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21. 发明申请

US20070066932A1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US20070066932A1
公开(公告)日：2007-03-22
申请号：US11522095
申请日：2006-09-14
申请人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
发明人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/303 , A61N5/0601 , A61N5/0603 , A61N5/062 , A61N2005/0606 , A61N2005/063 , A61N2005/0644 , A61N2005/0651
摘要： An shaped iontophoresis device is capable of permeating an active agent (e.g., a drug solution) into an oral cavity, a skin cancer, or the like by iontophoresis in a pinpoint manner. A catheter-type iontophoresis device includes a small working electrode assembly and a small non-working electrode assembly at the tip of a holding portion. A first ion exchange membrane and a fourth ion exchange membrane at the tips of the assemblies are brought into close contact with a target area so that a drug solution is permeated by iontophoresis in a pinpoint manner. The working electrode assembly and the non-working electrode assembly 14 are attached to the tip of a rod-shaped member. The rod-shaped member is detachable from the tip of the holding portion, and is exchangeable integrally with the portion. The iontophoresis device may advantageously take the form of a rod or catheter.
摘要翻译：成形的离子电渗装置能够以精确的方式通过离子电渗法将活性剂（例如药物溶液）渗透到口腔，皮肤癌等中。导管型离子电渗疗法装置包括小型工作电极组件和在保持部分的尖端处的小型非工作电极组件。在组件顶端的第一离子交换膜和第四离子交换膜与目标区域紧密接触，使得药液以精确的方式通过离子电渗渗透。工作电极组件和非工作电极组件14附接到杆状构件的尖端。杆状构件可从保持部的顶端拆卸，并且与该部分一体地更换。离子电渗装置可以有利地采取棒或导管的形式。

22. 发明申请

US20060116628A1 Iontophoresis device 审中-公开
标题翻译：离子渗透装置
公开(公告)号：US20060116628A1
公开(公告)日：2006-06-01
申请号：US11172058
申请日：2005-06-30
申请人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
发明人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0436 , A61N1/0448
摘要： An iontophoresis device is capable of suppressing the change in a composition of a drug solution and/or an electrolyte solution of a working electrode structure, thereby allowing the working electrode structure to be retained in a stable state for a long period of time. The iontophoresis device includes: an electrolyte solution holding part for holding an electrolyte solution in which an electrolyte to be dissociated, in a solution, to first electrolytic ions of a first polarity and second electrolytic ions of a second polarity is dissolved; and a drug solution holding part for holding a drug solution in which a drug to be dissociated, in a solution, to the drug ions of the first polarity and drug counter ions of the second polarity is dissolved. A first ion-exchange membrane for selectively passing the ions of the second polarity and a porous separation membrane for blocking passage of molecules and ions each having a molecular weight exceeding a threshold are placed between the electrolyte solution holding part and the drug solution holding part.
摘要翻译：离子电渗疗法装置能够抑制药液和/或工作电极结构体的电解质溶液的组成变化，从而使工作电极结构长期保持在稳定状态。离子电渗装置包括：电解液保持部，其用于保持电解质溶液，其中溶解有解离的电解质溶解于第一极性的第一电解质离子和第二极性的第二电解质离子; 并且溶解有溶液中解离药物的第一极性的药物离子和第二极性的药物抗衡离子的药液的药物溶液保持部溶解。用于选择性地通过第二极性的离子的第一离子交换膜和用于阻止分子量超过阈值的分子和离子通过的多孔分离膜被放置在电解质溶液保持部和药物溶液保持部之间。

23. 发明申请

US20060095001A1 Electrode and iontophoresis device 审中-公开
标题翻译：电极和离子电渗装置
公开(公告)号：US20060095001A1
公开(公告)日：2006-05-04
申请号：US11171953
申请日：2005-06-30
申请人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
发明人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/0428 , A61N1/0436 , A61N1/0444 , A61N1/0448 , A61N1/048 , A61N1/0492
摘要： There are provided an electrode that is capable of allowing a current to flow at a uniform current density from the entire surface of a conductive sheet during the passage of a current and that solves the problem of the transfer of metal ions to a living body. The electrode comprises a conductive terminal member formed of a non-metal material; and a conductive sheet formed of a non-metal material and attached to the terminal member, the conductive sheet having a specific resistance lower than a specific resistance of the terminal member. An lontophoresis device and a low-frequency treatment device utilizing the electrode is also disclosed.
摘要翻译：提供了一种电极，其能够在电流通过期间允许电流以均匀的电流密度从导电片的整个表面流动，并且解决了金属离子转移到生物体的问题。电极包括由非金属材料形成的导电端子构件; 以及由非金属材料形成并附接到端子构件的导电片，所述导电片具有比端子构件的电阻率低的电阻率。还公开了一种使用电极的离子电泳装置和低频处理装置。

24. 发明申请

US20090254018A1 Electrode assembly for freezing-type iontophoresis device 审中-公开
标题翻译：用于冷冻型离子电渗装置的电极组件
公开(公告)号：US20090254018A1
公开(公告)日：2009-10-08
申请号：US11990882
申请日：2006-08-24
申请人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/0428 , A61N1/0444 , A61N1/0448
摘要： An iontophoresis device capable of stably holding a drug during a storage period and of transdermally administering the drug to an organism at a high transport number during use. The iontophoresis device includes an electric power source. A first electrode assembly may be electrically coupled to the electric power source to store and transdermally administer an ionic drug to an organism via iontophoresis. The first electrode assembly stores the ionic drug at a temperature less than or equal to zero degrees Celsius and administers the ionic drug at a temperature greater than zero degrees Celsius. A second electrode assembly may be electrically coupled to the electric power source as a counter electrode to the first electrode assembly.
摘要翻译：一种离子电渗疗法装置，其能够在保存期间稳定地保持药物，并且在使用期间以高转运数量将药物透皮给药至生物体。离子电渗装置包括电源。第一电极组件可以电耦合到电源，以通过离子电渗法存储并透皮地将离子药物施用于生物体。第一电极组件将离子药物存储在低于或等于零摄氏度的温度，并在高于零摄氏度的温度下施用离子药物。第二电极组件可以作为与第一电极组件的对电极电耦合到电源。

25. 发明申请

US20090214625A1 DRUG DELIVERY PATCH 审中-公开
标题翻译：药物输送管
公开(公告)号：US20090214625A1
公开(公告)日：2009-08-27
申请号：US11995796
申请日：2006-07-18
申请人： Mizuo Nakayama , Akihiko Matsumura , Takehiko Matsumura , Hidero Akiyama
发明人： Mizuo Nakayama , Akihiko Matsumura , Takehiko Matsumura , Hidero Akiyama
IPC分类号： A61K9/70 , A61P43/00
CPC分类号： A61N1/30 , A61F13/0213 , A61K9/0009 , A61K9/703 , A61K9/7038
摘要： The site to which a patch was stuck may be identified even after the patch is removed.A patch for drug delivery includes a drug holding portion and a backing layer. The patch further includes a marker capable of indicating a site to which the patch was stuck even after the patch is removed therefrom.
摘要翻译：即使在补丁被删除之后，也可能会识别补丁被卡住的站点。用于药物递送的贴剂包括药物保持部分和背衬层。斑块还包括能够指示斑块被卡住的位置的标记，即使在贴片从其移除之后。

26. 发明申请

US20070088332A1 Iontophoresis device 审中-公开
标题翻译：离子渗透装置
公开(公告)号：US20070088332A1
公开(公告)日：2007-04-19
申请号：US11508732
申请日：2006-08-22
申请人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
发明人： Hidero Akiyama , Mizuo Nakayama , Takehiko Matsumura , Akihiko Matsumura
IPC分类号： A61K9/22
CPC分类号： A61N1/0448 , A61N1/044 , A61N1/0444
摘要： Contamination between an active agent solution in an active agent reservoir and an electrolyte solution in an electrolyte solution reservoir may be reduced in an iontophoresis device, thus helping to suppress the generation of gas and helping to reduce changes in pH upon energization. A gel matrix that transforms into a liquid state upon thermal excitation and/or mechanical excitation may be used in one or more reservoirs in the iontophoresis device.
摘要翻译：活性剂储存器中的活性剂溶液与电解质溶液储存器中的电解质溶液之间的污染可以在离子电渗装置中减少，从而有助于抑制气体的产生并有助于减少通电时的pH变化。在热激发和/或机械激发时转变为液态的凝胶基质可用于离子电渗装置中的一个或多个储存器。

27. 发明申请

US20070088331A1 Method and apparatus for managing active agent usage, and active agent injecting device 审中-公开
标题翻译：用于管理活性剂使用的方法和装置，以及活性剂注入装置
公开(公告)号：US20070088331A1
公开(公告)日：2007-04-19
申请号：US11506404
申请日：2006-08-18
申请人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61K9/22
CPC分类号： A61N1/303 , A61K9/0009 , A61N1/08
摘要： Whether or not a prescribed active agent is properly used may be confirmed. Usage of an active agent to be administered by an active agent injecting device (such as an iontophoresis device) driven by a drive signal may managed through a server based on actual drive information from the active agent injecting device.
摘要翻译：可以确认是否正确使用规定的活性剂。通过由驱动信号驱动的活性剂注入装置（例如离子渗透装置）施用的活性剂的使用可以基于来自活性剂注入装置的实际驱动信息通过服务器进行管理。

28. 发明申请

US20070066931A1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US20070066931A1
公开(公告)日：2007-03-22
申请号：US11501176
申请日：2006-08-07
申请人： Kiyoshi Kanamura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Akihiko Matsumura
发明人： Kiyoshi Kanamura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/0444
摘要： An iontophoresis device may be capable of preventing or reducing the generation of gas, or the production of undesirable ions, due to an electrode reaction occurring in an electrode assembly; or the alteration of an active agent due to a chemical reaction upon energization. A doping layer made of a substance such as a conductive polymer that effects an electrochemical reaction due to the doping or de-doping of an ion, may be formed in an electrode in an active electrode assembly or counter electrode assembly of an iontophoresis device.
摘要翻译：离子电渗装置可以由于在电极组件中发生电极反应而能够防止或减少气体的产生或不需要的离子的产生; 或由于通电时的化学反应引起的活性剂的改变。可以在离子电渗装置的有源电极组件或对电极组件中的电极中形成由诸如导电聚合物的物质制成的掺杂层，其由于离子的掺杂或去掺杂而实现电化学反应。

29. 发明申请

US20070060859A1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US20070060859A1
公开(公告)日：2007-03-15
申请号：US11501672
申请日：2006-08-08
申请人： Kiyoshi Kanamura , Nobuharu Kosiba , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Kiyoshi Kanamura , Nobuharu Kosiba , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044 , A61N1/0444 , A61N1/0448
摘要： An iontophoresis device including an active electrode assembly or a counter electrode assembly with a polarizable electrode containing any one of a conductive material having a capacitance per unit weight of 1 F/g or greater, a conductive material having a specific surface area of 10 m2/g or greater, and activated carbon is disclosed. The generation of gas or ions due to an electrode reaction occurring in an electrode assembly may be reduced or prevented. In addition, the alteration of an active agent due to a chemical reaction upon energization may be reduced or prevented.
摘要翻译： 1.一种离子电渗疗法装置，其特征在于，包括具有可极化电极的活性电极组件或对电极组件，所述可极化电极含有每单位重量的电容为1F / g以上的导电材料，比表面积为10m 2 / g以上，并且公开了活性炭。可以减少或防止由于在电极组件中发生电极反应而产生气体或离子。此外，可以减少或防止由于通电时的化学反应引起的活性剂的改变。

30. 发明授权

US08386030B2 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US08386030B2
公开(公告)日：2013-02-26
申请号：US11501672
申请日：2006-08-08
申请人： Kiyoshi Kanamura , Nobuharu Kosiba , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Kiyoshi Kanamura , Nobuharu Kosiba , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30 , A61M31/00 , A61F13/00
CPC分类号： A61N1/0436 , A61N1/044 , A61N1/0444 , A61N1/0448
摘要： An iontophoresis device including an active electrode assembly or a counter electrode assembly with a polarizable electrode containing any one of a conductive material having a capacitance per unit weight of 1 F/g or greater, a conductive material having a specific surface area of 10 m2/g or greater, and activated carbon is disclosed. The generation of gas or ions due to an electrode reaction occurring in an electrode assembly may be reduced or prevented. In addition, the alteration of an active agent due to a chemical reaction upon energization may be reduced or prevented.
摘要翻译： 1.一种离子电渗疗法装置，其特征在于，包括具有可极化电极的活性电极组件或对电极组件，所述可极化电极含有每单位重量的电容为1F / g以上的导电材料，比表面积为10m 2 / g以上，并且公开了活性炭。可以减少或防止由于在电极组件中发生电极反应而产生气体或离子。此外，可以减少或防止由于通电时的化学反应引起的活性剂的改变。

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