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21. 发明申请

US20100300978A1 DEVICE, SYSTEM AND METHOD FOR WASHING AND ISOLATING MAGNETIC PARTICLES IN A CONTINOUS FLUID FLOW 审中-公开
标题翻译：用于在连续流体流中洗涤和分离磁性颗粒的装置，系统和方法
公开(公告)号：US20100300978A1
公开(公告)日：2010-12-02
申请号：US12679013
申请日：2007-09-19
申请人： Qasem Ramadan , Liang Zhu , Hongmiao Ji , Wen-Tso Liu
发明人： Qasem Ramadan , Liang Zhu , Hongmiao Ji , Wen-Tso Liu
IPC分类号： B03C1/02
CPC分类号： G01N33/54326 , B01L9/52 , B01L13/00 , B03C1/0332 , B03C1/288 , B03C2201/18
摘要： A device for washing and isolating magnetic particles from a continuous fluid flow in at least one fluidic channel having an inlet at one end and an outlet at another end, said device comprising at least one magnetic source carrier arranged proximate to the at least one fluidic channel. The at least one magnetic source carrier is moveable between a first position and a second position. The at least one magnetic source carrier comprises at least one first magnetic source, wherein a movement of the at least one magnetic source carrier to the first position places the at least one first magnetic source at a first spatial location along the at least one fluidic channel such that said at least one first magnetic source generates a maxima magnetic field at said first spatial location that attracts the magnetic particles from the continuous fluid flow and assembles said magnetic particles at said first spatial location. A movement of the at least one magnetic source carrier to the second position places the at least one first magnetic source distal from the first spatial location such that said magnetic field at said first spatial location is at a minima and the magnetic particles disperse from said first spatial location.
摘要翻译：一种用于在至少一个具有一端的入口和另一端的出口的流体通道中从连续的流体流中洗涤和分离磁性颗粒的装置，所述装置包括至少一个靠近所述至少一个流体通道布置的磁源载体。所述至少一个磁源载体可在第一位置和第二位置之间移动。所述至少一个磁源载体包括至少一个第一磁源，其中所述至少一个磁源载体到所述第一位置的移动将所述至少一个第一磁源置于沿所述至少一个流体通道的第一空间位置使得所述至少一个第一磁源在所述第一空间位置产生最大磁场，其吸引来自连续流体流的磁性颗粒，并在所述第一空间位置组装所述磁性颗粒。至少一个磁源载体到第二位置的移动将至少一个第一磁源远离第一空间位置放置，使得所述第一空间位置处的所述磁场处于最小值，并且磁性颗粒从所述第一空间位置分散空间位置。

22. 发明申请

US20100075892A1 Inhibition of SKP2-Cyclin a Interaction 有权
标题翻译：抑制SKP2细胞周期蛋白相互作用
公开(公告)号：US20100075892A1
公开(公告)日：2010-03-25
申请号：US12226935
申请日：2007-05-23
申请人： Liang Zhu , Peng Ji
发明人： Liang Zhu , Peng Ji
IPC分类号： A61K38/00 , C12N5/02 , C07K14/00 , C07K7/08
CPC分类号： C07K14/47 , A61K38/00
摘要： Methods of killing a cancer cell are provided. Also provided are methods of treating a subject having a cancer. Additionally, compounds are provided that comprise a peptide from about 18 to about 100 amino acids or peptidomimetics comprising the sequence of SEQ ID NO:1. Additionally provided are methods of screening an agent for the ability to kill a cancer cell.
摘要翻译：提供杀死癌细胞的方法。还提供了治疗患有癌症的受试者的方法。此外，提供了包含约18至约100个氨基酸的肽或包含SEQ ID NO：1的序列的肽模拟物的化合物。另外提供了筛选药剂以杀死癌细胞的能力的方法。

23. 发明授权

US06957111B2 Automated system for cooking and method of use 失效
公开(公告)号：US06957111B2
公开(公告)日：2005-10-18
申请号：US09938386
申请日：2001-08-24
申请人： Liang Zhu , Richard Bryan Sagar
发明人： Liang Zhu , Richard Bryan Sagar
IPC分类号： A23L5/10 , A47J27/62 , G06F17/00
CPC分类号： A47J27/62 , A23L5/13
摘要： The present invention comprises an improved device and method for automated cooking foods with a liquid such as water. In a preferred embodiment, the system comprises a cooking chamber (46); a controller (20); a residential home gateway server (10) comprising a memory and a communications interface operatively connected to the controller (20) and to the Internet (104); a hopper (42) for containing food; a stopper (44) in communication with the cooking chamber (46) and the hopper (42), the stopper (44) operatively connected to and selectively controllable by the controller (20) to provide a predetermined portion of the food from the hopper (42) into the cooking chamber (46); the stopper having at least one position in which it is sealingly engaged against the cooking chamber (46) and the hopper (42) to prevent steam generated by the cooking process from entering into the hopper (42) during cooking; a conduit (30) in communication with the cooking chamber (46) for providing liquid into the cooking chamber (46); and a valve (32) disposed intermediate the conduit (30) and the cooking chamber (46) and operatively connected to and selectively controllable by the controller (20). The method comprises receiving data from a remote source, the data comprising a desired amount of servings of the food and a starting time for preparation of the food; determining the cooking characteristics of the food, comprising liquid needs for the food and cooking time; providing food into the cooking chamber (46) from the hopper (42) in a quantity sufficient to satisfy the desired servings; providing liquid into the compartment from the conduit (30) sufficient to satisfy liquid requirements of the food for the number of serving requirements; and engaging a cooking element accessible to the cooking chamber (46) sufficient to satisfy cooking time requirements for the desired number of servings.

24. 发明授权

US08173604B2 Inhibition of Skp2-cyclin a interaction 有权
标题翻译：抑制Skp2细胞周期蛋白的相互作用
公开(公告)号：US08173604B2
公开(公告)日：2012-05-08
申请号：US12226935
申请日：2007-05-23
申请人： Liang Zhu , Peng Ji
发明人： Liang Zhu , Peng Ji
IPC分类号： A61K38/10 , A61K38/16
CPC分类号： C07K14/47 , A61K38/00
摘要： Methods of killing a cancer cell are provided. Also provided are methods of treating a subject having a cancer. Additionally, compounds are provided that comprise a peptide from about 18 to about 100 amino acids or peptidomimetics comprising the sequence of SEQ ID NO:1. Additionally provided are methods of screening an agent for the ability to kill a cancer cell.
摘要翻译：提供杀死癌细胞的方法。还提供了治疗患有癌症的受试者的方法。此外，提供了包含约18至约100个氨基酸的肽或包含SEQ ID NO：1的序列的肽模拟物的化合物。另外提供了筛选药剂以杀死癌细胞的能力的方法。

25. 发明申请

US20110281308A1 Yellow Pigments Generation Deficient Sphingomonas Strain and Application Thereof in Gellan Gum Production 有权
标题翻译：黄色素生成缺乏的鞘氨醇单胞菌菌株及其在结冷胶生产中的应用
公开(公告)号：US20110281308A1
公开(公告)日：2011-11-17
申请号：US13142412
申请日：2010-08-13
申请人： Xuechang Wu , Rongming Wu , Ou Li , Liang Zhu , Yamin Chen , Chaodong Qian , Mei Chen
发明人： Xuechang Wu , Rongming Wu , Ou Li , Liang Zhu , Yamin Chen , Chaodong Qian , Mei Chen
IPC分类号： C12P19/04 , C12N1/20
CPC分类号： C12R1/01 , C12P19/04
摘要： A yellow pigments generation deficient Sphingomonas strain (Sphingomonas sp. ZD001) and application thereof in preparing gellan gum by microbial fermentation are provided. The strain is preserved in China Center for Type Culture Collection (CCTCC) with the address of Wuhan University, Wuhan, 430072, China, the preservation date of the strain is 10 Sep. 2009, and the preservation serial number is CCTCC No: M 209298. The main beneficial effect of the present invention is that the fermented liquor contains no yellow pigments but is milky white, colorless superior gellan gum can be obtained by only depositing polysaccharide with a small quantity of ethanol or isopropanol, so that the post purification and de-coloration techniques of gellan gum production can be simplified, the yield can be enhanced, and the production cost can be reduced.
摘要翻译：提供黄色色素代谢缺陷型鞘氨醇单胞菌（Sphingomonas sp。ZD001）及其通过微生物发酵制备吉兰糖胶的应用。该菌株保藏在中国类型培养物保藏中心（CCTCC），武汉大学地址，武汉，430072，保护期为2009年9月10日，保藏号为CCTCC号：209198 本发明的主要有益效果在于，发酵液不含黄色颜料，但为乳白色，仅通过少量乙醇或异丙醇沉淀多糖即可获得无色的优质结冷胶，因此后期纯化和脱色可以简化结冷胶生产的成色技术，可以提高产量，降低生产成本。

26. 发明申请

US20110229560A1 NLRC5 AS A TARGET FOR IMMUNE THERAPY 审中-公开
标题翻译： NLRC5作为免疫治疗的目标
公开(公告)号：US20110229560A1
公开(公告)日：2011-09-22
申请号：US13122838
申请日：2009-10-06
申请人： Rong-Fu Wang , Helen Y. Wang , Jun Cui , Liang Zhu
发明人： Rong-Fu Wang , Helen Y. Wang , Jun Cui , Liang Zhu
IPC分类号： A61K9/127 , A61K31/7105 , A61K38/02 , A61K31/7088 , A61K35/12 , A61P35/00 , A61P37/04 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/06 , A61P31/18 , A61P31/16 , A61P31/10 , A61P31/14 , A61P31/22
CPC分类号： C07K14/705 , C12N15/1138 , C12N2310/14
摘要： The present invention concerns the enhancement of immune response to microbial infection and/or inflammation-associated disease through at least partial inhibition of NLRC5. The inhibition may be of any suitable means, although in particular cases it is via siRNA agents. In specific embodiments, a particular domain of NLRC5 is targeted by the siRNA.
摘要翻译：本发明涉及通过至少部分抑制NLRC5来增强对微生物感染和/或炎症相关疾病的免疫应答。抑制可以是任何合适的手段，尽管在特定情况下它是通过siRNA试剂。在具体实施方案中，NLRC5的特定结构域被siRNA靶向。

27. 发明授权

US07408551B1 Performance-based representation for support of multiple decisions 失效
标题翻译：基于绩效的代表支持多项决策
公开(公告)号：US07408551B1
公开(公告)日：2008-08-05
申请号：US09578108
申请日：2000-05-24
申请人： David Kazmer , Liang Zhu
发明人： David Kazmer , Liang Zhu
IPC分类号： G06T11/20
CPC分类号： G06F17/10
摘要： A computer-implemented decision support system provides a performance-based representation using multi-dimensional clipping and transformation algorithms. Three types of supporting information are presented to the decision maker: a function matrix that describes the performance attributes varying with the decision variables; a decision space that illustrates the feasible decision set that meets performance requirements; and, a performance space that provides the feasible performance region displays the Pareto Optimal set.
摘要翻译：计算机实现的决策支持系统使用多维裁剪和变换算法提供基于性能的表示。向决策者提供三种类型的支持信息：描述根据决策变量变化的性能属性的函数矩阵; 说明满足性能要求的可行决策集的决策空间; 并且，提供可行性能区域的性能空间显示帕累托最优集。

28. 发明授权

US09075423B2 Generating a regulated signal from another regulated signal 有权
标题翻译：从另一个调节信号产生调节信号
公开(公告)号：US09075423B2
公开(公告)日：2015-07-07
申请号：US12859478
申请日：2010-08-19
申请人： Liang Zhu , Jun Liu , Hai Bo Zhang
发明人： Liang Zhu , Jun Liu , Hai Bo Zhang
IPC分类号： G05F1/577 , G05F1/575 , H02M3/145
CPC分类号： G05F1/575
摘要： An embodiment of a method includes generating a regulated output signal from a regulated intermediate signal in response to a reference signal and the regulated output signal, and generating the regulated intermediate signal from an input signal in response to the regulated output signal and the regulated intermediate signal. By generating one regulated signal (e.g., a regulated output voltage) from another regulated signal (e.g., a regulated intermediate voltage), the magnitude of the ripple component of the one regulated signal may be reduced. Furthermore, by generating the regulated intermediate signal in response to the regulated output signal, the efficiency of the regulation may be increased.
摘要翻译：一种方法的实施例包括响应于参考信号和调节的输出信号从调节的中间信号产生调节的输出信号，以及响应于调节的输出信号和调节的中间信号从输入信号产生调节的中间信号。通过从另一调节信号（例如，调节中间电压）产生一个调节信号（例如，调节输出电压），可以减小一个调节信号的纹波分量的幅度。此外，通过响应于调节的输出信号产生调节的中间信号，可以提高调节的效率。

29. 发明申请

US20140329799A1 AMINOPYRIMIDINONES AS INTERLEUKIN RECEPTOR-ASSOCIATED KINASE INHIBITORS 有权
标题翻译：作为白介素受体相关激酶抑制剂的氨基酰亚胺
公开(公告)号：US20140329799A1
公开(公告)日：2014-11-06
申请号：US14355353
申请日：2012-10-26
申请人： W. Michael Seganish , Stephanie Nicole Brumfield , Jongwon Lim , Julius J. Matasi , William T. Mcelroy , Deen B. Tulshian , Brian J. Lavey , Michael D. Altman , Criag R. Gibeau , John William Lampe , Joey Methot , Liang Zhu
发明人： W. Michael Seganish , Stephanie Nicole Brumfield , Jongwon Lim , Julius J. Matasi , William T. Mcelroy , Deen B. Tulshian , Brian J. Lavey , Michael D. Altman , Criag R. Gibeau , John William Lampe , Joey Methot , Liang Zhu
IPC分类号： C07D417/04 , A61K45/06 , C07D417/14 , C07D513/04 , C07D487/10 , C07D401/04 , A61K31/5377 , A61K31/513 , C07D491/107
CPC分类号： C07D417/04 , A61K31/513 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/08 , C07D487/10 , C07D491/08 , C07D491/10 , C07D491/107 , C07D495/08 , C07D513/04
摘要： This invention relates to aminopyrimidinone compounds of Formula (I) that are inhibitors of Interleukin receptor-associated kinases, in particular IRAK-4, and are useful in the treatment or prevention of inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease.
摘要翻译：本发明涉及作为白介素受体相关激酶抑制剂，特别是IRAK-4的式（I）的氨基嘧啶酮化合物，可用于治疗或预防炎性疾病，包括类风湿性关节炎和炎症性肠病。

30. 发明授权

US08693565B2 Method and device for transmitting and receiving signal in wireless communication system 有权
标题翻译：无线通信系统中发送和接收信号的方法和装置
公开(公告)号：US08693565B2
公开(公告)日：2014-04-08
申请号：US13223620
申请日：2011-09-01
申请人： Ning Ge , Liang Zhu , Yukui Pei
发明人： Ning Ge , Liang Zhu , Yukui Pei
IPC分类号： H04B7/02
CPC分类号： H04L25/03343
摘要： A method and device for transmitting and receiving a signal in a wireless communication system. The method for transmitting a signal in a wireless communication system includes: receiving an original data block to be transmitted, the length of the original data block being M, wherein M is an integer; disordering the original data block for one or more times, whereby M data symbols in the original data block are rearranged in each of the one or more times of the disordering, so as to obtain one or more disordered data blocks with length of M; cascading the original data block and the one or more disordered data blocks with a cyclic prefix, to form an equalized signal of frequency domain diversity with time-frequency interleaving; and transmitting the equalized signal of frequency domain diversity through a single carrier.
摘要翻译：一种用于在无线通信系统中发送和接收信号的方法和装置。在无线通信系统中发送信号的方法包括：接收要发送的原始数据块，原始数据块的长度为M，其中M为整数; 原始数据块一次或多次失调，由此原始数据块中的M个数据符号在一次或多次无序中的每一个中重新排列，以便获得长度为M的一个或多个无序数据块; 以循环前缀级联原始数据块和一个或多个无序数据块，以形成具有时频交织的频域分集的均衡信号; 并通过单载波传输频域分集的均衡信号。

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