00 , A61K2300/00
摘要： The invention relates to novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis.
摘要翻译：本发明涉及具有抗血管生成活性的新颖的桦木酸衍生物，用于制备此类衍生物的方法及其用于治疗肿瘤相关血管生成的用途。

29. 发明授权

US06214814B1 Use of betulinic acid derivatives for inhibiting cancer growth 失效
标题翻译：使用桦木酸衍生物抑制癌症生长
公开(公告)号：US06214814B1
公开(公告)日：2001-04-10
申请号：US09251309
申请日：1999-02-17
申请人： Sunder Ramadoss , Manu Jaggi , Mohammad Jamshed Ahmed Siddiqui , Achla B. Khanna
发明人： Sunder Ramadoss , Manu Jaggi , Mohammad Jamshed Ahmed Siddiqui , Achla B. Khanna
IPC分类号： A61K3156
CPC分类号： C07J63/008 , A61K31/15 , A61K31/21 , A61K31/56 , C07J53/00 , A61K2300/00
摘要： The invention relates to the use of betulinic acid and its derivatives for the inhibition and/or prevention or cancer growth. The invention also relates to novel betulinic acid derivatives useful for the inhibition of tumor/cancer cells and a process for the preparation of the derivatives. The invention also relates to the antileukemic, and anti-lymphoma activity of the betulinic acid derivatives, and the use of the derivatives for the treatment of prostate, ovarian and lung cancer.
摘要翻译：本发明涉及桦木酸及其衍生物用于抑制和/或预防或癌症生长的用途。本发明还涉及可用于抑制肿瘤/癌细胞的新型桦木酸衍生物和制备衍生物的方法。本发明还涉及桦木酸衍生物的抗白血病和抗淋巴瘤活性，以及该衍生物用于治疗前列腺癌，卵巢癌和肺癌的用途。

30. 发明申请

US20110034413A1 NOVEL QUERCETIN DERIVATIVES AS ANTI-CANCER AGENTS 审中-公开
标题翻译：作为抗癌药物的新型奎尼丁衍生物
公开(公告)号：US20110034413A1
公开(公告)日：2011-02-10
申请号：US12676709
申请日：2008-08-08
申请人： Narendra Shriram Joshi , Pawan Aggarwal , Vitthalbhai Ketan Hirpara , Manu Jaggi , Anu Singh , Anshumali Awasthi , Ritu Verma
发明人： Narendra Shriram Joshi , Pawan Aggarwal , Vitthalbhai Ketan Hirpara , Manu Jaggi , Anu Singh , Anshumali Awasthi , Ritu Verma
IPC分类号： A61K31/7008 , C07D311/30 , C07H5/06 , A61K31/352 , A61P35/00
CPC分类号： C07D311/30
摘要： The present invention provides novel Quercetin derivatives of formula (I) and pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1 is hydrogen, benzyl or substituted benzyl; R2 is hydrogen, benzyl or substituted benzyl, linear or branched (C1-C6) alkyl, substituted alkyl, aryl, substituted aryl, heterocycle and substituted heterocycle, useful for treatment of various disorders including cancer, multi-drug resistant cancers, viral infections etc. The invention also provides a process for the preparation of compounds of formula (I) and pharmaceutical compositions comprising the same.
摘要翻译：本发明提供新的式（I）槲皮素衍生物及其药学上可接受的盐，水合物和溶剂合物，其中R1是氢，苄基或取代的苄基; R2是氢，苄基或取代的苄基，直链或支链（C1-C6）烷基，取代的烷基，芳基，取代的芳基，杂环和取代的杂环，可用于治疗各种疾病，包括癌症，多药耐药性癌症，病毒感染等本发明还提供了制备式（I）化合物和包含其的药物组合物的方法。

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